プロフィール詳細

プロジェクトを作成

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Dr. Kazumichi Y.に依頼

Japan

Physician & data scientist specializing in clinical epidemiology, biostatistics, and digital health solutions

プロフィール概要

I am a physician and data scientist with extensive experience in clinical epidemiology, biostatistics, and the development of digital tools for medical research. Over the past two decades, I have worked in both hospital settings and multi-center research projects in Europe and Japan, bridging the gap between clinical practice and data-driven research. My expertise spans study design, statistical analysis, predictive modeling, and implementation of digital systems to streamline clinical research workflows. I have served as principal investigator and research supervisor for numerous prospective and retrospective studies, collaborating with universities, hospitals, and industry partners. My methodological experience includes advanced biostatistics, time-series analysis, and machine learning applications in medicine. I am proficient in R, Python, and web-based platforms such as R Shiny, with experience building secure, user-friendly applications for data collection, visualization, and predictive analytics. My ongoing projects focus on real-world clinical monitoring systems, predictive models for cardiovascular and pulmonary outcomes, and tools for evaluating clinical decision-making and diagnostic accuracy. I have successfully integrated multi-institutional data sources, ensuring compliance with data governance and ethical standards, while delivering actionable insights for both clinicians and researchers. In addition to research and software development, I provide consultancy services for study design, data analysis, and digital implementation. I aim to support academic and industry partners in translating complex clinical data into evidence-based solutions, from initial concept through practical deployment. Fluent in English, French, German, Spanish, and Japanese, I am well-positioned to collaborate on international projects and provide comprehensive support for multi-national research initiatives.

専門分野

• ★ Biostatistics
• ★ E-Health & Telemedicine
• ★ Health Informatics

サービス

• Writing
• Research
• Data & AI

Writing Clinical Trial Documentation, Medical Writing

Research Scientific and Technical Research, Systematic Literature Review

Data & AI Predictive Modeling, Statistical Analysis

職務経験

Chief researcher

Institute for Airway Disease

7月 2017 - 現在

Visiting researcher

Kyoto University

4月 2017 - 現在

Visiting physician

University of Tokyo Hospital

11月 2019 - 3月 2025

Stellevertretender Oberarzt

Inselspital, Universitätsspital Bern

2月 2015 - 11月 2015

Advanced clinical fellow

Centre Hospitalier Universitaire Vaudois

12月 2011 - 12月 2013

学歴

PhD (Medicine)

Saga University

- 11月 2016

Certificate of Advanced Study in Clinical Epidemiology

University of Lausanne

9月 2013 - 8月 2014

MD (School of medicine)

Kyoto University

4月 1989 - 3月 1995

認定資格

• Certificate of Advanced Study in Clinical Epidemiology

  University of Lausanne

  9月 2013 - 現在

出版物

JOURNAL ARTICLE

Shinohara Y, Yamaguchi M, Wannous M, Luo Y, Yamamoto K, Sato M (2025). Criteria for identifying acute respiratory events based on FEV1 decline in home spirometry for lung transplant patients . BMC pulmonary medicine.

Kawashima M, Konoeda C, Yamamoto K, Sato M (2024). Improved Pulmonary Hypertension and Heart Failure by Diaphragmatic Plication and Tracheal Resection . Annals of thoracic surgery short reports.

Kaga T, Inaba S, Shikano Y, Watanabe Y, Fujisawa T, Akazawa Y, Ohshita M, Kawakami H, Higashi H, Aono J, et al. (2024). Utility of RAND/UCLA appropriateness method in validating multiple-choice questions on ECG . BMC medical education.

Yamamoto, Kazumichi, Kaga, Tomohiro, Inaba, Shinji, Shikano, Yukari, Watanabe, Yasuyuki, Fujisawa, Tomoki, Akazawa, Yusuke, Ohshita, Muneaki, Kawakami, Hiroshi, Higashi, Haruhiko, et al.(2024). Utility of RAND/UCLA appropriateness method in validating multiple-choice questions on ECG . BMC medical education.

A prediction model for estimating NT-proBNP in a general Japanese population: the Toon Health Study @article{PMID:38303572,Title={A prediction model for estimating NT-proBNP in a general Japanese population: the Toon Health Study},Author={Inoue, Katsuji and Yamamoto, Kazumichi and Higashi, Haruhiko and Takata, Yasunori and Inaba, Shinji and Miyazaki, Shigehiro and Higaki, Akinori and Saito, Makoto and Osawa, Haruhiko and Yamaguchi, Osamu},DOI={10.1002/ehf2.14691},Number={3},Volume={11},Month={June},Year={2024},Journal={ESC heart failure},ISSN={2055-5822},Pages={1483—1492},Abstract={<h4>Aims</h4>As part of the Toon Health Study, which is an ongoing population-based cohort study, we aimed to develop a prediction model for N-terminal pro-brain natriuretic peptide (NT-proBNP) in a general Japanese population. We sought to explore the influence of various demographic and clinical factors on NT-proBNP levels and assess the model's performance. In addition, our objectives included internal validation and investigation of the diagnostic potential of the observed-to-predicted NT-proBNP ratio (OPR) at baseline for predicting the risk of heart failure with preserved ejection fraction (HFpEF).<h4>Methods and results</h4>In this prospective cohort study, participants were recruited from Toon City, Japan, as part of the larger Toon Health Study, focusing on cardiovascular risk factors. We measured the NT-proBNP levels and used linear regression with penalization (ridge regression) to develop the model. The model incorporated 10 prespecified predictors (age, gender, body mass index, diastolic blood pressure, heart rate, haemoglobin, albumin, total cholesterol, haemoglobin A1c, and estimated glomerular filtration rate) and underwent assessment using R<sup>2</sup> and root mean squared error (RMSE). Internal validation was conducted through bootstrapping. In a post hoc analysis, we explored the OPR's diagnostic potential using 5 year follow-up data (n = 636) to predict the elevation of NT-proBNP > 125 pg/mL at the 5 year follow-up as the risk of HFpEF. A total of 2505 participants (age: 60.4 ± 12.9 years, men: 35%) were enrolled in this study. There was a linear relationship between the observed and predicted values of NT-proBNP in which the logarithm of observed NT-proBNP was <6, which corresponds to 403 pg/mL in NT-proBNP. The prediction model demonstrated satisfactory performance (R<sup>2</sup>: 0.291, RMSE: 0.688), with age identified as a dominant predictor. The stability of the model was underscored by the internal validation. The OPR at baseline predicted NT-proBNP > 125 pg/mL at the 5 year follow-up with an area under the curve of 0.793.<h4>Conclusions</h4>This study introduces the first prediction model for NT-proBNP in a general Japanese population. Although the model has acceptable performance, ongoing refinement is essential. Our transparent approach to model development, alongside a web-based interactive tool, lays the groundwork for further improvements and external validation. The OPR holds potential for predicting the future risk of HFpEF. This research contributes to understanding the nuanced influence of patient backgrounds on levels of NT-proBNP in asymptomatic individuals within the context of a broader population-based cohort study.},URL={https://europepmc.org/articles/PMC11098656}} . ESC heart failure.

Nakao Y, Kawakami H, Miyazaki S, Saito M, Luo Y, Yamamoto K, Yamaguchi O (2023). Evaluation of health utility in trial-based cost-utility analyses for major cardiovascular disease: protocol for a systematic review . BMJ open.

Kazumichi Yamamoto, Shinji Inaba, Tomohiro Kaga, Muhammad Wannous, Masatsugu Sakata, Osamu Yamaguchi, Toshi A Furukawa (2023). Protocol for development of an assessment tool for competency of ECG interpretation: expert consensus by the RAND/UCLA appropriateness method and cross-sectional testing using multidimensional item response theory . BMJ Open.

Yamaguchi H, Sato M, Yamamoto K, Shinohara K, Yanagiya M, Hashisako M, Wannous M, Nakajima J (2022). Availability of virtual-assisted lung mapping affects procedure selection for early-stage lung cancer: a web-based cross-sectional study . European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Shinohara Y, Yamamoto K, Ito M, Sakata M, Koizumi S, Hashisako M, Sato M, Wannous M, Stoyanov SR, Nakajima J, et al. (2022). Development and validation of the Japanese version of the uMARS (user version of the mobile app rating system) . International journal of medical informatics.

Kazumichi Yamamoto, Masami Ito, Masatsugu Sakata, Shiho Koizumi, Mizuho Hashisako, Masaaki Sato, Stoyan R Stoyanov, Toshi A Furukawa(2022). Japanese Version of the Mobile App Rating Scale (MARS): Development and Validation . JMIR mHealth and uHealth. 10. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e33725. {JMIR} Publications Inc.

Yamaguchi H, Sato M, Yamamoto K, Ueda K, Date H, Chen-Yoshikawa T, Yamada Y, Tokuno J, Yanagiya M, Kojima F, et al. (2022). Virtual-assisted lung mapping in sublobar resection of small pulmonary nodules, long-term results . European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Kazumichi Yamamoto, Morihiro Katsura, Akira Kuriyama, Masafumi Tada, Yasushi Tsujimoto, Yan Luo, Ryuhei So, Masaharu Aga, Kazuhide Matsushima, Shingo Fukuma, et al.(2021). High variability in results and methodological quality among overlapping systematic reviews on the same topics in surgery: a meta-epidemiological study . British Journal of Surgery. 108. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1521--1529. Oxford University Press ({OUP})

Katsura M, Kuriyama A, Tada M, Yamamoto K, Furukawa TA (2017). Redundant systematic reviews on the same topic in surgery: a study protocol for a meta-epidemiological investigation . BMJ open.

Honda M, Yamamoto K, Furukawa TA (2014). Retrospective propensity score matching and the selection of surgical procedures: how precise can a propensity estimate be? . Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Yamamoto K, Jaquet Y, Ikonomidis C, Monnier P (2014). Partial cricotracheal resection for paediatric subglottic stenosis: update of the Lausanne experience with 129 cases . European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Yamamoto K, Monnier P, Holtz F, Jaquet Y (2014). Laryngotracheal reconstruction for pediatric glotto-subglottic stenosis . International journal of pediatric otorhinolaryngology.

Yamamoto K, Honda M, Furukawa TA (2013). Video-assisted thoracoscopic surgery lobectomy or open lobectomy for non-small-cell lung cancer? Minimizing selection bias in observational studies . European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Yamamoto K, Honda M, Yamamoto T, Nakamura T (2012). Healing process after total cricoidectomy and laryngotracheal reconstruction: endoscopic and histologic evaluation in a canine model . The Journal of thoracic and cardiovascular surgery.

Yamamoto K, Tomiyama K, Mitsuoka M (2011). Total cricoidectomy and laryngotracheal reconstruction for subglottic stenosis with glottic involvement . Interactive cardiovascular and thoracic surgery.

Yamamoto K, Tomiyama K, Mitsuoka M (2011). Total cricoidectomy and laryngotracheal reconstruction for subglottic stenosis with glottic involvement . Interactive cardiovascular and thoracic surgery.

Yamamoto K, Kojima F, Tomiyama K, Nakamura T, Hayashino Y (2011). Meta-analysis of therapeutic procedures for acquired subglottic stenosis in adults . The Annals of thoracic surgery.

Honda M, Nakamura T, Hori Y, Shionoya Y, Yamamoto K, Nishizawa Y, Kojima F, Shigeno K (2011). Feasibility study of corticosteroid treatment for esophageal ulcer after EMR in a canine model . Journal of gastroenterology.

Kojima F, Yamamoto K, Matsuoka K, Ueda M, Hamada H, Imanishi N, Miyamoto Y (2011). Factors affecting survival after lobectomy with pulmonary artery resection for primary lung cancer . European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Honda M, Hori Y, Nakada A, Uji M, Nishizawa Y, Yamamoto K, Kobayashi T, Shimada H, Kida N, Sato T, et al. (2011). Use of adipose tissue-derived stromal cells for prevention of esophageal stricture after circumferential EMR in a canine model . Gastrointestinal endoscopy.

Homma S, Yamamoto K, Ueda M, Miyamoto Y (2010). [Thoracoscopic right middle lobectomy and adjuvant chemotherapy for pulmonary mucosal associated lymphoid tissue (MALT) lymphoma; report of a case]. Kyobu geka. The Japanese journal of thoracic surgery.

Yamamoto K, Ohsumi A, Kojima F, Imanishi N, Matsuoka K, Ueda M, Miyamoto Y (2010). Long-term survival after video-assisted thoracic surgery lobectomy for primary lung cancer . The Annals of thoracic surgery.

Maeda R, Isowa N, Miura H, Tokuyasu H, Kawasaki Y, Yamamoto K (2009). Bilateral multiple sclerosing hemangiomas of the lung . General thoracic and cardiovascular surgery.

Maeda R, Isowa N, Onuma H, Miura H, Kawasaki Y, Yamamoto K (2009). Biphasic pulmonary blastoma with rapid progression . General thoracic and cardiovascular surgery.

Yamamoto K, Miyamoto Y, Ohsumi A, Kojima F, Imanishi N, Matsuoka K, Ueda M, Hamada C (2008). Sleeve lung resection for lung cancer: analysis according to the type of procedure . The Journal of thoracic and cardiovascular surgery.

Yamamoto K, Miyamoto Y, Ohsumi A, Imanishi N, Kojima F (2007). Surgical results of carinal reconstruction: an alterative technique for tumors involving the tracheal carina . The Annals of thoracic surgery.

Yamamoto K, Miyamoto Y, Ohsumi A, Imanishi N, Kojima F (2007). Results of surgical resection for tracheobronchial cancer involving the tracheal carina . General thoracic and cardiovascular surgery.

Yamamoto K, Padilla Alarcón J, Calvo Medina V, García-Zarza A, Pastor Guillen J, Blasco Armengod E, París Romeu F (2003). Surgical results of stage I non-small cell lung cancer: comparison between elderly and younger patients . European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.