プロフィール詳細

プロジェクトを作成

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Dr. Paromita I.に依頼

Canada

Expert in drug delivery, gene therapy, medical devices & preclinical in-vitro and in-vivo | Protocol & Medical writer

プロフィール概要

I am a Ph.D.-trained biomedical scientist and medical writer with over a decade of multidisciplinary research experience spanning drug delivery systems, gene therapy, and therapeutic biomaterials. Key Research Projects (Current) Development of Innovative Dressing Scaffolds for Chronic Wounds (Diabetic Foot Ulcer) in B6.Cg-Lepob/J mice: Formulated and collaborated with cross-functional teams to support the development of nano-embedded growth factors to promote cellular proliferation and angiogenesis with anti-inflammatory effects, resulting in accelerated wound closure and improved tissue regeneration in preclinical chronic skin wound models for human usability. Skills: Animal handling (B6.Cg-Lepob/J mice), development of in-vivo protocols, surgical techniques (biopsy punch and silicone ring adhesion), Masson's trichrome, H&E and Sirius red staining for histological examination, immunohistochemistry (IHC), metabolite analysis, ELISA, BCA, SDS-PAGE, western blot, gel electrophoresis, UV-Vis, and CE-SDS. Statistical study using R programming. Probiotic Nanoparticles for Gut-Brain Axis Modulation: Developed probiotic-based nanoparticle formulations to mitigate obesity and psoriasis and enhance longevity via the gut-brain axis. Handled human biological samples under GLP-aligned protocols and contributed to experimental designs requiring ethics compliance and consent documentation. Skills: Microbiome research methods i.e. CFU counts, ZOI assay, bacterial viability assays (Live/Dead Staining), nanoparticle synthesis, data interpretation and QuPath. Development of Bioresorbable Precision Stents: Engineered cardiac stents capable of delivering therapeutic genes, growth factors, and miRNA antagomirs, demonstrating a significant reduction in neointimal hyperplasia in preclinical models. Skills: FDA & Health Canada guidelines for pharmaceuticals and medical devices, baculovirus production and transduction, transfection, mammalian cell culture, protein quantification & expression analysis, flow cytometry, microfluidics, and maintaining good laboratory practices (GLP). Design of Chemotherapeutics for Colorectal Cancer: Engineered PLGA nanoparticles delivering combinatorial treatment of siRNAs, showing enhanced apoptosis and reduced tumor drug resistance in preclinical colon cancer rat models. Skills: Nanoparticle formulation, qPCR, FACS, flowcytometry and FlowJo, ELISA, SEM/TEM/AFM imaging, and data analysis using GraphPad Prism and MATLAB. Previous Projects: Development of Nano-Embedded Microparticles (NEMs) via Spray Drying of Chitosan-Based Nanogels Formulated and optimized chitosan-based nanogels incorporating alginate and/or sodium tri-penta phosphate (TPP), then converted these nanogels into stable nano-embedded microparticles (NEMs) using spray drying with trehalose or mannitol matrices. Investigated how polymer composition and matrix excipient affected nanogel size, zeta potential, solid-state properties, redispersibility, and aerodynamic behaviour. Demonstrated superior nanogel recovery using amorphous trehalose matrix, enabling potential applications in pulmonary and injectable drug delivery. Skills: Nanogel formulation, spray drying, DLS, zeta potential, SEM, TEM, XRPD, TGA, redispersion studies, statistical design and analysis, formulation characterization under GLP. I hold a Ph.D. in Biological and Biomedical Engineering from McGill University, an MSc in Pharmaceutical Sciences (Drug Development) from the University of Copenhagen. Knowledgeable about experimental design and statistical analysis. Ten years of experience as a professional scientific writer. Native English speaker with excellent attention to detail. Professionally proficient in French.

専門分野

• ☆ Nanotechnology
• ☆ Microbiology
• ☆ Microbiome Research
• ☆ Molecular Biology
• ☆ Gene Expression Analysis
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Nanobiotechnology
• ☆ Biomedical Engineering
• ☆ Data Analysis
• ☆ Microfluidics
• ☆ Cell Culture
• ☆ Large Scale Cell Culture
• ☆ Tissue Engineering
• ☆ Drug Development
• ☆ Drug Formulation
• ☆ Preclinical Research
• ☆ Preclinical Pharmacology
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ Pharmaceutical Manufacturing
• ☆ Pharmaceutical Process Development
• ☆ Medical Devices
• ☆ Chemotherapy
• ☆ Gastroenterology & Hepatology
• ☆ Wound Care
• ☆ Gene Therapy
• ☆ Inflammation
• ☆ Research Methodology
• ☆ Medical Writing
• ☆ Formulation
• ☆ Pharmaceutical Formulation

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Medical Writing, Technical Writing

Research Gap Analysis, Scientific and Technical Research, Systematic Literature Review

Consulting Go-to-Market Strategy Consulting, Scientific and Technical Consulting, Manufacturing Consulting

Data & AI Image Processing, Image Analysis, Data Cleaning

Product Development Formulation, Stability/Shelf Life Testing, Product Validation, Concept Development, Device Fabrication

職務経験

Doctoral Researcher

McGill University Faculty of Engineering

1月 2021 - 現在

Senior Lecturer

North South University

1月 2015 - 現在

Graduate Research Assistant / Research Assistant

University of Copenhagen

7月 2014 - 12月 2014

Oncology Associate

Sanofi

11月 2011 - 8月 2012

学歴

PhD in Biological and Biomedical Engineering (Biomedical Engineering)

McGill University

1月 2021 - 現在

Msc. in Pharmaceutical Sciences (Pharmacy)

University of Copenhagen

9月 2012 - 8月 2014

Bachelor of Pharmacy (Pharmaceutical Sciences)

North South University

9月 2006 - 12月 2010

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Paromita Islam, Editha Renesteen, Jacqueline L. Boyajian, Amal Kassab, Ahmed Abosalha, Stephanie Makhlouf, Madison Santos, Hongmei Chen, Cedrique Shum-Tim, Satya Prakash (2025). Microbiome Engineering for Biotherapeutic in Alzheimer’s Disease Through the Gut–Brain Axis: Potentials and Limitations . International Journal of Molecular Sciences.

PAROMITA ISLAM, Editha Renesteen, Jacqueline L. Boyajian, Amal Kassab, Ahmed Abosalha, Stephanie Makhlouf, Madison Santos, Hongmei Chen, Cedrique Shum-Tim, Satya Prakash (2025). Microbiome Engineering for Biotherapeutic in Alzheimer’s Disease Through the Gut–Brain Axis: Potentials and Limitations . International Journal of Molecular Sciences.

Paromita Islam, Sabrina Schaly, Ahmed Kh. Abosalha, Jacqueline Boyajian, Rahul Thareja, Waqar Ahmad, Dominique Shum‐Tim, Satya Prakash (2024). Nanotechnology in development of next generation of stent and related medical devices: Current and future aspects . WIREs Nanomedicine and Nanobiotechnology.

Paromita Islam, Sabrina Schaly, Ahmed Abosalha, Jacqueline L. Boyajian, Dominique Shum-Tim, Satya Prakash (2022). Alginate–Chitosan Hydrogel Formulations Sustain Baculovirus Delivery and VEGFA Expression Which Promotes Angiogenesis for Wound Dressing Applications . Pharmaceuticals.

PAROMITA ISLAM, Sabrina Schaly, Ahmed Abosalha, Jacqueline L. Boyajian, Dominique Shum-Tim, Satya Prakash (2022). Alginate–Chitosan Hydrogel Formulations Sustain Baculovirus Delivery and VEGFA Expression Which Promotes Angiogenesis for Wound Dressing Applications . Pharmaceuticals.

Paromita Islam, Waqar Ahmad, Jacqueline L. Boyajian, Ahmed Abosalha, Anam Nasir, Iram Ashfaq, Sabrina Schaly, Rahul Thareja, Azam Hayat, Mujaddad ur Rehman, et al. (2022). High-Molecular-Weight Dextran-Type Exopolysaccharide Produced by the Novel Apilactobacillus waqarii Improves Metabolic Syndrome: In Vitro and In Vivo Analyses . International Journal of Molecular Sciences.

PAROMITA ISLAM, Waqar Ahmad, Jacqueline L. Boyajian, Ahmed Abosalha, Anam Nasir, Iram Ashfaq, Sabrina Schaly, Rahul Thareja, Azam Hayat, Mujaddad ur Rehman, et al. (2022). High-Molecular-Weight Dextran-Type Exopolysaccharide Produced by the Novel <i>Apilactobacillus waqarii</i> Improves Metabolic Syndrome: In Vitro and In Vivo Analyses . International Journal of Molecular Sciences.

Islam P, Water JJ, Bohr A, Rantanen J(2016). Chitosan-Based Nano-Embedded Microparticles: Impact of Nanogel Composition on Physicochemical Properties . Pharmaceutics.