プロフィール詳細

プロジェクトを作成

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Dr. Narayanan P.に依頼

United States

Biomedical Research Consultant specializing in data analysis for drug discovery and development

プロフィール概要

- 14 years of pharmaceutical industry experience in Immunology and Inflammation (I&I) areas: Drug discovery and development from early to late phases - integration, analysis, and interpretation of data for target identification, validation, pre-clinical and clinical studies for go/no go decisions; Due diligence analyses of potential business development opportunities including recommendations on acquisitions and venture funding; Mentoring research associates, postdoctoral fellows, undergraduate and graduate level interns - 10 years of academic research experience in Immunology projects employing informatic techniques & methodologies to solve biological problems

専門分野

• ★ Bioinformatics
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Microarrays
• ☆ Omics
• ☆ Transcriptomics
• ☆ Genomics
• ☆ Epigenetics
• ☆ Next Generation Sequencing (NGS)
• ☆ ATAC-Seq
• ☆ Gene Expression Analysis
• ☆ Genome Sequencing
• ☆ RNA Sequencing
• ☆ Cell Biology
• ☆ Gene Regulation
• ☆ Data Analysis
• ☆ Gene & Protein Expression Analysis
• ☆ Systems Biology
• ☆ Python
• ☆ R

サービス

• Research
• Consulting
• Data & AI

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Data Visualization

職務経験

Senior Advisor - Biology

Eli Lilly and Company

8月 2011 - 4月 2025

Assistant Professor of Informatics

Indiana University Purdue University at Indianapolis

8月 2005 - 7月 2011

Visiting Assistant Professor

Indiana University Purdue University at Indianapolis

8月 2002 - 7月 2005

Visiting Assistant Professor

Indiana University

8月 2001 - 7月 2002

学歴

MSIS

Florida State University

8月 2000 - 5月 2001

PhD

Carnegie Mellon University

9月 1978 - 5月 1985

認定資格

• none

  None

  1月 2025 - 1月 2025

出版物

JOURNAL ARTICLE

Sho Sendo, Machado CRL, Boyle DL, Benschop RJ, Perumal NB, Choi E, Wang W, Gary S. Firestein (2024). Dysregulated NUB1 and Neddylation Enhances Rheumatoid Arthritis Fibroblast-Like Synoviocyte Inflammatory Responses . Arthritis & rheumatology (Hoboken, N.J.).

Van Espen B, Prideaux EB, Wilson AR, Machado CRL, Sho Sendo, Parker J, Seumois G, Sacchetti C, Belongia AC, Perumal NB, et al. (2024). Laser Capture Microscopy RNA Sequencing for Topological Mapping of Synovial Pathology During Rheumatoid Arthritis . Arthritis & rheumatology (Hoboken, N.J.).

Cecilia Ansalone, Richard I Ainsworth, Nygaard G, Ai R, Edward Prideaux, Deepa Hammaker, Perumal NB, Ken Weichert, Tung F, Kodandapani L, et al. (2021). Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior . ACR open rheumatology.

Hoffman RW, Merrill JT, Marta Eugenia Alarcón Riquelme, Petri M, Ernst R Dow, Nantz E, Nisenbaum LK, Schroeder KM, Komocsar WJ, Perumal NB, et al. (2017). Gene Expression and Pharmacodynamic Changes in 1,760 Systemic Lupus Erythematosus Patients From Two Phase III Trials of BAFF Blockade With Tabalumab . Arthritis & rheumatology (Hoboken, N.J.).

Riley JP, Kulkarni A, Mehrotra P, Koh B, Perumal NB, Kaplan MH, Goenka S (2013). PARP-14 binds specific DNA sequences to promote Th2 cell gene expression . PloS one.

Sawant DV, Sehra S, Nguyen ET, Rohit R. Jadhav, Englert K, Shinnakasu R, Hangoc G, Broxmeyer HE, Toshinori Nakayama, Perumal NB, et al. (2012). Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function . Journal of immunology (Baltimore, Md. : 1950).

Philips S, Richter A, Oesterreich S, Rae JM, Flockhart DA, Perumal NB, Skaar TC (2012). Functional characterization of a genetic polymorphism in the promoter of the ESR2 gene . Hormones & cancer.

Lepoivre C, Bergon A, Lopez F, Perumal NB, Nguyen C, Jean Imbert, denis puthier (2012). TranscriptomeBrowser 3.0: introducing a new compendium of molecular interactions and a new visualization tool for the study of gene regulatory networks . BMC bioinformatics.

Bhushan S, Perumal NB (2011). Disease associated cytokine SNPs database: an annotation and dissemination model . Cytokine.

Perumal NB, Kaplan MH (2011). Regulating Il9 transcription in T helper cells . Trends in immunology.

Kollipara RK, Perumal NB (2010). Motif prediction to distinguish LPS-stimulated pro-inflammatory vs. antibacterial macrophage genes . Immunome research.

Chang HC, Sehra S, Ritobrata Goswami, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, et al. (2010). The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation . Nature immunology.

Good SR, Thieu VT, Mathur AN, Yu Q, Stritesky GL, Yeh N, O'Malley JT, Perumal NB, Kaplan MH (2009). Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming . Journal of immunology (Baltimore, Md. : 1950).

Mo C, Chearwae W, O'Malley JT, Adams SM, Kanakasabai S, Crystal Walline, Stritesky GL, Good SR, Perumal NB, Kaplan MH, et al. (2008). Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis . Journal of immunology (Baltimore, Md. : 1950).

Childress PJ, Fletcher RL, Perumal NB (2007). LymphTF-DB: a database of transcription factors involved in lymphocyte development . Genes and immunity.

Liu J, Perumal NB, Oldfield CJ, Su EW, Uversky VN, Dunker AK (2006). Intrinsic disorder in transcription factors . Biochemistry.

Perumal NB, Kenniston TW Jr, Tweardy DJ, Dyer KF, Hoffman R, Peschon J, Appasamy PM (1997). TCR-gamma genes are rearranged but not transcribed in IL-7R alpha-deficient mice. Journal of immunology (Baltimore, Md. : 1950).

Perumal NB, Minkley EG Jr (1984). The product of the F sex factor traT surface exclusion gene is a lipoprotein . The Journal of biological chemistry.