プロフィール詳細

プロジェクトを作成

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Dr. Luca Z.に依頼

Austria

Neuroscientis with Medical Biotechnology background & Scientific Writer with 10+ years of experience

プロフィール概要

Since the beginning of my scientific carrer I had the chance of experiencing different research topics and working methods. I initially dedicated many years to behavioural studies, with a particular focus on addiction disorders, anxiety, depression and epilepsy. More recently, my focus moved towards the understanding of intracellular signaling cascades of receptors such as NMDA, opioid receptors as well as ion channels, this gave me the opportunity to travel and experience how research is conducted oversea, a life changing adventure. Beside the regular work routine I could acquire experience in writing scientific manuscripts and training many PhD students as well as technicians.

専門分野

• ★ Neurology
• ★ Epilepsy & Seizures
• ☆ Nanotechnology
• ☆ Animal Behavior/Ethology
• ☆ Molecular Biology
• ☆ Substance Abuse
• ☆ Stress Management
• ☆ Depression
• ☆ Psychopharmacology
• ☆ Research Methodology

サービス

• Writing
• Research
• Data & AI
• Product Development

Writing Technical Writing

Research Systematic Literature Review, Secondary Data Collection

Data & AI Statistical Analysis, Data Visualization

Product Development Formulation

職務経験

PostDoc

Charité

1月 2019 - 現在

PostDoc

Charité Universitätsmedizin Berlin Campus Benjamin Franklin

1月 2019 - 現在

PostDoc

Medizinische Universität Innsbruck

1月 2018 - 12月 2018

Postdoc

Northwestern University - Chicago

4月 2016 - 11月 2017

PhD student

Medizinische Universität Innsbruck

2月 2011 - 2月 2016

学歴

SPIN (Neuroscience) PhD program

Medizinische Universität Innsbruck

2月 2011 - 7月 2015

Master in Medical Biotechnologies

Universita degli Studi di Roma Tor Vergata

11月 2008 - 10月 2010

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

(2019). Dynorphin‐based “release on demand” gene therapy for drug‐resistant temporal lobe epilepsy . EMBO Molecular Medicine.

Agostinho, A.S., Mietzsch, M., Zangrandi, L., Kmiec, I., Mutti, A., Kraus, L., Fidzinski, P., Schneider, U.C., Holtkamp, M., Heilbronn, R., et al.(2019). Dynorphin-based “release on demand” gene therapy for drug-resistant temporal lobe epilepsy . EMBO Molecular Medicine.

Luca Zangrandi, Jeffrey J. Liu, Kirti Sharma, Chongguang Chen, Sean J. Humphrey, Yi-Ting Chiu, Mariana Spetea, Lee-Yuan Liu-Chen, Christoph Schwarzer, Matthias Mann(2018). In vivo brain {GPCR} signaling elucidated by phosphoproteomics . Science. 360. (6395). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString eaao4927. American Association for the Advancement of Science ({AAAS})

Liu, J.J., Sharma, K., Zangrandi, L., Chen, C., Humphrey, S.J., Chiu, Y.-T., Spetea, M., Liu-Chen, L.-Y., Schwarzer, C., Mann, M.(2018). In vivo brain GPCR signaling elucidated by phosphoproteomics . Science. 360. (6395).

Burtscher, J., Bean, C., Zangrandi, L., Kmiec, I., Agostinho, A., Scorrano, L., Gnaiger, E., Schwarzer, C.(2018). Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis . Frontiers in Molecular Neuroscience. 11.

Zangrandi L, Burtscher J, MacKay JP, Colmers WF, Schwarzer C(2016). The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion . British journal of pharmacology.

Thongrong S, Hausott B, Marvaldi L, Agostinho AS, Zangrandi L, Burtscher J, Fogli B, Schwarzer C, Klimaschewski L(2016). Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage . Hippocampus.

Weth-Malsch D, Langeslag M, Beroukas D, Zangrandi L, Kastenberger I, Quarta S, Malsch P, Kalpachidou T, Schwarzer C, Proia RL, et al.(2016). Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability In vitro and Spatial Working Memory In vivo . Frontiers in cellular neuroscience.

Thongrong, S., Hausott, B., Marvaldi, L., Agostinho, A.S., Zangrandi, L., Burtscher, J., Fogli, B., Schwarzer, C., Klimaschewski, L.(2016). Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage . Hippocampus. 26. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 658-667.

Zangrandi, L., Burtscher, J., Mackay, J.P., Colmers, W.F., Schwarzer, C.(2016). The G-protein biased partial κ opioid receptor agonist 6′-GNTI blocks hippocampal paroxysmal discharges without inducing aversion . British Journal of Pharmacology. 173. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1756-1767.

Weth-Malsch, D., Langeslag, M., Beroukas, D., Zangrandi, L., Kastenberger, I., Quarta, S., Malsch, P., Kalpachidou, T., Schwarzer, C., Proia, R.L., et al.(2016). Ablation of sphingosine 1-phosphate receptor subtype 3 impairs hippocampal neuron excitability in vitro and spatial working memory in vivo . Frontiers in Cellular Neuroscience. 10. (NOV2016).

Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E(2015). Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry . Mitochondrion.

Burtscher, J., Zangrandi, L., Schwarzer, C., Gnaiger, E.(2015). Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry . Mitochondrion. 25. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 104-112.

Busceti CL, Bucci D, Molinaro G, Di Pietro P, Zangrandi L, Gradini R, Moratalla R, Battaglia G, Bruno V, Nicoletti F, et al.(2012). Lack or inhibition of dopaminergic stimulation induces a development increase of striatal tyrosine hydroxylase-positive interneurons . PloS one.

Busceti, C.L., Bucci, D., Molinaro, G., Di Pietro, P., Zangrandi, L., Gradini, R., Moratalla, R., Battaglia, G., Bruno, V., Nicoletti, F., et al.(2012). Lack or Inhibition of Dopaminergic Stimulation Induces a Development Increase of Striatal Tyrosine Hydroxylase-Positive Interneurons . PLoS ONE. 7. (9).

Zangrandi L, Schwarzer C(2012). Activation of kappa opioid receptors reduces seizure activity in a dose-dependent way . BMC pharmacology & toxicology.

Zangrandi L, Schwarzer C(2011). Activation of kappa opioid receptors reduces EEG seizure activity in a mouse model of temporal lobe epilepsy . BMC pharmacology.

Chiamulera C, Tedesco V, Zangrandi L, Giuliano C, Fumagalli G(2010). Propranolol transiently inhibits reinstatement of nicotine-seeking behaviour in rats . Journal of psychopharmacology (Oxford, England).