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プロフィール詳細
プロジェクトを作成
★★★★★
☆☆☆☆☆
Dr. Mohammed G.に依頼
Netherlands

Biomedical Scientist & Scientific Consultant | Gastroenterology, Inflammatory Bowel Disease, Epigenetics & Multi-Omics

プロフィール概要
専門分野
サービス
Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Copywriting, Creative Writing
Consulting Healthcare Consulting, Scientific and Technical Consulting
Data & AI Predictive Modeling, Statistical Analysis, Image Processing, Data Visualization, Big Data Analytics
職務経験

Amsterdam University Medical Centers

- 現在

Scientist

GlaxoSmithKline ( GSK)

12月 2017 - 6月 2019

学歴

PhD Biomedical Sciences

Amsterdam University

6月 2015 - 9月 2022

Masters of Biology and Health

University of Franche-Comté

9月 2013 - 5月 2015

Masters of Pharmacology

Université Louis Pasteur (Strasbourg I) - France

9月 2011 - 6月 2013

Bachelors (Pharmacy)

Université de Sidi-Bel-Abbès (Djillali Liabès) - Algeria

9月 2003 - 6月 2008

認定資格

  • Bioinformatics

    Amsterdam University Medical Center

    1月 2019 - 現在

  • Scientific Writing in English for publication

    Amsterdam University Medical Center

    10月 2018 - 現在

  • BioBusiness Summer School

    Hyphen Projects

    6月 2018 - 現在

  • Data Analysis in Matlab

    Amsterdam University Medical Center

    5月 2018 - 現在

  • Computing in R

    Amsterdam University Medical Center

    1月 2018 - 現在

  • DNA Technology

    Amsterdam University Medical Center

    10月 2017 - 現在

  • PubMed Basics

    Amsterdam University Medical Center

    9月 2017 - 現在

  • Translational Medicine

    Eureka Institute

    2月 2017 - 現在

  • Advanced Immunology

    Free University of Amsterdam

    4月 2016 - 現在

  • Oral Presentation in English

    Amsterdam University Medical Center

    4月 2016 - 現在

  • Laboratory Animal Science

    Utrecht University

    11月 2015 - 現在

  • Avanced qPCR

    Amsterdam University Medical Center

    7月 2015 - 現在

  • Basic Safety Laboratory

    Amsterdam University Medical Center

    2月 2015 - 現在

出版物
JOURNAL ARTICLE
Mohammed Ghiboub, Naomi V. Wieser, Iris Admiraal, Roni Weiss, Mark Davids, Antoine Lefèvre, Patrick Emond, Elizabeth A. Powell, Kathleen Sim, J. Simon Kroll, et al. (2026). Fecal tryptophan metabolism predicts the development of infant eczema: a prospective longitudinal study . Gut Microbes.
Mohammed Ghiboub, Paula I. Metselaar, Mees J. van der Hoff, Naomi V. Wieser, Olaf Welting, Antoine Lefèvre, Camille Dupuy, Patrick Emond, Joep P. M. Derikx, Wouter J. de Jonge, et al. (2026). A Distinct Tryptophan Metabolic Phenotype Marks Severe Fatigue in Quiescent Crohn's Disease . JCC Plus.
Mohammed Ghiboub, Anne E. Petersen, Konstantina Zafeiropoulou, Claire P.M. van Helsdingen, Joop L.M. Konsten, Nicole D. Bouvy, Jan H.M.B. Stoot, Pieter J. Tanis, Wouter J. de Jonge, Joep P.M. Derikx (2026). Preoperative Gut Microbiome in Patients With Colorectal Cancer: Potential for Fecal Biomarker–Based Recurrence Risk Prediction . JCO Oncology Advances.
Mohammed Ghiboub, Dimitrios Nikolakis, Andrew Y F Li Yim, Kenneth L Overberg, Manon E Wildenberg, Wouter J de Jonge, Dalia Lartey, Florian Rieder, Geert R D’Haens, Marleen G H van de Sande, et al. (2025). Drug repurposing approach for the discovery of therapeutic agents for Crohn’s disease-associated intestinal fibrosis . Journal of Crohn’s and Colitis.
Mohammed Ghiboub, Andrew Yung Fong Li Yim, Ishtu Hageman, Vincent W. Joustra, Ahmed M. I. M. Elfiky, Evgeni Levin, Jan Verhoeff, Caroline Verseijden, Iris Admiraal, Manon de Krijger, et al. (2025). An exploratory single-cell analysis of peripheral blood mononuclear cells from vedolizumab-treated Crohn’s disease patients identifies response-associated differences among the plasmacytoid dendritic cells and classical monocytes . Frontiers in Immunology.
Mohammed Ghiboub, Rotem Sigall Boneh, Nikki van der Kruk, Eytan Wine, Charlotte M. Verburgt, Tim G. J. de Meij, Mark Löwenberg, Krisztina B. Gecse, Nicolette Wierdsma, Joep P. M. Derikx, et al. (2025). Tryptophan metabolites profile predict remission with dietary therapy in pediatric Crohn’s disease . Therapeutic Advances in Gastroenterology.
Mohammed Ghiboub, Ahmed M I Elfiky, Jessica López Canñizares, Jiarong Li, Andrew Y F Li Yim, Arthur J Verhoeven, Wouter J de Jonge (2024). Carboxylesterase 1 directs the metabolic profile of dendritic cells to a reduced inflammatory phenotype . Journal of Leukocyte Biology.
Mohammed Ghiboub, Naomi V. Wieser, Caroline Verseijden, Johannes B. van Goudoever, Anne Schoonderwoerd, Tim G. J. de Meij, Hendrik J. Niemarkt, Mark Davids, Antoine Lefèvre, Patrick Emond, et al. (2024). Exploring the Immunomodulatory Potential of Human Milk: Aryl Hydrocarbon Receptor Activation and Its Impact on Neonatal Gut Health . Nutrients.
Mohammed Ghiboub, Naomi V. Wieser, Caroline Verseijden, Johannes B. van Goudoever, Anne Schoonderwoerd, Tim G. J. de Meij, Hendrik J. Niemarkt, Mark Davids, Antoine Lefèvre, Patrick Emond, et al. (2024). Exploring the Immunomodulatory Potential of Human Milk: Aryl Hydrocarbon Receptor Activation and Its Impact on Neonatal Gut Health . Nutrients.
Wieser, N.V., Ghiboub, M., Verseijden, C., van Goudoever, J.B., Schoonderwoerd, A., de Meij, T.G.J., Niemarkt, H.J., Davids, M., Lefèvre, A., Emond, P., et al.(2024). Exploring the Immunomodulatory Potential of Human Milk: Aryl Hydrocarbon Receptor Activation and Its Impact on Neonatal Gut Health . Nutrients. 16. (10).
Elfiky, A.M.I., Canñizares, J.L., Li, J., Li Yim, A.Y.F., Verhoeven, A.J., Ghiboub, M., de Jonge, W.J.(2024). Carboxylesterase 1 directs the metabolic profile of dendritic cells to a reduced inflammatory phenotype . Journal of leukocyte biology. 116. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1094-1108.
Mohammed Ghiboub, Matthew Bell, Dovile Sinkeviciute, Rab K. Prinjha, Menno P. J. de Winther, Nicola R. Harker, David F. Tough, Wouter J. de Jonge (2023). The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential . Current Issues in Molecular Biology.
Mohammed Ghiboub, Rotem Sigall Boneh, Bruno Sovran, Eytan Wine, Antoine Lefèvre, Patrick Emond, Charlotte M Verburgt, Marc A Benninga, Wouter J de Jonge, Johan E Van Limbergen (2023). Sustained Diet-Induced Remission in Pediatric Crohn’s Disease Is Associated With Kynurenine and Serotonin Pathways . Inflammatory Bowel Diseases.
Mohammed Ghiboub, Matthew Bell, Dovile Sinkeviciute, Rab K. Prinjha, Menno P. J. de Winther, Nicola R. Harker, David F. Tough, Wouter J. de Jonge (2023). The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential . Current Issues in Molecular Biology.
Ghiboub, M., Bell, M., Sinkeviciute, D., Prinjha, R.K., de Winther, M.P.J., Harker, N.R., Tough, D.F., de Jonge, W.J.(2023). The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential . Current Issues in Molecular Biology. 45. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4228-4245.
Verburgt, C.M., Dunn, K.A., Ghiboub, M., Lewis, J.D., Wine, E., Boneh, R.S., Gerasimidis, K., Shamir, R., Penny, S., Pinto, D.M., et al.(2023). Successful DietaryTherapy in Paediatric Crohn’s Disease is Associated with Shifts in Bacterial Dysbiosis and Inflammatory MetabotypeTowards Healthy Controls . Journal of Crohn's and Colitis. 17. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 61-72.
Ghiboub, M., Boneh, R.S., Sovran, B., Wine, E., Lefèvre, A., Emond, P., Verburgt, C.M., Benninga, M.A., De Jonge, W.J., Van Limbergen, J.E.(2023). Sustained Diet-Induced Remission in Pediatric Crohn's Disease Is Associated With Kynurenine and Serotonin Pathways . Inflammatory Bowel Diseases. 29. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 684-694.
Metabolome Changes With Diet-Induced Remission in Pediatric Crohn’s Disease <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Gastroenterology.
Mohammed Ghiboub, Jan Koster, Peter D. Craggs, Andrew Y. F. Li Yim, Anthony Shillings, Sue Hutchinson, Ryan P. Bingham, Kelly Gatfield, Ishtu L. Hageman, Gang Yao, et al. (2022). Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140 . BMC Biology.
Elfiky, A.M.I., Ghiboub, M., Li Yim, A.Y.F., Hageman, I.L., Verhoeff, J., De Krijger, M., Van Hamersveld, P.H.P., Welting, O., Admiraal, I., Rahman, S., et al.(2022). Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease . Journal of Crohn's and Colitis. 16. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 668-681.
Ghiboub, M., Penny, S., Verburgt, C.M., Boneh, R.S., Wine, E., Cohen, A., Dunn, K.A., Pinto, D.M., Benninga, M.A., de Jonge, W.J., et al.(2022). Metabolome Changes With Diet-Induced Remission in Pediatric Crohn's Disease . Gastroenterology. 163. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 922-936.e15.
Ghiboub, M., Koster, J., Craggs, P.D., Li Yim, A.Y.F., Shillings, A., Hutchinson, S., Bingham, R.P., Gatfield, K., Hageman, I.L., Yao, G., et al.(2022). Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140 . BMC Biology. 20. (1).
Mohammed Ghiboub, Shafaque Rahman, Joanne M. Donkers, Evita van de Steeg, Eric A. F. van Tol, Theodorus B. M. Hakvoort, Wouter J. de Jonge (2021). The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-Chip . International Journal of Molecular Sciences.
Mohammed Ghiboub, Shafaque Rahman, Joanne M. Donkers, Evita van de Steeg, Eric A. F. van Tol, Theodorus B. M. Hakvoort, Wouter J. de Jonge (2021). The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-Chip . International Journal of Molecular Sciences.
Mohammed Ghiboub, Ahmed M. I. Elfiky, Menno P. J. de Winther, Nicola R. Harker, David F. Tough, Wouter J. de Jonge (2021). Selective Targeting of Epigenetic Readers and Histone Deacetylases in Autoimmune and Inflammatory Diseases: Recent Advances and Future Perspectives . Journal of Personalized Medicine.
Leonie C S De Vries and Mohammed Ghiboub and Patricia H P van Hamersveld and Olaf Welting and Caroline Verseijden and Matthew J Bell and Inmaculada Rioja and Rabinder K Prinjha and Pim J Koelink and Birgit Strobl and Mathias Müller and Geert R D'Haens and Manon E Wildenberg and Wouter J De Jonge(2021). Tyrosine Kinase 2 Signalling Drives Pathogenic T cells in Colitis . Journal of Crohn's and Colitis. 15. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 617--630. Oxford University Press ({OUP})
Mohammed Ghiboub, Ahmed M. I. Elfiky, Menno P. J. de Winther, Nicola R. Harker, David F. Tough, Wouter J. de Jonge (2021). Selective Targeting of Epigenetic Readers and Histone Deacetylases in Autoimmune and Inflammatory Diseases: Recent Advances and Future Perspectives . Journal of Personalized Medicine.
Mohammed Ghiboub, Charlotte M. Verburgt, Marc A. Benninga, Wouter J. de Jonge, Johan E. Van Limbergen (2021). Nutritional Therapy Strategies in Pediatric Crohn’s Disease . Nutrients.
Mohammed Ghiboub, Charlotte M. Verburgt, Marc A. Benninga, Wouter J. de Jonge, Johan E. Van Limbergen (2021). Nutritional Therapy Strategies in Pediatric Crohn’s Disease . Nutrients.
Ghiboub, M., Elfiky, A.M.I., de Winther, M.P.J., Harker, N.R., Tough, D.F., de Jonge, W.J.(2021). Selective targeting of epigenetic readers and histone deacetylases in autoimmune and inflammatory diseases: Recent advances and future perspectives . Journal of Personalized Medicine. 11. (5).
Rahman, S., Ghiboub, M., Donkers, J.M., van de Steeg, E., van Tol, E.A.F., Hakvoort, T.B.M., de Jonge, W.J.(2021). The progress of intestinal epithelial models from cell lines to gut-on-chip . International Journal of Molecular Sciences. 22. (24).
De Vries, L.C.S., Ghiboub, M., Van Hamersveld, P.H.P., Welting, O., Verseijden, C., Bell, M.J., Rioja, I., Prinjha, R.K., Koelink, P.J., Strobl, B., et al.(2021). Tyrosine Kinase 2 Signalling Drives Pathogenic T cells in Colitis . Journal of Crohn's and Colitis. 15. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 617-630.
Verburgt, C.M., Ghiboub, M., Benninga, M.A., de Jonge, W.J., Van Limbergen, J.E.(2021). Nutritional therapy strategies in pediatric Crohn’s disease . Nutrients. 13. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-20.
Mohammed Ghiboub and Jing Zhao and Andrew Y. F. Li Yim and Ronald Schilderink and Caroline Verseijden and Patricia H. P. van Hamersveld and Jose M. Duarte and Theodorus B. M. Hakvoort and Iris Admiraal and Nicola R. Harker and David F. Tough and Peter Henneman and Menno P. J. de Winther and Wouter J. de Jonge(2020). HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages . Frontiers in Immunology. 11. Frontiers Media {SA}
Mohammed Ghiboub, Charlotte M. Verburgt, Bruno Sovran, Marc A. Benninga, Wouter J. de Jonge, Johan E. Van Limbergen (2020). Nutritional Therapy to Modulate Tryptophan Metabolism and Aryl Hydrocarbon-Receptor Signaling Activation in Human Diseases . Nutrients.
Mohammed Ghiboub, Charlotte M. Verburgt, Bruno Sovran, Marc A. Benninga, Wouter J. de Jonge, Johan E. Van Limbergen (2020). Nutritional Therapy to Modulate Tryptophan Metabolism and Aryl Hydrocarbon-Receptor Signaling Activation in Human Diseases . Nutrients.
Mohammed Ghiboub, Andrew Y.F. Li Yim, Nicolette W. Duijvis, Catriona Sharp, Enrico Ferrero, Marcel M.A.M. Mannens, Geert R. D’Haens, Wouter J. de Jonge, Anje A. te Velde, Peter Henneman(2020). Whole-Genome DNA Methylation Profiling of CD14+ Monocytes Reveals Disease Status and Activity Differences in Crohn’s Disease Patients . Journal of Clinical Medicine. 9. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1055. {MDPI} {AG}
Mohammed Ghiboub, Andrew Y.F. Li Yim, Nicolette W. Duijvis, Catriona Sharp, Enrico Ferrero, Marcel M.A.M. Mannens, Geert R. D’Haens, Wouter J. de Jonge, Anje A. te Velde, Peter Henneman (2020). Whole-Genome DNA Methylation Profiling of CD14+ Monocytes Reveals Disease Status and Activity Differences in Crohn’s Disease Patients . Journal of Clinical Medicine.
Li Yim, A.Y.F., Duijvis, N.W., Ghiboub, M., Sharp, C., Ferrero, E., Mannens, M.M.A.M., D’Haens, G.R., De Jonge, W.J., Te Velde, A.A., Henneman, P.(2020). Whole-genome DNA methylation profiling of CD14+ monocytes reveals disease status and activity differences in crohn’s disease patients . Journal of Clinical Medicine. 9. (4).
Ghiboub, M., Verburgt, C.M., Sovran, B., Benninga, M.A., de Jonge, W.J., Van Limbergen, J.E.(2020). Nutritional therapy to modulate tryptophan metabolism and aryl hydrocarbon-receptor signaling activation in human diseases . Nutrients. 12. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-21.
Ghiboub, M., Zhao, J., Li Yim, A.Y.F., Schilderink, R., Verseijden, C., van Hamersveld, P.H.P., Duarte, J.M., Hakvoort, T.B.M., Admiraal, I., Harker, N.R., et al.(2020). HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages . Frontiers in Immunology. 11.
(2017). Reduced IL-37 Production Increases Spontaneous Chemokine Expressions in Colon Epithelial Cells . Digestive diseases and sciences.
G&#252;naltay, S., Ghiboub, M., Hultgren, O., H&#246;rnquist, E.H.(2017). Reduced IL-37 Production Increases Spontaneous Chemokine Expressions in Colon Epithelial Cells . Digestive Diseases and Sciences. 62. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1204-1215.
van der Mark, V.A., Ghiboub, M., Marsman, C., Zhao, J., van Dijk, R., Hiralall, J.K., Ho-Mok, K.S., Castricum, Z., de Jonge, W.J., Elferink, R.P.J.O., et al.(2017). Erratum to: Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 (Cellular and Molecular Life Sciences, (2017), 74, 4, (715-730), 10.1007/s00018-016-2360-5) . Cellular and Molecular Life Sciences. 74. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1365.
van der Mark, V.A., Ghiboub, M., Marsman, C., Zhao, J., van Dijk, R., Hiralall, J.K., Ho-Mok, K.S., Castricum, Z., de Jonge, W.J., Oude Elferink, R.P.J., et al.(2017). Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 . Cellular and Molecular Life Sciences. 74. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 715-730.
(2016). Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 . Cellular and molecular life sciences : CMLS.
PREPRINT
Mohammed Ghiboub, Andrew Y.F. Li Yim, Ishtu L. Hageman, Vincent W. Joustra, Ahmed M.I.M. Elfiky, Evgeni Levin, Jan Verhoeff, Caroline Verseijden, Iris Admiraal-van den Berg, Marcel M.A.M. Mannens, et al. (2023). Single-cell characterization of peripheral blood mononuclear cells from vedolizumab-treated patients with Crohn's disease identifies response-associated differences among the plasmacytoid dendritic cell and classical monocyte populations .
Mohammed Ghiboub, Jan Koster, Peter D. Craggs, Andrew Y.F. Li Yim, Anthony Shillings, Sue Hutchinson, Ryan P. Bingham, Kelly Gatfield, Ishtu L. Hageman, Gang Yao, et al. (2020). Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140 .
OTHER
Li Yim, A.Y.F., Hageman, I.L., Joustra, V., Elfiky, A., Ghiboub, M., Levin, E., Verhoeff, J., Verseijden, C., Admiraal-Van den Berg, Mannens, M.M.A.M., et al.(2023). Single-cell characterization of peripheral blood mononuclear cells from vedolizumab-treated patients with Crohn’s disease identifies response-associated differences among the plasmacytoid dendritic cell and classical monocyte populations . medRxiv.
Mohammed Ghiboub, Andrew Y.F. Li Yim, Nicolette W. Duijvis, Catriona Sharp, Enrico Ferrero, Marcel M.A.M. Mannens, Geert R. D’Haens, Wouter J. de Jonge, Anje A. te Velde, Peter Henneman(2020). Whole-genome DNA methylation profiling of CD14+ monocytes reveals disease status and activity differences in Crohn’s disease patients . Cold Spring Harbor Laboratory
Li Yim, A.Y.F., Duijvis, N.W., Ghiboub, M., Sharp, C., Ferrero, E., Mannens, M.M.A.M., D’Haens, G.R., de Jonge, W.J., te Velde, A.A., Henneman, P.(2020). Whole-genome DNA methylation profiling of CD14+ monocytes reveals disease status and activity differences in Crohn’s disease patients . medRxiv.
Ghiboub, M., Koster, J., Craggs, P.D., Li Yim, A.Y.F., Shillings, A., Hutchinson, S., Bingham, R.P., Gatfield, K., Hageman, I.L., Yao, G., et al.(2020). Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140 . bioRxiv.