プロフィール詳細

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Dr. Leal O.に依頼

Switzerland

Stem Cell Biologist | Hematopoiesis Expert | Cell Metabolism Researcher | Academic Writer/Reviewer | PhD in Biomedicine

プロフィール概要

Dedicated stem cell biologist and metabolism researcher with over a decade of experience in hematopoiesis and immunology. PhD in Biomedicine from the University of Montpellier, with a strong track record of publications in high-impact journals such as Cell Stem Cell and EMBO Reports. Currently an Associate Researcher at the Institute for Regenerative Medicine, University of Zurich, focusing on cell and gene therapy. Proven expertise in: Hematopoietic stem cell biology Metabolic regulation of cell fate decisions Gene editing techniques (CRISPR) In vitro and in vivo models of hematopoiesis Active in the scientific community as a peer reviewer for journals including Experimental Hematology and Scientific Reports. Guest editor for JoVE Journal's "In vivo and in vitro models of developmental hematopoiesis" Methods Collection. Authored multiple peer-reviewed articles and review papers in the field of hematopoiesis and stem cell metabolism. Recipient of several grants and fellowships, including the EMBO Long-Term Fellowship and the Young Investigator Grant from the Novartis Foundation. Regularly invited to present research findings at international conferences and seminars.

専門分野

• ★ Stem Cell Research
• ★ Hematology
• ★ Metabolism & Metabolic Disease
• ☆ Developmental Biology
• ☆ Cell Biology
• ☆ Clinical Immunology
• ☆ Human Biology
• ☆ Precision Medicine
• ☆ Hematology-Oncology

サービス

• Writing
• Research
• Consulting

Writing Medical Writing, Creative Writing, General Proofreading & Editing

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

職務経験

Associate Researcher

University of Zurich

11月 2023 - 現在

University of Zurich

11月 2023 - 現在

Associate Researcher

Lund University

10月 2018 - 10月 2023

Post-doctoral researcher

Lund University

2月 2016 - 9月 2018

Post-doctoral researcher

Université Montpellier Faculté des Sciences de Montpellier

10月 2014 - 12月 2015

学歴

PhD (Montpellier Institute of Molecular Genetics (IGMM), CNRS)

Université Montpellier Faculté des Sciences de Montpellier

10月 2010 - 9月 2014

Master's degree (Immunology (Host-Pathogen Interactions and Defense Mechanisms))

Université Montpellier Faculté des Sciences de Montpellier

2008 - 2010

Bachelor's degree (Biochemistry)

Université Montpellier Faculté des Sciences de Montpellier

2005 - 2008

認定資格

• Medical Affairs

  Svensk Medicin AB

  1月 2024 - 現在

• Medical writing

  Svensk Medicin AB

  1月 2024 - 現在

• Research Integrity

  Epigeum

  1月 2017 - 現在

出版物

JOURNAL ARTICLE

Leal Oburoglu, Mehrnaz Safaee Talkhoncheh, Aurélie Baudet, Fredrik Ek, Agatheeswaran Subramaniam, Yun-Ruei Kao, Natsumi Miharada, Christine Karlsson, Anna Rydström, Kristijonas Zemaitis, et al. (2023). Ciclopirox ethanolamine preserves the immature state of human HSCs by mediating intracellular iron content . Blood Advances.

Leal Oburoglu, Maria Rodriguez-Zabala, Ramprasad Ramakrishnan, Katrin Reinbach, Somadri Ghosh, Antoni Falqués-Costa, Kishan Bellamkonda, Mats Ehinger, Pablo Peña-Martínez, Noelia Puente-Moncada, et al. (2023). Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity . Blood Advances.

Leal Oburoglu, Ludwig Schmiderer, David Yudovich, Martin Hjort, Jonas Larsson(2022). Site-specific CRISPR-based mitochondrial DNA manipulation is limited by gRNA import . Scientific Reports. 12. (1). Springer Science and Business Media {LLC}

Leal Oburoglu, Anuntxi Monsalve, Isaac Canals(2022). FOXO1 regulates pentose phosphate pathway-mediated induction of developmental erythropoiesis . Frontiers in Cell and Developmental Biology. 10. Frontiers Media {SA}

Leal Oburoglu, Els Mansell, Isaac Canals, Valgardur Sigurdsson, Carolina Guibentif, Shamit Soneji, Niels‐Bjarne Woods (2022). Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence . EMBO reports.

Monsalve, A., Canals, I., Oburoglu, L.(2022). FOXO1 regulates pentose phosphate pathway-mediated induction of developmental erythropoiesis . Frontiers in Cell and Developmental Biology. 10.

Schmiderer, L., Yudovich, D., Oburoglu, L., Hjort, M., Larsson, J.(2022). Site-specific CRISPR-based mitochondrial DNA manipulation is limited by gRNA import . Scientific Reports. 12. (1).

Oburoglu, L., Mansell, E., Canals, I., Sigurdsson, V., Guibentif, C., Soneji, S., Woods, N.-B.(2022). Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence . EMBO Reports. 23. (2).

Gonzalez-Menendez, P., Romano, M., Yan, H., Deshmukh, R., Papoin, J., Oburoglu, L., Daumur, M., Dumé, A.-S., Phadke, I., Mongellaz, C., et al.(2021). An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism . Cell Reports. 34. (5).

Oburoglu, L., Mansell, E., Woods, N.-B.(2021). Glutamine metabolism regulates endothelial to hematopoietic transition and hematopoietic lineage specification . Scientific Reports. 11. (1).

Leal Oburoglu, Tan Hooi Min Grahn, Abhishek Niroula, Ákos Végvári, Maroulio Pertesi, Sarah Warsi, Fatemeh Safi, Natsumi Miharada, Sandra Capellera-Garcia, Kavitha Siva, et al. (2020). Correction: S100A6 is a critical regulator of hematopoietic stem cells . Leukemia.

Leal Oburoglu, Tan Hooi Min Grahn, Abhishek Niroula, Ákos Végvári, Maroulio Pertesi, Sarah Warsi, Fatemeh Safi, Natsumi Miharada, Sandra C. Garcia, Kavitha Siva, et al. (2020). S100A6 is a critical regulator of hematopoietic stem cells . Leukemia.

Leal Oburoglu, Els Mansell, Isaac Canals, Carolina Guibentif, Shamit Soneji, Niels-Bjarne Woods(2020). 3118 – METABOLIC REGULATION OF LINEAGE SPECIFICATION DURING ENDOTHELIAL TO HEMATOPOIETIC TRANSITION . Experimental Hematology. 88. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S74. Elsevier {BV}

(2020). S100A6 is a critical regulator of hematopoietic stem cells . Leukemia.

Grahn, T.H.M., Niroula, A., Végvári, Á., Oburoglu, L., Pertesi, M., Warsi, S., Safi, F., Miharada, N., Garcia, S.C., Siva, K., et al.(2020). S100A6 is a critical regulator of hematopoietic stem cells . Leukemia. 34. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3323-3337.

Grahn, T.H.M., Niroula, A., Végvári, Á., Oburoglu, L., Pertesi, M., Warsi, S., Safi, F., Miharada, N., Capellera-Garcia, S., Siva, K., et al.(2020). Correction: S100A6 is a critical regulator of hematopoietic stem cells (Leukemia, (2020), 34, 12, (3323-3337), 10.1038/s41375-020-0901-2) . Leukemia. 34. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3439.

(2019). Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells . Nature Metabolism.

Clerc, I., Abba Moussa, D., Vahlas, Z., Tardito, S., Oburoglu, L., Hope, T.J., Sitbon, M., Dardalhon, V., Mongellaz, C., Taylor, N.(2019). Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells . Nature Metabolism. 1. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 717-730.

Leal Oburoglu, Carolina Guibentif, Niels-Bjarne Woods(2018). Glycolysis is Essential for Metabolic Switch-Mediated Endothelial to Hematopoietic Transition . Experimental Hematology. 64. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S90. Elsevier {BV}

Leal Oburoglu, Marie Pouzolles, Naomi Taylor, Valérie S. Zimmermann(2016). Hematopoietic stem cell lineage specification . Current Opinion in Hematology. 23. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 311--317. Ovid Technologies (Wolters Kluwer Health)

Leal Oburoglu, Manuela Romano, Naomi Taylor, Sandrina Kinet(2016). Metabolic regulation of hematopoietic stem cell commitment and erythroid differentiation . Current Opinion in Hematology. 23. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 198--205. Ovid Technologies (Wolters Kluwer Health)

Leal Oburoglu, Gaspard Cretenet, Isabelle Clerc, Maria Matias, Severine Loisel, Marco Craveiro, Sandrina Kinet, Cédric Mongellaz, Valérie Dardalhon, Naomi Taylor(2016). Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions . Sci. Rep. 6. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 24129. Nature Publishing Group

Cretenet, G., Clerc, I., Matias, M., Loisel, S., Craveiro, M., Oburoglu, L., Kinet, S., Mongellaz, C., Dardalhon, V., Taylor, N.(2016). Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions . Scientific Reports. 6.

Oburoglu, L., Romano, M., Taylor, N., Kinet, S.(2016). Metabolic regulation of hematopoietic stem cell commitment and erythroid differentiation . Current Opinion in Hematology. 23. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 198-205.

Pouzolles, M., Oburoglu, L., Taylor, N., Zimmermann, V.S.(2016). Hematopoietic stem cell lineage specification . Current Opinion in Hematology. 23. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 311-317.

D. Klysz, X. Tai, P. A. Robert, M. Craveiro, G. Cretenet, L. Oburoglu, C. Mongellaz, S. Floess, V. Fritz, M. I. Matias, et al.(2015). Glutamine-dependent  -ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation . Science Signaling. 8. (396). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString ra97--ra97. American Association for the Advancement of Science ({AAAS})

Klysz, D., Tai, X., Robert, P.A., Craveiro, M., Cretenet, G., Oburoglu, L., Mongellaz, C., Floess, S., Fritz, V., Matias, M.I., et al.(2015). Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation . Science Signaling. 8. (396).

Leal Oburoglu, Saverio Tardito, Vanessa Fritz, Stéphanie C. de Barros, Peggy Merida, Marco Craveiro, João Mamede, Gaspard Cretenet, Cédric Mongellaz, Xiuli An, et al.(2014). Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification . Cell Stem Cell. 15. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 666--668. Elsevier {BV}

Leal Oburoglu, Saverio Tardito, Vanessa Fritz, Stéphanie C. de Barros, Peggy Merida, Marco Craveiro, João Mamede, Gaspard Cretenet, Cédric Mongellaz, Xiuli An, et al.(2014). Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification . Cell Stem Cell. 15. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 169--184. Elsevier {BV}

Oburoglu, L., Tardito, S., Fritz, V., De Barros, S.C., Merida, P., Craveiro, M., Mamede, J., Cretenet, G., Mongellaz, C., An, X., et al.(2014). Erratum: Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification (Cell Stem Cell (2014) 15 (169-184)) . Cell Stem Cell. 15. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 666-668.

Oburoglu, L., Tardito, S., Fritz, V., De Barros, S.C., Merida, P., Craveiro, M., Mamede, J., Cretenet, G., Mongellaz, C., An, X., et al.(2014). Erratum: Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification (Cell Stem Cell (2014) 15 (169-184)) . Cell Stem Cell. 15. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 666-668.

Oburoglu, L., Tardito, S., Fritz, V., De Barros, S.C., Merida, P., Craveiro, M., Mamede, J., Cretenet, G., Mongellaz, C., An, X., et al.(2014). Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification . Cell Stem Cell. 15. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 169-184.

S. Loisel-Meyer, L. Swainson, M. Craveiro, L. Oburoglu, C. Mongellaz, C. Costa, M. Martinez, F.-L. Cosset, J.-L. Battini, L. A. Herzenberg, et al.(2012). Glut1-mediated glucose transport regulates HIV infection . Proceedings of the National Academy of Sciences. 109. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2549--2554. Proceedings of the National Academy of Sciences

Loisel-Meyer, S., Swainson, L., Craveiro, M., Oburoglu, L., Mongellaz, C., Costa, C., Martinez, M., Cosset, F.-L., Battini, J.-L., Herzenberg, L.A., et al.(2012). Glut1-mediated glucose transport regulates HIV infection . Proceedings of the National Academy of Sciences of the United States of America. 109. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2549-2554.

OTHER

Gonzalez-Menendez, P., Romano, M., Yan, H., Oburoglu, L., Tardito, S., Daumur, M., Dumé, A.-S., Phadke, I., Qu, X., Bories, P.-N., et al.(2020). An IDH1-Vitamin C Crosstalk Drives Human Erythroid Development By Inhibiting Pro-Oxidant Mitochondrial Metabolism . SSRN.