プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Partha C.に依頼

United States

Seasoned Immunologist Specializing in T Cell Biology, Pre-Clinical Development, and Translational Research

プロフィール概要

As a highly skilled Immunologist, I bring extensive expertise in T cell biology, biomarker discovery, assay development, and translational research, with experience spanning both industry and academia. My background includes implementing clinical trial biomarker strategies, managing outsourced biomarker analysis, and specializing in target identification, validation, and innovative immunotherapy strategies. My research has been published in top-tier journals, including work with Nobel Laureate Professor Tasuku Honjo, where I discovered how mitochondrial deactivation affects PD-1 blockade effectiveness. I enhanced PD-1 blockade therapy by combining it with a mitochondrial activator and developed advanced flow cytometry assays for evaluating CAR T-cell persistence and metabolism. In the industry, I have led pre-clinical development projects for antibody-based cancer immunotherapies, including bispecific and multispecific T cell engagers. I have managed projects in target discovery, compound optimization, antibody format selection, and proof-of-concept studies, utilizing diverse preclinical models such as xenogeneic, syngeneic, and humanized mouse tumor models. My technical skills include cell culture, multi-parameter flow cytometry, ELISA, multiplex cytokine measurements, Western blotting, and qPCR. My broad expertise enables me to tackle challenges and drive projects to success. I offer comprehensive consulting throughout all phases of drug discovery, including project conception, experimental design, assay development and optimization, analysis, in vivo model selection, manuscript writing/editing, and scientific presentations.

専門分野

• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Biomarker Discovery
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Line Engineering
• ☆ Cell Surface Receptors
• ☆ Cytometry
• ☆ Drug Development
• ☆ Biologic & Biosimilar Development
• ☆ Bioanalytical Testing
• ☆ Preclinical Research
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ In vitro Diagnostics
• ☆ Biomarker Analysis
• ☆ Immunotherapy

サービス

• Writing
• Research
• Consulting

Writing Medical Writing, Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

職務経験

Independent Consultant

Consulting

6月 2024 - 現在

Senior scientist, preclinical development

Sanofi

2月 2023 - 6月 2024

Scientist, preclinical development

Regeneron Pharmaceuticals

8月 2020 - 2月 2023

Postdoctoral Fellow - Research Associate

St. Jude Children's Research Hospital

8月 2019 - 8月 2020

Postdoctoral Fellow

Kyoto University

4月 2015 - 8月 2019

学歴

PhD

University of Pune

8月 2007 - 3月 2014

認定資格

• 認定資格の詳細は未入力です。