プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Leonard E.に依頼

United States

20 years experience in pharmaceutical and academic research with expertise in genomics, gene editing, and hematology.

プロフィール概要

Accomplished scientific leader in functional genomics with experience in biomarker analysis, pharmacogenetics, molecular biology, gene editing tools, cell therapy development, target discovery, CAR-T and T-cell engager analysis, virology, oncology, and immunology. Proven track record in managing cross-functional teams, fostering partnerships and delivering critical data to advance biopharmaceutical science. Successful application of CRISPR/genome editing screens for Target Identification and Validation, awarded NIH and AHA funding. Finalist for AHA Brinkhous Early Career Investigator Award in Thrombosis.

専門分野

• ☆ Microbiology
• ☆ Virology
• ☆ Molecular Virology
• ☆ Biochemistry
• ☆ Biochemical Assays
• ☆ Molecular Biology
• ☆ Genetics
• ☆ Omics
• ☆ Transcriptomics
• ☆ Genomics
• ☆ Epigenetics
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Biomolecular Engineering
• ☆ Gene Editing/CRISPR
• ☆ Drug Development
• ☆ Drug Substance Characterization
• ☆ Hematology
• ☆ Hematology-Oncology
• ☆ Medical Writing
• ☆ Research Summaries & Abstracts
• ☆ Grant Writing

サービス

• Writing
• Research
• Consulting

Writing Technical Writing

Research Technology Scouting, Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

職務経験

Janssen Research and Development Spring House

5月 2020 - 現在

Assistant Professor

Thomas Jefferson University

10月 2010 - 5月 2020

Adjunct Assistant Professor

Rutgers Robert Wood Johnson Medical School

10月 2006 - 7月 2010

Instructor

Harvard Medical School

5月 2005 - 7月 2006

Postdoctoral Fellow

Harvard Medical School

7月 2002 - 4月 2005

Graduate Student

Rutgers Robert Wood Johnson Medical School

9月 1996 - 6月 2002

学歴

(Pathology)

Harvard Medical School

7月 2002 - 4月 2005

PhD (Biochemisty)

Rutgers University - Busch Campus

8月 1996 - 6月 2002

BS (Biology)

Cornell University

8月 1992 - 5月 1996

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

(2022). Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice . Journal of thrombosis and haemostasis : JTH.

(2021). PCTP contributes to human platelet activation by enhancing dense granule secretion . Thrombosis research.

Seema Bhatlekar, Bhanu K. Manne, Indranil Basak, Leonard C. Edelstein, Emilia Tugolukova, Michelle L. Stoller, Mark J. Cody, Sharon C. Morley, Srikanth Nagalla, Andrew S. Weyrich, et al.(2020). miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin . Blood. American Society of Hematology

Andrew R. Ghazi, Jian Ma, Xianguo Kong, Ed S. Chen, Leonard C. Edelstein, Chad A. Shaw(2020). Bayesian modelling of high-throughput sequencing assays with malacoda . PLOS Computational Biology. 16. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e1007504. Public Library of Science ({PLoS})

Namrata Madan, Folkert Wouter Asselbergs, Andrew R. Ghazi, Xianguo Kong, Edward S. Chen, Chad A. Shaw, Leonard C. Edelstein(2019). Functionalization of CD36 cardiovascular disease and expression associated variants by interdisciplinary high throughput analysis . PLOS Genetics. 15. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e1008287. Public Library of Science ({PLoS})

Lawrence E. Goldfinger, Leonard C. Edelstein (2019). Horizontal RNA transfer goes deep: platelet consumption and microRNA utilization by vascular smooth muscle cells . Journal of Thrombosis and Haemostasis.

Basak I, Bhatlekar S, Manne BK, Stoller M, Hugo S, Kong X, Ma L, Rondina MT, Weyrich AS, Edelstein LC, et al.(2019). miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway . Journal of thrombosis and haemostasis : JTH.

Basak, I., Bhatlekar, S., Manne, B.K., Stoller, M., Hugo, S., Kong, X., Ma, L., Rondina, M.T., Weyrich, A.S., Edelstein, L.C., et al.(2019). miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway . Journal of Thrombosis and Haemostasis. 17. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 511-524.

Goldfinger, L.E., Edelstein, L.C.(2019). Horizontal RNA transfer goes deep: platelet consumption and microRNA utilization by vascular smooth muscle cells . Journal of Thrombosis and Haemostasis. 17. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1014-1017.

Kong, X., Ma, L., Chen, E., Shaw, C.A., Edelstein, L.C.(2019). Identification of the Regulatory Elements and Target Genes of Megakaryopoietic Transcription Factor MEF2C . Thrombosis and Haemostasis. 119. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 716-725.

Whitley MJ, Henke DM, Ghazi A, Nieman M, Stoller M, Simon LM, Chen E, Vesci J, Holinstat M, McKenzie SE, et al.(2018). The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition . Journal of thrombosis and haemostasis : JTH.

Ghazi AR, Chen ES, Henke DM, Madan N, Edelstein LC, Shaw CA(2018). Design tools for MPRA experiments . Bioinformatics (Oxford, England).

Tricoci P, Neely M, Whitley MJ, Edelstein LC, Simon LM, Shaw C, Fortina P, Moliterno DJ, Armstrong PW, Aylward P, et al.(2018). Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial . Blood cells, molecules & diseases.

Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M(2018). Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics . Arteriosclerosis, thrombosis, and vascular biology.

Tourdot, B.E., Stoveken, H., Trumbo, D., Yeung, J., Kanthi, Y., Edelstein, L.C., Bray, P.F., Tall, G.G., Holinstat, M.(2018). Genetic variant in human PAR (Protease-Activated Receptor) 4 enhances thrombus formation resulting in resistance to antiplatelet therapeutics . Arteriosclerosis, Thrombosis, and Vascular Biology. 38. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1632-1643.

Tricoci, P., Neely, M., Whitley, M.J., Edelstein, L.C., Simon, L.M., Shaw, C., Fortina, P., Moliterno, D.J., Armstrong, P.W., Aylward, P., et al.(2018). Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial . Blood Cells, Molecules, and Diseases. 72. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 37-43.

Whitley, M.J., Henke, D.M., Ghazi, A., Nieman, M., Stoller, M., Simon, L.M., Chen, E., Vesci, J., Holinstat, M., McKenzie, S.E., et al.(2018). The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y<inf>12</inf> inhibition . Journal of Thrombosis and Haemostasis. 16. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2501-2514.

Ghazi, A.R., Chen, E.S., Henke, D.M., Madan, N., Edelstein, L.C., Shaw, C.A.(2018). Design tools for MPRA experiments . Bioinformatics (Oxford, England). 34. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2682-2683.

Michael JV, Wurtzel JGT, Mao GF, Rao AK, Kolpakov MA, Sabri A, Hoffman NE, Rajan S, Tomar D, Madesh M, et al.(2017). Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth . Blood.

Kong X, Simon LM, Holinstat M, Shaw CA, Bray PF, Edelstein LC(2017). Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP . Thrombosis and haemostasis.

Kong, X., Simon, L.M., Holinstat, M., Shaw, C.A., Bray, P.F., Edelstein, L.C.(2017). Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP . Thrombosis and Haemostasis. 117. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 962-970.

Edelstein, L.C.(2017). The role of platelet microvesicles in intercellular communication . Platelets. 28. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 222-227.

Michael, J.V., Wurtzel, J.G.T., Mao, G.F., Rao, A.K., Kolpakov, M.A., Sabri, A., Hoffman, N.E., Rajan, S., Tomar, D., Madesh, M., et al.(2017). Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth . Blood. 130. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 567-580.

Edelstein LC(2016). The role of platelet microvesicles in intercellular communication . Platelets.

Simon, L.M., Chen, E.S., Edelstein, L.C., Kong, X., Bhatlekar, S., Rigoutsos, I., Bray, P.F., Shaw, C.A.(2016). Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2 . American Journal of Human Genetics. 98. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 883-897.

Lindsay, C.R., Edelstein, L.C.(2016). MicroRNAs in platelet physiology and function . Seminars in Thrombosis and Hemostasis. 42. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 215-222.

Zhou, Y., Abraham, S., Renna, S., Edelstein, L.C., Dangelmaier, C.A., Tsygankov, A.Y., Kunapuli, S.P., Bray, P.F., McKenzie, S.E.(2016). TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (FcγRIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice . Arteriosclerosis, Thrombosis, and Vascular Biology. 36. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2315-2323.

Yuhang Zhou, Shaji Abraham, Pierrette Andre, Leonard C. Edelstein, Chad A. Shaw, Carol A. Dangelmaier, Alexander Y. Tsygankov, Satya P. Kunapuli, Paul F. Bray, Steven E. McKenzie(2015). Anti–miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice . Blood. 126. (26). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2871--2881. American Society of Hematology

Zhou, Y., Abraham, S., Andre, P., Edelstein, L.C., Shaw, C.A., Dangelmaier, C.A., Tsygankov, A.Y., Kunapuli, S.P., Bray, P.F., McKenzie, S.E.(2015). Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice . Blood. 126. (26). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2871-2881.

et al., Edelstein, L.C., Simon, L.M., Lindsay, C.R., Kong, X., Teruel-Montoya, R., Tourdot, B.E., Chen, E.S., Ma, L., Coughlin, S., Nieman, M.(2014). Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race . Blood. 124. (23). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3450-3458.

Simon, L.M., Edelstein, L.C., Nagalla, S., Woodley, A.B., Chen, E.S., Kong, X., Ma, L., Fortina, P., Kunapuli, S., Holinstat, M., et al.(2014). Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics . Blood. 123. (16).

Tourdot, B.E., Conaway, S., Niisuke, K., Edelstein, L.C., Bray, P.F., Holinstat, M.(2014). Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis . Arteriosclerosis, Thrombosis, and Vascular Biology. 34. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2644-2650.

Teruel-Montoya, R., Kong, X., Abraham, S., Ma, L., Kunapuli, S.P., Holinstat, M., Shaw, C.A., McKenzie, S.E., Edelstein, L.C., Bray, P.F.(2014). MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression . PLoS ONE. 9. (7).

Londin, E.R., Hatzimichael, E., Loher, P., Edelstein, L., Shaw, C., Delgrosso, K., Fortina, P., Bray, P.F., McKenzie, S.E., Rigoutsos, I.(2014). The human platelet: Strong transcriptome correlations among individuals associate weakly with the platelet proteome . Biology Direct. 9. (1).

Edelstein, L.C., Mckenzie, S.E., Shaw, C., Holinstat, M.A., Kunapuli, S.P., Bray, P.F.(2013). MicroRNAs in platelet production and activation . Journal of Thrombosis and Haemostasis. 11. (SUPPL.1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 340-350.

Edelstein, L.C., Simon, L.M., Montoya, R.T., Holinstat, M., Chen, E.S., Bergeron, A., Kong, X., Nagalla, S., Mohandas, N., Cohen, D.E., et al.(2013). Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c . Nature Medicine. 19. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1609-1616.

Edelstein LC, Bray PF(2012). Small RNAs as potential platelet therapeutics . Handbook of experimental pharmacology.

Edelstein, L.C., Luna, E.J., Gibson, I.B., Bray, M., Jin, Y., Kondkar, A., Nagalla, S., Hadjout-Rabi, N., Smith, T.C., Covarrubias, D., et al.(2012). Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress . Circulation. 125. (22). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2762-2771.

Edelstein, L.C., Bray, P.F.(2011). MicroRNAs in platelet production and activation . Blood. 117. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5289-5296.

Nagalla, S., Shaw, C., Kong, X., Kondkar, A.A., Edelstein, L.C., Ma, L., Chen, J., McKnight, G.S., L&#243;pez, J.A., Yang, L., et al.(2011). Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity . Blood. 117. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5189-5197.

Micheva-Viteva, S., Kobayashi, Y., Edelstein, L.C., Pacchia, A.L., Lee, H.-L.R., Graci, J.D., Breslin, J., Phelan, B.D., Miller, L.K., Colacino, J.M., et al.(2011). High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor . Journal of Biological Chemistry. 286. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 21083-21091.

Edelstein, L.C., Micheva-Viteva, S., Phelan, B.D., Dougherty, J.P.(2009). Short communication: Activation of latent HIV type 1 gene expression by suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor approved for use to treat cutaneous T cell lymphoma . AIDS Research and Human Retroviruses. 25. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 883-887.

Edelstein, L.C., Collins, T.(2005). The SCAN domain family of zinc finger transcription factors . Gene. 359. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-17.

Edelstein, L.C., Pan, A., Collins, T.(2005). Chromatin Modification and the Endothelial-specific activation of the E-selectin gene . Journal of Biological Chemistry. 280. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 11192-11202.

D&#39;Souza, B.N., Edelstein, L.C., Pegman, P.M., Smith, S.M., Loughran, S.T., Clarke, A., Mehl, A., Rowe, M., G&#233;linas, C., Walls, D.(2004). Nuclear Factor κB-Dependent Activation of the Antiapoptotic bfl-1 Gene by the Epstein-Barr Virus Latent Membrane Protein 1 and Activated CD40 Receptor . Journal of Virology. 78. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1800-1816.

Edelstein, L.C., Lagos, L., Simmons, M., Tirumalai, H., G&#233;linas, C.(2003). NF-κB-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1 . Molecular and Cellular Biology. 23. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2749-2761.

Suh, J., Payvandi, F., Edelstein, L.C., Amenta, P.S., Zong, W.-X., G&#233;linas, C., Rabson, A.B.(2002). Mechanisms of constitutive NF-κB activation in human prostate cancer cells . Prostate. 52. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 183-200.

Chen, C., Edelstein, L.C., G&#233;linas, C.(2000). The Rel/NF-κb family directly activates expression of the apoptosis inhibitor BCl-x(L) . Molecular and Cellular Biology. 20. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2687-2695.

Zong, W.-X., Edelstein, L.C., Chen, C., Bash, J., G&#233;linas, C.(1999). The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis . Genes and Development. 13. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 382-387.

OTHER

Namrata Madan, Andrew R. Ghazi, Xianguo Kong, Edward S. Chen, Chad A. Shaw, Leonard C. Edelstein(2019). Identification of functional variants for platelet CD36 expression by Massively Parallel Reporter Assay . Cold Spring Harbor Laboratory

Claire Simonneau, Junning Yang, Xianguo Kong, Robert Kilker, Leonard Edelstein, Paolo Fortina, Eric Londin, Arie Horowitz(2018). Validation of a Miniaturized Permeability Assay Compatible with CRISPR-Mediated Genome-Wide Screen . Cold Spring Harbor Laboratory

Simonneau C, Yang J, Kong X, Kilker R, Edelstein L, Fortina P, Londin E, Horowitz A(2018). Miniaturized Permeability Assay for CRISPR-Mediated Genome-Wide Screens .

Bray, P.F., McKenzie, S.E., Edelstein, L.C., Nagalla, S., Delgrosso, K., Ertel, A., Kupper, J., Jing, Y., Londin, E., Loher, P., et al.(2013). The complex transcriptional landscape of the anucleate human platelet . BMC genomics. 14.

BOOK CHAPTER

Edelstein, L.C., Bray, P.F.(2017). Noncoding RNAs in platelet biology . Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 239-252.

Edelstein, L.C., Nagalla, S., Bray, P.F.(2013). MicroRNAs in Platelet Production and Activation . MicroRNAs in Medicine. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 101-116.

BOOK

Edelstein, L.C., Bray, P.F.(2012). Small RNAs as potential platelet therapeutics . Handbook of Experimental Pharmacology. 210. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 435-445.