プロフィール詳細

プロジェクトを作成

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Dr. Joshua S.に依頼

United States

Neuroscientist and biochemist with 10+ years experience. Specific expertise in -omic data analysis and drug screening.

プロフィール概要

A neuroscientist and biochemist at Tufts University, Boston. Research interests include the characterization of neuronal plasma membrane protein complex composition in order to identify novel drug targets. This work involves the development large data-rich 'omic' technologies and bioinformatic analyses. Published in numerous high-impact journals and also provide regular peer review for several journals.

専門分野

• ★ Proteomics
• ★ Data Analysis
• ★ Peer Review
• ☆ Biochemistry
• ☆ Transcriptomics
• ☆ Neuroscience
• ☆ Scientific Proofreading & Editing

サービス

• Writing
• Consulting
• Data & AI

Writing Technical Writing

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization

職務経験

Research Associate (Research Scientist)

Tufts University

7月 2020 - 現在

Postdoctoral Scholar

Tufts University

9月 2015 - 7月 2020

Postdoctoral Scholar

University of Leciester

2月 2013 - 9月 2015

学歴

Doctor of Philosophy (Ph.D)

University of Leicester

9月 2008 - 9月 2012

Masters of Science

University of Surrey

9月 2007 - 9月 2008

Bachelor of Science (Honours)

University of Surrey

9月 2003 - 7月 2007

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Kontou G, Josephine Ng SF, Cardarelli RA, Howden JH, Choi C, Ren Q, Rodriguez Santos MA, Bope CE, Dengler JS, Kelley MR, et al.(2021). KCC2 is required for the survival of mature neurons but not for their development . The Journal of biological chemistry.

Kontou, G., Josephine, S.F., Cardarelli, R.A., Howden, J.H., Choi, C., Ren, Q., Rodriguez Santos, M.A., Bope, C.E., Dengler, J.S., Kelley, M.R., et al.(2021). KCC2 is required for the survival of mature neurons but not for their development . Journal of Biological Chemistry. 296.

Smalley M, Natarajan SK, Mondal J, Best D, Goldman D, Shanthappa B, Pellowe M, Dash C, Saha T, Khiste S, et al.(2020). Nanoengineered Disruption of Heat Shock Protein 90 Targets Drug-Induced Resistance and Relieves Natural Killer Cell Suppression in Breast Cancer . Cancer research.

Smalley JL, Kontou G, Choi C, Ren Q, Albrecht D, Abiraman K, Santos MAR, Bope CE, Deeb TZ, Davies PA, et al.(2020). Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes . Frontiers in molecular neuroscience.

Smalley, J.L., Kontou, G., Choi, C., Ren, Q., Albrecht, D., Abiraman, K., Santos, M.A.R., Bope, C.E., Deeb, T.Z., Davies, P.A., et al.(2020). Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes . Frontiers in Molecular Neuroscience. 13.

Goldman A, Smalley JL, Mistry M, Krenzlin H, Zhang H, Dhawan A, Caldarone B, Moss SJ, Silbersweig DA, Lawler SE, et al.(2019). A computationally inspired in-vivo approach identifies a link between amygdalar transcriptional heterogeneity, socialization and anxiety . Translational psychiatry.

Nathanson AJ, Zhang Y, Smalley JL, Ollerhead TA, Rodriguez Santos MA, Andrews PM, Wobst HJ, Moore YE, Brandon NJ, Hines RM, et al.(2019). Identification of a Core Amino Acid Motif within the α Subunit of GABA_ARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures . Cell reports.

Goldman, A., Smalley, J.L., Mistry, M., Krenzlin, H., Zhang, H., Dhawan, A., Caldarone, B., Moss, S.J., Silbersweig, D.A., Lawler, S.E., et al.(2019). A computationally inspired in-vivo approach identifies a link between amygdalar transcriptional heterogeneity, socialization and anxiety . Translational Psychiatry. 9. (1).

Nathanson, A.J., Zhang, Y., Smalley, J.L., Ollerhead, T.A., Rodriguez Santos, M.A., Andrews, P.M., Wobst, H.J., Moore, Y.E., Brandon, N.J., Hines, R.M., et al.(2019). Identification of a Core Amino Acid Motif within the α Subunit of GABA<inf>A</inf>Rs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures . Cell Reports. 28. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 670-681.e8.

Schiavon E, Smalley JL, Newton S, Greig NH, Forsythe ID(2018). Neuroinflammation and ER-stress are key mechanisms of acute bilirubin toxicity and hearing loss in a mouse model . PloS one.

Kelley MR, Cardarelli RA, Smalley JL, Ollerhead TA, Andrew PM, Brandon NJ, Deeb TZ, Moss SJ(2018). Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy . EBioMedicine.

Lucas SJ, Michel CB, Marra V, Smalley JL, Hennig MH, Graham BP, Forsythe ID(2018). Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse . The Journal of physiology.

Lucas, S.J., Michel, C.B., Marra, V., Smalley, J.L., Hennig, M.H., Graham, B.P., Forsythe, I.D.(2018). Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse . Journal of Physiology. 596. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1699-1721.

Kelley, M.R., Cardarelli, R.A., Smalley, J.L., Ollerhead, T.A., Andrew, P.M., Brandon, N.J., Deeb, T.Z., Moss, S.J.(2018). Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy . EBioMedicine. 32. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 62-71.

Schiavon, E., Smalley, J.L., Newton, S., Greig, N.H., Forsythe, I.D.(2018). Neuroinflammation and ER-stress are key mechanisms of acute bilirubin toxicity and hearing loss in a mouse model . PLoS ONE. 13. (8).

Erhardt, S., Pocivavsek, A., Repici, M., Liu, X.-C., Imbeault, S., Maddison, D.C., Thomas, M.A.R., Smalley, J.L., Larsson, M.K., Muchowski, P.J., et al.(2017). Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders . Biological Psychiatry. 82. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 756-765.

Erhardt S, Pocivavsek A, Repici M, Liu XC, Imbeault S, Maddison DC, Thomas MAR, Smalley JL, Larsson MK, Muchowski PJ, et al.(2016). Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders . Biological psychiatry.

Smalley, J.L., Breda, C., Mason, R.P., Kooner, G., Luthi-Carter, R., Gant, T.W., Giorgini, F.(2016). Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models . Journal of Molecular Medicine. 94. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 235-245.

Smalley JL, Breda C, Mason RP, Kooner G, Luthi-Carter R, Gant TW, Giorgini F(2015). Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington's disease models . Journal of molecular medicine (Berlin, Germany).

Varadarajan S, Breda C, Smalley JL, Butterworth M, Farrow SN, Giorgini F, Cohen GM(2015). The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration . Cell death and differentiation.

Varadarajan, S., Breda, C., Smalley, J.L., Butterworth, M., Farrow, S.N., Giorgini, F., Cohen, G.M.(2015). The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration . Cell Death and Differentiation. 22. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1388-1396.

Miller-Fleming L, Antas P, Pais TF, Smalley JL, Giorgini F, Outeiro TF(2014). Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase . Proceedings of the National Academy of Sciences of the United States of America.

Miller-Fleming, L., Antas, P., Pais, T.F., Smalley, J.L., Giorgini, F., Outeiro, T.F.(2014). Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase . Proceedings of the National Academy of Sciences of the United States of America. 111. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7012-7017.

Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM(2013). Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis . PloS one.

Varadarajan, S., Tanaka, K., Smalley, J.L., Bampton, E.T.W., Pellecchia, M., Dinsdale, D., Willars, G.B., Cohen, G.M.(2013). Endoplasmic Reticulum Membrane Reorganization Is Regulated by Ionic Homeostasis . PLoS ONE. 8. (2).

Varadarajan S, Bampton ET, Smalley JL, Tanaka K, Caves RE, Butterworth M, Wei J, Pellecchia M, Mitcheson J, Gant TW, et al.(2012). A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum . Cell death and differentiation.

Varadarajan, S., Bampton, E.T.W., Smalley, J.L., Tanaka, K., Caves, R.E., Butterworth, M., Wei, J., Pellecchia, M., Mitcheson, J., Gant, T.W., et al.(2012). A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum . Cell Death and Differentiation. 19. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1896-1907.

Smalley, J.L., Gant, T.W., Zhang, S.-D.(2010). Application of connectivity mapping in predictive toxicology based on gene-expression similarity . Toxicology. 268. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 143-146.

Smalley JL, Gant TW, Zhang SD(2009). Application of connectivity mapping in predictive toxicology based on gene-expression similarity . Toxicology.

PREPRINT

Kontou G, Ng J, Cardarelli RA, Howden J, Choi C, Ren Q, Kittler J, Brandon N, Moss SJ, Smalley JL(2020). KCC2 is required for the survival of mature neurons but not for their development .

Smalley JL, Kontou G, Choi C, Ren Q, Albrecht D, Abiraman K, Rodriguez Santos MA, Bope CE, Deeb TZ, Davies PA, et al.(2020). Isolation and characterization of multi-protein complexes enriched in the K-Cl co-transporter 2 from brain plasma membranes .

Smalley JL, Kontou G, Choi C, Ren Q, Albrecht D, Abiraman K, Rodriguez Santos MA, Bope CE, Deeb TZ, Davies PA, et al.(2020). The K-Cl co-transporter 2 is a point of convergence for multiple autism spectrum disorder and epilepsy risk gene products .