プロフィール詳細

プロジェクトを作成

★★★★★

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Jose Francis O.に依頼

Brazil

Pharmacist and Neuroscientist for scientific and medical writing

プロフィール概要

I have a wide background in neurosciences, with expertise in the serotonergic system and how it can affect behavior. In my PhD thesis, I investigated depressive-like behavior and the serotonergic system using the maternal separation model, looking at the role of potassium channel TREK-1 and 5HT1A receptors on synaptic plasticity at the prelimbic cortex and the neural stress response. Currently, the cingulate cortex is my focus, with emphasis on the projection from cingulate to prelimbic cortex and its role in modulating social and depressive-like behavior. My skills include molecular biology techniques such as immunohistochemistry, immunofluorescence and western blot, drug administration in rodents, behavioral testing, brain slice electrophysiology and stereotaxic surgery in rodents. At the moment I'm working to further develop techniques in the neurosciences, such as in vivo calcium imaging and optogenetics. Have some experience writing grants, as I got funding for my PhD project and participated in writing two grants for the laboratory which was awarded. Alongside my Master’s and PhD, I cooperated with my peers and guided other undergraduate and Master students, giving me teamwork experience. Additionally, I acquired teaching skills when I worked as faculty for undergraduate and graduate courses for some years in Brazilian universities, where I taught physiology, biophysics, pharmacology and neurosciences.

専門分野

• ★ Neuroscience
• ☆ Neurophysiology
• ☆ Drug Development
• ☆ Preclinical Pharmacology
• ☆ Human Physiology
• ☆ Psychopharmacology
• ☆ Medical Sciences

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing, Technical Writing, Creative Writing, Translation

Research Scientific and Technical Research, Systematic Literature Review

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization

職務経験

Postdoctoral Fellow

The University of Alabama at Birmingham

5月 2021 - 現在

Professor Assistente (Temporário) - Farmacologia

Universidade Estadual do Oeste do Paraná

1月 2021 - 4月 2021

Professor Assistente (Temporário) - Farmacologia

Universidade Estadual de Londrina

8月 2020 - 4月 2021

Professor de Neurociências

Unicampo

11月 2014 - 12月 2015

Professor Fisiologia e Biofísica

Faculdade Dom Bosco

3月 2014 - 12月 2015

Professor Análises Clínicas

Centro Universitário Filadélfia

3月 2011 - 2月 2014

学歴

PhD in Human Physiology (Fisiologia e Biofísica)

Universidade de São Paulo

5月 2016 - 5月 2020

MSc in Physiological Sciences (Ciências Fisiológicas)

Universidade Estadual de Londrina

3月 2011 - 2月 2013

Pharmacy (Farmácia)

Universidade Estadual de Londrina

3月 2006 - 12月 2010

認定資格

• C2 English

  Cambridge English

  1月 2026 - 現在

出版物

JOURNAL ARTICLE

Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, José Francis-Oliveira, Emily Cruvinel, Thainá Soares Franchin, Tania Marcourakis, Henning Ulrich, Roberto De Pasquale (2024). Serotonergic Neuromodulation of Synaptic Plasticity . Neuropharmacology.

Owen Leitzel, Jose Francis-Oliveira, Shaimaa M. Khedr, Lila Ariste, Stefanie Robel, Shin-ichi Kano, Andrew Arrant, Minae Niwa (2024). Adolescent stress accelerates postpartum novelty recognition impairment in 5xFAD mice . Frontiers in Neuroscience.

Niwa M, Lockhart S, Wood DJ, Yang K, Francis-Oliveira J, Kin K, Ahmed A, Wand GS, Kano SI, Payne JL, et al. (2024). Prolonged HPA axis dysregulation in postpartum depression associated with adverse early life experiences: A cross-species translational study . Nature. Mental health.

José Francis-Oliveira, Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, Emily Cruvinel, Estevão Carlos-Lima, Fernando da Silva Borges, Thais Tessari Zampieri, Fernanda Pereira Rebello, Henning Ulrich, Roberto De Pasquale (2024). TREK-1 inhibition promotes synaptic plasticity in the prelimbic cortex . Experimental Neurology.

Estevão Carlos-Lima, Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, Alicia Moraes Tamais, Emily Cruvinel, Fernando da Silva Borges, José Francis-Oliveira, Henning Ulrich, Roberto De Pasquale (2023). Serotonergic Modulation of the Excitation/Inhibition Balance in the Visual Cortex . International Journal of Molecular Sciences.

Estevão Carlos-Lima, Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, Alicia Moraes Tamais, Emily Cruvinel, Fernando da Silva Borges, José Francis-Oliveira, Henning Ulrich, Roberto De Pasquale (2023). Serotonergic Modulation of the Excitation/Inhibition Balance in the Visual Cortex . International Journal of Molecular Sciences.

Lucila Emiko Tsugiyama, Ruan Carlos Macedo Moraes, Yaslle Andrade Cavalcante Moraes, Jose Francis-Oliveira (2023). Promising new pharmacological targets for depression: The search for efficacy . Drug Discovery Today.

Kyohei Kin, Jose Francis-Oliveira, Shin-ichi Kano, Minae Niwa (2023). Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice . Nature Communications.

Carolina Parga Martins Pereira, José Francis-Oliveira, Monique Patricio Singulani, Ana Flávia Fernandes Ferreira, Luiz Roberto G. Britto (2023). Microglial depletion exacerbates motor impairment and dopaminergic neuron loss in a 6-OHDA model of Parkinson's disease . Journal of Neuroimmunology.

Guilherme Shigueto Vilar Higa, José Francis-Oliveira, Estevão Carlos-Lima, Alicia Moraes Tamais, Fernando da Silva Borges, Alexandre Hiroaki Kihara, Ianê Carvalho Shieh, Henning Ulrich, Silvana Chiavegatto, Roberto De Pasquale (2022). 5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development . Scientific Reports.

Sara Joushi, Vahid Sheibani, Khadijeh Esmaeilpour, José Francis‐Oliveira, Zahra Taherizadeh, Fatemeh Mohtashami Borzadaran(2021). Maternal separation impairs mother's cognition 1 month beyond the separation . International Journal of Developmental Neuroscience. 81. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 605--615. Wiley

Sara Joushi and Vahid Sheibani and Khadijeh Esmaeilpour and Jos{\'{e}} Francis-Oliveira and Zahra Taherizadeh and Fatemeh Mohtashami Borzadaran(2021). Maternal separation impairs mother's cognition 1 month beyond the separation . International Journal of Developmental Neuroscience. Wiley

J. Francis-Oliveira and I.C Shieh and G.S. Vilar Higa and M.A. Barbosa and R. De Pasquale(2021). Maternal separation induces changes in TREK-1 and 5HT1A expression in brain areas involved in the stress response in a sex-dependent way . Behavioural Brain Research. 396. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 112909. Elsevier {BV}

(2018). Maternal exposure to fluoxetine during gestation and lactation induces long lasting changes in the DNA methylation profile of offspring’s brain and affects the social interaction of rat . Brain Research Bulletin.

A.S. Silva, L.V. Toffoli, V.B. Estrada, L.F. Veríssimo, J. Francis-Oliveira, E.G. Moreira, M.V. Gomes, G.G. Pelosi(2018). Maternal exposure to fluoxetine during gestation and lactation induces long lasting changes in the DNA methylation profile of offspring’s brain and affects the social interaction of rat . Brain Research Bulletin. 142. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 409--413. Elsevier {BV}

José Francis-Oliveira, Guilherme S. Vilar Higa, Lívia Mendonça Munhoz Dati, Ianê Carvalho Shieh, Roberto De Pasquale(2018). Metaplasticity in the Visual Cortex: Crosstalk Between Visual Experience and Reactive Oxygen Species . The Journal of Neuroscience. 38. (25). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5649--5665. Society for Neuroscience

Francis-Oliveira J, Vilar Higa GS, Mendonça Munhoz Dati L, Carvalho Shieh I, De Pasquale R(2018). Metaplasticity in the Visual Cortex: Crosstalk Between Visual Experience and Reactive Oxygen Species . The Journal of neuroscience : the official journal of the Society for Neuroscience.

Beckhauser, T. F., Francis-Oliveira, J., De Pasquale, R.(2016). Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity . J Exp Neurosci. 10. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 23-48.

Rodrigues, G.M., Toffoli, L.V., Manfredo, M.H., Francis-Oliveira, J., Silva, A.S., Raquel, H.A., Martins-Pinge, M.C., Moreira, E.G., Fernandes, K.B., Pelosi, G.G., et al.(2015). Acute stress affects the global DNA methylation profile in rat brain: Modulation by physical exercise . Behavioural Brain Research. 279. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 123-128.

Toffoli, L.V., Rodrigues, G.M., Oliveira, J.F., Silva, A.S., Moreira, E.G., Pelosi, G.G., Gomes, M.V.(2014). Maternal exposure to fluoxetine during gestation and lactation affects the DNA methylation programming of rat's offspring: Modulation by folic acid supplementation . Behavioural Brain Research. 265. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 142-147.

Francis-Oliveira, J., Ponte, B., Barbosa, A.P.M., Veríssimo, L.F., Gomes, M.V., Pelosi, G.G., de Britto, L.R.G., Moreira, E.G.(2013). Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats . Behavioural Brain Research. 252. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 195-203.