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プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Mauro F.に依頼

United States

プロフィール概要

I am a senior neuroscientist with a proven expertise in neuropharmacology and neurophysiology. I focus mainly on synaptic dysfunctions in neurological disorders for the identification of both molecular mechanisms of disease and potential translational neuroscience targets, achieved by implementing state-of-art techniques, for both in vivo and in vitro settings. In a team-oriented environment, I leverage expertise and knowledge among my direct collaborators and trainees to drive scientific objectives and to build professional relationships with both internal and external clinical and translational specialists. My formal education and training as well as a long history of hands-on experience outline a consistent history of advancing R&D and educational goals, and make me an excellent match for your expertise requirements.

専門分野

• ☆ Biomarkers
• ☆ Electrophysiology
• ☆ Neurochemistry
• ☆ Neuropharmacology
• ☆ Higher Education
• ☆ Alzheimer's Disease
• ☆ Psychopharmacology

サービス

• Consulting
• Product Development

職務経験

non Tenure Track Research Faculty

Columbia University

7月 2009 - 1月 2015

Visiting Professor

University of Catania

5月 2011 - 6月 2011

PostDoctoral Research Scientist

Columbia University

7月 2004 - 6月 2009

Junior Investigator

Neuroscience sc.arl

9月 1998 - 9月 2000

Junior Researcher

University of Cagliari

4月 1996 - 4月 1998

学歴

PhD Neuroscience

Universita' di Cagliari

10月 2000 - 2月 2004

M.Sc (Biological Sciences)

Universita di Cagliari

10月 1988 - 7月 1993

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Daniela Puzzo, Elentina K. Argyrousi, Agnieszka Staniszewski, Hong Zhang, Elisa Calcagno, Elisa Zuccarello, Erica Acquarone, Mauro Fà, Domenica Donatella Li Puma, Claudio Grassi, et al.(2020). Tau is not necessary for amyloid-beta-induced synaptic and memory impairments . Journal of Clinical Investigation. American Society for Clinical Investigation

(2019). Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade . Molecular Neurodegeneration.

(2018). Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade . Journal of Alzheimer's disease : JAD.

(2017). LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent . eLife.

(2016). Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease . Scientific Reports.

Fá, M., Puzzo, D., Piacentini, R., Staniszewski, A., Zhang, H., Baltrons, M. A., Li Puma, D. D., Chatterjee, I., Li, J., Saeed, F., et al.(2016). Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory . Sci Rep. 6. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 19393.

(2015). Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia . BMC Neuroscience.

(2015). Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus . Journal of Visualized Experiments.

Fà, M., Zhang, H., Staniszewski, A., Saeed, F., Shen, L. W., Schiefer, I. T., Siklos, M. I., Tapadar, S., Litosh, V. A., Libien, J., et al.(2015). Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease . J Alzheimers Dis. 49. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 707-21.

Jean, Y. Y., Baleriola, J., Fà, M., Hengst, U., Troy, C. M.(2015). Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus . J Vis Exp. (100). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e52805.

Teich, AndrewF, Nicholls, RussellE, Puzzo, Daniela, Fiorito, Jole, Purgatorio, Rosa, Fa’, Mauro, Arancio, Ottavio(2015). Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach . Neurotherapeutics. 12. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 29-41.

Izzo, N. J., Staniszewski, A., To, L., Fa, M., Teich, A. F., Saeed, F., Wostein, H., Walko, T., Vaswani, A., Wardius, M., et al.(2014). Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits . PLoS One. 9. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e111898.

Izzo, N.J., Staniszewski, A., To, L., Fa, M., Teich, A.F., Saeed, F., Wostein, H., Walko, T., Vaswani, A., Wardius, M., et al.(2014). Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits . PLoS ONE. 9. (11).

Fa, M., Staniszewski, A., Saeed, F., Francis, Y.I., Arancio, O.(2014). Dynamin 1 is required for memory formation . PLoS ONE. 9. (3).

Lee L, Dale E, Staniszewski A, Zhang H, Saeed F, Sakurai M, Fa' M, Orozco I, Michelassi F, Akpan N, Lehrer H, Arancio O, Scientific reports, 2014, vol. 4, pp. 7190 .

Schiefer, I.T., Tapadar, S., Litosh, V., Siklos, M., Scism, R., Wijewickrama, G.T., Chandrasena, E.P., Sinha, V., Tavassoli, E., Brunsteiner, M., et al.(2013). Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors . Journal of Medicinal Chemistry. 56. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6054-6068.

Qin, Z., Luo, J., Vandevrede, L., Tavassoli, E., Fa, M., Teich, A.F., Arancio, O., Thatcher, G.R.J.(2012). Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy . Journal of Medicinal Chemistry. 55. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6784-6801.

Schiefer, I.T., Vandevrede, L., Fa', M., Arancio, O., Thatcher, G.R.J.(2012). Furoxans (1,2,5-Oxadiazole- N -oxides) as novel no mimetic neuroprotective and procognitive agents . Journal of Medicinal Chemistry. 55. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3076-3087.

Puzzo, D., Privitera, L., Fa', M., Staniszewski, A., Hashimoto, G., Aziz, F., Sakurai, M., Ribe, E.M., Troy, C.M., Mercken, M., et al.(2011). Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory . Annals of Neurology. 69. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 819-830.

Fa, M., Orozco, I.J., Francis, Y.I., Saeed, F., Gong, Y., Arancio, O.(2010). Preparation of oligomeric β-amyloid1-42 and induction of synaptic plasticity impairment on hippocampal slices . Journal of Visualized Experiments. (41).

Tamayev, R., Matsuda, S., Fà, M., Arancio, O., D'Adamio, L.(2010). Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits . Proceedings of the National Academy of Sciences of the United States of America. 107. (48). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 20822-20827.

Fa, M., Orozco, I.J., Francis, Y.I., Saeed, F., Gong, Y., Arancio, O.(2010). Preparation of oligomeric beta-amyloid 1-42 and induction of synaptic plasticity impairment on hippocampal slices . Journal of visualized experiments : JoVE. (41).

Bortolato, M., Frau, R., Orrù, M., Fà, M., Dessì, C., Puligheddu, M., Barberini, L., Pillolla, G., Polizzi, L., Santoni, F., et al.(2010). GABAB receptor activation exacerbates spontaneous spike-and-wave discharges in DBA/2J mice . Seizure. 19. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 226-231.

Francis, Y.I., Fà, M., Ashraf, H., Zhang, H., Staniszewski, A., Latchman, D.S., Arancio, O.(2009). Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease . Journal of Alzheimer's Disease. 18. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 131-139.

Puzzo, D., Privitera, L., Leznik, E., Fà, M., Staniszewski, A., Palmeri, A., Arancio, O.(2008). Picomolar amyloid-β positively modulates synaptic plasticity and memory in hippocampus . Journal of Neuroscience. 28. (53). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 14537-14545.

Trinchese, F., Fa', M., Liu, S., Zhang, H., Hidalgo, A., Schmidt, S.D., Yamaguchi, H., Yoshii, N., Mathews, P.M., Nixon, R.A., et al.(2008). Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease . Journal of Clinical Investigation. 118. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2796-2807.

Frau, R., Orrù, M., Fà, M., Casti, A., Manunta, M., Fais, N., Mereu, G., Gessa, G., Bortolato, M.(2007). Effects of topiramate on the prepulse inhibition of the acoustic startle in rats . Neuropsychopharmacology. 32. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 320-331.

Marrosu, F., Bortolato, M., Frau, R., Orrù, M., Puligheddu, M., Fà, M., Muroni, A., Tuveri, A., Mereu, G.(2007). Levetiracetam attenuates spontaneous spike-and-wave discharges in DBA/2J mice . Epilepsy Research. 75. (2-3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 224-227.

Liu, S., Fa, M., Ninan, I., Trinchese, F., Dauer, W., Arancio, O.(2007). α-Synuclein involvement in hippocampal synaptic plasticity: Role of NO, cGMP, cGK and CaMKII . European Journal of Neuroscience. 25. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3583-3596.

Bortolato, M., Frau, R., Orrù, M., Piras, A.P., Fà, M., Tuveri, A., Puligheddu, M., Gessa, G.L., Castelli, M.P., Mereu, G., et al.(2007). Activation of GABAB receptors reverses spontaneous gating deficits in juvenile DBA/2J mice . Psychopharmacology. 194. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 361-369.

Bortolato, M., Frau, R., Orrù, M., Casti, A., Aru, G.N., Fà, M., Manunta, M., Usai, A., Mereu, G., Gessa, G.L.(2006). Prenatal exposure to a cannabinoid receptor agonist does not affect sensorimotor gating in rats . European Journal of Pharmacology. 531. (1-3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 166-170.

Marrosu, F., Santoni, F., Fà, M., Puligheddu, M., Barberini, L., Genugu, F., Frau, R., Manunta, M., Mereu, G.(2006). Beta and gamma range EEG power-spectrum correlation with spiking discharges in DBA/2J mice absence model: Role of GABAB receptors . Epilepsia. 47. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 489-494.

Fa, M., Diana, A., Carta, G., Cordeddu, L., Melis, M.P., Murru, E., Sogos, V., Banni, S.(2005). Incorporation and metabolism of c9,t11 and t10,c12 conjugated linoleic acid (CLA) isomers in rat brain . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1736. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 61-66.

Devoto, P., Flore, G., Saba, P., Fà, M., Gessa, G.L.(2005). Stimulation of the locus coeruleus elicits noradrenaline and dopamine release in the medial prefrontal and parietal cortex . Journal of Neurochemistry. 92. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 368-374.

Zhang, H., Gong, B., Liu, S., Fa', M., Ninan, I., Staniszewski, A., Arancio, O.(2005). Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's disease . Current Alzheimer Research. 2. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 137-140.

Bortolato, M., Aru, G.N., Fà, M., Frau, R., Orrù, M., Salis, P., Casti, A., Luckey, G.C., Mereu, G., Gessa, G.L.(2005). Activation of D1, but not D2 receptors potentiates dizocilpine-mediated disruption of prepulse inhibition of the startle . Neuropsychopharmacology. 30. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 561-574.

Devoto, P., Flore, G., Saba, P., Fà, M., Gessa, G.L.(2005). Co-release of noradrenaline and dopamine in the cerebral cortex elicited by single train and repeated train stimulation of the locus coeruleus . BMC Neuroscience. 6.

Bortolato, M., Aru, G.N., Frau, R., Orrù, M., Fà, M., Manunta, M., Puddu, M., Mereu, G., Gessa, G.L.(2005). Kappa opioid receptor activation disrupts prepulse inhibition of the acoustic startle in rats . Biological Psychiatry. 57. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1550-1558.

Fà, M., Dessì, C., Carta, G., Salis, P., Barberini, L., Marrosu, F., Bourov, Y., Gessa, G.L., Mereu, G.(2003). DBA/2J mice as experimental model for petit mal epilepsy: Role of GABAb - GHB neurotrasmission | I topi DBA/2J come modello sperimentale di epilessia di tipo piccolo male: Ruolo della transmissione GABAb - GHB . Bollettino - Lega Italiana contro l'Epilessia. (121-122). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 85-87.

Santoni, F., Mereu, G.P., Fà, M., Carta, G., Meloni, A., Ghiglieri, V., Genugu, F., Puligheddu, M., Barberini, L., Marrosu, F.(2003). EEG variations following GABAB agonist and antagonist treatment in DBA/2J mice | Modificazione del segnale EEG nei topi DBA/2J dopo trattamento agonistico e antagonistico dei recettori GABAB . Bollettino - Lega Italiana contro l'Epilessia. (121-122). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 317-319.

Mereu, G., Fà, M., Ferraro, L., Cagiano, R., Antonelli, T., Tattoli, M., Ghiglieri, V., Tanganelli, S., Gessa, G.L., Cuomo, V.(2003). Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release . Proceedings of the National Academy of Sciences of the United States of America. 100. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4915-4920.

Dessì, C., Fà, M., Carta, G., Salis, P., Puligheddu, M., Genugu, F., Marrosu, F., Bourov, Y., Gessa, G.L., Mereu, G.(2003). DBA/2J mice as experimental model for petit mal epilepsy: Experimental evidences | Itopi DBA/2J come modello sperimentale di epilessia di tipo piccolo male: Evidenze sperimentali . Bollettino - Lega Italiana contro l'Epilessia. (121-122). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 309-311.

Fà, M., Dessì, C., Carta, G., Salis, P., Puligheddu, M., Genugu, F., Marrosu, F., Bourov, Y., Gessa, G.L., Mereu, G.(2003). DBA/2J mice as experimental model for petit mal epilepsy: Pharmacological validation | Itopi DBA/2J come modello sperimentale di epilessia di tipo piccolo male: Validazione farmacologica . Bollettino - Lega Italiana contro l'Epilessia. (121-122). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 313-315.

Fà, M., Mereu, G., Ghiglieri, V., Meloni, A., Salis, P., Gessa, G.L.(2003). Electrophysiological and pharmacological characteristics of nigral dopaminergic neurons in the conscious, head-restrained rat . Synapse. 48. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-9.

Vaccari, A., Ruiu, S., Saba, P., Fà, M., Cagiano, R., Coluccia, A., Mereu, G., Steardo, L., Tattoli, M., Trabace, L., et al.(2001). Prenatal low-level exposure to CO alters postnatal development of hippocampal nitric oxide synthase and haem-oxygenase activities in rats . International Journal of Neuropsychopharmacology. 4. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 219-222.

Mereu, G., Cammalleri, M., Fa, M., Francesconi, W., Saba, P., Tattoli, M., Trabace, L., Vaccari, A., Cuomo, V.(2000). Prenatal exposure to a low concentration of carbon monoxide disrupts hippocampal long-term potentiation in rat offspring . Journal of Pharmacology and Experimental Therapeutics. 294. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 728-734.

Fà, M., Carcangiu, G., Passino, N., Ghiglieri, V., Gessa, G.L., Mereu, G.(2000). Cigarette smoke inhalation stimulates dopaminergic neurons in rats . NeuroReport. 11. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3637-3639.

Colombo, G., Agabio, R., Diaz, G., Fà, M., Lobina, C., Reali, R., Gessa, G.L.(1998). γ-hydroxybutyric acid intake in ethanol-preferring sP and - nonpreferring sNP rats . Physiology and Behavior. 64. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 197-202.

Colombo, G., Agabio, R., Fà, M., Guano, L., Lobina, C., Loche, A., Reali, R., Gessa, G.L.(1998). Reduction of voluntary ethanol intake in ethanol-preferring sP rats by the cannabinoid antagonist SR-141716 . Alcohol and Alcoholism. 33. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 126-130.

Lobina, C., Agabio, R., Diaz, G., Fa, M., Fadda, F., Gessa, G.L., Reali, R., Colombo, G.(1997). Constant absolute ethanol intake by Sardinian alcohol preferring rats independent of ethanol concentrations . Alcohol and Alcoholism. 32. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 19-22.

Colombo, G., Agabio, R., Diaz, G., Fà, M., Lobina, C., Reali, R., Gessa, G.L.(1997). Sardinian alcohol-preferring rats prefer chocolate and sucrose over ethanol . Alcohol. 14. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 611-615.

Marrosu, F., Portas, C., Mascia, M.S., Casu, M.A., Fà, M., Giagheddu, M., Imperato, A., Gessa, G.L.(1995). Microdialysis measurement of cortical and hippocampal acetylcholine release during sleep-wake cycle in freely moving cats . Brain Research. 671. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 329-332.