プロフィール詳細

プロジェクトを作成

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Dr. Miguel M.に依頼

Portugal

Preclinical Scientist & Advisor | Scientific Due Diligence, Electrophysiology & In Vivo Chronic Pain Models

プロフィール概要

I am a PhD-trained preclinical scientist with over 10 years of experience in pharmaceutical and biotechnology R&D, specializing in the design, execution, and critical evaluation of preclinical studies. My work focuses on the scientific assessment of preclinical data, with particular expertise in electrophysiology and in vivo chronic pain models (CCI, CFA, CIPN, etc.). I have extensive hands-on experience evaluating study design, endpoints, data robustness, and technical risks that can impact decision-making in early-stage programs. I have acted as Study Director for multiple GLP-compliant toxicology preclinical studies and have managed complex research programs across multidisciplinary teams, combining strong scientific judgment with a quality- and risk-focused mindset. I support biotech teams and investors through focused preclinical due diligence and scientific advisory engagements, helping identify key strengths, data gaps, and preclinical risks.

専門分野

• ☆ Neuroscience
• ☆ Electrophysiology
• ☆ Patch-Clamp Electrophysiology
• ☆ Neurochemistry
• ☆ Drug Development
• ☆ Preclinical Research
• ☆ In vivo Preclinical Toxicology
• ☆ Quality Assurance & Quality Control (QA/QC)

サービス

• Research
• Consulting
• Product Development

Research Feasibility Study, Scientific and Technical Research

Consulting Healthcare Consulting, Scientific and Technical Consulting

Product Development Quality Assurance & Control (QA/QC)

職務経験

Health Project Manager

P-BIO

1月 2025 - 現在

Head of GLP Services

VectorB2B

1月 2024 - 1月 2025

In vivo Scientist - Study Director

VectorB2B

9月 2022 - 12月 2023

Researcher and Project Manager

Sea4Us

3月 2017 - 9月 2022

Researcher

Universidade Nova de Lisboa

3月 2017 - 9月 2022

Research Assistant

Fundação Champalimaud

7月 2016 - 12月 2016

Research Assistant

Stazione Zoologica Anton Dohrn

2月 2011 - 8月 2011

学歴

PhD

Heinrich-Heine-Universitat Düsseldorf

6月 2012 - 12月 2015

Master

Universidade de Lisboa

9月 2008 - 10月 2010

Bachelor

Universidade Nova de Lisboa

9月 2004 - 7月 2008

認定資格

• Project Management

  Rumos

  https://www.credly.com/badges/f15f9d88-ade7-4ff5-acb0-6b355114ff59/linked_in_profile

  7月 2025 - 現在

出版物

PATENT

Miguel Mondragão (2021). KV1.3 ANTAGONISTS FOR USE IN THE TREATMENT OF CHRONIC AND ACUTE PAIN .

Miguel Mondragão (2021). NITENIN ANALOGUE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CHRONIC AND ACUTE PAIN .

JOURNAL ARTICLE

Gilberto Pereira, Beatriz Szwarc, Miguel A. Mondragão, Pedro A. Lima, Florbela Pereira(2018). A Ligand-Based Approach to the Discovery of Lead-Like Potassium Channel K_V1.3 Inhibitors . ChemistrySelect. 3. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1352--1364. Wiley

Gilberto Pereira, Beatriz Szwarc, Miguel A. Mondragão, Pedro A. Lima, Florbela Pereira (2018). A Ligand‐Based Approach to the Discovery of Lead‐Like Potassium Channel KV1.3 Inhibitors . ChemistrySelect.

Mondragão, M.A., Schmidt, H., Kleinhans, C., Langer, J., Kafitz, K.W., Rose, C.R.(2016). Extrusion versus diffusion: mechanisms for recovery from sodium loads in mouse CA1 pyramidal neurons . Journal of Physiology. 594. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5507-5527.

Karus, C., Mondragão, M.A., Ziemens, D., Rose, C.R.(2015). Astrocytes restrict discharge duration and neuronal sodium loads during recurrent network activity . GLIA. 63. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 936-957.