プロフィール詳細

プロジェクトを作成

★★★★★

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★★★★★

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Dr. Borhane G.に依頼

Germany

Hematology & oncology scientist | 15+ years in clinical research, manuscripts, grants and medical writing

プロフィール概要

I am a hematology and oncology scientist with over 15 years of experience in clinical and translational research. I support researchers, clinicians, and biotech companies with scientific writing, critical review, and research strategy. My expertise spans hematology, immunology, and cancer biology, with a focus on epigenetics and omics-driven approaches. I combine subject-matter depth with strong analytical and editorial skills to strengthen the clarity, rigor, and impact of scientific work. I provide support in: • Manuscript writing, editing, and journal revision responses • Grant proposal development and strategic positioning • Literature reviews and evidence synthesis • Methodological evaluation and peer review • Study design for preclinical and translational research • Scientific due diligence for biotech and investment projects As a principal investigator and reviewer for leading journals and international funding bodies, I understand how manuscripts and proposals are evaluated. I help clients sharpen hypotheses, improve structure, refine experimental design, and clearly communicate translational relevance. I have published in high-impact journals and led multiple competitively funded research programs. My work is structured, precise, and confidential, and tailored to the expectations of academic, regulatory, and industry audiences.

専門分野

• ☆ Molecular Biology
• ☆ Omics
• ☆ Transcriptomics
• ☆ Epigenetics
• ☆ Cell Biology
• ☆ Stem Cell Research
• ☆ Clinical Immunology
• ☆ Hematology
• ☆ Hematology-Oncology
• ☆ Leukemia & Lymphoma
• ☆ Inflammation
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Medical Writing
• ☆ Healthcare Communications
• ☆ Technical & Scientific Writing
• ☆ Science Communication

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing, Technical Writing, Copywriting, General Proofreading & Editing

Research Meta-Research, Fact Checking, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Image Analysis, Data Visualization, Data Processing

職務経験

DKTK Young Investigator (Group Leader)

Deutsches Krebsforschungszentrum

3月 2017 - 現在

Director of Oncology

Anantlife Canada Inc - Canada

5月 2016 - 12月 2020

Researcher, Research Associate

McMaster University Faculty of Health Sciences

1月 2014 - 1月 2017

Postdoctoral Fellow

McMaster University Faculty of Health Sciences - Canada

1月 2007 - 1月 2014

学歴

PhD in Immunology

Université Pierre et Marie Curie (Paris VI) - France

1月 2002 - 9月 2006

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Karin D. Prummel, Kevin Woods, Maksim Kholmatov, Eric C. Schmitt, Evi P. Vlachou, Mayssa Labyadh, Rebekka Wehner, Gereon Poschmann, Kai Stühler, Susann Winter, et al. (2025). Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia . Nature Communications.

Maksim Kholmatov, Karin D. Prummel, Borhane Guezguez, Eva Hellström-Lindberg, Pedro L. Moura, Judith B. Zaugg (2025). SpliceUp: Predicting SF3B1 mutations in individual cells via aberrant splice site activation from scRNA-seq data . bioRxiv.

Karin Prummel, Kevin Woods, Maksim Kholmatov, Eric Schmitt, Evi Vlachou, Gereon Poschmann, Kai Stühler, Rebekka Wehner, Marc Schmitz, Susann Winter, et al. (2025). THE TITO BASTIANELLO AND MDSF YOUNG INVESTIGATORS AWARDS . Leukemia Research.

Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Aaron Gallego-Crespo, Malte A Behrendt, Maria Saura-Pañella, Aarti Tarkar, Benedict Schubert, et al. (2025). Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation . Blood.

Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Aarón Gallego-Crespo, Malte Andreas Behrendt, Maria Saura-Pañella, Benedict Schubert, Haiyang Yun, et al. (2024). Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation . Blood.

Dual Inhibition of Histone and DNA Methylation in AML Enhances the Effectiveness of TCR-Based Cellular Therapy through Upregulation of Surface MHC Class I/p53 Antigen Complex @article{Schmits_2024, title={Dual Inhibition of Histone and DNA Methylation in AML Enhances the Effectiveness of TCR-Based Cellular Therapy through Upregulation of Surface MHC Class I/p53 Antigen Complex}, volume={144}, ISSN={1528-0020}, url={http://dx.doi.org/10.1182/blood-2024-201347}, DOI={10.1182/blood-2024-201347}, number={Supplement 1}, journal={Blood}, publisher={American Society of Hematology}, author={Schmits, Ulrike Regina and Antunes Ferreira, Edite and Guezguez, Borhane and Gomez-Zepeda, David and Tenzer, Stefan and Legscha, Kevin Jan and Theobald, Matthias and Echchannaoui, Hakim}, year={2024}, month=nov, pages={3444–3444} } . Blood.

Alicia-Marie K. Beier, Celina Ebersbach, Tiziana Siciliano, Jana Scholze, Jörg Hofmann, Pia Hönscheid, Gustavo B. Baretton, Kevin Woods, Borhane Guezguez, Anna Dubrovska, et al. (2024). Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer . Oncogene.

Susann Winter, Katharina S. Götze, Judith S. Hecker, Klaus H. Metzeler, Borhane Guezguez, Kevin Woods, Hind Medyouf, Alexander Schäffer, Marc Schmitz, Rebekka Wehner, et al. (2024). Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche . Leukemia.

P1367: REFINED PHENOTYPE OF SENESCENT T CELLS UNVEILS HIGH ANTI-TUMOR ACTIVITY DESPITE IMPAIRED PROLIFERATION AND DISTURBED METABOLIC ACTIVITY: NEW IMPLICATIONS FOR CANCER IMMUNOTHERAPY @article{Legscha_2023, title={P1367: REFINED PHENOTYPE OF SENESCENT T CELLS UNVEILS HIGH ANTI-TUMOR ACTIVITY DESPITE IMPAIRED PROLIFERATION AND DISTURBED METABOLIC ACTIVITY: NEW IMPLICATIONS FOR CANCER IMMUNOTHERAPY}, volume={7}, ISSN={2572-9241}, url={http://dx.doi.org/10.1097/01.hs9.0000972356.86118.43}, DOI={10.1097/01.hs9.0000972356.86118.43}, number={S3}, journal={HemaSphere}, publisher={Wiley}, author={Legscha, Kevin and Yilmaz, Abdulkadir and Märker, Lea and Antunes, Edite and Wölfel, Catherine and Guezguez, Borhane and Porubsky, Stefan and Theobald, Matthias and Echchannaoui, Hakim}, year={2023}, month=aug, pages={e8611843} } . HemaSphere.

Author Correction: Dithranol as novel co-adjuvant for non-invasive dermal vaccination @article{Sohl_2023, title={Author Correction: Dithranol as novel co-adjuvant for non-invasive dermal vaccination}, volume={8}, ISSN={2059-0105}, url={http://dx.doi.org/10.1038/s41541-023-00689-9}, DOI={10.1038/s41541-023-00689-9}, number={1}, journal={npj Vaccines}, publisher={Springer Science and Business Media LLC}, author={Sohl, Julian and Hartmann, Ann-Kathrin and Hahlbrock, Jennifer and Bartneck, Joschka and Stassen, Michael and Klein, Matthias and Bros, Matthias and Grabbe, Stephan and Marini, Federico and Woods, Kevin and Guezguez, Borhane and Mack, Matthias and Schild, Hansjörg and Muth, Sabine and Melchior, Felix and Probst, Hans Christian and Langguth, Peter and Radsak, Markus P.}, year={2023}, month=jun } . npj Vaccines.

Telaglenastat as a potential therapy in docetaxel resistant prostate cancer with a mesenchymal phenotype @article{Beier_2022, title={Telaglenastat as a potential therapy in docetaxel resistant prostate cancer with a mesenchymal phenotype}, volume={44}, ISSN={2666-1683}, url={http://dx.doi.org/10.1016/s2666-1683(22)01927-9}, DOI={10.1016/s2666-1683(22)01927-9}, journal={European Urology Open Science}, publisher={Elsevier BV}, author={Beier, A-M.K. and Puhr, M. and Woods, K. and Dubrovska, A. and Guezguez, B. and Thomas, C. and Erb, H.H.H.}, year={2022}, month=oct, pages={S160} } . European Urology Open Science.

Dithranol as novel co-adjuvant for non-invasive dermal vaccination @article{Sohl_2022, title={Dithranol as novel co-adjuvant for non-invasive dermal vaccination}, volume={7}, ISSN={2059-0105}, url={http://dx.doi.org/10.1038/s41541-022-00530-9}, DOI={10.1038/s41541-022-00530-9}, number={1}, journal={npj Vaccines}, publisher={Springer Science and Business Media LLC}, author={Sohl, Julian and Hartmann, Ann-Kathrin and Hahlbrock, Jennifer and Bartneck, Joschka and Stassen, Michael and Klein, Matthias and Bros, Matthias and Grabbe, Stephan and Marini, Federico and Woods, Kevin and Guezguez, Borhane and Mack, Matthias and Schild, Hansjörg and Muth, Sabine and Melchior, Felix and Probst, Hans Christian and Langguth, Peter and Radsak, Markus P.}, year={2022}, month=sep } . npj Vaccines.

Guezguez B(2021). Editorial: the new age of clinical research in clonal hematopoiesis and myeloid malignancies . Current opinion in hematology.

Sasca D, Guezguez B, Kühn MWM(2021). Next generation epigenetic modulators to target myeloid neoplasms . Current opinion in hematology.

Woods K, Guezguez B(2021). Dynamic Changes of the Bone Marrow Niche: Mesenchymal Stromal Cells and Their Progeny During Aging and Leukemia . Frontiers in cell and developmental biology.

Legscha KJ, Antunes Ferreira E, Chamoun A, Lang A, Awwad MHS, Ton GNHQ, Galetzka D, Guezguez B, Hundemer M, Bourdon JC, et al.(2021). Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity . Journal for immunotherapy of cancer.

p53 Isoform D133p53a: A Novel Transcriptional Enhancer of T-Cell Effector Function to Improve T-Cell Based Cancer Immunotherapy @article{Legscha_2018, title={p53 Isoform D133p53a: A Novel Transcriptional Enhancer of T-Cell Effector Function to Improve T-Cell Based Cancer Immunotherapy}, volume={132}, ISSN={1528-0020}, url={http://dx.doi.org/10.1182/blood-2018-99-116208}, DOI={10.1182/blood-2018-99-116208}, number={Supplement 1}, journal={Blood}, publisher={American Society of Hematology}, author={Legscha, Kevin Jan and Antunes, Edite and Guezguez, Borhane and Theobald, Matthias and Echchannaoui, Hakim}, year={2018}, month=nov, pages={3489–3489} } . Blood.

Guezguez, B., Almakadi, M., Benoit, Y.D., Shapovalova, Z., Rahmig, S., Fiebig-Comyn, A., Casado, F.L., Tanasijevic, B., Bresolin, S., Masetti, R., et al.(2016). GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia . Cancer Cell. 29. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 61-74.

Histone Deacetylase Inhibition Impairs Normal Intestinal Cell Proliferation and Promotes Specific Gene Expression @article{Roostaee_2015, title={Histone Deacetylase Inhibition Impairs Normal Intestinal Cell Proliferation and Promotes Specific Gene Expression}, volume={116}, ISSN={1097-4644}, url={http://dx.doi.org/10.1002/jcb.25274}, DOI={10.1002/jcb.25274}, number={11}, journal={Journal of Cellular Biochemistry}, publisher={Wiley}, author={Roostaee, Alireza and Guezguez, Amel and Beauséjour, Marco and Simoneau, Aline and Vachon, Pierre H. and Levy, Emile and Beaulieu, Jean‐François}, year={2015}, month=sep, pages={2695–2708} } . Journal of Cellular Biochemistry.

Dingwall S, Lee JB, Guezguez B, Fiebig A, McNicol J, Boreham D, Collins TJ, Bhatia M(2015). Neoplastic human embryonic stem cells as a model of radiation resistance of human cancer stem cells . Oncotarget.

Dingwall, S., Lee, J.B., Guezguez, B., Fiebig, A., McNicol, J., Boreham, D., Collins, T.J., Bhatia, M.(2015). Neoplastic human embryonic stem cells as a model of radiation resistance of human cancer stem cells . Oncotarget. 6. (26). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 22258-22269.

(2014). Volume 3 Acknowledgments . Stem Cells Translational Medicine.

Yannick D. Benoit, Borhane Guezguez, Allison L. Boyd, Mickie Bhatia (2014). Molecular Pathways: Epigenetic Modulation of Wnt–Glycogen Synthase Kinase-3 Signaling to Target Human Cancer Stem Cells . Clinical Cancer Research.

Allison L. Boyd, Clinton J.V. Campbell, Claudia I. Hopkins, Aline Fiebig-Comyn, Jennifer Russell, Jelena Ulemek, Ronan Foley, Brian Leber, Anargyros Xenocostas, Tony J. Collins, et al. (2014). Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs . Journal of Experimental Medicine.

Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway @article{Guezguez_2014, title={Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway}, volume={322}, ISSN={0014-4827}, url={http://dx.doi.org/10.1016/j.yexcr.2014.02.009}, DOI={10.1016/j.yexcr.2014.02.009}, number={2}, journal={Experimental Cell Research}, publisher={Elsevier BV}, author={Guezguez, Amel and Paré, Fréderic and Benoit, Yannick D. and Basora, Nuria and Beaulieu, Jean-François}, year={2014}, month=apr, pages={355–364} } . Experimental Cell Research.

(2014). Thank you to our reviewers . Clinical & Experimental Immunology.

Guezguez, B., Bhatia, M.(2014). Driving human-mouse avatars to understand the HSC niche . Cell Cycle. 13. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1511-1512.

Mcintyre, B.A.S., Alev, C., Mechael, R., Salci, K.R., Lee, J.B., Fiebig-Comyn, A., Guezguez, B., Wu, Y., Sheng, G., Bhatia, M.(2014). Expansive generation of functional airway epithelium from human embryonic stem cells . Stem Cells Translational Medicine. 3. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7-17.

Kushwah, R., Guezguez, B., Lee, J.B., Hopkins, C.I., Bhatia, M.(2014). Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human . EMBO Reports. 15. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1128-1138.

Benoit, Y.D., Guezguez, B., Boyd, A.L., Bhatia, M.(2014). Molecular pathways: Epigenetic modulation of wnt-glycogen synthase kinase-3 signaling to target human cancer stem cells . Clinical Cancer Research. 20. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5372-5378.

Schnerch, A., Lee, J.B., Graham, M., Guezguez, B., Bhatia, M.(2013). Human embryonic stem cell-derived hematopoietic cells maintain core epigenetic machinery of the Polycomb group/Trithorax group complexes distinctly from functional adult hematopoietic stem cells . Stem Cells and Development. 22. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 73-89.

Guezguez, B., Campbell, C.J.V., Boyd, A.L., Karanu, F., Casado, F.L., Di Cresce, C., Collins, T.J., Shapovalova, Z., Xenocostas, A., Bhatia, M.(2013). Regional localization within the bone marrow influences the functional capacity of human HSCs . Cell Stem Cell. 13. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 175-189.

Trowbridge, J.J., Guezguez, B., Moon, R.T., Bhatia, M.(2010). Wnt3a activates dormant c-Kit^- bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity . Stem Cells. 28. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1379-1389.

Clint Campbell, Ruth M Risueno, Simona Salati, Borhane Guezguez, Mickie Bhatia (2008). Signal control of hematopoietic stem cell fate: Wnt, Notch, and Hedgehog as the usual suspects . Current Opinion in Hematology.

Borhane Guezguez, Mickie Bhatia (2008). Transplantation of human hematopoietic repopulating cells: mechanisms of regeneration and differentiation using human–mouse xenografts . Current Opinion in Organ Transplantation.

Guezguez, B., Bhatia, M.(2008). Transplantation of human hematopoietic repopulating cells: Mechanisms of regeneration and differentiation using human-mouse xenografts . Current Opinion in Organ Transplantation. 13. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 44-52.

Campbell, C., Risueno, R.M., Salati, S., Guezguez, B., Bhatia, M.(2008). Signal control of hematopoietic stem cell fate: Wnt, Notch, and Hedgehog as the usual suspects . Current Opinion in Hematology. 15. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 319-325.

Guezguez B, Vigneron P, Lamerant N, Kieda C, Jaffredo T, Dunon D(2007). Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor . Journal of immunology (Baltimore, Md. : 1950).

Guezguez, B., Vigneron, P., Lamerant, N., Kieda, C., Jaffredo, T., Dunon, D.(2007). Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor . Journal of Immunology. 179. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6673-6685.

Guezguez, B., Vigneron, P., Alais, S., Jaffredo, T., Gavard, J., Mège, R.-M., Dunon, D.(2006). A dileucine motif targets MCAM-l cell adhesion molecule to the basolateral membrane in MDCK cells . FEBS Letters. 580. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3649-3656.

Thierry Jaffredo, Sandrine Alais, Karine Bollerot, Cecile Drevon, Rodolphe Gautier, Borhane Guezguez, Krisztina Minko, Pascale Vigneron, Dominique Dunon (2003). Avian HSC emergence, migration, and commitment toward the T cell lineage . Pathogens and Disease.

Jaffredo, T., Alais, S., Bollerot, K., Drevon, C., Gautier, R., Guezguez, B., Minko, K., Vigneron, P., Dunon, D.(2003). Avian HSC emergence, migration, and commitment toward the T cell lineage . FEMS Immunology and Medical Microbiology. 39. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 205-212.

Pujades, C., Guez-Guez, B., Dunon, D.(2002). Melanoma cell adhesion molecule (MCAM) expression in the myogenic lineage during early chick embryonic development . International Journal of Developmental Biology. 46. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 263-266.

OTHER

DNMT/G9a Complex Inhibition Uncovers Epigenetic Vulnerabilities and Induces IFN-Response in Acute Myeloid Leukemia @article{Sch_nefeld_2024, title={DNMT/G9a Complex Inhibition Uncovers Epigenetic Vulnerabilities and Induces IFN-Response in Acute Myeloid Leukemia}, url={http://dx.doi.org/10.1101/2024.12.11.627891}, DOI={10.1101/2024.12.11.627891}, publisher={Cold Spring Harbor Laboratory}, author={Schönefeld, Angelique and Zanetti, Costanza and Schmitt, Eric C. and Woods, Kevin and Westerback, Ashley and Mitsch, Sidney M. and Rühle, Frank and Kelekci, Simge and Fol, Lisa and Shah, Viral and Sanchez-Saez, Miriam and Thevissen, Sophia and Schäffer, Alexander and Schmits, Ulrike Regina and Sasca, Daniel and Kindler, Thomas and Wölfel, Catherine and Feuerstein-Akgoz, Clarissa and Gerhäuser, Clarissa and Lutsik, Pavlo and Rivière, Jennifer and Hecker, Judith S and Götze, Katharina S and Platzbecker, Uwe and Echchannaoui, Hakim and Theobald, Matthias and Plass, Christoph and Padeken, Jan and Medyouf, Hind and Guezguez, Borhane}, year={2024}, month=dec } .

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activation @article{Shah_2022, title={Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activation}, url={http://dx.doi.org/10.1101/2022.09.14.507850}, DOI={10.1101/2022.09.14.507850}, publisher={Cold Spring Harbor Laboratory}, author={Shah, Viral and Giotopoulos, George and Osaki, Hikari and Meyerhöfer, Markus and Meduri, Eshwar and Schubert, Benedict and Yun, Haiyang and Horton, Sarah J and Agrawal-Singh, Shuchi and Haehnel, Patricia S and Basheer, Faisal and Lugo, Dave and Kühn, Michael WM and Guezguez, Borhane and Theobald, Matthias and Kindler, Thomas and Gallipoli, Paolo and Prinjha, Rab K and Huntly, Brian JP and Sasca, Daniel}, year={2022}, month=sep } .

Inflammatory Mesenchymal Stromal Cells and IFN-responsive T cells are key mediators of human bone marrow niche remodeling in CHIP and MDS @article{Prummel_2024, title={Inflammatory Mesenchymal Stromal Cells and IFN-responsive T cells are key mediators of human bone marrow niche remodeling in CHIP and MDS}, url={http://dx.doi.org/10.1101/2024.11.27.625734}, DOI={10.1101/2024.11.27.625734}, publisher={Cold Spring Harbor Laboratory}, author={Prummel, Karin D. and Woods, Kevin and Kholmatov, Maksim and Schmitt, Eric C. and Vlachou, Evi P. and Poschmann, Gereon and Stühler, Kai and Wehner, Rebekka and Schmitz, Marc and Winter, Susann and Oelschlaegel, Uta and Schwartz, Logan S. and Moura, Pedro L. and Hellström-Lindberg, Eva and Theobald, Matthias and Trowbridge, Jennifer J. and Platzbecker, Uwe and Zaugg, Judith B. and Guezguez, Borhane}, year={2024}, month=nov } .