プロフィール詳細

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Dr. Matthew W.に依頼

United Kingdom

Biomedical Scientist & Bioengineer | 13+ Years’ Experience | Cell Biology, Mechanobiology & Biomaterials

プロフィール概要

I am a biomedical scientist and bioengineer with 13+ years of academic and research experience, including 7+ years of postdoctoral research at the University of Glasgow. My expertise spans cell biology, mechanobiology, tissue engineering, biomaterials, biophysics and cancer research, with particular experience developing physiologically relevant in vitro models for disease research, regenerative medicine and therapeutic development. I currently work as a Postdoctoral Research Associate in Bioengineering and Mechanobiology at the University of Glasgow's Centre for the Cellular Microenvironment (CeMi), where I develop bioengineered models of breast cancer dormancy and recurrence within the bone marrow microenvironment. My research integrates cell and molecular biology, biomaterials, tissue engineering, nanoparticle-based delivery and advanced biophysical characterisation to investigate disease mechanisms and support diagnostic and therapeutic development. Areas of expertise • Cell & molecular biology – mammalian cell culture, immunofluorescence microscopy, biochemical and molecular assays, cellular phenotype analysis and experimental optimisation • Mechanobiology & biophysics – cellular mechanosensing, extracellular matrix biology, atomic force microscopy (AFM), nanoindentation and mechanical characterisation of cells and biomaterials • Biomaterials & tissue engineering – design and characterisation of 2D/3D hydrogel systems with controlled mechanical, viscoelastic and biochemical properties; biomaterial functionalisation and bioactive materials • In vitro disease models – physiologically relevant models of cancer, tissue regeneration and mechanically regulated disease, including breast and pancreatic cancer and bone-marrow microenvironments • Regenerative medicine – stem-cell mechanobiology, cartilage regeneration, tissue engineering and bioactive biomaterials • Drug & nanoparticle delivery – nanoparticle/LNP-based delivery systems and responsive biomaterials for controlled therapeutic delivery • Experimental design & scientific consulting – study design, methodology development, troubleshooting, literature evaluation, data interpretation and research strategy • Scientific writing & editing – manuscripts, literature reviews, research proposals, grant/fellowship applications, technical reports, scientific editing and figure/data presentation My previous research has included developing viscoelastic hydrogels to control mesenchymal stem-cell chondrogenesis, investigating extracellular-matrix mechanosensing in cancer, engineering mechanically responsive and bioactive materials, developing low-molecular-weight gel structures for regenerative medicine, and designing magnetically responsive nanoparticles for controlled therapeutic protein delivery. I have also established independent research investigating how altered tissue mechanics and cellular mechanosensing contribute to early pancreatic cancer development. I have contributed to 20+ peer-reviewed scientific publications, including multiple first-author research papers and review articles, across biomaterials, mechanobiology, cell biology, regenerative medicine and cancer research. My first-author work has involved leading experimental design, data generation and interpretation, figure preparation and manuscript writing. I also have extensive experience with manuscript editing, peer review, literature reviews, grant applications and research proposals. I regularly work within multidisciplinary teams involving biologists, biomedical engineers, physicists, chemists, materials scientists and clinicians, and have established collaborations across UK and European institutions. I have secured competitive research and travel funding, presented at national and international conferences, and received awards for scientific presentations. Teaching and mentoring are also significant components of my work. I have co-supervised 13 undergraduate and postgraduate research students and have experience teaching undergraduate and Master's students. I regularly advise researchers on experimental design, cell biology, bioengineering approaches, mechanobiology, data interpretation and scientific communication. I hold a PhD in Biology from the University of York, an MSc by Research in Biology, and a BSc (Hons) in Biology. This strong biological foundation combined with extensive postdoctoral experience in biomedical engineering enables me to bridge fundamental biological research with engineering and quantitative approaches. Available for freelance projects involving Scientific & technical consulting | Experimental design | Cell & molecular biology | Cancer biology | Mechanobiology | Biomaterials | Tissue engineering | In vitro models | Regenerative medicine | AFM & mechanical characterisation | Nanoparticle delivery | Literature reviews | Scientific writing & editing | Manuscript preparation | Research proposals & grant applications | Data interpretation Professional & research profiles: University of Glasgow Staff Profile: https://www.gla.ac.uk/schools/molecularbiosciences/staff/matthewwalker/ LinkedIn: https://www.linkedin.com/in/mattwalker1993/ ResearchGate: https://www.researchgate.net/profile/Matthew-Walker-39 ORCID: https://orcid.org/0000-0001-5119-9118 Google Scholar: https://scholar.google.com/citations?user=B5cVTy8AAAAJ&hl=en Web of Science: https://www.webofscience.com/wos/author/record/AAE-5446-2021

専門分野

• ★ Cell Biology
• ★ Biotechnology & Bioengineering
• ★ Tissue Engineering
• ☆ Materials Science & Engineering
• ☆ Nanotechnology & Nanomaterials
• ☆ Molecular Engineering
• ☆ Molecular Modeling
• ☆ Molecular Docking
• ☆ Analytical Chemistry
• ☆ Spectroscopy
• ☆ Fluorescence Spectroscopy
• ☆ Molecular Imaging
• ☆ Supramolecular Chemistry
• ☆ Biomaterials
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Microarrays
• ☆ Molecular Evolution
• ☆ Chromatin
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Next Generation Sequencing (NGS)
• ☆ ATAC-Seq
• ☆ DNA Sequencing
• ☆ Synthetic Genomics
• ☆ Protein Sequencing
• ☆ Gene Expression Analysis
• ☆ Genome Sequencing
• ☆ Microinjection
• ☆ Mutagenesis
• ☆ Exome Sequencing
• ☆ Recombinant DNA
• ☆ RNA Synthesis
• ☆ RNA Sequencing
• ☆ DNA/Gene Synthesis
• ☆ Oligonucleotide Synthesis
• ☆ Plasmid DNA
• ☆ DNA Damage & Repair
• ☆ ChIP-Seq
• ☆ Kinases
• ☆ Monoclonal Antibody Production
• ☆ Cell-Based Assays
• ☆ Cytochemistry
• ☆ Cytogenetics
• ☆ Cell Signaling Pathways
• ☆ Membrane Biology
• ☆ Gene Regulation
• ☆ Stem Cell Research
• ☆ Basic Immunology
• ☆ Adjuvant & Antigen Research
• ☆ Biophysics
• ☆ Histology
• ☆ Recombinant Protein Expression
• ☆ Nanobiotechnology
• ☆ Bioprinting
• ☆ Microscopy
• ☆ Light Microscopy
• ☆ Electron Microscopy
• ☆ Fluorescence Microscopy
• ☆ Scanning Probe Microscopy
• ☆ Biological Engineering
• ☆ Mechanical Engineering
• ☆ Gene & Protein Expression Analysis
• ☆ Plant-Based Protein
• ☆ Biomarker Discovery
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Line Engineering
• ☆ Large Scale Cell Culture
• ☆ Cell Surface Receptors
• ☆ 3D Cell Culture
• ☆ Industrial Biotechnology
• ☆ Biomolecular Engineering
• ☆ Gene Synthesis
• ☆ Genetic Engineering
• ☆ Gene Editing/CRISPR
• ☆ Protein/Enzyme Engineering
• ☆ Antibody Engineering
• ☆ Gene Delivery
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Phylogenetics
• ☆ Cytometry
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ In vitro Preclinical Toxciology
• ☆ In vitro Diagnostics
• ☆ In vitro Diagnostic Validation
• ☆ In vitro Diagnostic Design
• ☆ Point-of-Care Devices
• ☆ Biomarker Analysis
• ☆ Lab-on-a-Chip Devices
• ☆ Breast Cancer
• ☆ Pancreatic Cancer
• ☆ Endocrinology
• ☆ Clinical Laboratory Science
• ☆ Cytopathology & Histopathology
• ☆ Cytopathology
• ☆ Medical Sciences
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Metabolism & Metabolic Disease

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Medical Writing, Technical Writing, General Proofreading & Editing

Research Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization, Data Insights

Product Development Product Evaluation, Product Validation, Concept Development, Prototyping

職務経験

Postdoctoral Research Associate

University of Glasgow

1月 2019 - 現在

学歴

PhD in Biology

University of York (UK)

9月 2015 - 12月 2018

Masters of Science

University of York (UK)

9月 2014 - 9月 2015

BSc (Hons) in Biology (Biology)

University of Hull

9月 2011 - 7月 2014

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Matthew Walker, Harini Sampath Kumar, Adaiti Yadima, Ketan Pancholi, Ranjeetkumar Gupta, Amit Kumar, Judith Abolle-Okoyeagu, David Flynn (2026). Dual-functional LDPE and PP films with SiO₂-microbubble hybrid structures for thermal resistance and intelligent food spoilage detection . Materials Today Communications.

Matthew Walker, W. Sebastian Doherty-Boyd, P. Monica Tsimbouri, Vineetha Jayawarna, Aqeel F. Taqi, Niall Mahon, Dominic Meek, Peter Young, Aline Miller, Adam West, et al. (2026). Synthetic peptide hydrogels as a model of the bone marrow niche demonstrate efficacy of a combined CRISPR-CAR T-cell therapy for acute myeloid leukaemia . Biomaterials.

Antonella Pascucci, Sadia A Karim, Jennifer P Morton, Massimo Vassalli, Matthew Joseph Walker (2026). Viscoelasticity drives EMT in pancreatic intraepithelial neoplasia . Mechanobiology.

Antonella Pascucci, Sadia A Karim, Jennifer P Morton, Massimo Vassalli, Matthew Joseph Walker (2026). Viscoelasticity drives EMT in pancreatic intraepithelial neoplasia . Mechanobiology.

Matthew Walker, Dipankar Ghosh, Lauren Matthews, Charlie Patterson, Oana Dobre, Massimo Vassalli, Dave J. Adams (2026). Shear‐Induced Anisotropic Supramolecular Gel Noodles for Improved Cell Guidance in Polarized Tissue Engineering . Small.

Matthew Walker, Philip Binner, Jack Radford, Ilya Starshynov, Mansa Madhusudan, Karen Strathdee, Katrina Stevenson, Giuseppe Ciccone, Gonzalo Tejeda, Andrew Tobin, et al. (2026). Wide-Field and Non-Invasive Imaging of Brain Tumours with Scattered Light Techniques . Biomedical Optics Express.

Matthew Walker, Garima Saini, Mei Jun Tan, Maximillian G. Stanzione, Ketan Pancholi, Harini Sampathkumar, Charlie Patterson, Massimo Vassalli, Aaron B. Naden, Oxana V. Magdysyuk, et al. (2026). Polyetherureas as aqueous binders for Li ion batteries . Green Chemistry.

Matthew Walker, Chloe B. Rodgers, Giedrė Astrauskaitė, Rebecca E. Ginesi, Theodora Rogkoti, Greg Wardle, Troy R. Allen, Oana Dobre, Massimo Vassalli (2025). Mechanical Mapping of Spheroids Using Brillouin Spectroscopy . Journal of Visualized Experiments.

Matthew Walker, Erin Boland, Anna Hoyle, Olivia Robertson-Gray, William Fuller, Joe Swift, Marco Cantini, Eline Huethorst, Eilidh MacDonald, Christoper Loughrey, et al. (2025). Biomechanical and compositional basement membrane defects due to a Col4a1 mutation affect cardiac morphology and function . Matrix Biology.

Matthew Walker, Garima Saini, Mei J Tan, Maximillian G Stanzione, Ketan P Pancholi, Harini Kumar, Charlie Patterson, Massimo Vassalli, Aaron Naden, Oxana V. Magdysyuk, et al. (2025). Polyetherureas as aqueous binders for Li ion Batteries . Green Chemistry.

Matthew Walker, Philip Binner, Ilya Starshynov, Gonzalo Tejeda, Aisling McFall, Colin Molloy, Giuseppe Ciccone, Massimo Vassalli, Andrew Tobin, Daniele Faccio (2024). Optical, contact-free assessment of brain tissue stiffness and neurodegeneration . Biomedical Optics Express.

M Walker, JP Morton (2024). Hydrogel models of pancreatic adenocarcinoma to study cell mechanosensing . Biophysical Reviews.

M. Walker, D. Gourdon, M. Cantini (2024). Beyond static models: Mechanically dynamic matrices reveal new insights into cancer and fibrosis progression . Current Opinion in Biomedical Engineering.

Matthew Walker, Pavel S. Kulyabin, Oxana V. Magdysyuk, Aaron B. Naden, Daniel M. Dawson, Ketan Pancholi, Massimo Vassalli, Amit Kumar (2024). Manganese-Catalyzed Synthesis of Polyketones Using Hydrogen-Borrowing Approach . ACS Catalysis.

Matthew Walker, Pavel S. Kulyabin, Oxana V. Magdysyuk, Aaron B. Naden, Daniel M. Dawson, Ketan Pancholi, Massimo Vassalli, Amit Kumar (2024). Manganese-Catalyzed Synthesis of Polyketones Using Hydrogen-Borrowing Approach . ACS Catalysis.

Matthew Walker, Farid Torabizadeh, Tahereh Talaei-Khozani, Atefeh Yaghobi, Esmaeil Mirzaei (2024). Enhancing chondrogenic differentiation of mesenchymal stem cells through synergistic effects of cellulose nanocrystals and plastic compression in collagen-based hydrogel for cartilage formation . International Journal of Biological Macromolecules.

Matthew Walker, Eonan William Pringle, Giuseppe Ciccone, Lluís Oliver‐Cervelló, Manlio Tassieri, Delphine Gourdon, Marco Cantini (2023). Mind The Viscous Modulus: The Mechanotransductive Response to The Viscous Nature of Isoelastic Matrices Regulates Stem Cell Chondrogenesis . Advanced Healthcare Materials.

Matthew Walker, Jiajun Luo, Yinbo Xiao, Hannah Donnelly, Matthew J. Dalby, Manuel Salmeron-Sanchez (2022). The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – A review . Bioactive Materials.

Maryam Asadishekari and Elie N. Mpoyi and Yifan Li and Javad Eslami and Matthew Walker and Marco Cantini and Delphine Gourdon(2022). Three-Dimensional Tunable Fibronectin-Collagen Platforms for Control of Cell Adhesion and Matrix Deposition . Frontiers in Physics. 10. Frontiers Media {SA}

Jiajun Luo and Matthew Walker and Yinbo Xiao and Hannah Donnelly and Matthew J. Dalby and Manuel Salmeron-Sanchez(2021). The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – A review . Bioactive Materials. Elsevier {BV}

Matthew Walker and Jiajun Luo and Eonan William Pringle and Marco Cantini(2021). ChondroGELesis: Hydrogels to harness the chondrogenic potential of stem cells . Materials Science and Engineering: C. 121. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 111822. Elsevier {BV}

Daniel McDowall and Matthew Walker and Massimo Vassalli and Marco Cantini and Nikul Khunti and Charlotte J. C. Edwards-Gayle and Nathan Cowieson and Dave Adams(2021). Controlling the formation and alignment of low molecular weight gel ‘noodles’ . Chemical Communications. Royal Society of Chemistry ({RSC})

Matthew Walker, Daniel McDowall, Massimo Vassalli, Marco Cantini, Nikul Khunti, Charlotte Jennifer Chante Edwards-Gayle, Nathan Cowieson, Dave J. Adams (2021). Controlling the formation and alignment of low molecular weight gel ‘noodles’ . Chemical Communications.

(2020). Magnetically Triggered Release of Entrapped Bioactive Proteins from Thermally Responsive Polymer-Coated Iron Oxide Nanoparticles for Stem-Cell Proliferation . ACS Applied Nano Materials.

(2018). Glycans modify mesenchymal stem cell differentiation to impact on the function of resulting osteoblasts . Journal of Cell Science.

(2017). One Filter, One Sample, and the N- and O-Glyco(proteo)me: Toward a System to Study Disorders of Protein Glycosylation . Analytical Chemistry.

PREPRINT

A. Pascucci, SA. Karim, JP. Morton, M. Vassalli, M. Walker (2026). Viscoelasticity drives EMT in pancreatic intraepithelial neoplasia .

A. Pascucci, SA. Karim, JP. Morton, M. Vassalli, M. Walker (2026). Viscoelasticity drives EMT in pancreatic intraepithelial neoplasia .

Matthew Walker, Ketan Pancholi, Harini Sampathkumar, Adeati Yadima, David Flynn, Amit Kumar, Judith Abolle-Okoyeagu, Ranjeetkumar Gupta (2026). Dual-Functional LDPE and PP Films with SiO₂–Microbubble Hybrid Structures for Thermal Resistance and Intelligent Food Spoilage Detection .

Matthew Walker, Dave J. Adams, Dipankar Ghosh, Lauren Matthews, Charlie Patterson, Oana Dobre, Massimo Vassalli (2025). Shear-Induced Anisotropic Supramolecular Gel Noodles for Improved Cell Guidance in Polarized Tissue Engineering .

Matthew Walker, W. Sebastian Doherty-Boyd, P. Monica Tsimbouri, Vineetha Jayawarna, Aqeel F. Taqi, Niall Mahon, Dominic Meek, Peter Young, Aline Miller, Adam West, et al. (2025). Synthetic peptide hydrogels as a model of the bone marrow niche demonstrate efficacy of a combined CRISPR-CAR T-cell therapy for acute myeloid leukaemia .

Matthew Walker, Jade A. Phillips, Jessica Perochon, Cai T. Johnson, Colin Nixon, Mark Hughes, André Barros-Carvalho, Yachuan Yu, Louise Mitchell, Karen Blyth, et al. (2025). Intestinal Tissue Mechanics Regulate Angiogenesis and Stem Cell Proliferation via Vascular Piezo .

Matthew Walker, Mei Tan, Garima Saini, Maximillian Stanzione, Ketan Pancholi, Harini Sampathkumar, Charlie Patterson, Massimo Vassalli, Aaron Naden, Oxana Magdysyuk, et al. (2024). Polyetherureas as aqueous binders for Li ionBatteries .

Matthew Walker, Pavel Kulyabin, Oxana Magdysyuk, Aaron B Naden, Daniel M Dawson, Ketan Pancholi, Massimo Vassalli, Amit Kumar (2024). Manganese Catalysed Synthesis of Polyketones Using Hydrogen Borrowing Approach .

Pavel Kulyabin, Aaron B Naden, Daniel M Dawson, Julia L Payne, Amit Kumar (2023). Manganese Catalysed Synthesis of Polyketones Using Hydrogen Borrowing Approach .

Matthew Walker, Eonan William Pringle, Giuseppe Ciccone, Manlio Tassieri, Delphine Gourdon, Marco Cantini (2023). Mind the viscous modulus: The mechanotransductive response to the viscous nature of isoelastic matrices regulates stem cell chondrogenesis .

BOOK CHAPTER

K. Witte and J. Luo and M. Walker and M. Cantini and F. P. Seib and M. Salmeron-Sanchez(2021). Chapter 12. Bioinspired and Bioinstructive Surfaces to Control Mesenchymal Stem Cells . Soft Matter Series. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 301--325. Royal Society of Chemistry