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プロフィール詳細
プロジェクトを作成
★★★★★
☆☆☆☆☆
Dr. Julio Cesar C.に依頼
United States

Biologist with 15 years of experience on immunology, genetics and antibody development

プロフィール概要
専門分野
サービス
Research Market Research, Feasibility Study, Systematic Literature Review, Secondary Data Collection
職務経験

Pos Doctoral Fellow

Rockefeller University

2月 2014 - 現在

Principal Scientist

Moderna Inc

12月 2020 - 12月 2024

学歴

Ph.D. (Genetics)

Universidade de São Paulo

8月 2009 - 12月 2013

Master (Immunology)

Universidade de São Paulo

2月 2006 - 5月 2008

Bachelor (Biology)

Universidade Federal de Alfenas

3月 2002 - 12月 2005

認定資格
  • 認定資格の詳細は未入力です。
出版物
JOURNAL ARTICLE
Fabian Schmidt, Yiska Weisblum, Frauke Muecksch, Hans-Heinrich Hoffmann, Eleftherios Michailidis, Julio C.C. Lorenzi, Pilar Mendoza, Magdalena Rutkowska, Eva Bednarski, Christian Gaebler, et al. (2020). Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses . Journal of Experimental Medicine.
Davide F. Robbiani, Christian Gaebler, Frauke Muecksch, Julio C. C. Lorenzi, Zijun Wang, Alice Cho, Marianna Agudelo, Christopher O. Barnes, Anna Gazumyan, Shlomo Finkin, et al.(2020). Convergent antibody responses to {SARS}-{CoV}-2 in convalescent individuals . Nature. Springer Science and Business Media {LLC}
Yehuda Z. Cohen, Julio C.C. Lorenzi, Lisa Krassnig, John P. Barton, Leah Burke, Joy Pai, Ching-Lan Lu, Pilar Mendoza, Thiago Y. Oliveira, Christopher Sleckman, et al.(2018). Relationship between latent and rebound viruses in a clinical trial of anti{\textendash}{HIV}-1 antibody 3BNC117 . The Journal of Experimental Medicine. 215. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2311--2324. Rockefeller University Press
Cohn LB, da Silva IT, Valieris R, Huang AS, Lorenzi JCC, Cohen YZ, Pai JA, Butler AL, Caskey M, Jankovic M, et al.(2018). Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation . Nature medicine.
Cohen, Yehuda Z., Lorenzi, Julio C. C., Seaman, Michael S., Nogueira, Lilian, Schoofs, Till, Krassnig, Lisa, Butler, Allison, Millard, Katrina, Fitzsimons, Tomas, Daniell, Xiaoju, et al.(2018). Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells . Journal of Virology. 92. (5).
Horwitz, Joshua A., Bar-On, Yotam, Lu, Ching-Lan, Fera, Daniela, Lockhart, Ainsley A. K., Lorenzi, Julio C. C., Nogueira, Lilian, Golijanin, Jovana, Scheid, Johannes F., Seaman, Michael S., et al.(2017). Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo . Cell. 170. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 637-+.
Ruhrmann, S., Ewing, E., Piket, E., Kular, L., Cetrulo Lorenzi, J.C., Fernandes, S.J., Morikawa, H., Aeinehband, S., Sayols-Baixeras, S., Aslibekyan, S., et al.(2017). Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes . Multiple Sclerosis Journal.
Lorenzi, Julio C. C., Cohen, Yehuda Z., Cohn, Lillian B., Kreider, Edward F., Barton, John P., Learn, Gerald H., Oliveira, Thiago, Lavine, Christy L., Horwitz, Joshua A., Settler, Allison, et al.(2017). Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA (vol 113, pg E7908, 2016) . Proceedings of the National Academy of Sciences of the United States of America. 114. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString E648-E649.
Freund, Natalia T., Wang, Haoqing, Scharf, Louise, Nogueira, Lilian, Horwitz, Joshua A., Bar-On, Yotam, Golijanin, Jovana, Sievers, Stuart A., Sok, Devin, Cai, Hui, et al.(2017). Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller . Science Translational Medicine. 9. (373).
Marchini, J. F. M., Pinto, M. R., Novaes, G. C., Badran, A. V., Pavao, R. B., Figueiredo, G. L., Lago, I. M., Lima-Filho, M. O., Lemos, D. C., Tonani, M., et al.(2017). Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients . Brazilian Journal of Medical and Biological Research. 50. (1).
Cetrulo Lorenzi, Julio Cesar, Malardo, Thiago, Gardinassi, Luiz Gustavo, Moreira, Bernardo Pereira, Padilha, Everton, Soares, Luana Silva, Gembre, Ana Flavia, Fontoura, Isabela Cardoso, de Almeida, Luciana Previato, Ferreira de Miranda Santos, Isabel Kinney, et al.(2016). MicroRNA expression signatures in lungs of mice infected with Mycobacterium tuberculosis . Tuberculosis. 101. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 151-159.
Schoofs, Till, Klein, Florian, Braunschweig, Malte, Kreider, Edward F., Feldmann, Anna, Nogueira, Lilian, Oliveira, Thiago, Lorenzi, Julio C. C., Parrish, Erica H., Learn, Gerald H., et al.(2016). HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1 . Science. 352. (6288). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 997-1001.
Cetrulo Lorenzi, Julio Cesar, Kaneto, Carla M., Lima, Patricia S. P., Zanette, Dalila Luciola, Kikuchi Oliveira, Thiago Yukio, Pereira, Francisco de Assis, dos Santos, Jane Lima, Prata, Karen L., Pina Neto, Joao M., de Paula, Francisco J. A., et al.(2016). Osteoblastic differentiation of bone marrow mesenchymal stromal cells in Bruck Syndrome . Bmc Medical Genetics. 17.
Cetrulo Lorenzi, Julio Cesar, Muys, Bruna Rodrigues, Zanette, Dalila Luciola, Lima e Bueno, Rafaela de Barros, de Araujo, Luza Ferreira, Dinarte-Santos, Anemari Ramos, Alves, Cleidson Padua, Ramao, Anelisa, de Molfetta, Greice Andreotti, Vidal, Daniel Onofre, et al.(2016). Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line . Plos One. 11. (3).
Scheid, Johannes F., Horwitz, Joshua A., Bar-On, Yotam, Kreider, Edward F., Lu, Ching-Lan, Lorenzi, Julio C. C., Feldmann, Anna, Braunschweig, Malte, Nogueira, Lilian, Oliveira, Thiago, et al.(2016). HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption . Nature. 535. (7613). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 556-+.
Zanette, D.L., Lorenzi, J.C.C., Panepucci, R.A., Palma, P.V.B., Dos Santos, D.F., Prata, K.L., Silva, W.A.(2015). Simvastatin modulates mesenchymal stromal cell proliferation and gene expression . PLoS ONE. 10. (4).
Arruda, L.C.M., Lorenzi, J.C.C., Sousa, A.P.A., Zanette, D.L., Palma, P.V.B., Panepucci, R.A., Brum, D.S., Barreira, A.A., Covas, D.T., Simões, B.P., et al.(2015). Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients . Bone Marrow Transplantation. 50. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 380-389.
Arruda, L. C. M., Lorenzi, J. C. C., Sousa, A. P. A., Zanette, D. L., Palma, P. V. B., Panepucci, R. A., Brum, D. S., Barreira, A. A., Covas, D. T., Simoes, B. P., et al.(2015). Autologous hematopoietic SCT normalizes miR-16,-155 and-142-3p expression in multiple sclerosis patients . Bone Marrow Transplantation. 50. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 380-389.
Caskey, Marina, Klein, Florian, Lorenzi, Julio C. C., Seaman, Michael S., West, Anthony P., Jr., Buckley, Noreen, Kremer, Gisela, Nogueira, Lilian, Braunschweig, Malte, Scheid, Johannes F., et al.(2015). Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 . Nature. 522. (7557). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 487-+.
de Araujo, L.F., Fonseca, A.S., Muys, B.R., Plaça, J.R., Bueno, R.B.L., Lorenzi, J.C.C., Santos, A.R.D., Molfetta, G.A., Zanette, D.L., Souza, J.E.S., et al.(2015). Mitochondrial genome instability in colorectal adenoma and adenocarcinoma . Tumor Biology.
Caskey, M., Klein, F., Lorenzi, J.C.C., Seaman, M.S., West, A.P., Buckley, N., Kremer, G., Nogueira, L., Braunschweig, M., Scheid, J.F., et al.(2015). Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 . Nature. 522. (7557). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 487-491.
Julio Cesar Cetrulo Lorenzi, Sabrina Ruhrmann, Eliane Piket, Petra Bergman, Lara Kular, Shahin Aeinehband, Roham Parsa, David Gomez-cabrero, Jesper Tegnér, Fredrik Piehl, et al.(2014). Methylome characterization of {CD}4$\mathplus$ T cells in multiple sclerosis {\textemdash} Establishing a role for {miR}-21 in autoimmune disease . Journal of Neuroimmunology. 275. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 112. Elsevier {BV}
Shingai, M., Donau, O.K., Plishka, R.J., Buckler-White, A., Mascola, J.R., Nabel, G.J., Nason, M.C., Montefiori, D., Moldt, B., Poignard, P., et al.(2014). Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques . Journal of Experimental Medicine. 211. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2061-2074.
Shingai, Masashi, Donau, Olivia K., Plishka, Ronald J., Buckler-White, Alicia, Mascola, John R., Nabel, Gary J., Nason, Martha C., Montefiori, David, Moldt, Brian, Poignard, Pascal, et al.(2014). Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques . Journal of Experimental Medicine. 211. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2061-2074.
Zanette, D.L., Lorenzi, J.C.C., Panepucci, R.A., Santos, A.R.D., Molfetta, G.A., Araujo, A.G., Silva Junior, W.A., Zago, M.A.(2013). Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling . Genetics and Molecular Research. 12. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1691-1697.
Zanette, D. L., Lorenzi, J. C. C., Panepucci, R. A., Santos, A. R. D., Molfetta, G. A., Araujo, A. G., Silva Junior, W. A., Zago, M. A.(2013). Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling . Genetics and Molecular Research. 12. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1691-1697.
Lorenzi, J.C.C., Brum, D.G., Zanette, D.L., De Paula Alves Souza, A., Barbuzano, F.G., Dos Santos, A.C., Barreira, A.A., Da Silva Jr., W.A.(2012). miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients . International Journal of Neuroscience. 122. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 466-471.
Rocha, C.D., Trombone, A.P.F., Lorenzi, J.C.C., Almeida, L.P., Gembre, A.F., Padilha, E., Ramos, S.G., Silva, C.L., Coelho-Castelo, A.A.M.(2012). Antigen-presenting cells transfected with Hsp65 messenger RNA fail to treat experimental tuberculosis . Brazilian Journal of Medical and Biological Research. 45. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1183-1194.
Padilha, E., Malardo, T., Moreira, B. P., Lorenzi, J. C. C., Fontoura, I. C., Silva, C. L., Coelho-Castelo, A. A. M.(2012). mRNA and plasmideal DNA stimuli for different times may change microRNA expression in murine dendritic cells. Immunology. 137. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 119.
Padilha, E., Malardo, T., Moreira, B. P., Lorenzi, J. C. C., Fontoura, I. C., Silva, C. L., Coelho-Castelo, A. A. M.(2012). mRNA and plasmideal DNA stimuli for different times may change microRNA expression in murine dendritic cells . Immunology. 137. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 119.
Rocha, C. D., Trombone, A. P. F., Lorenzi, J. C. C., Almeida, L. P., Gembre, A. F., Padilha, E., Ramos, S. G., Silva, C. L., Coelho-Castelo, A. A. M.(2012). Antigen-presenting cells transfected with Hsp65 messenger RNA fail to treat experimental tuberculosis . Brazilian Journal of Medical and Biological Research. 45. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1183-1194.
Lorenzi, J. C. C., Brum, D. G., Zanette, D. L., Souza, A. D. A., Barbuzano, F. G., dos Santos, A. C., Barreira, A. A., Silva, W. A.(2012). miR-15a and 16-1 Are Downregulated in CD4(+) T Cells of Multiple Sclerosis Relapsing Patients . International Journal of Neuroscience. 122. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 466-471.
Brum, D. G., Lorenzi, J. C. C., Zanette, D. L., de Paula, A., Barbuzano, F. G., Santos, A. C., Barreira, A. A., da Silva, W. A.(2011). miR-16 Is Downregulated in CD4+T Cells of Multiple Sclerosis Relapsing Patients. Neurology. 76. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString A139.
Almeida, L.P., Trombone, A.P.F., Lorenzi, J.C.C., Rocha, C.D., Malardo, T., Fontoura, I.C., Gembre, A.F., Silva, R.L.L., Silva, C.L., Castelo, A.P., et al.(2011). B cells Can Modulate the CD8 Memory T Cell after DNA Vaccination Against Experimental Tuberculosis . Genetic Vaccines and Therapy. 9.
Almeida, L. P., Trombone, A. P., Lorenzi, J. C., Rocha, C. D., Malardo, T., Fontoura, I. C., Gembre, A. F., Silva, R. L., Silva, C. L., Castelo, A. P., et al.(2011). B cells Can Modulate the CD8 Memory T Cell after DNA Vaccination Against Experimental Tuberculosis . Genet Vaccines Ther. 9. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5.
Lorenzi, J. C. C., Trombone, A. P. F., Rocha, C. D., Almeida, L. P., Lousada, R. L., Malardo, T., Fontoura, I. C., Rossetti, R. A. M., Gembre, A. F., Silva, A. M., et al.(2010). Intranasal vaccination with messenger RNA as a new approach in gene therapy: Use against tuberculosis . Bmc Biotechnology. 10. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 11.
Lorenzi, J.C.C., Trombone, A.P.F., Rocha, C.D., Almeida, L.P., Lousada, R.L., Malardo, T., Fontoura, I.C., Rossetti, R.A.M., Gembre, A.F., Silva, A.M., et al.(2010). Intranasal vaccination with messenger RNA as a new approach in gene therapy: Use against tuberculosis . BMC Biotechnology. 10.
Tereza Cristina Orlando, Adriene Ribeiro Lima, Ariadne Mendes da Silva, Carolina Nakau Fuzissaki, Cíntia Lacerda Ramos, Daisy Machado, Fabrício Freitas Fernandes, Júlio César C. Lorenzi, Marisa Aparecida de Lima, Sueli Gardim, et al.(2009). {PLANEJAMENTO}, {MONTAGEM} E {APLICA}{\c{C}}{\~{A}}O {DE} {MODELOS} {DID}{\'{A}}{TICOS} {PARA} {ABORDAGEM} {DE} {BIOLOGIA} {CELULAR} E {MOLECULAR} {NO} {ENSINO} M{\'{E}}{DIO} {POR} {GRADUANDOS} {DE} {CI}{\^{E}}{NCIAS} {BIOL}{\'{O}}{GICAS} . Revista de Ensino de Bioqu{\'{\i}}mica. 7. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1. Sociedade Brasileira de Bioquimica e Biologia Molecular - {SBBq}
Rosseti, R.A.M., LORENZI, J. C. C., GIULIATTI, S., COELHO-CASTELO, A. A. M.(2008).  In Silico Prediction of the Tertiary Structure of M. leprae Hsp65 Protein Shows an Unusual Structure in Carboxy-terminal Region .  Journal of Computer Science & Systems Biology. 1. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5.
Pelizon, A., Martins, D.R., Zorzella, S.F.G., Trombone, A.P., Lorenzi, J.C.C., Carvalho, R.F., Brandão, I.T., Coelho-Castelo, A.A.M., Silva, C.L., Sartori, A.(2007). Genetic vaccine for tuberculosis (pVAXhsp65) primes neonate mice for a strong immune response at the adult stage . Genetic Vaccines and Therapy. 5.
Pelizon, AC, Martins, DR, Zorzella, SF, Trombone, AP, Lorenzi, JC, Carvalho, RF, Brandão, IT, Coelho-Castelo, AA, Silva, CL, Sartori, A(2007). Genetic vaccine for tuberculosis (pVAXhsp65) primes neonate mice for a strong immune response at the adult stage . Genet Vaccines Ther. 5. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 12.
OTHER
Julio C.C. Lorenzi, Pilar Mendoza, Yehuda Z. Cohen, Lilian Nogueira, Christy Lavine, Joseph Sapiente, Michael S. Seaman, Marie Wiatr, Nelly R. Mugo, Andrew Mujugira, et al.(2020). Neutralizing activity of broadly neutralizing anti-{HIV}-1 antibodies against primary African isolates . Cold Spring Harbor Laboratory
Zijun Wang, Julio C. C. Lorenzi, Frauke Muecksch, Shlomo Finkin, Charlotte Viant, Christian Gaebler, Melissa Cipolla, Hans-Heinrich Hoffman, Thiago Y. Oliveira, Deena A. Oren, et al.(2020). Enhanced {SARS}-{CoV}-2 Neutralization by Secretory {IgA} in vitro . Cold Spring Harbor Laboratory
Christian Gaebler, Julio C. C. Lorenzi, Thiago Y. Oliveira, Lilian Nogueira, Victor Ramos, Ching-Lan Lu, Joy A. Pai, Pilar Mendoza, Mila Jankovic, Marina Caskey, et al.(2019). Quadruplex {qPCR} for qualitative and quantitative analysis of the {HIV}-1 latent reservoir . Cold Spring Harbor Laboratory
Line K. Vibholm, Julio C.C. Lorenzi, Joy A. Pai, Yehuda Z. Cohen, Thiago Y. Oliveira, John P. Barton, Marco Garcia Noceda, Ching-Lan Lu, Yuria Ablanedo-Terrazas, Perla M. Del Rio Estrada, et al.(2018). Characterization of intact proviruses in blood and lymph node from {HIV}-infected individuals undergoing analytical treatment interruption . Cold Spring Harbor Laboratory
Yehuda Z. Cohen, Julio C. C. Lorenzi, Lisa Krassnig, John P. Barton, Leah Burke, Joy Pai, Ching-Lan Lu, Pilar Mendoza, Thiago Y. Oliveira, Christopher Sleckman, et al.(2018). Analysis of {HIV}-1 latent reservoir and rebound viruses in a clinical trial of anti-{HIV}-1 antibody 3BNC117 . Cold Spring Harbor Laboratory
BOOK CHAPTER
Lorenzi, J. C. C., Trombone, A. P. F., Rocha, C. D., De Almeida, L. P., Lousada, R., Malardo, T., Silva, C. L., Coelho-Castelo, A. A. M.(2010). New approaches using genetic material as a control to tuberculosis. Advances in Biomedical Research, Proceedings. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 426-430.