プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Marcelo O.に依頼

Argentina

Computational Chemistry - Drug discovery - Evolutionary Biology

プロフィール概要

I have 35 years of experience as a scientist. I’m a biochemist, pharmacolgist and evolutionary biologist. I'm also involved in several computational chemistry projects with pharma companies. A brief description of my current and former activities can be found in: 1) https://www.linkedin.com/in/marceloortells/ 2) http://www.conicet.gov.ar/new_scp/detalle.php?id=29695 3) www.researchgate.net/profile/Marcelo_Ortells 4) http://scholar.google.com.ar/citations?user=U8cHvE4AAAAJ&hl=en 5) http://www.webometrics.info/es/node/93 6) https://orcid.org/0000-0003-4910-9798. I have also 25 years of experience modelling market research data in Argentina with the French company Ipsos (www.ipsos.com), where I was manager of the Data processing Department (from 1996 to 2006). I was also involved in data modelling for a direct sales (like Avon) company in Argentina, where I was the manager of the Production Planning and Sales forecasting department (2006-2011).

専門分野

• ★ Computational Biology
• ★ Neurochemistry
• ★ Drug Development
• ☆ Natural Product Chemistry
• ☆ Molecular Modeling
• ☆ Molecular Docking
• ☆ Supramolecular Chemistry
• ☆ Biochemistry
• ☆ Molecular Evolution
• ☆ Neuroscience
• ☆ Computational Neuroscience
• ☆ Neuropsychology
• ☆ Neuropharmacology
• ☆ Neurobiology
• ☆ Biophysics
• ☆ Computer Simulation/Computational Modeling
• ☆ SPSS
• ☆ Drug Design
• ☆ Alzheimer's Disease
• ☆ Tobacco Use Prevention & Control
• ☆ Drug Addiction Treatment
• ☆ Depression
• ☆ Neuropsychiatry
• ☆ Psychoactive Drugs

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing

Research Market Research, Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis

職務経験

RESEARCH SCIENTIST

CONICET BUENOS AIRES

7月 1994 - 現在

RESEARCH OFFICER

British Council

10月 1993 - 7月 1994

POSTDOC FELLOW

CONICET BUENOS AIRES

8月 1991 - 9月 1993

POSTDOC FELLOW

British Council

6月 1991 - 8月 1991

FELLOW

CONICET BUENOS AIRES

1月 1989 - 5月 1991

FELLOW

CONCEJO DE INVESTIGACIONES CIENTIFICAS PCIA BUENOS AIRES

1月 1985 - 12月 1988

TECHNICIANT

INIDEP - NATIONAL INSTITUTE OF FISHERY

7月 1978 - 1月 1979

学歴

PhD

University of Buenos Aires

3月 1985 - 9月 1990

LICENCIADO (FACULTY OF SCIENCES)

UNIVERSITY OF MAR DEL PLATA

4月 1976 - 3月 1981

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Arias, H.R., Ortells, M.O., Feuerbach, D., Burgos, V., Paz, C.(2019). Alkaloids Purified from Aristotelia chilensis Inhibit the Human α3β4 Nicotinic Acetylcholine Receptor with Higher Potencies Compared with the Human α4β2 and α7 Subtypes . Journal of Natural Products. 82. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1953-1960.

Arias, H.R., Jin, X.-T., Gallino, S., Peng, C., Feuerbach, D., García-Colunga, J., Elgoyhen, A.B., Drenan, R.M., Ortells, M.O.(2019). Selectivity of (±)-citalopram at nicotinic acetylcholine receptors and different inhibitory mechanisms between habenular α3β4* and α9α10 subtypes . Neurochemistry International. 131.

(2018). Bupropion inhibits human $\upalpha$3$\upbeta$4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites . Neurotransmitter. 5. Smart Science and Technology

Arias, H.R., Feuerbach, D., Schmidt, B., Heydenreich, M., Paz, C., Ortells, M.O.(2018). Drimane Sesquiterpenoids Noncompetitively Inhibit Human α4β2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human α3β4 and α7 Subtypes . Journal of Natural Products. 81. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 811-817.

Arias, H.R., Vázquez-Gómez, E., Hernández-Abrego, A., Gallino, S., Feuerbach, D., Ortells, M.O., Elgoyhen, A.B., García-Colunga, J.(2018). Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms . International Journal of Biochemistry and Cell Biology. 100. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-10.

(2016). Structure and function development during evolution of pentameric ligand gated ion channels . Neurotransmitter. Smart Science and Technology

Arias, H.R., Feuerbach, D., Ortells, M.O.(2016). Bupropion and its photoreactive analog (±)-SADU-3-72 interact with luminal and non-luminal sites at human α4β2 nicotinic acetylcholine receptors . Neurochemistry International. 100. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 67-77.

Arias, H.R., Feuerbach, D., Ortells, M.(2015). Functional and structural interaction of (-)-lobeline with human α4β2 and α4β4 nicotinic acetylcholine receptor subtypes . International Journal of Biochemistry and Cell Biology. 64. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 15-24.

Arias, H.R., Ortells, M.O., Feuerbach, D.(2013). (-)-Reboxetine inhibits muscle nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites . Neurochemistry International. 63. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 423-431.

Arias, H.R., Fedorov, N.B., Benson, L.C., Lippiello, P.M., Gatto, G.J., Feuerbach, D., Ortells, M.O.(2013). Functional and structural interaction of (-)-reboxetine with the human α4β2 nicotinic acetylcholine receptor . Journal of Pharmacology and Experimental Therapeutics. 344. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 113-123.

Arias, H.R., López, J.J., Feuerbach, D., Fierro, A., Ortells, M.O., Pérez, E.G.(2013). Novel 2-(substituted benzyl)quinuclidines inhibit human α7 and α4β2 nicotinic receptors by different mechanisms . International Journal of Biochemistry and Cell Biology. 45. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2420-2430.

Ortells, M.O., Arias, H.R.(2010). Molecular mechanisms of nicotine dependence . Journal of Pediatric Biochemistry. 1. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 75-89.

Arias, H.R., Feuerbach, D., Bhumireddy, P., Ortells, M.O.(2010). Inhibitory mechanisms and binding site location for serotonin selective reuptake inhibitors on nicotinic acetylcholine receptors . International Journal of Biochemistry and Cell Biology. 42. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 712-724.

Ortells, M.O., Arias, H.R.(2010). Neuronal networks of nicotine addiction . International Journal of Biochemistry and Cell Biology. 42. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1931-1935.

Ortells, M.O., Barrantes, G.E.(2010). Tobacco addiction: A biochemical model of nicotine dependence . Medical Hypotheses. 74. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 884-894.

Ortells, M.O., Arias, H.R.(2010). Molecular mechanisms of nicotine dependence . Journal of Pediatric Biochemistry. 1. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 75-89.

Arias, HR, Feuerbach, D, Ortells, MO. 2018 Bupropion inhibits human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites. Neurotransmiter 5: e1631. doi: 10.14800/nt.1631 .

Ortells, M.O., Barrantes, G.E.(2008). A model for the assembly of nicotinic receptors based on subunit-subunit interactions . Proteins: Structure, Function and Genetics. 70. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 473-488.

Barrantes, GE, & Ortells, MO. 2007 Receptores nicotínicos y tabaquismo: una trampa evolutiva Psicofarmacología, 7 (47): 18-26.

Barrantes, GE, & Ortells, MO. 2006 A working hypothesis on the interactions between antipsychotics and nicotinic receptors in schizophrenia. Psicofarmacología, 6 (39:) 16-22.

Ortells, M.O., Barrantes, G.E.(2002). Molecular modelling of the interactions of carbamazepine and a nicotinic receptor involved in the autosomal dominant nocturnal frontal lobe epilepsy . British Journal of Pharmacology. 136. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 883-895.

Ortells, M.O., Barrantes, G.E.(2001). Understanding channel blocking in the nicotinic acetylcholine receptor . Receptors and Channels. 7. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 273-288.

Ortells, M.O., Barrantes, G.E., Wood, C., Lunt, G.G., Barrantes, F.J.(1997). Molecular modelling of the nicotinic acetylcholine receptor transmembrane region in the open state . Protein Engineering. 10. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 511-517.

Ortells, M.O.(1997). Prediction of the secondary structure of the nicotinic acetylcholine receptor nontransmembrane regions. Proteins: Structure, Function and Genetics. 29. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 391-398.

Barrantes, G.E., Ortells, M.O., Barrantes, F.J.(1997). Screening structural-functional relationships of neuropharmacologically active organic compounds at the nicotonic acetylcholine receptor . Neuropharmacology. 36. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 269-279.

Ortells, M.O., Lunt, G.G.(1996). A mixed helix-beta-sheet model of the transmembrane region of the nicotinic acetylcholine receptor . Protein Engineering. 9. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 51-59.

10) Otero, AR & Ortells, MO, 1995 Intravenous blood extracting method in penguins: a detailed description in Pygoscelis papua. Contribuciones Instituto Antártico Argentino, 444:1-6.

Massarini A I, Barros, M A, Ortells, MO & Reig, O A, 1995 Chromosome variability in Ctenomys talarum (Rodentia, Octodontidae) from Argentina. Revista Chilena de Historia Natural, 68(2):207-214.

Ortells, M.O., Lunt, G.G.(1995). Evolutionary history of the ligand-gated ion-channel superfamily of receptors . Trends in Neurosciences. 18. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 121-127.

Ortells, M.O., Lunt, G.G.(1995). Reply . Trends in Neurosciences. 18. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 298-299.

Ortells, M.O.(1995). Phylogenetic analysis of G-banded karyotypes among the South American subterranean rodents of the genus Ctenomys (Caviomorpha: Octodontidae), with special reference to chromosomal evolution and speciation . Biological Journal of the Linnean Society. 54. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 43-70.

Lees, G., Ortells, M.O., Lunt, G.G.(1994). Molecular biology and fine structure of ion channels: Potential targets for general anaesthetics in the central nervous system . Anaesthetic Pharmacology Review. 2. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 11-28.

Ortells, M.O., Lunt, G.G.(1994). The transmembrane region of the nicotinic acetylcholine receptor: Is it an all-helix bundle? . Receptors and Channels. 2. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 53-59.

ORTELLS, M.O., BARRANTES, G.E.(1994). A study of genetic distances and variability in several species of the genus Ctenomys (Rodentia: Octodontidae) with special references to a probable causal role of chromosomes in speciation . Biological Journal of the Linnean Society. 53. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 189-208.

Ortells, M.O., Cockcroft, V.B., Lunt, G.G.(1993). Cedit: A c interface and macro facility for protein sequence alignment editing in colour with microsoft word 5.0 for pcs . Bioinformatics. 9. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 741-744.

Cockcroft, V.B., Ortells, M.O., Thomas, P., Lunt, G.G.(1993). Homologies and disparities of glutamate receptors: A critical analysis . Neurochemistry International. 23. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 583-594.

Barrantes, G.E., Ortells, M.O., Reig, O.A.(1993). New studies on allozyme genetic distance and variability in akodontine rodents (Cricetidae) and their systematic implications . Biological Journal of the Linnean Society. 48. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 283-298.

Reig, O.A., Massarini, A.I., Ortells, M.O., Barros, M.A., Dyzenchauz, F.J., Tiranti, S.I.(1992). New karyotypes and C-banding patterns of the subterranean rodents of the genus Ctenomys (Caviomorpha, Octodontidae) from Argentina . Mammalia. 56. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 603-624.

Massarini, A.I., Barros, M.A., Ortells, M.O., Reig, O.A.(1991). Chromosomal polymorphism and small karyotypic differentiation in a group of Ctenomys species from Central Argentina (Rodentia: Octodontidae) . Genetica. 83. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 131-144.

Reig, O.A., Busch, C., Ortells, M.O., Contreras, J.R.(1990). An overview of evolution, systematics, population biology, cytogenetics, molecular biology and speciation in Ctenomys . Progress in clinical and biological research. 335. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 71-96.

Ortells, M.O., Contreras, J.R., Reig, O.A.(1990). New Ctenomys karyotypes (Rodentia, Octodontidae) from north-eastern Argentina and from Paraguay confirm the extreme chromosomal multiformity of the genus . Genetica. 82. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 189-201.

Ortells, M. O.; Reig, O. A.; Wainberg, R. L.; Hurtado De Catalfo, G. E.; Gentile De Fronza, T. M. L. (1989): Cytogenetics and karyosystematics of Phyllotine rodens (Cricetidae, Sigmodontinae). II. Chromosome multiformity and autosomal polymorphism in Eligmodontia. Z. Saugetierkunde 54, 129–140.

Ortells, M.O., Reig, O.A., Brum-Zorrilla, N., Scaglia, O.A.(1988). Cytogenetics and karyosystematics of phyllotine rodents (Cricetidae, Sigmodontinae) I. Chromosome multiformity and gonosomal-autosomal translocation in Reithrodon . Genetica. 77. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 53-63.

BOOK CHAPTER

Ortells, MO & Arias, HR 2011 Neurochemical mechanisms underlying nicotine dependence. In: Pharmacology of Nicotinic Acetylcholine Receptors from the Basic and Therapeutic Perspectives. Research Signpost, Kerala, India, Chapter 10: 199-221.

Marcelo O. Ortells(1998). Evolution of the AChR and Other Ligand-Gated Ion Channels . The Nicotinic Acetylcholine Receptor. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 11--30. Springer Berlin Heidelberg

(1998). Molecular Modeling of the Nicotinic Acetylcholine Receptor . The Nicotinic Acetylcholine Receptor.

M. O. Ortells and V. B. Cockcroft and G. G. Lunt and D. Marsh and F. J. Barrantes(1992). The Nicotinic Acetylcholine Receptor and its Lipid Microenvironment . The Jerusalem Symposia on Quantum Chemistry and Biochemistry. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 185--198. Springer Netherlands

BOOK

COCKCROFT, V., ORTELLS, M., LUNT, G.(1995). Ligands, Receptor Models, and Evolution . Annals of the New York Academy of Sciences. 757. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 40-47.