プロフィール詳細

プロジェクトを作成

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Dr. Marta L.に依頼

United States

Senior Scientist | CRISPR, LNPs Expert | Gene Therapy & Genomic Technologies | Co-inventor 2 US Patents | 10+ Years R&D

プロフィール概要

I am a Senior Scientist with 10+ years of experience in translational R&D, spanning gene therapy, gene regulation, and developmental biology. I specialize in CRISPR/Cas9 genome editing, LNP and AAV delivery, transcriptional regulation, and preclinical development, with a proven track record of leading cross-functional programs in both academic and biotech settings. 🔎 Core Expertise: - In vivo and ex vivo gene editing using CRISPR/Cas technologies, LNPs, and AAV vectors - mRNA sequence engineering and SAR studies of modified guide RNAs - Genomic and transcriptomic analysis (RNA-seq, scRNA-seq, ChIP-seq, RNAscope) - Off-target and integration site profiling, genome editing specificity 🧬Gene Regulation & Developmental Biology: - Expertise in transcriptional control of craniofacial and cardiovascular development - NIH-funded leadership in multi-institutional research projects - Deep experience with transcription factors, enhancer activity, and GRN analysis 🧪 Preclinical & Translational Research: - Led IND-enabling studies and platform development for CRISPR-based therapeutics - Designed and executed in vivo pharmacology studies in multiple rodent models - Developed and optimized LNP formulations with superior in vivo performance - Engineered hepatic-targeted AAV vectors for gene therapy applications 🧾 Highlights: - Co-inventor on two U.S. patent applications for novel in vivo gene editing (2025) - First-author presentations at ASGCT 2024 & 2025; reviewer for peer-reviewed journals

専門分野

• ☆ Developmental Biology
• ☆ Embryology
• ☆ Immunoassay
• ☆ Molecular Biology
• ☆ Genetics
• ☆ Epigenetics
• ☆ ChIP-Seq
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Gene Regulation
• ☆ Histology
• ☆ Microscopy
• ☆ Cryosectioning
• ☆ Fluorescence Microscopy
• ☆ Primary Cells
• ☆ Gene Editing/CRISPR
• ☆ Gene Delivery
• ☆ Drug Discovery
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Preclinical Research
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ Gene Therapy

サービス

• Writing
• Research
• Consulting

Writing Non-Medical Regulatory Writing, Technical Writing, General Proofreading & Editing, Translation

Research Fact Checking, Scientific and Technical Research

Consulting Go-to-Market Strategy Consulting, Scientific and Technical Consulting

職務経験

Senior Scientist

Caribou Biosciences (United States)

9月 2023 - 5月 2025

Scientist II

Caribou Biosciences (United States)

8月 2022 - 8月 2023

Assistant Professional Researcher

University of California, San Francisco

9月 2021 - 10月 2022

Postdoctoral Researcher

University of California, San Francisco

11月 2016 - 8月 2021

Research Associate

University of Manchester

9月 2015 - 7月 2016

学歴

PhD Molecular Genetics

University of Manchester

9月 2012 - 1月 2016

MSc Medical Diagnostics

Cranfield University

8月 2010 - 10月 2011

BSc Biotechnology

Universitat Politecnica de Valencia

9月 2006 - 9月 2010

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Viviana Hermosilla Aguayo, Peter Martin, Nuo Tian, James Zheng, Robert Aho, Marta Losa, Licia Selleri (2023). ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling . Developmental Biology.

Losa M, Iros Barozzi, Marco Osterwalder, Viviana Hermosilla, Morabito A, Brandon Chacón, Zarrineh P, Girdziusaite A, Benazet JD, Zhu J, et al. (2023). A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2 . Nature communications.

Marta Losa Llabata, Brandon Chacón, Louis Faure, Igor Adameyko, Licia Selleri (2021). Single‐Cell Level Identification Of Cephalic Epithelial Transcriptomic Signatures To Elucidate The Pathogenesis Of Cleft Lip/Palate . The FASEB Journal.

Laure Bridoux, Richard S. Mann, Peyman Zarrineh, Joshua Mallen, Mike Phuycharoen, Victor Latorre, Frank Ladam, Marta Losa, Syed Murtuza Baker, Charles Sagerstrom, et al.(2020). HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation . PLOS Genetics. 16. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e1009162. Public Library of Science ({PLoS})

Licia Selleri, Ian Welsh, Karissa Hansen, Marco Osterwalder, Marta Losa-Llabata, Julie Wells, Carol Bult, Timothy Mohun, Diane Hu, Ralph Marcucio, et al. (2020). Regulatory Dynamics of Midfacial Growth in Evolution and Disease . The FASEB Journal.

Mike Phuycharoen, Peyman Zarrineh, Laure Bridoux, Shilu Amin, Marta Losa, Ke Chen, Nicoletta Bobola, Magnus Rattray (2020). Uncovering tissue-specific binding features from differential deep learning . Nucleic Acids Research.

Losa, M., Risolino, M., Li, B., Hart, J., Quintana, L., Grishina, I., Yang, H., Choi, I.F., Lewicki, P., Khan, S., et al.(2018). Face morphogenesis is promoted by Pbx-dependent EMT via regulation of snail1 during frontonasal prominence fusion . Development (Cambridge). 145. (5).

Losa, M., Latorre, V., Andrabi, M., Ladam, F., Sagerström, C., Novoa, A., Zarrineh, P., Bridoux, L., Hanley, N.A., Mallo, M., et al.(2017). A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree . eLife. 6.

Slavotinek, A., Risolino, M., Losa, M., Cho, M.T., Monaghan, K.G., Schneidman-Duhovny, D., Parisotto, S., Herkert, J.C., Stegmann, A.P., Miller, K., et al.(2017). De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects . Human Molecular Genetics. 26. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4849-4860.

Amin, S., Donaldson, I., Zannino, D.A., Hensman, J., Rattray, M., Losa, M., Spitz, F., Ladam, F., Sagerström, C., Bobola, N.(2015). Hoxa2 selectively enhances meis binding to change a branchial arch ground state . Developmental Cell. 32. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 265-277.

PREPRINT

Marta Losa Llabata, Ryan M. Samuel, Albertas Navickas, Ashley Maynard, Eliza A. Gaylord, Kristle Garcia, Samyukta Bhat, Homa Majd, Mikayla N. Richter, Nicholas Elder, et al. (2023). Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma .