プロフィール詳細

プロジェクトを作成

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Mohammad Nazmul H.に依頼

United States

Biomedical Scientist I Drug Delivery I Cell and Molecular Biology I Liver Disease

プロフィール概要

I am a Biomedical Scientist dedicated to uncovering novel therapeutic targets for chronic liver and metabolic diseases. My research bridges the gap between molecular mechanisms and advanced drug delivery systems, with specialized expertise in bile acid metabolism, cholestasis, NAFLD/NASH and liver fibrosis. Throughout my career, I have developed a deep technical and analytical toolkit spanning: Liver Pathology & Metabolic Disease Models: Extensive experience utilizing specialized in vivo models, including db/db and ob/ob mice for diabetes, obesity, and NAFLD/NASH, as well as cholestatic models for Primary Sclerosing Cholangitis (PSC) and Primary Biliary Cholangitis (PBC). Advanced Therapeutics: Designing and evaluating nanoparticle-based platforms for targeted drug and gene delivery. Mechanistic Biology: Utilizing advanced cell and molecular biology techniques to identify disease drivers and evaluate therapeutic efficacy. I am passionate about translating complex bench science into life-changing therapies and welcome connections with researchers, innovators, and industry professionals in the hepatology and metabolic disease space.

専門分野

• ☆ Biochemistry
• ☆ Cell Biology
• ☆ Endocrinology
• ☆ Diabetes

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Medical Writing, Non-Medical Regulatory Writing, Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Processing

Product Development Formulation

職務経験

Postdoctoral Research Fellow

The University of Oklahoma Health Sciences Center

1月 2021 - 現在

学歴

Doctoral Degree (Department of Green Bioengineering)

Korea National University of Transportation

8月 2016 - 8月 2020

Master Degree in Chemistry Chemical Biology (Department of Chemistry)

Uppsala University

- 8月 2014

Master Degree in Chemistry (Department of Chemistry)

National University Bangladesh

- 5月 2010

Bachelor Degree in Chemistry (Department of Chemistry)

National University Bangladesh

- 8月 2008

認定資格

• Ph.D. in Chemical and Biological Engineering

  KNUT

  8月 2020 - 現在

出版物

JOURNAL ARTICLE

Gu L, Xiong L, Hasan MN, Du Y, Wu T, Li T (2026). A Selective Cullin 3 RING E3 Ligase Inhibitor Attenuates Hyperglycemia via Dual Insulin Sensitizing and Insulinotropic Action . Diabetes.

Mohammad Nazmul Hasan, Huaiwen Wang, Wenyi Luo, Yanhong Du, Lei Xiong, Lijie Gu, Tiangang Li (2025). A Gly-β-muricholic acid and FGF15 combination therapy synergistically reduces “humanized” bile acid pool toxicity in cholestasis mice . Journal of Lipid Research.

Mohammad Nazmul Hasan, Lijie Gu, Yanhong Du, Yung-Dai Clayton, Tiangang Li (2025). Adipose cullin 3 mediates the antiobesity effect of pan neddylation inhibitors . Proceedings of the National Academy of Sciences.

Mohammad Nazmul Hasan, Huaiwen Wang, Wenyi Luo, Yanhong Du, Tiangang Li (2025). Gly-βMCA modulates bile acid metabolism to reduce hepatobiliary injury in Mdr2 KO mice . American Journal of Physiology-Gastrointestinal and Liver Physiology.

Mohammad Nazmul Hasan, Huaiwen Wang, Wenyi Luo, Yung Dai Clayton, Lijie Gu, Yanhong Du, Sirish K. Palle, Jianglei Chen, Tiangang Li (2024). Gly-β-MCA is a potent anti-cholestasis agent against “human-like” hydrophobic bile acid-induced biliary injury in mice . Journal of Lipid Research.

Mohammad Nazmul Hasan, Lijie Gu, Yanhong Du, Jianglei Chen, Yung Dai Clayton, David J. Matye, Jacob E. Friedman, Tiangang Li (2024). Cullin 3 RING E3 ligase inactivation causes NRF2-dependent NADH reductive stress, hepatic lipodystrophy, and systemic insulin resistance . Proceedings of the National Academy of Sciences.

Mohammad Nazmul Hasan, Jianglei Chen, David Matye, Yung Dai Clayton, Yanhong Du, Lijie Gu, Tiangang Li (2024). Deletion of hepatocyte cysteine dioxygenase type 1, a bile acid repressed gene, enhances glutathione synthesis and ameliorates acetaminophen hepatotoxicity . Biochemical Pharmacology.

Mohammad Nazmul Hasan, Jianglei Chen, Huaiwen Wang, Yanhong Du, Yung Dai Clayton, Lijie Gu, Tiangang Li (2023). Glycine-β-Muricholic Acid Improves Liver Fibrosis and Gut Barrier Function by Reducing Bile Acid Pool Size and Hydrophobicity in Male Cyp2c70 Knockout Mice . Cells.

Mohammad Nazmul Hasan, Jianglei Chen, Huaiwen Wang, Yanhong Du, Yung Dai Clayton, Lijie Gu, Tiangang Li (2023). Glycine-β-Muricholic Acid Improves Liver Fibrosis and Gut Barrier Function by Reducing Bile Acid Pool Size and Hydrophobicity in Male <i>Cyp2c70</i> Knockout Mice . Cells.

Mohammad Nazmul Hasan, Jianglei Chen, David Matye, Huaiwen Wang, Wenyi Luo, Lijie Gu, Yung Dai Clayton, Yanhong Du, Tiangang Li (2023). Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice . Journal of Lipid Research.

Mohammad Nazmul Hasan, David J. Matye, Xuan Qin, Lijie Gu, Yung Dai Clayton, Feng Li, Tiangang Li (2022). Effects of apical sodium-bile acid transporter inhibitor and obeticholic acid co-treatment in experimental non-alcoholic steatohepatitis . Liver Research.

TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Nature Communications.

Lijie Gu and Cheng Chen and David J. Matye and Mohammad N. Hasan and Yung-Dai Clayton and Tiangang Li(2022). Pharmacological Inhibition of Cullin Neddylation Improves Hepatic Insulin Sensitivity . The FASEB Journal. 36. (S1). Wiley

Mohammad Nazmul Hasan, Cheng Chen, Lijie Gu, David J. Matye, Yung-Dai Clayton, Yifeng Wang, Jacob E. Friedman, Tiangang Li(2022). Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization . Proceedings of the National Academy of Sciences. 119. (6). Proceedings of the National Academy of Sciences

Chen, Cheng and Gu, Lijie and Matye, David J. and Clayton, Yung-Dai and Hasan, Mohammad Nazmul and Wang, Yifeng and Friedman, Jacob E. and Li, Tiangang(2022). Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization . Proceedings of the National Academy of Sciences. 119. (6). National Academy of Sciences

Mohammad Nazmul Hasan, S. M. Shatil Shahriar, Jeong Man An, Sachin S. Surwase, Yeu-Chun Kim, Dong Yun Lee, Sungpil Cho, Yong-kyu Lee(2021). Plasmid DNA Nanoparticles for Nonviral Oral Gene Therapy . Nano Letters. 21. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4666--4675. American Chemical Society ({ACS})

Mohammad Nazmul Hasan, Jeong Man An, S. M. Shatil Shahriar, Sungpil Cho, Yong-kyu Lee(2021). Carboxymethyl Cellulose, Pluronic, and Pullulan-Based Compositions Efficiently Enhance Antiadhesion and Tissue Regeneration Properties without Using Any Drug Molecules . ACS Applied Materials & Interfaces. 13. (14). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 15992--16006. American Chemical Society ({ACS})

Mohammad Nazmul Hasan, Yong Hwa Hwang, Jeong Man An, S. M. Shatil Shahriar, Sungpil Cho, Yong-kyu Lee(2020). Oral GLP1 Gene Delivery by an Antibody-Guided Nanomaterial to Treat Type 2 Diabetes Mellitus . ACS Applied Materials & Interfaces. 12. (35). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 38925--38935. American Chemical Society ({ACS})

(2020). Oral GLP1 gene delivery by antibody guided nanomaterial to treat type 2 diabetes mellitus . ACS Applied Materials & Interfaces.

(2019). Electrospinning Nanofibers for Therapeutics Delivery . Nanomaterials.

(2019). Oral siRNA delivery using dual transporting systems to efficiently treat colorectal liver metastasis . International Journal of Pharmaceutics.

(2018). Antibody-mediated oral delivery of therapeutic DNA for type 2 diabetes mellitus . Biomaterials Research.

(2018). Oral Vaccines-Types, Delivery Strategies, Current and Future Perspectives . Biomedical Journal of Scientific & Technical Research.

(2018). Nanoparticles and Their Utilization in Cancer Detection and Treatment . Scholar Journal of Applied Sciences and Research.

REVIEW

Mohammad Nazmul Hasan (2024). Bile acids regulation of cellular stress responses in liver physiology and diseases . BMJ.

BOOK CHAPTER

S. M. Shatil Shahriar and Mohammad Nazmul Hasan and Md Nurunnabi and Yong-kyu Lee(2021). Bile acid transporter as a bioinspired method for oral therapeutics delivery system . Bioinspired and Biomimetic Materials for Drug Delivery. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 105--138. Elsevier

Md Nafiujjaman and S. M. Shatil Shahriar and Mohammad Nazmul Hasan(2021). Bile acid-inspired oral small molecules drug delivery . Bioinspired and Biomimetic Materials for Drug Delivery. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 171--186. Elsevier

Jagannath Mondal and Vishnu Revuri and Mohammad Nazmul Hasan and Yong-kyu Lee(2021). Bio inspired materials for nonviral vaccine delivery . Bioinspired and Biomimetic Materials for Drug Delivery. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 139--170. Elsevier

Mohammad Nazmul Hasan and S.M. Shatil Shahriar and Jagannath Mondal and Md Nurunnabi and Yong-kyu Lee(2021). Bioinspired and biomimetic materials for oral drug delivery . Bioinspired and Biomimetic Materials for Drug Delivery. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 89--104. Elsevier

(2019). 2D Nanomaterials for Gene Delivery . Biomedical Applications of Graphene and 2D Nanomaterials.