プロフィール詳細

プロジェクトを作成

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Dr. Mamali D.に依頼

India

PhD Biotechnologist, Neurotherapeutics, Molecular Biology & Drug Discovery Researcher, Scientific writer

プロフィール概要

Ph.D. in Biotechnology with strong expertise in biochemistry, molecular biology, and translational biomedical research. Completed B.Sc. (Zoology) and M.Sc. (Biotechnology) from Utkal University; M.Phil. (Life Sciences) from Sambalpur University; Ph.D. from Alagappa University (2021). Doctoral research focused on neuroprotection, oxidative stress, and molecular mechanisms of neurodegenerative disorders. Investigated natural bioactive compounds (e.g., dihydroactinidiolide) targeting Nrf2/HO-1 pathways, apoptosis signaling (caspase-3/Bax), and amyloid-beta–induced toxicity using in vitro neuronal models and in vivo mouse studies. Integrated molecular biology techniques, biochemical assays, behavioral analysis, and in silico molecular docking for drug discovery applications. Research experience at CSIR-Central Salt and Marine Chemicals Research Institute on genetic improvement of Jatropha curcas, with hands-on expertise in RNA isolation, gene expression studies, and plant molecular biology. Technical proficiency in molecular cloning, genomic DNA/RNA isolation, qPCR, western blotting, protein engineering, immunohistochemistry, PBMC isolation, and cell culture (HEK293, SHSY5Y, N2A, primary astrocytes). Experienced in in vitro biochemical assays, toxicity evaluation, behavioral assays in mice, oxidative stress assays, neurotoxicity models, and molecular docking using AutoDock. Served as Assistant Professor and currently Teaching Assistant in Biomedical Science, mentoring postgraduate students and guiding research projects. Coordinated value-added courses in Biomedical Innovation, Regenerative Medicine, AI in Biomedical Science, and Medical Writing, integrating emerging technologies with life sciences education. Senior Medical Freelance Writer contributing scientific and healthcare content. Published multiple research articles in high-impact international journals and contributed book chapters with Springer and Elsevier. Core research interest: developing mechanism-based therapeutic strategies for neurological disorders, cancer, and metabolic diseases through integration of molecular biology, bioinformatics, and translational pharmacology.

専門分野

• ☆ Neuroscience
• ☆ Neuropharmacology
• ☆ Neurobiology
• ☆ Neurology
• ☆ Alzheimer's Disease

サービス

• Writing
• Research
• Consulting

Writing Medical Writing, Technical Writing, Creative Writing

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

職務経験

Assistant Teacher

Alagappa University

1月 2024 - 現在

学歴

PhD, Biotechnology

Alagappa University

6月 2018 - 1月 2026

認定資格

• PhD

  Alagappa University

  1月 2018 - 11月 2021

出版物

BOOK CHAPTER

Mamali Das, Chandramohan Kiruthiga, Arumugam Kamaladevi, K. Langeswaran (2026). Diabetes in Cancer Survivors . Diabetes and Cancer: Association, Mechanism, and Therapeutic Implications.

Mamali Das, Arumugam Kamaladevi, Chandramohan Kiruthiga, K. Langeswaran (2026). Strategies for Reducing the Risk of Diabetes and Cancer . Diabetes and Cancer: Association, Mechanism, and Therapeutic Implications.

Mamali Das, Arumugam Kamaladevi, Chandramohan Kiruthiga, K. Langeswaran (2026). Strategies for Reducing the Risk of Diabetes and Cancer . Diabetes and Cancer: Association, Mechanism, and Therapeutic Implications.

Mamali Das, Chandramohan Kiruthiga, Arumugam Kamaladevi, K. Langeswaran (2026). The Importance of Understanding the Link Between Diabetes and Cancer . Diabetes and Cancer: Association, Mechanism, and Therapeutic Implications.

(2019). Potential Role of Curcumin and Its Derivatives Against Alzheimer Disease . Curcumin for Neurological and Psychiatric Disorders.

(2018). Neuroprotective and Antiaging Essential Oils and Lipids in Plants . Reference Series in Phytochemistry.

JOURNAL ARTICLE

Mamali Das, Chandramohan Kiruthiga, Rakesh Sahu, Sarvananda L, Amal D. Premarathna (2025). Seaweed as a functional food: Exploring bioactive compounds for neuroprotection and gut-brain health in Parkinson's disease . Next Research.

Mamali Das, Chandramohan Kiruthiga, Nachammai Kathiresan, Dipali Desai, William C. Cho, Chandrabose Selvaraj, Langeswaran Kulanthaivel (2025). Stem-like CD4+ T cells mediate T-cell state transitions to enhance tumor control and immunotherapy response . International Immunopharmacology.

Mamali Das, Chandramohan Kiruthiga, R. Beema Shafreen, Kathiresan Nachammai, Chandrabose Selvaraj, K. Langeswaran (2025). Harnessing the human microbiome and its impact on immuno-oncology and nanotechnology for next-generation cancer therapies . European Journal of Pharmacology.

Mamali Das, Sengodu Prakash, Veeman Sannasi (2023). Symmetric supercapacitors assembled using electrolyte embedded V2O5-rGO composites . Diamond and Related Materials.

Mamali Das, Kasi Pandima Devi, Tarun Belwal, Hari Prasad Devkota, Devesh Tewari, Adeleh Sahebnasagh, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Mahsa Rasekhian, Suowen Xu, et al. (2023). Harnessing polyphenol power by targeting eNOS for vascular diseases . Critical Reviews in Food Science and Nutrition.

Mamali Das, Devasahayam Jaya Balan, Sethuraman Sathya, Chandramohan Kiruthiga, Mahalingam Jeyakumar, Mariya Gover Antoniraj, Kasi Pandima Devi (2022). Chitosan based encapsulation increased the apoptotic efficacy of thymol on A549 cells and exhibited non toxic response in swiss albino mice . International Journal of Biological Macromolecules.

Mamali Das, Devasahayam Jaya Balan, Pandima Devi Kasi (2021). Mitigation of oxidative stress with dihydroactinidiolide, a natural product against scopolamine-induced amnesia in Swiss albino mice . NeuroToxicology.

(2021). Dihydroactinidiolide regulates Nrf2/HO-1 expression and inhibits caspase-3/Bax pathway to protect SH-SY5Y human neuroblastoma cells from oxidative stress induced neuronal apoptosis. Neurotoxicology.

Mamali Das, Devasahayam Jaya Balan, Tamilselvam Rajavel, Sethuraman Sathya, Mahalingam Jeyakumar, Kasi Pandima Devi (2021). Thymol induces mitochondrial pathway-mediated apoptosis via ROS generation, macromolecular damage and SOD diminution in A549 cells . Pharmacological Reports.

(2019). A Mini Review on the Protective Effect of Lignans for the Treatment of Neurodegenerative Disorders . Journal of Nutrition, Food and Lipid Science.

(2018). Dihydroactinidiolide, a natural product against Aβ25-35 induced toxicity in Neuro2a cells: Synthesis, in silico and in vitro studies . Bioorganic Chemistry.

(2015). An economical and efficient protocol for total RNA isolation fromJatropha curcas . International Journal of Environmental Studies.

(2013). Pathogenesis-Related Gene, JcPR-10a from Jatropha curcas Exhibit RNase and Antifungal Activity . Molecular Biotechnology.

BOOK

(2020). Plant Antioxidants and Health . Springer International Publishing.