プロフィール詳細

プロジェクトを作成

★★★★★

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Dr. Mayasah A.に依頼

Canada

Postdoctoral Research Fellow | Medical Writer & Editor | Researcher experienced in Computer-Aided Drug Design

プロフィール概要

I am a multidisciplinary researcher with a diverse skill set in the field of drug design, blending my expertise as a researcher, computational-drug designer, medical writer, and pharmacist. As a medical writer, my goal is to effectively communicate complex scientific information to diverse audiences. With a strong foundation in scientific research and writing, I have experience crafting a wide range of materials, from research/review articles and scientific books to medical and health content. I have published several articles and books in international, peer-reviewed journals. My doctoral project was a real highlight, as I worked on identifying a dual inhibitor of PDE1B and PDE10A using a structure-based approach. My work has focused on exploring complex areas of drug design, including structure-based drug design, enzyme kinetics, and preclinical studies utilizing animal models. The result was a promising antipsychotic agent that demonstrated activity in a rat model of schizophrenia. Further, my passion for computational chemistry and drug design has led me to participate in numerous other projects, working with ligand and structure-based approaches and collaborating with fellow scientists.

専門分野

• ☆ Computational Chemistry
• ☆ Computational Biology
• ☆ Biochemistry
• ☆ Structural Biology
• ☆ Enzyme Activity Assays
• ☆ Recipe Formulation
• ☆ Pharmacy
• ☆ Pharmacy Education
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Research
• ☆ In vivo Preclinical Toxicology

サービス

• Writing
• Research
• Consulting
• Product Development

Writing Medical Writing, Technical Writing

Research Fact Checking, Scientific and Technical Research

Consulting Scientific and Technical Consulting

Product Development Recipe Development

職務経験

Medical Editor

Medical Literacy Initiative

12月 2023 - 現在

Medical Writer-Article Writer

Klarity

3月 2023 - 現在

Peer-Reviewer Expert

Heliyon-Cell Press

9月 2020 - 現在

Founder

Choco Cream

6月 2016 - 現在

Researcher

UCSI University

1月 2022 - 5月 2023

Teaching assistant

UCSI University

12月 2018 - 1月 2022

学歴

Ph.D. Pharmaceutical Sciences (Faculty of Pharmaceutical Sciences)

UCSI University

8月 2018 - 8月 2022

MSc. Pharmaceutical chemistry (faculty of pharmaceutical sciences )

UCSI University

2016 - 2018

Advanced Diploma in Pastry and Bakery Arts

Academy of Pastry Arts Malaysia

8月 2015 - 6月 2016

B.Sc. pharmacy (faculty of pharmacy)

Al-Yarmouk University College

- 2015

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Mayasah Al-Nema, Anand Gaurav, Vannajan Sanghiran Lee(2023). Designing of 2,3-dihydrobenzofuran derivatives as inhibitors of PDE1B using pharmacophore screening, ensemble docking and molecular dynamics approach . Computers in Biology and Medicine. 159. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 106869. Elsevier {BV}

Al-Nema M, Anand Gaurav, Lee MT, Okechukwu P, Nimmanpipug P, Lee VS (2022). Evaluation of the acute oral toxicity and antipsychotic activity of a dual inhibitor of PDE1B and PDE10A in rat model of schizophrenia . PloS one.

Gaurav, Anand, Agrawal, Neetu, Al-Nema, Mayasah, Gautam, Vertika (2022). Computational Approaches in the Discovery and Development of Therapeutic and Prophylactic Agents for Viral Diseases . Current Topics in Medicinal Chemistry.

Wei, Foong Xi, Gaurav, Anand, Al-Nema, Mayasah (2022). In silico investigation on the probable macromolecular drug targets involved in the anti-schizophrenia activity of Nardostachys jatamansi . Brazilian Journal of Pharmaceutical Sciences.

Mayasah Al-Nema and Anand Gaurav and Vannajan Sanghiran Lee and Baskaran Gunasekaran and Ming Tatt Lee and Patrick Okechukwu and Piyarat Nimmanpipug(2022). Structure-based discovery and bio-evaluation of a cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one as a phosphodiesterase 10A inhibitor . RSC Advances. 12. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1576--1591. Royal Society of Chemistry ({RSC})

Al-Nema, Mayasah, Gaurav, Anand, Lee, Vannajan Sanghiran, Gunasekaran, Baskaran, Lee, Ming Tatt, Okechukwu, Patrick, Nimmanpipug, Piyarat (2022). Structure-based discovery and bio-evaluation of a cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one as a phosphodiesterase 10A inhibitor . RSC Advances.

Fei, Lim Chiew, Gaurav, Anand, Al-Nema, Mayasah (2022). In Silico Investigations on the Probable Macromolecular Drug Targets Involved in the Anti-Schizophrenia Activity of Terminalia bellerica . Letters in Organic Chemistry.

Mayasah Al-Nema and Anand Gaurav and Vannajan Sanghiran Lee and Baskaran Gunasekaran and Ming Tatt Lee and Patrick Okechukwu(2021). Identification of dual inhibitor of phosphodiesterase 1B/10A using structure-based drug design approach . Journal of Molecular Liquids. 342. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 117485. Elsevier {BV}

Lim Chiew Fei and Anand Gaurav and Mayasah Al-Nema(2021). In Silico Investigations on the Probable Macromolecular Drug Targets Involved in the Anti-Schizophrenia Activity of Terminalia bellerica . Letters in Organic Chemistry. 18. Bentham Science Publishers Ltd.

Al-Nema, Mayasah, Gaurav, Anand, Lee, Vannajan Sanghiran, Gunasekaran, Baskaran, Lee, Ming Tatt, Okechukwu, Patrick (2021). Identification of dual inhibitor of phosphodiesterase 1B/10A using structure-based drug design approach . Journal of Molecular Liquids.

Patrick Okechukwu and Mridula Sharma and Wen Hui Tan and Hor Kuan Chan and Kavita Chirara and Anand Gaurav and Mayasah Al-Nema(2020). In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes . Pharmacia. 67. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 363--371. Pensoft Publishers

Mayasah Y. Al-Nema and Anand Gaurav(2020). Phosphodiesterase as a Target for Cognition Enhancement in Schizophrenia . Current Topics in Medicinal Chemistry. 20. (26). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2404--2421. Bentham Science Publishers Ltd.

Mayasah Al-Nema and Anand Gaurav and Vannajan Sanghiran Lee(2020). Docking based screening and molecular dynamics simulations to identify potential selective PDE4B inhibitor . Heliyon. 6. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e04856. Elsevier {BV}

Goh Yen Joe and Anand Gaurav and Mayasah Al Nema(2020). In Silico Investigation on the Probable Macromolecular Drug Targets Involved in the Anti-Schizophrenia Activity of Ocimum sanctum . Current Trends in Biotechnology and Pharmacy. 14. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--10. {EManuscript} Technologies

Okechukwu, P., Sharma, M., Tan, W.H., Chan, H.K., Chirara, K., Gaurav, A., Al-Nema, M.(2020). In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes . Pharmacia. 67. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 363-371.

Al-Nema, Mayasah Y., Gaurav, Anand (2020). Phosphodiesterase as a Target for Cognition Enhancement in Schizophrenia . Current Topics in Medicinal Chemistry.

Al-Nema, Mayasah, Gaurav, Anand, Lee, Vannajan Sanghiran (2020). Docking based screening and molecular dynamics simulations to identify potential selective PDE4B inhibitor . Heliyon.

Al-Nema, M., Gaurav, A., Lee, V.S.(2020). Docking based screening and molecular dynamics simulations to identify potential selective PDE4B inhibitor . Heliyon. 6. (9).

Al-Nema, M.Y., Gaurav, A.(2020). Phosphodiesterase as a target for cognition enhancement in schizophrenia . Current Topics in Medicinal Chemistry. 20. (26). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2404-2421.

Okechukwu, Patrick, Sharma, Mridula, Tan, Wen Hui, Chan, Hor Kuan, Chirara, Kavita, Gaurav, Anand, Al-Nema, Mayasah (2020). In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes . Pharmacia.

Mayasah Al-Nema, Anand Gaurav (2020). Advanced Applications of Gene Therapy in the Treatment of Haematologic Disorders . Frontiers in Clinical Drug Research: Hematology: Volume 4.

(2019). Molecular Modeling-Based Delivery System Enhances Everolimus-Induced Apoptosis in Caco-2 Cells . ACS Omega.

(2019). Protein-Protein Interactions of Phosphodiesterases . Current Topics in Medicinal Chemistry.

Al-Nema, M.Y., Gaurav, A.(2019). Protein-protein interactions of phosphodiesterases . Current Topics in Medicinal Chemistry. 19. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 555-564.

Al-Nema, Mayasah Y., Gaurav, Anand (2019). Protein-Protein Interactions of Phosphodiesterases . Current Topics in Medicinal Chemistry.

Gaurav, Anand, Al-Nema, Mayasah (2019). Polymerases of Coronaviruses: Structure, Function, and Inhibitors . Viral Polymerases: Structures, Functions, and Roles as Antiviral Drug Targets.

Maki, M.A.A., Kumar, P.V., Cheah, S.-C., Siew Wei, Y., Al-Nema, M., Bayazeid, O., Majeed, A.B.B.A.(2019). Molecular Modeling-<inf>B</inf>ased Delivery System Enhances Everolimus-Induced Apoptosis in Caco-2 Cells . ACS Omega. 4. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 8767-8777.

Maki, Marwan Abdelmahmoud Abdelkarim, Kumar, Palanirajan Vijayaraj, Cheah, Shiau-Chuen, Wei, Yeong Siew, Al-Nema, Mayasah, Bayazeid, Omer, Majeed, Abu Bakar Bin Abdul (2019). Molecular Modeling-(B)ased Delivery System Enhances Everolimus-Induced Apoptosis in Caco-2 Cells . ACS Omega.

(2018). Discovery of natural product inhibitors of phosphodiesterase 10A as novel therapeutic drug for schizophrenia using a multistep virtual screening . Computational Biology and Chemistry.

(2018). Management and treatment of atopic dermatitis with modern therapies, complementary and alternative medicines: a review . Oriental Pharmacy and Experimental Medicine.

Al-Nema, Mayasah, Gaurav, Anand, Akowuah, Gabriel (2018). Discovery of natural product inhibitors of phosphodiesterase 10A as novel therapeutic drug for schizophrenia using a multistep virtual screening . Computational Biology and Chemistry.

Chew, Y.-L., Al-Nema, M., Ong, V.W.-M.(2018). Management and treatment of atopic dermatitis with modern therapies, complementary and alternative medicines: a review . Oriental Pharmacy and Experimental Medicine. 18. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 67-76.

Chew, Yik-Ling, Al-Nema, Mayasah, Ong, Vivian Wai-Mun (2018). Management and treatment of atopic dermatitis with modern therapies, complementary and alternative medicines: a review . Oriental Pharmacy and Experimental Medicine.

(2018). Identification of Selective Inhibitors of Phosphodiesterase 4B using Pharmacophore-Based Virtual Screening and Molecular Docking Approaches . Frontiers in Pharmacology.

Al-Nema, M., Gaurav, A., Akowuah, G.(2018). Discovery of natural product inhibitors of phosphodiesterase 10A as novel therapeutic drug for schizophrenia using a multistep virtual screening . Computational Biology and Chemistry. 77. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 52-63.

Anand Gaurav, Ming Xing, Mayasah Al‐Nema (2017). Computational Approaches in the Development of Phosphodiesterase Inhibitors . Quantitative Structure-Activity Relationship.

BOOK CHAPTER

Mayasah Al-Nema and Anand Gaurav(2020). Advanced Applications of Gene Therapy in the Treatment of Haematologic Disorders . Frontiers in Clinical Drug Research: Hematology: Volume 4. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 84--123. {BENTHAM} {SCIENCE} {PUBLISHERS}

Anand Gaurav and Mayasah Al-Nema(2019). Polymerases of Coronaviruses . Viral Polymerases. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 271--300. Elsevier

Gaurav, A., Al-Nema, M.(2018). Polymerases of coronaviruses: Structure, function, and inhibitors . Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 271-300.

(2017). Computational Approaches in the Development of Phosphodiesterase Inhibitors . Quantitative Structure-activity Relationship.