プロフィール詳細

プロジェクトを作成

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Mary Sravani Galla M.に依頼

India

A passionate medicinal chemistry researcher with core expertise in drug discovery, synthesis and scientific writing

プロフィール概要

• Experience in manuscript writing, including preparation of research articles, review papers, and scientific reports for peer-reviewed journals. • Proven experience in writing research proposals and projects for funding agencies such as ICMR and ANRF, including concept development, literature support, and proposal structuring. • Strong scientific writing skills, including editing, proofreading, and reviewing peer-reviewed manuscripts to ensure clarity, accuracy, and compliance with journal guidelines. • Strong background in structure–activity relationship (SAR), ADME prediction, and analytical characterization using NMR, IR, and mass spectrometry. • Conducted literature review on anticancer drug discovery, kinase inhibitors, and bioactive heterocycles. • Identified new molecular scaffolds, synthetic methodologies, and therapeutic targets for cancer therapy. • Explored innovative strategies including multi-target therapeutics, dual-mechanism drug design, tumor microenvironment targeting, and pH-dependent drug design. • Designed new chemical entities using medicinal chemistry principles and SAR analysis. • Performed molecular docking and virtual screening to predict ligand–target binding interactions. • Evaluated ADME, toxicity, and pharmacokinetic properties using SwissADME, Protox II, and Schrödinger Maestro. • Conducted multi-step organic synthesis of heterocyclic compounds and drug-like molecules. • Performed cyclization, coupling reactions, and functional group transformations. • Executed inert atmosphere reactions using specialized laboratory setups. • Optimized reaction conditions to improve yield and purity. • Characterized synthesized compounds using 1 H NMR, 13 C NMR, IR spectroscopy, and mass spectrometry. • Interpreted spectral data for structural confirmation.

専門分野

• ★ Cancer Research
• ★ Medical Content Writing
• ★ Manuscript & Journal Article Writing
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Cancer Biology
• ☆ Medical Writing
• ☆ Technical & Scientific Writing

サービス

• Writing
• Research

Writing Medical Writing, Technical Writing, Copywriting, Creative Writing

Research Technology Scouting

職務経験

Research scholar

National Institute of Pharmaceutical Education and Research

- 現在

PhD. Researcher

National Institute of Pharmaceutical Education and Research Hyderabad

9月 2021 - 現在

Student Internship

Granules Pvt.Ltd

5月 2019 - 6月 2019

学歴

PhD (Medicinal Chemistry)

NIPER Hyderabad

9月 2021 - 8月 2026

M.S. (Pharma)

National Institute of Pharmaceutical Education and Research Hyderabad

7月 2019 - 6月 2021

認定資格

• Masters degree

  National Institute of Pharmaceutical Education and Research

  10月 2021 - 現在

出版物

JOURNAL ARTICLE

Mary Sravani Galla, Shivam Gupta, A. Ezhilmathe, Chandraiah Godugu, Nagula Shankaraiah (2026). Copper(II)-catalysed one-pot synthesis of thiazole/benzothiazole-based isoquinolin-1(2H)-ones as potential cytotoxic and VEGFR-2 inhibitors . Bioorganic Chemistry.

Mary Sravani Galla, Shivam Gupta, A. Ezhilmathe, Chandraiah Godugu, Nagula Shankaraiah (2026). Copper(II)-catalysed one-pot synthesis of thiazole/benzothiazole-based isoquinolin-1(2H)-ones as potential cytotoxic and VEGFR-2 inhibitors . Bioorganic Chemistry.

Mary Sravani Galla, Swetha Singitham, Subha Jahnavi Avvaru, Manda Sathish, Pooja Kumari, Amol G. Dikundwar, Nagula Shankaraiah (2026). Visible‐Light Mediated One‐Pot Synthesis of Pyrazolo[3,4‐ <i>b</i> ]Pyridines <i>via</i> Intramolecular Rearrangement . Asian Journal of Organic Chemistry.

Mary Sravani Galla, Nandini B. Kale, Nagula Shankaraiah (2026). Harnessing Functionalized Alkynes in Annulation Reactions: A Comprehensive Review . Asian Journal of Organic Chemistry.

Mary Sravani Galla, Akshay Kumawat, Himaja Ambati, Kanchan Kuralkar, M. Venkatesh, Balaram Ghosh, Nagula Shankaraiah (2025). β-Carbolines linked γ-amino butyric acid/p-amino benzoic acid based carboxamides as histone deacetylase inhibitors: Design, synthesis, cytotoxicity and in silico studies . International Journal of Biological Macromolecules.

Mary Sravani Galla, Shivam Gupta, Kshirsagar Prasad Suhas, Nagula Shankaraiah (2025). Carboxylic acids as enabling directing groups in C−H activation and functionalization: A decade review . Advanced Synthesis &amp; Catalysis.

Mary Sravani Galla, Akshay Kumawat, Sumbul Mansuri, Nagula Shankaraiah (2024). KSCN‐Mediated One‐Pot Thiocyanation Tandem Cyclization of Enaminones: a Facile Access to 2‐amino/imino Thiazolo Fused Chromone and Coumarin Frameworks . European Journal of Organic Chemistry.

Mary Sravani Galla, Akshay Kumawat, Sumbul Mansuri, Nagula Shankaraiah (2024). KSCN‐Mediated One‐Pot Thiocyanation Tandem Cyclization of Enaminones: a Facile Access to 2‐amino/imino Thiazolo Fused Chromone and Coumarin Frameworks . European Journal of Organic Chemistry.

Mary Sravani Galla, Nandini B. Kale, Anamika Sharma, Aditya Hajare, Chandraiah Godugu, Nagula Shankaraiah (2024). Development of chromone-thiazolidine-2,4-dione Knoevenagel conjugates as apoptosis inducing agents . Bioorganic &amp; Medicinal Chemistry Letters.

Mary Sravani Galla, Nitika Sharma, Priyanka Mishra, Nagula Shankaraiah (2024). Recent insights of PROTAC developments in inflammation-mediated and autoimmune targets: a critical review . RSC Medicinal Chemistry.

Mary Sravani Galla, Nandini B. Kale, Akshay Kumawat, Darshana Bora, Nagula Shankaraiah (2024). Rh(<scp>iii</scp>)-catalysed C–H annulation of <i>cis</i>-stilbene acids with 2-diazo-1,3-diketones: facile access to 6,7-dihydrobenzofuran-4(5<i>H</i>)-one and α-pyrone scaffolds . Organic &amp; Biomolecular Chemistry.

Mary Sravani Galla, Darshana Bora, Stephy Elza John, Manda Sathish, Nagula Shankaraiah (2022). Rh(III)-catalysed site-selective alkylation of β-carbolines/isoquinolines and tandem C H/C N functionalization to construct indolizine-indole frameworks . Molecular Catalysis.

Mary Sravani Galla, Darshana Bora, Nagula Shankaraiah (2021). The Role of Sulphonamides and <i>N</i>‐Sulphonyl Ketimines/Aldimines as Directing Groups in the Field of C−H Activation . Chemistry – An Asian Journal.