プロフィール詳細

プロジェクトを作成

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Mariajose M.に依頼

United States

Neuroscience & Life Sciences Consultant | Preclinical Research, Scientific Writing & Grant Strategy

プロフィール概要

PhD neuroscientist and NIH-funded principal investigator with 15+ years of biomedical research experience. My expertise includes neuroscience, CNS injury and repair, gene therapy, viral vectors, and preclinical therapeutic development. I provide scientific writing and editing, grant review and strategy, literature reviews, study design, data interpretation, and scientific consulting. I also have experience integrating AI-based tools into research and data-analysis workflows. I work with biotech, healthcare, and research organizations to evaluate complex science and translate it into clear, actionable recommendations.

専門分野

• ★ Gene Therapy
• ☆ Molecular Biology
• ☆ Gene Expression Analysis
• ☆ Systems Science
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Research
• ☆ Neurology
• ☆ Spinal Cord Injury
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Science Communication
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Grant Writing

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Medical Writing, Technical Writing, General Proofreading & Editing

Research Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Secondary Data Collection

Consulting Business Strategy Consulting, Healthcare Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Analysis, Data Visualization, Data Insights

Product Development Product Evaluation, Product Validation, Concept Development

職務経験

Assistant Professor

University of Louisville

8月 2024 - 現在

Project Scientist

University of California Irvine

6月 2019 - 8月 2024

Specialist

University of California Irvine

12月 2011 - 4月 2019

Postdoctoral Fellow

Burke Medical Research Institute

8月 2011 - 11月 2014

Research Assistant

Rockefeller University

11月 2004 - 7月 2007

学歴

PhD (Neuroscience)

The Graduate Center, CUNY

9月 2007 - 5月 2012

MS (Neuroscience)

The Graduate Center, CUNY

9月 2008 - 8月 2009

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Brian T. David, Jessica J. Curtin, Jennifer L. Brown, Kerri Scorpio, Veena Kandaswamy, David J. C. Coutts, Ana Vivinetto, Paola Bianchimano, Saravanan S. Karuppagounder, Mariajose Metcalfe, et al. (2023). Temporary induction of hypoxic adaptations by preconditioning fails to enhance Schwann cell transplant survival after spinal cord injury . Glia.

Front. Integr. Neurosci., 08 February 2023 Volume 17 - 2023 .

(2021). Harnessing rAAV-retro for gene manipulations in multiple pathways that are interrupted after spinal cord injury . Experimental neurology.

Oswald Steward, Aminata P. Coulibaly, Mariajose Metcalfe, Jamie M. Dam, Kelly M. Yee(2021). AAV vectors accumulate in the pineal gland after injections into the brain or spinal cord . Molecular Therapy - Methods & Clinical Development. 23. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 406--417. Elsevier {BV}

(2021). Rostro-Caudal Specificity of Corticospinal Tract Projections in Mice . Cerebral cortex (New York, N.Y. : 1991).

(2019). AAVshRNA-mediated PTEN knockdown in adult neurons attenuates activity-dependent immediate early gene induction . Experimental neurology.

(2012). Coordination between proteasome impairment and caspase activation leading to tau pathology: neuroprotection by cAMP . Cell Death Dis.

(2011). Assessment of proteasome impairment and accumulation/aggregation of ubiquitinated proteins in neuronal cultures . Methods Mol Biol.

(2010). Relationship between tau pathology and neuroinflammation in Alzheimer’s disease .

(2008). Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons . J Biol Chem.

(2005). Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway . J Biol Chem.

PREPRINT

Mariajose Metcalfe, Brian T. David, Brett C. Langley, Caitlin E. Hill (2023). Elevation of NAD+ by nicotinamide riboside spares spinal cord tissue from injury and promotes locomotor recovery .