プロフィール詳細

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Dr. Kevin Z.に依頼

United States

PhD Microfluidics Expert | Microfluidic Chip Design & Simulation | Rapid Prototyping & System Integration | 10+ Patents

プロフィール概要

I'm an expert in the microfluidics field with 10+ years of industry and academic experience in advanced microfluidic platforms, fluidic automation, and system integration. Currently a Sr. Microfluidic Engineer at Genus PLC (IntelliGen Technologies), I lead development of high-efficiency microfluidic chips integrated with flow cytometry for bovine/porcine semen sexing, resulting in >20% production efficiency gains, global adoption, and significant revenue impact. My expertise spans the full R&D cycle: microfluidic chip design, prototyping (soft lithography, thermoplastic manufacturing with COC/COP/PMMA, and glass), cartridge/manifold engineering, automated fluid handling, and process optimization for biomedical, reproductive, and diagnostic applications. Key Achievements: Led cross-functional teams to develop 12+ patented microfluidic devices for organ-on-chip, cell sorting/separation and semen sexing applications. 7 issued US patents + multiple international applications/provisionals in microfluidic devices, particle focusing, and sperm selection. Prior roles: Microfluidics Consultant (FCS Technology LLC), Scientist at Ohana Biosciences (human sperm selection for ART/IVF), Postdoc at Lawrence Berkeley National Lab. PI on NIH STTR grant for ferrohydrodynamic cell separation technology. 10+ peer-reviewed publications in high-impact journals (e.g., Lab on a Chip, Advanced Functional Materials, ACS Nano, Green Chemistry, etc.). Key Projects: Leading development of multiple advanced microfluidic chips incorporating with laser-ablation technology and flow cytometry for semen sexing and reproductive research. Development, designing, prototyping, and manufacturing of precision thermoplastic microfluidic chips for advanced cell sorting applications. Utilizing microfluidic devices to facilitate handling of semen sample and selection of the most competent human sperm for assisted reproductive technologies (ARTs), such as IVF, IUI and ICSI. Hybrid microfluidic system for real-time chemical imaging of biological materials in fluids integrated with broadband infrared nano-spectroscopy. Tumor antigen-independent and cell size variation-inclusive enrichment of the complete repertoire of viable circulating tumor cells (CTCs) from clinical samples via an integrated microfluidic device. Development of biocompatible colloidal magnetic nanoparticles for screening and enrichment of abnormal cervical cells from cervical specimens with a versatile microfluidic chip. Microfluidic three-dimensional brain-on-a-chip platform for neuroscience research. I offer freelance consulting to biotech startups, medtech/agtech companies, and labs needing expertise in microfluidic system development, failure analysis, or rapid prototyping. Available for part-time projects. Let's collaborate to innovate in lab-on-a-chip, diagnostics, or reproductive technologies!

専門分野

• ★ Microfluidics
• ★ Product Design
• ★ Product Prototyping

サービス

• Writing
• Research
• Consulting
• Product Development

Writing Technical Writing, Translation

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting, Manufacturing Consulting

Product Development Product Evaluation, Product Validation, Manufacturing, Concept Development, Product Launch Support, Prototyping, Device Fabrication

職務経験

Sr. Microfluidic Engineer

Genus PLC

12月 2020 - 現在

Microfluidic Consultant

FCS Technology LLC

9月 2019 - 8月 2023

Microfluidic Scientist

Ohana Biosciences Inc.

2月 2020 - 12月 2020

Postdoctoral Scholar

Lawrence Berkeley National Laboratory

1月 2019 - 1月 2020

学歴

Ph.D. (Chemistry)

University of Georgia

8月 2013 - 3月 2018

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

(2024). CTC-Race: Single-Cell Motility Assay of Circulating Tumor Cells from Metastatic Lung Cancer Patients . ACS NANO.

(2024). Spatiotemporal dynamics of cellulose during enzymatic hydrolysis studied by infrared spectromicroscopy . GREEN CHEMISTRY.

(2021). Brain-on-a-Chip Device for Modeling Multiregional Networks . ACS BIOMATERIALS SCIENCE & ENGINEERING.

(2021). Fundamentals of integrated ferrohydrodynamic cell separation in circulating tumor cell isolation . LAB ON A CHIP.

(2021). Label-free inertial-ferrohydrodynamic cell separation with high throughput and resolution . LAB ON A CHIP.

(2021). Simultaneous biochemical and functional phenotyping of single circulating tumor cells using ultrahigh throughput and recovery microfluidic devices . LAB ON A CHIP.

(2020). Label-free ferrohydrodynamic separation of exosome-like nanoparticles . LAB ON A CHIP.

(2019). Cell size variation-inclusive, tumor antigen-independent enrichment of viable circulating tumor cells. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

(2019). Manipulation of Single Cells Using a Ferromagnetic Nanorod Cluster Actuated by Weak AC Magnetic Fields . ADVANCED BIOSYSTEMS.

(2019). Surfen-mediated blockade of extratumoral chondroitin sulfate glycosaminoglycans inhibits glioblastoma invasion . FASEB JOURNAL.

(2019). Tumor antigen-independent and cell size variation-inclusive enrichment of viable circulating tumor cells . LAB ON A CHIP.

(2018). Magnetic resonance conditional paramagnetic choke for suppression of imaging artifacts during magnetic resonance imaging . PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE.

(2018). Microfluidics in Malignant Glioma Research and Precision Medicine . ADVANCED BIOSYSTEMS.

(2017). Biocompatible and label-free microfluidic separation of cancer cells from blood in ferrofluids. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

(2017). Biocompatible and label-free separation of cancer cells from cell culture lines from white blood cells in ferrofluids . LAB ON A CHIP.

(2017). Ferrofluid-Based Droplet Interface Bilayer Networks . LANGMUIR.

(2017). Label-free ferrohydrodynamic cell separation of circulating tumor cells . LAB ON A CHIP.

(2016). Glioma cell invasion is significantly enhanced in composite hydrogel matrices composed of chondroitin 4-and 4,6-sulfated glycosaminoglycans . JOURNAL OF MATERIALS CHEMISTRY B.

(2016). Label-Free Microfl uidic Manipulation of Particles and Cells in Magnetic Liquids . ADVANCED FUNCTIONAL MATERIALS.

(2016). Label-Free and Continuous-Flow Ferrohydrodynamic Separation of HeLa Cells and Blood Cells in Biocompatible Ferrofluids . ADVANCED FUNCTIONAL MATERIALS.

(2016). MAGNETICALLY RESPONSIVE DROPLET INTERFACE BILAYER NETWORKS. ASME CONFERENCE ON SMART MATERIALS, ADAPTIVE STRUCTURES AND INTELLIGENT SYSTEMS, 2015, VOL 2.

(2013). A totally phosphine-free synthesis of metal telluride nanocrystals by employing alkylamides to replace alkylphosphines for preparing highly reactive tellurium precursors . NANOSCALE.