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プロフィール詳細
専門分野
サービス
職務経験
Clinical Variant Scientist
Counsyl Inc
8月 2016 - 現在 
Post Doctoral Researcher
Memorial Sloan-Kettering Cancer Center
8月 2010 - 5月 2013
Doctoral Research Fellow
Memorial Sloan-Kettering Cancer Center
5月 2005 - 7月 2010
Teaching Assistant
University of North Carolina at Greensboro
8月 2002 - 6月 2004
Instructor
MCKV Institute of Engineering
8月 2001 - 6月 2002
学歴
PhD, Applied Biomedical Sciences (Chemical Biology)
Joan and Sanford I Weill Medical College of Cornell University
7月 2004 - 7月 2010
MS (Chemistry and Biochemistry)
University of North Carolina at Greensboro
8月 2002 - 6月 2004
Post Graduate Diploma in Computer Applications (RCC)
Jadavpur University
8月 1999 - 8月 2000
認定資格
- 認定資格の詳細は未入力です。
出版物
JOURNAL ARTICLE
(2017). Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss–Driven Tumorigenesis . Molecular cancer therapeutics.
(2012). Biochemical evidence towards the existence of an oncogenic Hsp90 complex. Cancer Research.
(2011). Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature Chemical Biology.
(2011). Design, synthesis, and evaluation of small molecule Hsp90 probes. Bioorg. Med. Chem.
(2010). Design of a Flexible Cell-Based Assay for the Evaluation of Heat Shock Protein 70 Expression Modulators. Assay Drug Dev. Technol.
(2009). Heat shock protein inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A.
(2007). Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A.
(2007). Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nature Chemical Biology.
(2007). Effects of herbal products and their constituents on human cytochrome P450(2E1) activity. Food Chem. Toxicol.
(2007). High-throughput screening fluorescence polarization assay for tumor-specific hsp90. Biomol. Screen.
(2006). Synthesis of a red-shifted fluorescence polarization probe for Hsp90. Bioorg. Med. Chem. Lett.
(2006). Emerging Hsp90 inhibitors: from discovery to clinic. Anticancer Agents Med. Chem.
CONFERENCE POSTER
(2009). Probing cancer-specific activating signaling pathways through a tumor-specific Hsp90 inhibitor. American Association of Cancer Research (AACR), Annual Meeting.
(2008). Cell-based assay for rapid identification of Hsp70 Modulators. World Pharmaceutical Congress.
(2007). High-throughput screening fluorescence polarization assay for tumor-specific Hsp90. American Association of Cancer Research (AACR), Annual Meeting.
(2006). 419 POSTER Defining Hsp90 as inhibitor of apoptosis in small cell lung cancer . European Journal of Cancer Supplements.
(2006). Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. American Association of Cancer Research (AACR), Annual Meeting.
(2004). Inhibition of Human Cytochrome P4502e1 by Herbal Extracts and Their Major Isolated Constituents. Southeast Regional Meeting, American Chemical Society (ACS).
(2003). Effects of Echinacea on human metabolizing systems. American Chemical Society (ACS).
CONFERENCE PAPER
(2007). Targeting basal-like breast cancer via purine-scaffold Hsp90 inhibitors. American Association of Cancer Research (AACR), Annual Meeting.
DISSERTATION THESIS
(2006). Interactions of Echinacea and Spilanthes with Human Metabolizing Systems . University of North Carolina at Greensboro.
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