プロフィール詳細

プロジェクトを作成

★★★★★

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Dr. Miguel C.に依頼

United Kingdom

Drug Discovery & TPD Expert | Oncology, Target Validation & Translational R&D Consultant

プロフィール概要

I am a biologist and drug discovery leader with over 20 years of experience in oncology and targeted protein degradation (TPD). Most recently, I served as Associate Director of Drug Discovery at PhoreMost, where I led cross-functional programmes integrating assay biology, protein sciences, and computational chemistry to advance novel oncology degraders from target validation through preclinical development. I specialise in: • Target identification & validation (oncology, immunology, TPD) • Chemical biology & assay design (AlphaLISA, FP, SPR, cell-based readouts) • Omics data interpretation (RNAseq, proteomics) • Programme & portfolio management, CRO coordination, and translational strategy I offer freelance support in scientific consulting, literature analysis, target feasibility assessment, experimental design, and scientific writing or review for grant applications, investor decks, or publications.

専門分野

• ★ Biochemical Assays
• ★ Drug Target Identification
• ★ Scientific Proofreading & Editing
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Structural Biology
• ☆ Apoptosis
• ☆ Enzyme Activity Assays
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Microarrays
• ☆ Omics
• ☆ Transcriptomics
• ☆ Proteomics
• ☆ Chromatin
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Next Generation Sequencing (NGS)
• ☆ DNA Sequencing
• ☆ Protein Sequencing
• ☆ Gene Expression Analysis
• ☆ Mutagenesis
• ☆ Exome Sequencing
• ☆ Recombinant DNA
• ☆ RNA Synthesis
• ☆ RNA Sequencing
• ☆ Plasmid DNA
• ☆ DNA Damage & Repair
• ☆ ChIP-Seq
• ☆ Kinases
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Biophysics
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Microscopy
• ☆ Light Microscopy
• ☆ Fluorescence Microscopy
• ☆ Biomarker Discovery
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Banking
• ☆ Cell Line Engineering
• ☆ Large Scale Cell Culture
• ☆ Synthetic Biology
• ☆ Chemical Biology
• ☆ Biomolecular Engineering
• ☆ Genetic Engineering
• ☆ Gene Editing/CRISPR
• ☆ Protein/Enzyme Engineering
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Cytometry
• ☆ Cell Aging
• ☆ Leadership
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Phenotypic Assays
• ☆ High Content Screening/Imaging
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Manuscript & Journal Article Writing
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ White Papers
• ☆ Textbook Content Writing
• ☆ Science Communication
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Systematic Literature Review
• ☆ Project Management
• ☆ Risk Management

サービス

• Writing
• Research
• Consulting

Writing Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

職務経験

Associate Director

PhoreMost Ltd

6月 2022 - 7月 2025

Team Leader

PhoreMost Ltd

7月 2019 - 6月 2022

Senior Scientist

PhoreMost Ltd

10月 2016 - 6月 2019

Postdoc Research Associate

University of Cambridge

4月 2010 - 2月 2016

学歴

PhD

UNIVERSITY OF CAMBRIDGE

10月 2006 - 4月 2010

認定資格

• Leadership Programme

  Babraham Research Campus & Focal Point

  4月 2025 - 現在

• Project Leadership and Managing Meetings

  Michael Heath Consulting

  1月 2022 - 現在

• Managing Mental Health in Workplace

  MIND / MHFA

  1月 2021 - 現在

• Introduction to Project Management

  RiverRhee Consulting

  1月 2018 - 現在

出版物

JOURNAL ARTICLE

Miguel Coelho, Amy Emery, Bryn S. Hardwick, Alex T. Crooks, Nadia Milech, Paul M. Watt, Chandan Mithra, Vikrant Kumar, Saranya Giridharan, Gayathri Sadasivam, et al. (2021). Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library . Cell Chemical Biology.

Coelho MB, Ascher DB, Gooding C, Lang E, Maude H, Turner D, Llorian M, Pires DE, Attig J, Smith CW(2016). Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins . Biochemical Society transactions.

Coelho MB, Attig J, Ule J, Smith CW(2016). Matrin3: connecting gene expression with the nuclear matrix . Wiley interdisciplinary reviews. RNA.

Coelho MB, Attig J, Bellora N, König J, Hallegger M, Kayikci M, Eyras E, Ule J, Smith CW(2015). Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB . The EMBO journal.

Coelho MB, Smith CW(2014). Regulation of alternative pre-mRNA splicing . Methods in molecular biology (Clifton, N.J.).

Gooding C, Edge C, Lorenz M, Coelho MB, Winters M, Kaminski CF, Cherny D, Eperon IC, Smith CW(2013). MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3 . Nucleic acids research.

Miguel Coelho, Panagiota Kafasla, Ian Mickleburgh, Miriam Llorian, Clare Gooding, Dmitry Cherny, Amar Joshi, Olga Kotik-Kogan, Stephen Curry, Ian C. Eperon, et al. (2012). Defining the roles and interactions of PTB . Biochemical Society Transactions.

Joshi A, Coelho MB, Kotik-Kogan O, Simpson PJ, Matthews SJ, Smith CW, Curry S(2011). Crystallographic analysis of polypyrimidine tract-binding protein-Raver1 interactions involved in regulation of alternative splicing . Structure (London, England : 1993).

Cherny D, Gooding C, Eperon GE, Coelho MB, Bagshaw CR, Smith CW, Eperon IC(2010). Stoichiometry of a regulatory splicing complex revealed by single-molecule analyses . The EMBO journal.

Pacheco TR, Coelho MB, Desterro JM, Mollet I, Carmo-Fonseca M(2006). In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site . Molecular and cellular biology.

OTHER

Rajgor D, Gooding C, Hayward R, Coelho MB, Smith CW, Shanahan CM(2018). Lamin A/C controls nuclear matrin-3 levels and localization, but not alternative splicing of cassette exons .

EDITED BOOK

Miguel B. Coelho, Miguel B. Coelho (2012). Alternative pre‐mRNA Splicing .

Miguel B. Coelho, Miguel B. Coelho, Christopher W. J. Smith (2012). Alternative Splice Site Selection . Alternative pre‐mRNA Splicing.