プロフィール詳細

プロジェクトを作成

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Dr. María Cruz M.に依頼

Argentina

PhD in Pharmaceutical Sciences | Expert in Organic Synthesis, Medicinal Chemistry & Drug Discovery

プロフィール概要

I am a PhD in Pharmaceutical Sciences with over 12 years of experience in organic and medicinal chemistry, drug discovery, and academic research. Currently, I work as a Research Scientist at CONICET (Argentina), focusing on the design and synthesis of bioactive compounds against neglected viral and parasitic diseases (Chagas, Dengue, Zika, Chikungunya). I completed postdoctoral fellowships renowned universities of Argentina and Brazil. My research has led to 12+ publications in peer-reviewed journals (ACS Omega, Organic Letters, Beilstein J. Org. Chem., among others) and one patent in heterocyclic synthesis. In parallel, I have 14 years of teaching experience in Organic Chemistry at the University of Buenos Aires, mentoring undergraduate and postgraduate students. As a freelancer, I offer: Scientific consulting in organic synthesis, drug design, and preclinical discovery. Translation of scientific documents (English ↔ Spanish, Portuguese ↔ Spanish). My goal is to provide clear, accurate, and professional support to researchers, startups, and organizations in the pharmaceutical and life sciences fields.

専門分野

• ☆ Organic Chemistry
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Phenotypic Assays
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical ADME/PK/PD

サービス

• Consulting

Consulting Scientific and Technical Consulting

職務経験

Assistant Researcher

CONICET

12月 2022 - 現在

Postdoctoral Research fellow

UNICAMP

1月 2021 - 12月 2022

学歴

PhD in Pharmacy

University of Buenos Aires

4月 2011 - 4月 2016

B.Sc. in Pharmacy

University of Buenos Aires

4月 2005 - 12月 2011

認定資格

• PhD in Pharmacy and Biochemistry; Subfield: Chemical, Physical and Mathematical Sciences

  University of Buenos Aires

  4月 2016 - 現在

出版物

JOURNAL ARTICLE

Ramon G. de Oliveira, Luiza R. Cruz, Marco A. Dessoy, Paul J. Koovits, Deborah A. dos Santos, Luiz F. N. de Oliveira, Rafael A. Ferreira, María C. Mollo, Eun Lee, Simone M. Duarte, et al. (2025). Discovery and Early Optimization of 1H-Indole-2-carboxamides with Anti-Trypanosoma cruzi Activity . Journal of Medicinal Chemistry.

Brian W. Slafer, Marco A. Dessoy, Ramon G. de Oliveira, Maria C. Mollo, Eun Lee, An Matheeussen, Louis Maes, Guy Caljon, Leonardo L. G. Ferreira, Renata Krogh, et al. (2024). Synthesis and Anti-Trypanosoma cruzi Activity of 3-Cyanopyridine Derivatives . ACS Omega.

(2020). Microwave-Assisted Synthesis of 2-Substituted 2-Thiazolines and 5,6-Dihydro-4H-1,3-thiazines . Synthesis.

María C Mollo, Natalia B Kilimciler, Juan A Bisceglia, Liliana R Orelli(2020). Microwave-assisted synthesis of 2-substituted 4,5,6,7-tetrahydro-1,3-thiazepines from 4-aminobutanol . Beilstein Journal of Organic Chemistry. 16. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 32--38. Beilstein Institut

(2018). Polyamines and Related Nitrogen Compounds in the Chemotherapy of Neglected Diseases Caused by Kinetoplastids . Current Topics in Medicinal Chemistry.

(2016). Microwave-Assisted Synthesis of 2-Aryl-2-oxazolines, 5,6-Dihydro-4H-1,3-oxazines, and 4,5,6,7-Tetrahydro-1,3-oxazepines . Organic Letters.

(2016). Microwave-assisted cyclizations promoted by polyphosphoric acid esters: a general method for 1-aryl-2-iminoazacycloalkanes . Beilstein Journal of Organic Chemistry.

(2014). An Efficient Synthesis ofN-Alkyl-N-arylputrescines and Cadaverines . Organic Preparations and Procedures International.

(2012). E/Z equilibrium in tertiary amides – Part 3: N-acyl-N′-arylhexahydro-1,3-diazepines . Journal of Molecular Structure.

(2012). Microwave-Enhanced Synthesis of Phosphonoacetamides . Synthetic Communications.

(2011). 1,n-Diamines. Part 2: Synthesis of acyclic and heterocyclic N-arylputrescine derivatives . Tetrahedron Letters.

(2010). E/Z equilibrium in tertiary amides. Part 2: N-acyl-N′-arylhexahydropyrimidines . Journal of Molecular Structure.

PREPRINT

(2019). Microwave-assisted Synthesis of 2-Substituted 4,5,6,7-Tetrahydro-1,3-thiazepines from 4-Aminobutanol . [].

PATENT

(2019). Nuevo procedimiento para la síntesis de 2-oxazolinas, 5,6-dihidro-4H-1,3-oxazinas y 4,5,6,7-tetrahidro-1,3-oxazepinas promovida por ésteres del ácido polifosfórico. Boletín del INPI.

BOOK CHAPTER

Recent applications of microwaveassisted cyclizations promoted by polyphosphoric acid esters to the synthesis of nitrogen heterocycles. Synthetic approaches to nonaromatic nitrogen heterocycles.