プロフィール詳細

プロジェクトを作成

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Dr. Julia M.に依頼

Germany

Principal Investigator advancing drug development through human-relevant models and translational research

プロフィール概要

I am a Principal Investigator, Course Director and translational pharmacologist with over 10 years of experience spanning academia and the biotechnology industry. My expertise lies in developing human-relevant preclinical models, including organ-on-chip and advanced in vitro systems, to improve the prediction of drug efficacy, safety and pharmacokinetics while reducing reliance on animal models. My research focuses on translational science, women's health, drug transport and medicines development, with a strong track record of securing competitive research funding and leading multidisciplinary collaborations with academia, healthcare organisations and industry partners. Previously, I worked at Femtogenix (now Pheon Therapeutics), where I contributed to antibody-drug conjugate (ADC) discovery by developing and applying analytical methods, including HPLC-MS, to support preclinical drug development and candidate evaluation. This experience provided valuable insight into early drug discovery and the translation of innovative therapeutics towards clinical development. Alongside my research, I have extensive experience in higher education as a Course Director and academic leader, designing research-led curricula, supervising undergraduate and postgraduate researchers, and mentoring multidisciplinary teams. I also provide consultancy in translational research strategy, grant writing, preclinical model development, scientific communication and industry–academic partnerships, helping organisations accelerate innovation and translate scientific discoveries into healthcare impact.

専門分野

• ☆ Pharmacy
• ☆ Drug Development
• ☆ Medical Sciences
• ☆ Cancer Research

サービス

• Writing
• Research
• Consulting

Writing Medical Writing, Translation

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

職務経験

Senior Lecturer in Pharmaceutical Science

London South Bank University

9月 2024 - 現在

Lecturer in Biomedical Science

Anglia Ruskin University

11月 2021 - 9月 2024

Teaching Fellow

King's College London

11月 2019 - 11月 2021

Community Pharmacist

Chelsea Pharmacy

4月 2017 - 6月 2021

Research Associate

King's College London

4月 2018 - 10月 2019

Research Associate

Femtogenix Ltd

1月 2016 - 11月 2017

学歴

PhD in Pharmaceutical Science

King's College London, University of London - United Kingdom

1月 2012 - 1月 2016

MPharm

TU Braunschweig

4月 2004 - 9月 2009

認定資格

• Fellow of AvanceHE

  AdvanceHE

  1月 2023 - 現在

出版物

JOURNAL ARTICLE

Julia Mantaj, Kosha J. Mehta, Javier Aula-Blasco (2024). University students’ preferences of learning modes post COVID-19-associated lockdowns: In-person, online, and blended . PLOS ONE.

Yunyue Zhang, Mona Belaid, Xiang Luo, Armond Daci, Rinë Limani, Matthias Zilbauer, Komal Nayak, Driton Vllasaliu, Julia Mantaj (2023). Probing milk extracellular vesicles for intestinal delivery of RNA therapies . Journal of Nanobiotechnology.

Greta Carobolante and Julia Mantaj and Enrico Ferrari and Driton Vllasaliu(2020). Cow Milk and Intestinal Epithelial Cell-Derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery . Pharmaceutics. 12. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 226. {MDPI} {AG}

Jing M. Yong and Julia Mantaj and Yiyi Cheng and Driton Vllasaliu(2019). Delivery of Nanoparticles across the Intestinal Epithelium via the Transferrin Transport Pathway . Pharmaceutics. 11. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 298. {MDPI} {AG}

Andreea Aprodu and Julia Mantaj and Bahijja Raimi-Abraham and Driton Vllasaliu(2019). Evaluation of a Methylcellulose and Hyaluronic Acid Hydrogel as a Vehicle for Rectal Delivery of Biologics . Pharmaceutics. 11. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 127. {MDPI} {AG}

Vishnaka Muraleetharan and Julia Mantaj and Magda Swedrowska and Driton Vllasaliu(2019). Nanoparticle modification in biological media: implications for oral nanomedicines . RSC Advances. 9. (69). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 40487--40497. Royal Society of Chemistry ({RSC})

Julia Mantaj and Tamara Abu-Shams and Zachary Enlo-Scott and Magda Swedrowska and Driton Vllasaliu(2018). Role of the Basement Membrane as an Intestinal Barrier to Absorption of Macromolecules and Nanoparticles . Molecular Pharmaceutics. 15. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5802--5808. American Chemical Society ({ACS})

Jinyi Zhai and Julia Mantaj and Driton Vllasaliu(2018). Ascorbyl Palmitate Hydrogel for Local, Intestinal Delivery of Macromolecules . Pharmaceutics. 10. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 188. {MDPI} {AG}

Driton Vllasaliu and Maya Thanou and Snjezana Stolnik and Robyn Fowler(2018). Recent advances in oral delivery of biologics: nanomedicine and physical modes of delivery . Expert Opinion on Drug Delivery. 15. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 759--770. Informa {UK} Limited

Julia Mantaj and Paul J. M. Jackson and Khondaker M. Rahman and David E. Thurston(2017). Entwicklung Pyrrolobenzodiazepin(PBD)-haltiger Antikörper-Wirkstoff-Konjugate (ADCs) ausgehend von Anthramycin . Angewandte Chemie. 129. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 474--502. Wiley

Julia Mantaj and Paul J. M. Jackson and Khondaker M. Rahman and David E. Thurston(2017). From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs) . Angewandte Chemie International Edition. 56. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 462--488. Wiley

Julia Mantaj and Paul J. M. Jackson and Kersti Karu and Khondaker M. Rahman and David E. Thurston(2016). Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments . PLOS ONE. 11. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e0152303. Public Library of Science ({PLoS})

Julia Mantaj and S. M. Abdur Rahman and Bishwajit Bokshi and Choudhury M. Hasan and Paul J. M. Jackson and Richard B. Parsons and Khondaker M. Rahman(2015). Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells . Organic & Biomolecular Chemistry. 13. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3882--3886. Royal Society of Chemistry ({RSC})

CONFERENCE PAPER

Nicolas Veillard and Paolo Andriollo and Julia Mantaj and Keith R. Fox and K Miraz Rahman and George Procopiou and Francesco Cascio and David B. Corcoran and Ilona Pysz and Patricia A. Cooper and Steven D. Shnyder and Yawen Ju and Edwin Tan and William M. Schopperle and Paul J. Jackson and David E. Thurston(2018). Abstract 736: Pyridinobenzodiazepines (PDDs): A new class of sequence-selective DNA mono-alkylating ADC payloads with low hydrophobicity . Experimental and Molecular Therapeutics. American Association for Cancer Research

Julia Mantaj and Paul J. Jackson and David E. Thurston and Khondaker Miraz Rahman(2017). Abstract 5242: Further evidence that the DNA-interactive Pyrrolobenzodiazepine (PBD) Dimer SJG-136 works through a transcription factor inhibition mechanism . Cancer Chemistry. American Association for Cancer Research

Julia Mantaj and Paul J. M. Jackson and Khondaker Miraz Jackson and David E. Thurston(2016). Abstract 4778: Covalent bonding of a C8-conjugated pyrrolobenzodiazepine (PBD) monomer and dimer to a terminal guanine residue of DNA duplex and hairpin fragments . Experimental and Molecular Therapeutics. American Association for Cancer Research

Paul J. M. Jackson and George Procopiou and Nicolas Veillard and Julia Mantaj and K Miraz Rahman and David E. Thurston(2016). Abstract 4779: In silico design, synthesis and evaluation of a new family of C1-substituted pyrrolobenzodiazepines (PBDs) . Experimental and Molecular Therapeutics. American Association for Cancer Research

Julia Mantaj and David E. Thurston and Khondaker M. Rahman(2015). Abstract 1986: Effect of the PBD dimer SJG-136 on expression of STAT3 dependent genes . Molecular and Cellular Biology. American Association for Cancer Research

Julia Mantaj and Paul JM Jackson and Chris Pepper and David E. Thurston and Khondaker M. Rahman(2014). Abstract 1630: C8-linked pyrrolobenzodiazepine (pbd)-benzofused conjugates with low-picomolar in vitro cytotoxicity . Cancer Chemistry. American Association for Cancer Research

Paul J M Jackson and Colin M. James and Khondaker M. Rahman and David E. Thurston(2013). Abstract 4549: Use of molecular dynamic simulations to explore changes in conformation and sequence preference for DNA-binding biaryl polyamide structures . Cancer Chemistry. American Association for Cancer Research