プロフィール詳細

プロジェクトを作成

★★★★★

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★★★★★

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Dr. Kasper F.に依頼

United Kingdom

Experienced life sciences researcher | Cancer Biology | Biochemistry | Drug target discovery

プロフィール概要

I am an accomplished life sciences researcher with over 20 years experience. Group leader at University College London’s (UCL) Cancer Institute and visiting scientist at the Francis Crick Institute. My expertise lies in cancer cell biology and biochemistry, and my work is aimed at biological discoveries with a translational focus on uncovering new therapeutic targets for drug development. I have expert experience in developing and implementing innovative methodologies to address complex scientific questions. My skill set includes CRISPR genome editing and screens, drug target validation and engagement, high-throughput screening, in vitro biochemistry, and a wide range of molecular and cellular biology methodologies. With a proven track record in project conception, experimental design, and advanced data analysis, I have delivered significant insights into biological processes relating to genome stability, identified and developed new targets for cancer therapy. I have authored numerous publications in high-impact journals (incl. Science and Nature) and have thorough experience in grant writing which has successfully secured me substantial research funding. Through collaborations with world-class researchers at UCL, the Francis Crick Institute, and pharmaceutical and biotech industry partners, I have access to an exceptional knowledge base and cutting-edge resources. As a problem solver driven by innovation, I am dedicated to providing strategic consultancy to address scientific challenges, support project development, and accelerate discovery in life sciences and drug target identification and development. Specific expertises and methodologies: I have thorough expertise and hand-on experience with cell biology, CRISPR genome editing and functional screens, cell- and protein-based functional assays, in vitro biochemistry, protein expression, protein structure-function analysis, early-stage drug development, drug screening and target validation, drug-target engagement studies, high-throughput screening assays, phenotypic assays (e.g. high-content microscopy, flow cytometry), metabolomics, DNA and RNA modifications, epigenetics, multi-omics approaches, advanced sequencing (e.g. NGS and nanopore), molecular biology techniques (e.g. cloning, mutagenesis), and immunological assays.

専門分野

• ★ Biochemical Assays
• ★ Drug Target Identification
• ★ Cancer Biology
• ☆ Biochemistry
• ☆ Enzyme Activity Assays
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Omics
• ☆ Genomics
• ☆ Chromatin
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Next Generation Sequencing (NGS)
• ☆ DNA Sequencing
• ☆ Genome Sequencing
• ☆ Mutagenesis
• ☆ RNA Sequencing
• ☆ DNA Damage & Repair
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Data Analysis
• ☆ Image Processing
• ☆ Data Processing
• ☆ Data Visualization
• ☆ Biomarker Discovery
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Line Engineering
• ☆ Chemical Biology
• ☆ Blotting
• ☆ Cytometry
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Phenotypic Assays
• ☆ High Content Screening/Imaging
• ☆ Women's Health
• ☆ Breast Cancer
• ☆ Ovarian Cancer
• ☆ Men's Health
• ☆ Prostate Cancer
• ☆ Oncology
• ☆ Radiation Therapy
• ☆ Chemotherapy
• ☆ Cancer Research
• ☆ Carcinogenesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Skills Training
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing
• ☆ Experimental Protocols
• ☆ Science Communication
• ☆ Scientific Proofreading & Editing
• ☆ Grant Writing

サービス

• Writing
• Research
• Consulting

Writing Technical Writing

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

職務経験

Visiting Scientist

The Francis Crick Institute

3月 2022 - 現在

Group Leader

UCL Cancer Institute

3月 2022 - 現在

Postdoctoral Researcher

The Francis Crick Institute

6月 2014 - 2月 2022

学歴

PhD in cancer biology

University of Copenhagen

9月 2005 - 3月 2009

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Neil Rzechorzek, Simone Kunzelmann, Andrew Purkiss, Mariana Silva dos Santos, James MacRae, IAN TAYLOR, Fugger K, Stephen West (2023). Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1 . Nature communications.

Kasper Fugger (2021). Tackling PARP inhibitor resistance . Trends in cancer.

Kasper Fugger, Ilirjana Bajrami, Mariana Silva Dos Santos, Sarah Jane Young, Simone Kunzelmann, Geoff Kelly, Graeme Hewitt, Harshil Patel, Robert Goldstone, Thomas Carell, et al.(2021). Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA -deficient cells to PARP inhibitors . Science. 372. (6538). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 156--165. American Association for the Advancement of Science ({AAAS})

Hewitt G, Borel V, Segura-Bayona S, Takaki T, Ruis P, Bellelli R, Lehmann LC, Sommerova L, Vancevska A, Tomas-Loba A, et al.(2020). Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD . Molecular cell.

van Wietmarschen N, Sridharan S, Nathan WJ, Tubbs A, Chan EM, Callen E, Wu W, Belinky F, Tripathi V, Wong N, et al.(2020). Repeat expansions confer WRN dependence in microsatellite-unstable cancers . Nature.

Chan YW, Fugger K, West SC(2018). Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations . Nature cell biology.

Fugger K, West SC, Cell research, 2016, vol. 26, no. 4, pp. 397-398 .

Burkovics P, Dome L, Juhasz S, Altmannova V, Sebesta M, Pacesa M, Fugger K, Sorensen CS, Lee MY, Haracska L, Krejci L, Nucleic acids research, 2016, vol. 44, no. 7, pp. 3176-3189 .

Fugger K, Mistrik M, Neelsen KJ, Yao Q, Zellweger R, Kousholt AN, Haahr P, Chu WK, Bartek J, Lopes M, Hickson ID, Sørensen CS, Cell reports, 2015 .

Fugger, Kasper, Chu, Wai Kit, Haahr, Peter, Kousholt, Arne Nedergaard, Beck, Halfdan, Payne, Miranda J., Hanada, Katsuhiro, Hickson, Ian D., Sorensen, Claus Storgaard(2013). FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress . Nature Communications. 4.

Fugger, Kasper, Kousholt, Arne Nedergaard, Hoffmann, Saskia, Larsen, Brian D., Menzel, Tobias, Sartori, Alessandro A., Sorensen, Claus Storgaard(2012). CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation . Journal of Cell Biology. 197. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 869-876.

Fugger, Kasper, Daugaard, Mads, Baude, Annika, Povlsen, Lou Klitgaard, Beck, Halfdan, Sorensen, Claus Storgaard, Petersen, Nikolaj H. T., Sorensen, Pout H. B., Lukas, Claudia, Bartek, Jiri, et al.(2012). LEDGF (p75) promotes DNA-end resection and homologous recombination . Nature Structural & Molecular Biology. 19. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 803-810.

Fugger, Kasper, Jorgensen, Stine, Eskildsen, Morten, Hansen, Lisbeth, Larsen, Marie Sofie Yoo, Kousholt, Arne Nedergaard, Syljuasen, Randi G., Trelle, Morten Beck, Jensen, Ole Norregaard, Helin, Kristian, et al.(2011). SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation . Journal of Cell Biology. 192. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 43-54.

Fugger, Kasper, Bekker-Jensen, Simon, Danielsen, Jannie Rendtlew, Gromova, Irina, Nerstedt, Annika, Lukas, Claudia, Bartek, Jiri, Lukas, Jiri, Mailand, Niels(2010). HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes (vol 12, pg 80, 2010) . Nature Cell Biology. 12. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 412.

Fugger, Kasper, Bekker-Jensen, Simon, Danielsen, Jannie Rendtlew, Gromova, Irina, Nerstedt, Annika, Bartek, Jiri, Lukas, Jiri, Mailand, Niels(2010). HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes . Nature Cell Biology. 12. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 80-U209.

Fugger, Kasper, Mistrik, Martin, Danielsen, Jannie Rendtlew, Dinant, Christoffel, Falck, Jacob, Bartek, Jiri, Lukas, Jiri, Mailand, Niels(2009). Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities . Journal of Cell Biology. 186. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 655-663.

Fugger, Kasper, Bekker-Jensen, Simon, Danielsen, Jannie Rendtlew, Gromova, Irina, Sehested, Maxwell, Celis, Julio, Bartek, Jiri, Lukas, Jiri, Mailand, Niels(2007). Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks . Journal of Biological Chemistry. 282. (27). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 19638-19643.

Fugger, Kasper, Bartkova, Jirina, Rezaei, Nousin, Liontos, Michalis, Karakaidos, Panagiotis, Kletsas, Dimitris, Issaeva, Natalia, Vassiliou, Leandros-Vassilios F., Kolettas, Evangelos, Niforou, Katerina, et al.(2006). Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints . Nature. 444. (7119). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 633-637.

Syljuasen, RG, Sorensen, CS, Hansen, LT, Fugger, K, Lundin, C, Johansson, F, Helleday, T, Sehested, M, Lukas, J, Bartek, J(2005). Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage . Molecular and Cellular Biology. 25. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3553-3562.