プロフィール詳細

プロジェクトを作成

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Dr. Michael I.に依頼

United States

PhD Pharmacologist | GPCR Signaling, Drug Mechanisms, Biomedical Research & Scientific Analysis

プロフィール概要

I am a PhD-trained molecular pharmacologist specializing in GPCR signaling, receptor pharmacology, and small-molecule drug discovery. My research focuses on understanding how ligand–receptor interactions influence downstream signaling pathways and physiological outcomes, with particular expertise in biased signaling mechanisms and translational pharmacology. My doctoral work at Thomas Jefferson University investigated signaling bias at the β2-adrenergic receptor and strategies to improve therapeutic responses through selective pathway activation. This work involved biochemical and cell-based pharmacology assays, receptor signaling analysis, and mechanistic interpretation of ligand activity. I have also contributed to research on allosteric modulators of GPCRs and the structural determinants of receptor signaling bias. In addition to academic research, I have industry experience in assay development and early-stage drug discovery. My work has involved designing and optimizing screening platforms, evaluating small-molecule pharmacology, and interpreting experimental data to guide therapeutic development. Currently, my research focuses on the pharmacology of cannabinoids and related compounds in models of neuropathic pain and addiction, integrating molecular pharmacology with translational disease models. I can assist clients with: • Biomedical and pharmacology literature reviews • Scientific writing and editing • Drug mechanism and signaling pathway analysis • Experimental design and study interpretation • Pharmacology and receptor biology consulting • Technical review of biomedical content My goal is to help translate complex biological and pharmacological concepts into clear, accurate, and actionable scientific insight.

専門分野

• ★ Preclinical Pharmacology
• ☆ Biochemistry
• ☆ Neuropharmacology
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Research
• ☆ Literature Review
• ☆ Systematic Literature Review

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Clinical Trial Documentation, Medical Writing, Technical Writing

Research Technology Scouting, Fact Checking, Gap Analysis, Scientific and Technical Research, Systematic Literature Review

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Text Mining & Analytics, Data Insights

職務経験

Postdoctoral Fellow

Temple University

9月 2021 - 現在

Graduate Researcher

Thomas Jefferson University

9月 2014 - 9月 2021

Senior associate scientist

Chromocell Corporation

9月 2007 - 9月 2014

学歴

Masters in Medical Cannabis Science and Business

Thomas Jefferson University

9月 2018 - 9月 2022

PhD - Biochemistry and Molecular Pharmacology

Thomas Jefferson University

9月 2014 - 9月 2021

Masters of Clinical and Translational Science

University of Medicine and Dentistry of New JerseY

9月 2009 - 9月 2012

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Ippolito M, Maddox C, Inam A, Wimmer ME, Ward SJ (2025). Prevention of Allodynia and Hyperalgesia by Cannabidiol in a Rat Model of Chemotherapy-Induced Peripheral Neuropathy . Journal of visualized experiments : JoVE.

Michael Ippolito, Sean A. Hayduk, William Kinney, Douglas E. Brenneman, Sara Jane Ward (2024). KLS-13019, a Novel Structural Analogue of Cannabidiol and GPR55 Receptor Antagonist, Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy in Rats . The Journal of Pharmacology and Experimental Therapeutics.

Michael J. Ippolito, Eric R. Gross, Khaled S. Abd-Elrahman (2024). Minor Cannabinoids as an Emerging Frontier for Pain Relief . The Journal of Pharmacology and Experimental Therapeutics.

Brenneman DE, Kinney WA, McDonnell ME, Ippolito MJ, Ward SJ (2024). Knockdown siRNA Targeting GPR55 Reveals Significant Differences Between the Anti-inflammatory Actions of KLS-13019 and Cannabidiol . Journal of molecular neuroscience : MN.

Ippolito M, De Pascali F, Hopfinger N, Komolov KE, Laurinavichyute D, Reddy PAN, Sakkal LA, Rajkowski KZ, Nayak AP, Lee J, et al. (2023). Identification of a β-arrestin-biased negative allosteric modulator for the β₂-adrenergic receptor . Proceedings of the National Academy of Sciences of the United States of America.

De Pascali F, Ippolito M, Wolfe E, Komolov KE, Hopfinger N, Lemenze D, Kim N, Armen RS, An SS, Scott CP, et al. (2022). β₂ -Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β₂ -adrenoceptor with possible implications for the treatment of asthma . British journal of pharmacology.

Ippolito M, De Pascali F, Inoue A, Benovic JL (2021). Phenylalanine 193 in Extracellular Loop 2 of the <i>β</i> ₂-Adrenergic Receptor Coordinates <i>β</i>-Arrestin Interaction . Molecular pharmacology.

Ippolito M, Benovic JL (2020). Biased agonism at β-adrenergic receptors . Cellular signalling.

Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, et al. (2018). Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines . FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

PREPRINT

Douglas E. Brenneman, Dean Petkanas, Sara Jane Ward, Michael Ippolito (2025). Effect of Fatty Acyl Composition for Lysophosphatidylinositol on Neuroinflammatory Responses in Primary Neuronal Cultures .

PATENT

Ippolito, M., De Pascali, F., Hopfinger, N., Komolov, K. E., Laurinavichyute, D., Reddy, P. A. N., Sakkal, L. A., Rajkowski, K. Z., Nayak, A. P., Lee, J., Lee, J. Y., Cao, G., Donover, P. S., Reichman, M., An, S. S., Salvino, J. M., Penn, R. B., Armen, R. S., Scott, C. P., & Benovic, J. L. (2024). Compounds and methods for preventing, treating, or ameliorating airway disease (Patent No. US 2024/0166626 A1). U.S. Patent and Trademark Office. https://patents.google.com/patent/US20240166626A1/en .