プロフィール詳細

プロジェクトを作成

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Dr. Panagiotis F.に依頼

United States

Molecular Biology Expert with 6 Years of Experience Gene Transfer

プロフィール概要

I am a Molecular biologist with six years of experience on the metabolic and inflammatory mechanisms underlying the pathogenesis of atherosclerosis. My research is aiming at the development of new therapies for the treatment of Cardiovascular Disease. My studies have been focused on developing mouse models to characterized the structure/function relationship of the HDL (High Density Lipoproteins) and the risk of Cardiovascular Disease. This works has been published extensively (see publication record) and resulted on the identification of novel therapeutics for the treatment of alpha-hypolipoproteinemia and dominant type III hyperlipoproteinemia. I have also contributed in the discovery of a new role of apoA-IV in forming HDL particles. My current work is focused of the regulation of inflammatory responses in macrophages by HDL as well as the mechanism of atherosclerosis in mice lacking ABCA1 and ABCG1 transporters in macrophages. I have become proficient in gene transfer using adenoviruses, working with cell cultures and mice as well as in wide variety of molecular biology and biochemical assays employed to address scientific questions.

専門分野

• ☆ Adenoviruses
• ☆ Biochemistry
• ☆ Biochemical Assays
• ☆ Molecular Biology
• ☆ Lipidomics
• ☆ Pathogenesis
• ☆ Cardiovascular Disease

サービス

• Consulting
• Data & AI
• Product Development

職務経験

Post-doctoral Research Scientist

Columbia University

9月 2014 - 12月 2016

Research Assistant

Boston University

11月 2009 - 7月 2014

Research Assistant

University of Crete

6月 2005 - 4月 2009

学歴

PhD

University of Crete

4月 2009 - 7月 2014

MSc

University of Crete

9月 2006 - 11月 2008

BSc

University of Crete

9月 2002 - 8月 2006

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Westerterp, M., Tsuchiya, K., Tattersall, I.W., Fotakis, P., Bochem, A.E., Molusky, M.M., Ntonga, V., Abramowicz, S., Parks, J.S., Welch, C.L., et al.(2016). Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice . Arteriosclerosis, Thrombosis, and Vascular Biology. 36. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1328-1337.

Fotakis P, Kuivenhoven JA, Dafnis E, Kardassis D, Zannis VI, Biochemistry, 2015, vol. 54, no. 21, pp. 3348-3359 .

Fotakis, P., Kuivenhoven, J.A., Dafnis, E., Kardassis, D., Zannis, V.I.(2015). The effect of natural LCAT mutations on the biogenesis of HDL . Biochemistry. 54. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3348-3359.

Zannis VI, Fotakis P, Koukos G, Kardassis D, Ehnholm C, Jauhiainen M, Chroni A, Handbook of experimental pharmacology, 2015, vol. 224, pp. 53-111 .

Tiniakou, I., Kanaki, Z., Georgopoulos, S., Chroni, A., Van Eck, M., Fotakis, P., Zannis, V.I., Kardassis, D.(2015). Natural human apoA-I mutations L141R<inf>Pisa</inf> and L159R<inf>FIN</inf> alter HDL structure and functionality and promote atherosclerosis development in mice . Atherosclerosis. 243. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 77-85.

Fotakis P, Vezeridis A, Dafnis I, Chroni A, Kardassis D, Zannis VI, Journal of lipid research, 2014, vol. 55, no. 7, pp. 1310-1323 .

Fotakis, P., Vezeridis, A., Dafnis, I., Chroni, A., Kardassis, D., Zannis, V.I.(2014). ApoE3[K146N/R147W] acts as a dominant negative apoE form that prevents remnant clearance and inhibits the biogenesis of HDL . Journal of Lipid Research. 55. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1310-1323.

Fotakis P, Kateifides AK, Gkolfinopoulou C, Georgiadou D, Beck M, Gründler K, Chroni A, Stratikos E, Kardassis D, Zannis VI, Journal of lipid research, 2013, vol. 54, no. 12, pp. 3281-3292 .

Fotakis P, Tiniakou I, Kateifides AK, Gkolfinopoulou C, Chroni A, Stratikos E, Zannis VI, Kardassis D, Journal of lipid research, 2013, vol. 54, no. 12, pp. 3293-3302 .

Duka A, Fotakis P, Georgiadou D, Kateifides A, Tzavlaki K, von Eckardstein L, Stratikos E, Kardassis D, Zannis VI, Journal of lipid research, 2013, vol. 54, no. 1, pp. 107-115 .

Fotakis, P., Kateifides, A.K., Gkolfinopoulou, C., Georgiadou, D., Beck, M., Gr&#252;ndler, K., Chroni, A., Fotakis, P., Kateifides, A.K., Gkolfinopoulou, C., et al.(2013). Role of the hydrophobic and charged residues in the 218-226 region of apoA-I in the biogenesis of HDL . Journal of Lipid Research. 54. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3281-3292.

Fotakis, P., Tiniakou, I., Kateifides, A.K., Gkolfinopoulou, C., Fotakis, P., Tiniakou, I., Kateifides, A.K., Gkolfinopoulou, C., Chroni, A., Stratikos, E., et al.(2013). Significance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL . Journal of Lipid Research. 54. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3293-3302.

Duka, A., Fotakis, P., Georgiadou, D., Kateifides, A., Tzavlaki, K., Von Eckardstein, L., Stratikos, E., Kardassis, D., Zannis, V.I.(2013). ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT . Journal of Lipid Research. 54. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 107-115.

BOOK

Zannis, V.I., Fotakis, P., Koukos, G., Kardassis, D., Ehnholm, C., Jauhiainen, M., Chroni, A.(2015). Hdl biogenesis, remodeling, and catabolism . Handbook of Experimental Pharmacology. 224. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 53-111.

BOOK CHAPTER

(2012). Pleiotropic Functions of HDL Lead to Protection from Atherosclerosis and Other Diseases . Dyslipidemia - From Prevention to Treatment.