プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Karel P.に依頼

United Kingdom

An executive with 40 years of experience in the pharmaceutical industry, now focusing on precision drugs.

プロフィール概要

NangioTx – Newark, New Jersey (remote) (Jan 2016 – July 2023) Chief Scientific Officer Matrx Pharmaceuticals, New York, NY (remote) (June 2018 – present) Vice President for Research and Development Putting Rare Disease Patients First! (PRDPF!), San Diego, CA (Sept 2018 – 2020) VP / Board Member responsible for funding HARRIS HEALTH SYSTEM – Houston, Texas (2011–2014) Vice President – for grants-funded health-service improvement projects AGENNIX, INC. – Houston, Texas (xxxxxxxxxxx) Vice President, Research and Development GENERXPLUS, INC. – Vanderbilt Medical Centre, Nashville, Tennessee (xxxxxxxxxxx) Vice President, Research and Development GENEMEDICINE, INC. – The Woodlands, Texas (xxxxxxxxxxx) Director and Program Head LAVIPHARM – Attica, Greece (xxxxxxxxxxx) Director R&D of oral and transdermal drug delivery products. CIBA-GEIGY (1985 – 1993) (Now Novartis) Manager – Suffern, New York (1992–1993) Special Assignment – CIBA-Geigy, Basel, Switzerland Project Leader – Ardsley, New York (1991–1992) CIBA Geigy Pharmaceuticals, Basic Pharmaceutical Research Research Area Head (Macromolecules) – Horsham, U.K. (1985–1991) CIBA-Geigy Pharmaceuticals, Advanced Drug Delivery Research Unit KODAK LTD. – Harrow, U.K. (xxxxxxxxx) Scientist – Research Centre, Polymer Synthesis Department

専門分野

• ★ Drug Development
• ★ Technical & Scientific Writing
• ★ Scientific Proofreading & Editing
• ☆ Materials Science & Engineering
• ☆ Nanotechnology & Nanomaterials
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Preclinical Research
• ☆ Preclinical Pharmacology
• ☆ In vivo Preclinical Toxicology
• ☆ Investigational New Drug (IND) Application Consulting
• ☆ Pharmaceutical Manufacturing
• ☆ Biologic & Biosimilar Manufacturing
• ☆ Immunotherapy
• ☆ Gene Therapy
• ☆ Pharmaceutical Management
• ☆ Liposomes

サービス

• Writing
• Research
• Consulting
• Product Development

Writing Clinical Trial Documentation, Technical Writing, General Proofreading & Editing

Research Feasibility Study, Fact Checking, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting, Regulatory Consulting

Product Development Formulation, Stability/Shelf Life Testing, Product Evaluation, Product Validation, Manufacturing, Quality Assurance & Control (QA/QC), Product Compliance , Concept Development

職務経験

Strategic Plan Development

CIBA Geigy / Novartis

- 現在

Department Head

Novartis

- 現在

Project Leader

Novartis

- 現在

Vice President

Agennix Inc.

- 現在

Research Area Head

GeneMedicine

- 現在

学歴

D. Phil.

University of Sussex

- 現在

認定資格

• D. Phil.

  University of Sussex

  7月 1973 - 現在

出版物

JOURNAL ARTICLE

Karel Petrak, Ravi Vissapragada, Siyu Shi, Zain Siddiqui, Ka Kyung Kim, Biplab Sarkar, Vivek Kumar (2019). Challenges in Translating from Bench to Bed-Side: Pro-Angiogenic Peptides for Ischemia Treatment . Molecules.

Petrak, K.(2012). Targeted Drug Delivery - Quo Vadis? . Drug Development Research. 73. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 59-65.

Petrak, K.(2008). Familiar news? . Scientist. 22. (4).

Wolf, J.S., Li, G., Varadhachary, A., Petrak, K., Schneyer, M., Li, D., Ongkasuwan, J., Zhang, X., Taylor, R.J., Strome, S.E., et al.(2007). Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivo . Clinical Cancer Research. 13. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1601-1610.

Petrak, K., Hasirci, V.(2006). Foreword . Journal of Biomaterials Science, Polymer Edition. 17. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1207-1208.

Petrak, K.(2006). Nanotechnology and site-targeted drug delivery . Journal of Biomaterials Science, Polymer Edition. 17. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1209-1219.

Petrak, K.(2005). Essential properties of drug-targeting delivery systems . Drug Discovery Today. 10. (23-24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1667-1673.

Sherman, M.P., Petrak, K.(2005). Lactoferrin-enhanced anoikis: A defense against neonatal necrotizing enterocolitis . Medical Hypotheses. 65. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 478-482.

Varadhachary, A., Wolf, J.S., Petrak, K., O'Malley Jr., B.W., Spadaro, M., Curcio, C., Forni, G., Pericle, F.(2004). Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy . International Journal of Cancer. 111. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 398-403.

Freimark, B.D., Blezinger, H.P., Florack, V.J., Nordstrom, J.L., Long, S.D., Deshpande, D.S., Nochumson, S., Petrak, K.L.(1998). Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: Cationic lipid complexes . Journal of Immunology. 160. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4580-4586.

Pillai, R., Petrak, K., Blezinger, P., Deshpande, D., Florack, V., Freimark, B., Padmabandu, G., Rolland, A.(1998). Ultrasonic nebulization of cationic lipid-based gene delivery systems for airway administration . Pharmaceutical Research. 15. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1743-1747.

Petrak, K.(1994). Physico-chemical basis of specific interactions involving carbohydrates . Advanced Drug Delivery Reviews. 13. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 211-213.

Petrak, K.(1993). Biocompatible particles based on block-copolymer aggregates for intravascular administration . Journal of Bioactive and Compatible Polymers. 8. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 178-187.

Shevchuk, I., Comfort, A., Petrak, K.(1993). Caprylic acid esters as cosolvents for transdermal benazepril delivery . Proceedings of the Controlled Release Society. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 428-429.

Bayley, D., Sancho, M.-R., Brown, J., Brookman, L., Petrak, K., Goddard, P., Steward, A.(1993). Soluble polymeric carriers for drug delivery-Part 6: Preparation and biodistribution of N5-Hydroxyethyl-L-Glutamine-co-L-Glutamic acid copolymers in rats . Journal of Bioactive and Compatible Polymers. 8. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 51-68.

Matthews, I., Petrak, K.(1993). The preparation and characterization of a twin-tailed, lipid-linked polysialic acid . Biopolymers. 33. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 453-457.

Rolland, A., O'Mullane, J., Goddard, P., Brookman, L., Petrak, K.(1992). New macromolecular carriers for drugs. I. Preparation and characterization of poly(oxyethylene-b-isoprene-b-oxyethylene) block copolymer aggregates . Journal of Applied Polymer Science. 44. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1195-1203.

Ambler, L.E., Brookman, L., Brown, J., Goddard, P., Petrak, K.(1992). Soluble polymeric carriers for drug delivery: Part 5: Solution properties and biodistribution behaviour of N-(2-hydroxypropyl)methacrylamide-co-N-(2- [4-hydroxyphenyl]ethyl)acrylamide copolymer substituted with cholesterol . Journal of Bioactive and Compatible Polymers. 7. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 223-224.

Goddard, P., O'Mullane, J., Ambler, L., Daw, A., Brookman, L., Lee, A., Petrak, K.(1991). R-[N-acetyl]eglin c:poly(oxyethylene) conjugates: Preparation, plasma persistence, and urinary excretion . Journal of Pharmaceutical Sciences. 80. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1171-1176.

Goddard, P., Williamson, I., Brown, J., Hutchinson, L.E., Nicholls, J., Petrak, K.(1991). Soluble polymeric carriers for drug delivery - Part 4: Tissue autoradiography, and whole-body tissue distribution in mice, of N-(2-hydroxypropyl)methacrylamide copolymers following intravenous administration . Journal of Bioactive and Compatible Polymers. 6. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4-24.

Morgan, P.J., Harding, S.E., Petrak, K.(1990). Hydrodynamic properties of a polyisoprene/poly(oxyethylene) block copolymer . Macromolecules. 23. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4461-4464.

Morgan, P.J., Harding, S.E., Petrak, K.(1990). Interactions of a model block copolymer drug delivery system with two serum proteins and myoglobin . Biochemical Society Transactions. 18. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1021-1022.

Harding, S.E., Morgan, P.J., Petrak, K.(1990). Low-speed flotation equilibrium of macromolecules in the analytical ultracentrifuge . Journal of Physical Chemistry. 94. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 978-980.

Davison, C.J., Smith, K.E., Hutchinson, L.E.F., O'Mullane, J.E., Brookman, L., Petrak, K., Harding, S.E.(1990). Physical and biological properties of water soluble polyelectrolyte complexes . Journal of Bioactive and Compatible Polymers. 5. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 267-282.

Petrak, Karel, Artursson, Per, Brown, Lyndon, Dix, Jacqueline, Goddard, Peter(1990). Preparation of sterically stabilized nanoparticles by desolvation from graft copolymers . Journal of Polymer Science, Part A: Polymer Chemistry. 28. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2651-2663.

Petrak, K.(1990). Polymers for use in drug delivery. Property and structure requirements . British Polymer Journal. 22. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 213-219.

O'Mullane, J.E., Petrak, K., Hutchinson, L.E.F., Tomlinson, E.(1990). The effect of adsorbed coats of poloxamers 237 and 338 on the in vitro aggregation and in vivo distribution of polystyrene latex (PSL) particles . International Journal of Pharmaceutics. 63. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 177-180.

Petrak, K.(1989). The structure and properties of materials used in advanced drug delivery systems . Bulletin of Materials Science. 12. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 41-47.

Petrak, K., Goddard, P.(1989). Transport of macromolecules across the capillary walls . Advanced Drug Delivery Reviews. 3. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 191-214.

Petrak, K.(1989). Preface . Advanced Drug Delivery Reviews. 3. (2).

Goddard, P., Petrak, K.(1989). Biodegradation of drug-modified polymers in drug delivery - a critical analysis . Journal of Bioactive and Compatible Polymers. 4. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 372-402.

Boddy, A., Aarons, L., Petrak, K.(1989). Efficiency of drug targeting: steady-state considerations using a three-compartment model . Pharmaceutical research. 6. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 367-372.

Petrak, K.(1989). Pharmaceutical applications of functionalized polymers . Reactive Polymers. 10. (2-3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 231-237.

Brown, J., Goddard, P., Petrak, K.(1989). Soluble polymeric carriers for drug delivery. Part I. Free radical copolymerization of N-(2-hydroxypropyl)methacrylamide with N-[2-(4-hydroxyphenyl)ethyl]acrylamide . Journal of polymer science. Part C, Polymer letters. 27. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 515-525.

O'Mullane, J.E., Davison, C.J., Petrak, K., Tomlinson, E.(1988). Adsorption of fibrinogen on to polystyrene latex coated with the non-ionic surfactant, poloxamer 338 . Biomaterials. 9. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 203-204.

Petrak, K., Leyshon, L., Douglas, P.(1986). PHOTOREGULATED SORPTION DYES TO POLYMERS. II. ADSORPTION OF ACID YELLOW 38 TO HYDROPHILIC POLYMERS AND ITS LIGHT-INDUCED DESORPTION . Journal of Applied Polymer Science. 31. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1093-1100.

Petrak, K., Douglas, P., Leyshon, L.L.(1986). PHOTOREGULATED SORPTION OF DYES TO POLYMERS I. THE EFFECT OF POLYMERS ON SOME PHOTOCHEMICAL PROPERTIES OF ACID YELLOW 38 . Journal of Applied Polymer Science. 31. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 553-565.

Petrak, K.L.(1984). EFFECT OF PHASE SEPARATION ON THE STRUCTURE AND PERMEABILITY OF GELATIN-DEXTRAN FILMS . Journal of Applied Polymer Science. 29. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 555-565.

Petrak, K.(1984). INTERACTIONS BETWEEN DYES AND POLYELECTROLYTES: EFFECT OF POLYMER-POLYMER INTERACTIONS . Journal of Applied Polymer Science. 29. (12 pt 1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3991-3998.

Petrak, K.L., Pitts, E.(1983). Compositional analysis by g.l.c. of monomer feed in copolymerization - errors due to adsorption of monomer to copolymers . Polymer. 24. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 729-732.

Mijovic, M.V., Beynon, P.J., Shaw, T.J., Petrak, K., Reiser, A., Roberts, A.J., Phillips, D.(1982). Cross-link formation in a solid photopolymer based on the chromophore 1,2-diphenylcyclopropene . Macromolecules. 15. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1464-1471.

Petrak, K., Degen, I., Beynon, P.(1982). SOME 1-SUBSTITUTED QUATERNARY IMIDAZOLIUM COMPOUNDS AND RELATED POLYMERS: QUALITATIVE AND QUANTITATIVE INFRARED ANALYSIS . Journal of polymer science. Part A-1, Polymer chemistry. 20. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 783-793.

Petrak, K., Pitts, E.(1980). PERMEABILITY OF OXYGEN THROUGH POLYMERS - 2. THE EFFECT OF HUMIDITY AND FILM THICKNESS ON THE PERMEATION AND DIFFUSION COEFFICIENTS . Journal of Applied Polymer Science. 25. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 879-886.

Petrak, K.L., Bumfrey, T.J.(1980). The effect of glucose on the permeability of poly-(vinylpyrrolidone) films to oxygen . Polymer Bulletin. 3. (6-7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 311-317.

Petrak, K.(1979). PERMEABILITY OF OXYGEN THROUGH POLYMERS - 1. A NOVEL SPECTROPHOTOCHEMICAL METHOD . J Appl Polym Sci. 23. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2365-2371.

Petrak, K.L.(1978). REACTIVITY OF SOME VINYLIMIDAZOLES TOWARDS OTHER VINYL MONOMERS IN RADICAL COPOLYMERIZATION . J Polym Sci Polym Lett Ed. 16. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 393-399.

Jenkins, A.D., Petrak, K., Roberts, G.A.F., Walton, D.R.M.(1975). Monomers and polymers with silicon-containing functional groups . European Polymer Journal. 11. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 653-655.

OTHER

Petrak, Karel, Tomlinson, Eric(1987). SYNTHETIC POLYMERS FOR CONTROLLED DRUG RELEASE AND DIRECTED DRUG DELIVERY . Chemistry and Industry (London). (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 45-49.