プロフィール詳細

プロジェクトを作成

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Dr. Pratibha K.に依頼

India

Scientific Writer | PhD in Structural Biology | Therapeutic Antibodies | Protein Science | Biologics

プロフィール概要

I am a Ph.D.-trained Structural Biologist and Biopharmaceutical Scientist with over 10 years of international academic and industry experience in structural biology, protein biochemistry, therapeutic antibodies, and biologics process development. I have conducted research and led projects at ETH Zurich (Switzerland), INSA Toulouse (France), Uppsala University (Sweden), and Biocon Biologics (India), combining fundamental research with industrial product development. My expertise includes protein expression, purification and characterization, structural biology, downstream process development for monoclonal and bispecific antibodies, chromatography, biophysical characterization, NMR spectroscopy, experimental design, statistical data analysis, and scientific writing. At Biocon Biologics, I led downstream process development and technology transfer projects for biosimilar and novel therapeutic antibodies, working closely with cross-functional teams to optimize manufacturing processes and support CMC documentation. My academic research has focused on protein aggregation, neurodegenerative diseases, lipoproteins, protein structure-function relationships, and antibiotic resistance mechanisms using advanced structural biology and biophysical techniques. I have authored seven peer-reviewed publications in high-impact journals, including Nature, Nature Communications, PNAS, eLife, Journal of Biological Chemistry, FEBS Letters, and Journal of Biomolecular NMR. I also have extensive teaching and mentoring experience, having delivered over 400 hours of undergraduate and graduate STEM instruction at ETH Zurich while supervising Bachelor's, Master's, and Ph.D. students. This experience has strengthened my ability to communicate complex scientific concepts clearly and collaborate effectively with multidisciplinary teams. I can help clients with: Scientific and medical writing Literature reviews and systematic reviews Manuscript preparation and editing Grant writing and research proposals Protein expression, purification, and characterization Structural biology and NMR consulting Therapeutic antibody and biologics development Downstream process development and process optimization Experimental design, data analysis, and interpretation Scientific presentations and technical documentation I am committed to delivering high-quality, evidence-based scientific solutions tailored to each client's research and development needs, with a focus on clear communication, scientific rigor, and timely project completion.

専門分野

• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Industrial Biotechnology

サービス

• Writing

Writing Clinical Trial Documentation, Medical Writing, Technical Writing, Creative Writing

職務経験

PostdoctoralResearcher

Uppsala University

12月 2025 - 現在

Associate Manager

Biocon Biologics

9月 2021 - 10月 2024

PostdoctoralResearcher

INSA, Toulouse, France

2月 2020 - 7月 2021

学歴

Doctoral Program

ETHZ - ETH Zurich - Switzerland

3月 2015 - 12月 2019

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Pratibha Kumari, Dhiman Ghosh, Agathe Vanas, Yanick Fleischmann, Thomas Wiegand, Gunnar Jeschke, Roland Riek, Cédric Eichmann(2021). Structural insights into α-synuclein monomer–fibril interactions . Proceedings of the National Academy of Sciences. 118. (10). Proceedings of the National Academy of Sciences

Guerrero-Ferreira R, Taylor NM, Arteni AA, Kumari P, Mona D, Ringler P, Britschgi M, Lauer ME, Makky A, Verasdonck J, et al.(2019). Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy . eLife.

Burmann BM, Gerez JA, Matečko-Burmann I, Campioni S, Kumari P, Ghosh D, Mazur A, Aspholm EE, Šulskis D, Wawrzyniuk M, et al.(2019). Regulation of α-synuclein by chaperones in mammalian cells . Nature.

Kumari P, Frey L, Sobol A, Lakomek NA, Riek R(2018). 15N transverse relaxation measurements for the characterization of µs-ms dynamics are deteriorated by the deuterium isotope effect on 15N resulting from solvent exchange . Journal of biomolecular NMR.

Kumar H, Singh J, Kumari P, Udgaonkar JB(2017). Modulation of the extent of structural heterogeneity in α-synuclein fibrils by the small molecule thioflavin T . The Journal of biological chemistry.

Eichmann C, Kumari P, Riek R(2017). High-density lipoprotein-like particle formation of Synuclein variants . FEBS letters.

OTHER

Guerrero-Ferreira R, Taylor NM, Arteni A, Kumari P, Mona D, Ringler P, Britschgi M, Lauer ME, Makky A, Verasdock J, et al.(2019). Two new polymorphic structures of alpha-synuclein solved by cryo-electron microscopy .