プロフィール詳細

プロジェクトを作成

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Dr. Kaveh D.に依頼

United States

Lead Senior Scientist at Flagship Pioneering | Former Research Faculty at Harvard | RNA Therapeutics | Regenerative Medicine

プロフィール概要

Cell and molecular biologist with expertise in RNA-based therapeutics, functional genomics, genome editing, and regenerative medicine. Experienced in leading teams of scientists and innovators in fast-paced environments. Efficient communicator with several high-impact publications and presentations at international meetings. 10+ years of experience in leading and mentoring teams of academic and biotech industry researchers and innovators to conduct research projects related to human health. Stem cell biology - The culture of human embryonic stem cells (hESC), induced pluripotent stem cells (iPSC), and primary human cells. - Genome engineering of iPSCs and embryonic stem cells using TALEN and CRISPR to generate knockout lines for the use in disease modeling. - Scalable differentiation of pluripotent stem cells toward endoderm lineages. - Scalable differentiation of pluripotent stem cells into embryonic lineages and hepatic stellate cells to study hepatic fibrosis. Disease modeling - In vitro (human) and in vivo (mouse) models of hepatic fibrosis. - The culture of primary liver cells. - Using pluripotent stem cells to model human liver fibrosis. RNA biology - RNA and protein-centric biochemical approaches to reveal the RNA-protein interactome. - Optical and biochemical detection and quantification of RNA molecules. - Delivery of RNA molecules into the cells. - Engineering functional synthetic RNA molecules. Genomics, Epigenomics, and Epitranscriptomics -Genome-wide transcription factor binding and chromatin modification (ChIP-sequencing and CUT&RUN). - Epi-transcriptomic mapping of RNA modification. - Computational analysis of next-generation DNA sequencing data (sequence alignment, differential transcriptomic analysis, peak calling) using local computers and clusters.

専門分野

• ★ Molecular Biology
• ★ Genetics
• ★ Gene Editing/CRISPR
• ☆ Transcriptomics
• ☆ Chromatin
• ☆ RNA Sequencing
• ☆ Stem Cell Research
• ☆ Biotechnology & Bioengineering
• ☆ Bioinformatics
• ☆ Phylogenetics
• ☆ Audio Transcription

サービス

• Research

Research Gray Literature Search, Systematic Literature Review, Secondary Data Collection

職務経験

Senior Scientist

Flagship Pioneering

4月 2020 - 現在

Instructor

Massachusetts General Hospital

4月 2019 - 現在

Instructor in Medicine (Research Faculty)

Harvard Medical School

4月 2019 - 4月 2020

Postdoctoral Fellow

Massachusetts General Hospital, Harvard Medical School

10月 2012 - 4月 2019

学歴

PhD (Biology)

University of North Carolina at Charlotte

2007 - 2012

MSc (Biology)

Razi University

2004 - 2007

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Zhou, Chan and Molinie, Benoit and Daneshvar, Kaveh and Pondick, Joshua V and Wang, Jinkai and Van Wittenberghe, Nicholas and Xing, Yi and Giallourakis, Cosmas C and Mullen, Alan C(2017). Genome-wide maps of m6A circRNAs identify widespread and cell-type-specific methylation patterns that are distinct from mRNAs. Cell reports. 20. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2262--2276. Cell Press

Kaveh Daneshvar, Benoit Molinie, Jinkai Wang, Kok Seong Lim, Roman Hillebrand, Zhi-xiang Lu, Nicholas Van Wittenberghe, Benjamin D Howard, Alan C Mullen, Peter Dedon, et al.(2016). m6A-{LAIC}-seq reveals the census and complexity of the m6A epitranscriptome . Nature Methods. 13. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 692--698. Springer Nature

Daneshvar, Kaveh and Pondick, Joshua V and Kim, Byeong-moo and Zhou, Chan and York, Samuel R and Macklin, Jillian A and Abualteen, Ameed and Tan, Bo and Sigova, Alla A and Marcho, Chelsea and Tremblay, Kimberly D and Mager, Jesse and Choi, Michael Y and Mullen, Alan C(2016). DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells. Cell Reports. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--13.

Daneshvar, Kaveh(2015). CRISPR-Cas9 in gene therapy: much control on breaking, little control on repairing. PeerJ PrePrints. 3. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e818v4. PeerJ Inc. San Francisco, USA

Batista PJ, Molinie B, Wang J, Qu K, Zhang J, Li L, Bouley DM, Lujan E, Haddad B, Daneshvar K, Carter AC, Flynn RA, Zhou C, Lim KS, Dedon P, Wernig M, Mullen AC, Xing Y, Giallourakis CC, Chang HY, Cell stem cell, 2014, vol. 15, no. 6, pp. 707-719 .

Daneshvar K, Nath S, Khan A, Shover W, Richardson C, Goodliffe JM, Biology open, 2013, vol. 2, no. 1, pp. 1-9 .

Nath S, Daneshvar K, Roy LD, Grover P, Kidiyoor A, Mosley L, Sahraei M, Mukherjee P, Oncogenesis, 2013, vol. 2, pp. e51 .

Daneshvar K, Khan A, Goodliffe JM, PloS one, 2011, vol. 6, no. 8, pp. e23928 .