プロフィール詳細

プロジェクトを作成

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Paul C.に依頼

United States

PhD Medical Writer & Scientific Reviewer | Medical Education, Literature Review & Publication Support

プロフィール概要

I am a PhD-trained biomedical scientist and former Scientific Director with experience spanning academic research, pharmaceutical medical communications, and scientific peer review. My work has focused on translational biology, immunology, neuroinflammation, infectious disease, and oncology-adjacent medical strategy. My academic research at Rutgers University centered on HIV persistence and macrophage survival mechanisms, including metabolic adaptations that support viral reservoirs. I have also contributed to structural and imaging-based investigations using cryo-electron tomography and correlative light and electron microscopy to characterize protein organization and mechanisms of neurodegeneration. My work integrates molecular biology, cellular imaging, and translational disease modeling. In industry, I progressed from Scientific Associate to Scientific Director at VML, where I served as senior scientific lead across medical education initiatives in interstitial lung disease, migraine, and oncology. My responsibilities included interpretation of clinical trial data, guideline integration, advisory board development, cross-functional regulatory collaboration, and final scientific review of promotional and non-promotional materials. I routinely engaged with key opinion leaders and contributed to new business strategy through evidence-based positioning and competitive analysis. I currently serve as an ad-hoc peer reviewer for Springer Nature journals (Scientific Reports; Journal of Inflammation), evaluating experimental design, statistical rigor, data integrity, and translational relevance. My expertise includes: Translational and mechanistic biology Neuroinflammation and viral persistence Immunology and inflammatory signaling Advanced microscopy and imaging-based analysis Clinical data interpretation and evidence synthesis Regulatory-aligned scientific communications Advisory board strategy and KOL engagement I am particularly well suited for advisory discussions involving translational science, evidence evaluation, biomarker interpretation at a conceptual level, and scientific positioning within regulated healthcare environments.

専門分野

• ☆ Microbiology
• ☆ Mycology/Fungi
• ☆ Biostatistics
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Structural Biology
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Molecular Biology
• ☆ Microinjection
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cytochemistry
• ☆ Cell Signaling Pathways
• ☆ Membrane Biology
• ☆ Neuroscience
• ☆ Electrophysiology
• ☆ Patch-Clamp Electrophysiology
• ☆ Neurochemistry
• ☆ Neurobiology
• ☆ Biophysics
• ☆ Histology
• ☆ Microscopy
• ☆ Light Microscopy
• ☆ Electron Microscopy
• ☆ Fluorescence Microscopy
• ☆ X-Ray Technology
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Banking
• ☆ Cell Surface Receptors
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Drug Development
• ☆ Preclinical Research
• ☆ Medical Imaging/Radiology
• ☆ Human Biology
• ☆ Infectious Disease
• ☆ Sexually Transmitted Infections (STI)
• ☆ HIV/AIDS Treatment
• ☆ Pulmonology/Respiratory Disease
• ☆ Respiratory Therapy
• ☆ Computed Tomography (CT)
• ☆ Immunotherapy
• ☆ Medical Sciences
• ☆ Connective Tissue
• ☆ Inflammation
• ☆ Asthma
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Survey Design & Methodology
• ☆ User Research
• ☆ Quantitative User Research
• ☆ Qualitative User Research
• ☆ Feasibility Studies
• ☆ Technology Scouting
• ☆ Fact Checking
• ☆ Literature Search
• ☆ Gap Analysis
• ☆ Regulatory Writing
• ☆ Nonclinical Study Documentation
• ☆ Medical Writing
• ☆ Medical Content Writing
• ☆ Healthcare Communications
• ☆ Patient Education Materials
• ☆ Research Summaries & Abstracts
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Manuscript & Journal Article Writing
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Case Studies
• ☆ Science Communication
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Systematic Literature Review
• ☆ Copywriting
• ☆ Marketing Copy
• ☆ Web Copy
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing
• ☆ Speechwriting
• ☆ Grant Writing
• ☆ Marketing Strategy
• ☆ Lead Generation
• ☆ Nonprofit Organization Administration
• ☆ Project Management
• ☆ Advertising

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Business & Legal Writing, Copywriting, General Proofreading & Editing

Research Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Processing, Image Analysis, Data Visualization

職務経験

Peer Reviewer

Springer Nature

11月 2024 - 現在

Scientific Director

Mindshare (WPP)

10月 2018 - 4月 2024

Postdoctoral Researcher

Rutgers University

8月 2017 - 10月 2018

Graduate Researcher

Rutgers Biomedical and Health Sciences

8月 2012 - 6月 2017

学歴

Doctor of Philosophy (Cell Biology, Neuroscience, and Physiology)

Rutgers Biomedical and Health Sciences

- 現在

Bachelors (Biology and Chemistry)

Kean University

- 現在

Masters of Science (Science)

Montclair State University

- 現在

B.A.

Kean University

9月 1996 - 6月 2002

認定資格

• Teacher of Chemistry

  NJDOE

  6月 2004 - 現在

• Teacher of Biology

  NJDOE

  6月 2002 - 現在

出版物

JOURNAL ARTICLE

Kuang X, Nunn K, Jiang J, Castellano P, Hardikar U, Horgan A, Kong J, Tan Z, Dai W (2021). Structural insight into transmissive mutant huntingtin species by correlative light and electron microscopy and cryo-electron tomography . Biochemical and biophysical research communications.

Valdebenito S, Castellano P, Ajasin D, Eugenin EA (2021). Astrocytes are HIV reservoirs in the brain: A cell type with poor HIV infectivity and replication but efficient cell-to-cell viral transfer . Journal of neurochemistry.

Jiménez-Ortigosa C, Jiang J, Chen M, Kuang X, Healey KR, Castellano P, Boparai N, Ludtke SJ, Perlin DS, Dai W (2021). Cryo-Electron Tomography of Candida glabrata Plasma Membrane Proteins . Journal of fungi (Basel, Switzerland).

Castellano P, Prevedel L, Valdebenito S, Eugenin EA (2019). HIV infection and latency induce a unique metabolic signature in human macrophages . Scientific reports.

Prevedel L, Ruel N, Castellano P, Smith C, Malik S, Villeux C, Bomsel M, Morgello S, Eugenin EA (2018). Identification, Localization, and Quantification of HIV Reservoirs Using Microscopy . Current protocols in cell biology.

Tyler Weisbarth R, Das A, Castellano P, Fisher MA, Wu H, Bellofatto V (2018). The Trypanosoma cruzi RNA-binding protein RBP42 is expressed in the cytoplasm throughout the life cycle of the parasite . Parasitology research.

Castellano P, Prevedel L, Eugenin EA (2017). HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim . Scientific reports.

Castellano P, Nwagbo C, Martinez LR, Eugenin EA (2016). Methamphetamine compromises gap junctional communication in astrocytes and neurons . Journal of neurochemistry.

Avdoshina V, Fields JA, Castellano P, Dedoni S, Palchik G, Trejo M, Adame A, Rockenstein E, Eugenin E, Masliah E, et al. (2016). The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons . Neurotoxicity research.

Castellano P, Eugenin EA (2014). Regulation of gap junction channels by infectious agents and inflammation in the CNS . Frontiers in cellular neuroscience.