プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Marina T.に依頼

Greece

Formulation and Process Development Expert - Pharmaceuticals - Management level

プロフィール概要

Innovative and results-driven pharmaceutical scientist with extensive experience in formulation and process development and a PhD on Pharmaceuticals from Utrecht University. As a key member of the company's R&D team, I specialize in designing, optimizing, and scaling advanced drug delivery systems—from concept through commercial readiness. With a strong academic foundation (PhD and 4 years of postdoctoral experience( and a proven track record at a leading Greek pharmaceutical company, I bring deep technical knowledge paired with practical execution skills. 🔬 Core Competencies • Innovative Formulation Design – expertise in controlled-release and novel dosage forms • Process Optimization & Scale‑up – ensuring reproducible manufacturing quality at commercial scale • Cross-functional Collaboration – partnering closely with analytical, quality assurance, and manufacturing teams • Regulatory Liaison – supporting product registration through robust documentation and process knowledge • Continuous Improvement – utilizing data-driven methodologies to optimize formulations and processes

専門分野

• ☆ Drug Development
• ☆ Drug Formulation
• ☆ Drug Substance Characterization
• ☆ Drug Stability Testing
• ☆ Preclinical Research
• ☆ Preclinical Pharmacology
• ☆ Pharmaceutical Regulatory Affairs
• ☆ Pharmaceutical Manufacturing
• ☆ Extractable & Leachable Testing
• ☆ Pharmaceutical Process Development
• ☆ Pharmaceutical Management
• ☆ Drug Delivery Technologies
• ☆ Liposomes
• ☆ Pharmaceutical Technology
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Feasibility Studies
• ☆ Regulatory Writing
• ☆ CMC Documentation
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing
• ☆ Instructional Materials
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Spec Sheets
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing
• ☆ Language Translation

サービス

• Writing

Writing Technical Writing

職務経験

Formulation and Process Development Expert R&D Innovative Formulations

Pharmathen S.A.

1月 2025 - 現在

Senior R&D Formulation Scientist

Rafarm S.A.

2月 2016 - 12月 2021

学歴

PhD in Pharmaceutics

University of Utrecht

10月 2007 - 11月 2011

Chemistry degree

University of Athens

9月 2001 - 9月 2006

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Rojas, J. M., Gavilán, H., Del Dedo, V., Lorente-Sorolla, E., Sanz-Ortega, L., da Silva, G. B., Costo, R., Perez-Yagüe, S., Talelli, M., Marciello, M., et al.(2017). Time-course assessment of the aggregation and metabolization of magnetic nanoparticles . Acta Biomater. 58. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 181-195.

Rojas, J.M., Gavilán, H., del Dedo, V., Lorente-Sorolla, E., Sanz-Ortega, L., da Silva, G.B., Costo, R., Perez-Yagüe, S., Talelli, M., Marciello, M., et al.(2017). Time-course assessment of the aggregation and metabolization of magnetic nanoparticles . Acta Biomaterialia. 58. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 181-195.

Roncador, A., Oppici, E., Talelli, M., Pariente, A. N., Donini, M., Dusi, S., Voltattorni, C. B., Vicent, M. J., Cellini, B.(2017). Use of polymer conjugates for the intraperoxisomal delivery of engineered human alanine:glyoxylate aminotransferase as a protein therapy for primary hyperoxaluria type I . Nanomedicine. 13. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 897-907.

Roncador, A., Oppici, E., Talelli, M., Pariente, A.N., Donini, M., Dusi, S., Voltattorni, C.B., Vicent, M.J., Cellini, B.(2017). Use of polymer conjugates for the intraperoxisomal delivery of engineered human alanine:glyoxylate aminotransferase as a protein therapy for primary hyperoxaluria type I . Nanomedicine: Nanotechnology, Biology, and Medicine. 13. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 897-907.

Talelli, Marina, Guisasola, Eduardo, Baeza, Alejandro, Arcos, Daniel, Vallet-Regi, Maria(2016). Design of thermoresponsive polymeric gates with opposite controlled release behaviors . RSC Advances. 6. (48). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 42510-42516.

Guisasola, E., Baeza, A., Talelli, M., Arcos, D., Vallet-Regí, M.(2016). Design of thermoresponsive polymeric gates with opposite controlled release behaviors . RSC Advances. 6. (48). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 42510-42516.

Marina, Talelli, Antonio Aires and Marzia, Marciello(2016). Protein-Modified Magnetic Nanoparticles for Biomedical Applications . Current Organic Chemistry. 20. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1252-1261.

Talelli, M., Aires, A., Marciello, M.(2016). Protein-modified magnetic nanoparticles for biomedical applications . Current Organic Chemistry. 20. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1252-1261.

Zahraei, M., Marciello, M., Lazaro-Carrillo, A., Villanueva, A., Herranz, F., Talelli, M., Costo, R., Monshi, A., Shahbazi-Gahrouei, D., Amirnasr, M., et al.(2016). Versatile theranostics agents designed by coating ferrite nanoparticles with biocompatible polymers . Nanotechnology. 27. (25). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 255702.

Zahraei, M., Marciello, M., Lazaro-Carrillo, A., Villanueva, A., Herranz, F., Talelli, M., Costo, R., Monshi, A., Shahbazi-Gahrouei, D., Amirnasr, M., et al.(2016). Versatile theranostics agents designed by coating ferrite nanoparticles with biocompatible polymers . Nanotechnology. 27. (25).

Talelli, M., Barz, M., Rijcken, C. J., Kiessling, F., Hennink, W. E., Lammers, T.(2015). Core-Crosslinked Polymeric Micelles: Principles, Preparation, Biomedical Applications and Clinical Translation . Nano Today. 10. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 93-117.

Talelli, M., Barz, M., Rijcken, C.J.F., Kiessling, F., Hennink, W.E., Lammers, T.(2015). Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation . Nano Today. 10. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 93-117.

Guisasola, E., Baeza, A., Talelli, M., Arcos, D., Moros, M., de la Fuente, J. M., Vallet-Regí, M.(2015). Magnetic-Responsive Release Controlled by Hot Spot Effect . Langmuir. 31. (46). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 12777-82.

Guisasola, E., Baeza, A., Talelli, M., Arcos, D., Moros, M., De La Fuente, J.M., Vallet-Regí, M.(2015). Magnetic-Responsive Release Controlled by Hot Spot Effect . Langmuir. 31. (46). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 12777-12782.

Ruiz-Hernández, E., Hess, M., Melen, G.J., Theek, B., Talelli, M., Shi, Y., Ozbakir, B., Teunissen, E.A., Ramírez, M., Moeckel, D., et al.(2014). PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses . Polymer Chemistry. 5. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1674-1681.

Ruiz-Hernández, E., Hess, M., Melen, G. J., Theek, B., Talelli, M., Shi, Y., Ozbakir, B., Teunissen, E. A., Ramírez, M., Moeckel, D., et al.(2014). PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses . Polym Chem. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1674-1681.

Talelli, M., Vicent, M. J.(2014). Reduction sensitive Poly(l-glutamic acid) (PGA)-protein conjugates designed for polymer masked-unmasked protein therapy . Biomacromolecules. 15. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4168-77.

Talelli, M., Vicent, M.J.(2014). Reduction sensitive poly(l-glutamic acid) (PGA)-protein conjugates designed for polymer masked-unmasked protein therapy . Biomacromolecules. 15. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4168-4177.

Deckers, R., Paradissis, A., Oerlemans, C., Talelli, M., Storm, G., Hennink, W. E., Nijsen, J. F.(2013). New insights into the HIFU-triggered release from polymeric micelles . Langmuir. 29. (30). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9483-90.

Deckers, R., Paradissis, A., Oerlemans, C., Talelli, M., Storm, G., Hennink, W.E., Nijsen, J.F.W.(2013). New insights into the HIFU-triggered release from polymeric micelles . Langmuir. 29. (30). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9483-9490.

Talelli, M., Oliveira, S., Rijcken, C. J., Pieters, E. H., Etrych, T., Ulbrich, K., van Nostrum, R. C., Storm, G., Hennink, W. E., Lammers, T.(2013). Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy . Biomaterials. 34. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1255-60.

Talelli, M., Oliveira, S., Rijcken, C.J.F., Pieters, E.H.E., Etrych, T., Ulbrich, K., van Nostrum, R.C.F., Storm, G., Hennink, W.E., Lammers, T.(2013). Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy . Biomaterials. 34. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1255-1260.

Talelli, Marina, Rijcken, Cristianne J. F., Hennink, Wim E., Lammers, Twan(2012). Polymeric micelles for cancer therapy: 3 C's to enhance efficacy . Current Opinion in Solid State & Materials Science. 16. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 302-309.

Talelli, M., Rijcken, C.J.F., Hennink, W.E., Lammers, T.(2012). Polymeric micelles for cancer therapy: 3 C's to enhance efficacy . Current Opinion in Solid State and Materials Science. 16. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 302-309.

Khonkarn, R., Mankhetkorn, S., Talelli, M., Hennink, W. E., Okonogi, S.(2012). Cytostatic effect of xanthone-loaded mPEG-b-p(HPMAm-Lac2) micelles towards doxorubicin sensitive and resistant cancer cells . Colloids Surf B Biointerfaces. 94. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 266-73.

Khonkarn, R., Mankhetkorn, S., Talelli, M., Hennink, W.E., Okonogi, S.(2012). Cytostatic effect of xanthone-loaded mPEG-b-p(HPMAm-Lac 2) micelles towards doxorubicin sensitive and resistant cancer cells . Colloids and Surfaces B: Biointerfaces. 94. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 266-273.

Talelli, M., Rijcken, C. J., Oliveira, S., van der Meel, R., van Bergen En Henegouwen, P. M., Lammers, T., van Nostrum, C. F., Storm, G., Hennink, W. E.(2011). Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting . J Control Release. 151. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 183-92.

Talelli, M., Rijcken, C.J.F., Oliveira, S., Van Der Meel, R., Van Bergen En Henegouwen, P.M.P., Lammers, T., Van Nostrum, C.F., Storm, G., Hennink, W.E.(2011). Nanobody - Shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting . Journal of Controlled Release. 151. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 183-192.

Talelli, M., Rijcken, C. J., Oliveira, S., van der Meel, R., van Bergen en Henegouwen, P. M., Lammers, T., van Nostrum, C. F., Storm, G., Hennink, W. E.(2011). Reprint of "Nanobody--shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting" . J Control Release. 153. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 93-102.

Talelli, M., Rijcken, C.J.F., Oliveira, S., Van Der Meel, R., Van Bergen En Henegouwen, P.M.P., Lammers, T., Van Nostrum, C.F., Storm, G., Hennink, W.E.(2011). Reprint of "nanobody - Shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting" . Journal of Controlled Release. 153. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 93-102.

Talelli, M., Morita, K., Rijcken, C. J., Aben, R. W., Lammers, T., Scheeren, H. W., van Nostrum, C. F., Storm, G., Hennink, W. E.(2011). Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry . Bioconjug Chem. 22. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2519-30.

Talelli, M., Morita, K., Rijcken, C.J.F., Aben, R.W.M., Lammers, T., Scheeren, H.W., Van Nostrum, C.F., Storm, G., Hennink, W.E.(2011). Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry . Bioconjugate Chemistry. 22. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2519-2530.

Talelli, M., Hennink, W. E.(2011). Thermosensitive polymeric micelles for targeted drug delivery . Nanomedicine (Lond). 6. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1245-55.

Talelli, M., Hennink, W.E.(2011). Thermosensitive polymeric micelles for targeted drug delivery . Nanomedicine. 6. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1245-1255.

Talelli, M., Iman, M., Varkouhi, A. K., Rijcken, C. J., Schiffelers, R. M., Etrych, T., Ulbrich, K., van Nostrum, C. F., Lammers, T., Storm, G., et al.(2010). Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin . Biomaterials. 31. (30). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7797-804.

Talelli, M., Iman, M., Varkouhi, A.K., Rijcken, C.J.F., Schiffelers, R.M., Etrych, T., Ulbrich, K., van Nostrum, C.F., Lammers, T., Storm, G., et al.(2010). Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin . Biomaterials. 31. (30). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7797-7804.

Rijcken, C.J.F., Talelli, M., Van Nostrum, C.F., Storm, G., Hennink, W.E.(2010). Crosslinked micelles with transiently linked drugs - A versatile drug delivery system . European Journal of Nanomedicine. 3. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 19-24.

Talelli, M., Rijcken, C. J., van Nostrum, C. F., Storm, G., Hennink, W. E.(2010). Micelles based on HPMA copolymers . Adv Drug Deliv Rev. 62. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 231-9.

Talelli, M., Rijcken, C.J.F., van Nostrum, C.F., Storm, G., Hennink, W.E.(2010). Micelles based on HPMA copolymers . Advanced Drug Delivery Reviews. 62. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 231-239.

Talelli, M., Iman, M., Rijcken, C. J., van Nostrum, C. F., Hennink, W. E.(2010). Targeted core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin . J Control Release. 148. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e121-2.

Talelli, M., Iman, M., Rijcken, C.J., van Nostrum, C.F., Hennink, W.E.(2010). Targeted core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin . Journal of controlled release : official journal of the Controlled Release Society. 148. (1).

van Hasselt, P.M., Janssens, G.E.P.J., Slot, T.K., van der Ham, M., Minderhoud, T.C., Talelli, M., Akkermans, L.M., Rijcken, C.J.F., van Nostrum, C.F.(2009). The influence of bile acids on the oral bioavailability of vitamin K encapsulated in polymeric micelles . Journal of Controlled Release. 133. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 161-168.

Talelli, M., Rijcken, C. J., Lammers, T., Seevinck, P. R., Storm, G., van Nostrum, C. F., Hennink, W. E.(2009). Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: toward a targeted nanomedicine suitable for image-guided drug delivery . Langmuir. 25. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2060-7.

Talelli, M., Rijcken, C.J.F., Lammers, T., Seevinck, P.R., Storm, G., Van Nostrum, C.F., Hennink, W.E.(2009). Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: Toward a targeted nanomedicine suitable for image-guided drug delivery . Langmuir. 25. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2060-2067.

van Hasselt, P. M., Janssens, G. E., Slot, T. K., van der Ham, M., Minderhoud, T. C., Talelli, M., Akkermans, L. M., Rijcken, C. J., van Nostrum, C. F.(2009). The influence of bile acids on the oral bioavailability of vitamin K encapsulated in polymeric micelles . J Control Release. 133. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 161-8.

Talelli, M., Pispas, S.(2008). Complexes of cationic block copolymer micelles with DNA: histone/DNA complex mimetics . Macromol Biosci. 8. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 960-7.

Talelli, M., Pispas, S.(2008). Complexes of cationic block copolymer micelles with DNA: Histone/DNA complex mimetics . Macromolecular Bioscience. 8. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 960-967.

Karatzas, A., Talelli, M., Vasilakopoulos, T., Pitsikalis, M., Hadjichristidis, N.(2006). Micellization of omega-functionalized diblock copolymers in selective solvent. Study on the effect of hydrogen bonds . Macromolecules. 39. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 8456-8466.

Karatzas, A., Talelli, M., Vasilakopoulos, T., Pitsikalis, M., Hadjichristidis, N.(2006). Micellization of ω-functionalized diblock copolymers in selective solvent. Study on the effect of hydrogen bonds . Macromolecules. 39. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 8456-8466.

BOOK

Talelli, M., Duro-Castaño, A., Rodríguez-Escalona, G., Vicent, M.J.(2014). Smart polymer nanocarriers for drug delivery . Smart Polymers and their Applications. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 327-358.

OTHER

Therapeutic Nanomedicine: Cross linked micelles with transiently linked drugs – a versatile drug delivery system @misc{RID:0821171005886-63, title = {Therapeutic Nanomedicine: Cross linked micelles with transiently linked drugs – a versatile drug delivery system}, author = {Rijcken Cristianne, J. F. and Talelli, Marina and van Nostrum Cornelus, F. and Storm, Gert and Hennink Wim, E.}, volume = {3}, number = {1}, pages = {19}, month = {2010}, isbn = {1662596}, year = {2010} } . European Journal of Nanomedicine.