プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Piotr J.に依頼

Switzerland

Membrane Protein & GPCR Expert | Biomimetic Systems, Drug Discovery, Assay Design & Scientific Writing

プロフィール概要

I am an interdisciplinary scientist specialising in membrane proteins, biomimetic systems, and their applications in drug discovery and biotechnology. I recently completed a PhD in Nanosciences at the University of Basel (Switzerland), in collaboration with the Paul Scherrer Institute and the University Children’s Hospital Basel. My work focuses on solving key challenges in membrane protein production, stabilisation, and functional characterisation. I have extensive experience in reconstituting membrane proteins, including complex membrane protein systems such as GPCR-like targets, into lipid and polymer-based membranes (liposomes, polymersomes), enabling controlled and functional assay environments. During my PhD, I led multiple interdisciplinary projects developing biohybrid membrane platforms. This includes engineering systems with light-driven ion pumps (KR2 rhodopsin) and enzyme-loaded nanocompartments with controlled molecular transport via membrane pores (OmpF), supporting multi-step biochemical reactions. I also discovered and characterised a protein-induced membrane fusion mechanism, enabling controlled assembly and remodelling of vesicular systems. In parallel, I worked with cell-derived membrane models (GPMVs) generated from neuroblastoma cancer cells to investigate membrane permeability, enzymatic activity, and protein partitioning, linking synthetic systems to native-like membrane behaviour. My technical expertise spans membrane protein expression and purification, molecular biology, protein engineering, and a broad range of biophysical and imaging techniques (CLSM, FCS, NTA, DLS, nanoDSF, CD, electron microscopy). I design and analyse functional assays, including fluorescence-based systems, and support data interpretation and experimental strategy. Beyond experimental work, I support clients with: Scientific writing (manuscripts, reports, grant proposals) Experimental design and troubleshooting Assay development for membrane proteins and drug screening Literature analysis and data interpretation Early-stage innovation and strategy in biotech projects I have prior experience in structural biology and GPCRs' pharmacology, including radioligand binding assays and structure activity relationship (SAR) analysis of receptor-targeting compounds. I am particularly interested in projects involving membrane proteins - including GPCRs, drug discovery, biomimetic systems, and translational research.

専門分野

• ★ Membrane Biology
• ★ Recombinant Protein Expression
• ★ Biological Systems Engineering
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Structural Biology
• ☆ Enzyme Activity Assays
• ☆ Binding Assays
• ☆ Molecular Biology
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Biophysics
• ☆ Biotechnology & Bioengineering
• ☆ Nanobiotechnology
• ☆ Biomedical Engineering
• ☆ Biomimetics
• ☆ Microscopy
• ☆ Light Microscopy
• ☆ Electron Microscopy
• ☆ Fluorescence Microscopy
• ☆ Biomarker Discovery
• ☆ Cell Culture
• ☆ Cell Line Engineering
• ☆ Industrial Biotechnology
• ☆ Synthetic Biology
• ☆ Biosensors
• ☆ Chemical Biology

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Medical Writing, Technical Writing, Creative Writing

Research Market Research, Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Scientific and Technical Research

Consulting Business Strategy Consulting, Go-to-Market Strategy Consulting, Scientific and Technical Consulting, Manufacturing Consulting

Data & AI Text Mining & Analytics, Data Mining, Data Insights

Product Development Product Validation, Concept Development, Prototyping, Reverse Engineering

職務経験

Independent Researcher, Consultant

Consultant- Self-Employed

3月 2026 - 現在

PhD Research Fellow

University of Basel

3月 2021 - 12月 2025

Graduate Research Assistant / Research Assistant

Technical University of Munich

1月 2020 - 9月 2020

Research Internship

The University of Bonn

4月 2018 - 9月 2018

Research Internship

Ludwig-Maximilians Univerisity Munich

1月 2018 - 3月 2018

Student assistant

Technical University of Munich

11月 2017 - 1月 2018

学歴

PhD Nanosciences

University of Basel

3月 2021 - 3月 2026

BSc Biochemistry

Jagiellonian University Cracow - Poland

10月 2014 - 9月 2019

MSc Laboratory Medicine

Jagiellonian University Cracow - Poland

10月 2012 - 6月 2019

認定資格

• Entrepreneurship Training

  Innosuisse

  5月 2025 - 現在

出版物

JOURNAL ARTICLE

Piotr Jasko, Maryame Bina, Daniel Frey, Cora-Ann Schoenenberger, Cornelia G. Palivan, Richard A. Kammerer (2025). Diphtheria toxin T-domain as a tool for inducing lipid vesicle fusion . Communications Chemistry.

Piotr Jasko, Voichita Mihali, Michal Skowicki, Cornelia G. Palivan (2024). Controlled enzymatic reactions by programmed confinement in clusters of polymersomes and Janus nanoparticles . Materials Today.

Michał Załuski, Dorota Łażewska, Piotr Jaśko, Ewelina Honkisz-Orzechowska, Kamil J. Kuder, Andreas Brockmann, Gniewomir Latacz, Małgorzata Zygmunt, Maria Kaleta, Beril Anita Greser, et al.(2023). Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A2A and Dual A1/A2A Receptor Affinity . International Journal of Molecular Sciences. 24. (18). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 13707. {MDPI} {AG}

Piotr Jasko, Marwa Amer, Oneda Leka, Daniel Frey, Xiaodan Li, Richard A. Kammerer(2023). A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled receptors . Scientific Reports. 13. (1). Springer Science and Business Media {LLC}

Olivia M. Eggenberger, Piotr Jaśko, Shabnam Tarvirdipour, Cora‐Ann Schoenenberger, Cornelia G. Palivan(2023). Advances in Biohybridized Planar Polymer Membranes and Membrane‐Like Matrices . Helvetica Chimica Acta. 106. (4). Wiley

Michał Załuski, Jakub Schabikowski, Piotr Jaśko, Adrian Bryła, Agnieszka Olejarz-Maciej, Maria Kaleta, Monika Głuch-Lutwin, Andreas Brockmann, Sonja Hinz, Małgorzata Zygmunt, et al.(2020). 8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation . Bioorganic Chemistry. 101. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 104033. Elsevier {BV}

Kamil J. Kuder, Michał Załuski, Jakub Schabikowski, Gniewomir Latacz, Agnieszka Olejarz‐Maciej, Piotr Jaśko, Agata Doroz‐Płonka, Andreas Brockmann, Christa E. Müller, Katarzyna Kieć‐Kononowicz(2020). Novel, Dual Target‐Directed Annelated Xanthine Derivatives Acting on Adenosine Receptors and Monoamine Oxidase B . ChemMedChem. 15. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 772--786. Wiley