プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Radwa S.に依頼

United States

Genomics scientist | Proficient in python & R

プロフィール概要

I am passionate about the use of cutting-edge computational tools to study how human and pathogen genotypes affect cellular behavior and cancer development. I enjoy collaborating with other scientists and clinicians to develop innovative solutions and technologies that can address unmet medical needs. I am also an enthusiastic presenter who can communicate complex information in a clear and engaging way.

専門分野

• ☆ Molecular Biology
• ☆ Omics
• ☆ Genomics
• ☆ Next Generation Sequencing (NGS)
• ☆ Python
• ☆ R
• ☆ Cancer Research
• ☆ Cancer Biology

サービス

• Research
• Data & AI

Research User Research

Data & AI Statistical Analysis

職務経験

Foundation Medicine Inc

7月 2019 - 現在

Harvard Medical School

10月 2013 - 5月 2019

学歴

Viral Genomics

Harvard University

10月 2013 - 5月 2019

認定資格

• PhD Degree

  Harvard University

  5月 2019 - 現在

出版物

PREPRINT

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colon, Zoe Fleischmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2024). Data from Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colon, Zoe Fleischmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2024). Data from Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colon, Zoe Fleischmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2024). Supplementary Figures S1-S22 from Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colon, Zoe Fleischmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2024). Supplementary Figures S1-S22 from Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colon, Zoe Fleischmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2024). Supplementary Tables S1-S24 from Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colon, Zoe Fleischmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2024). Supplementary Tables S1-S24 from Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colón, Zoe Fleishmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2023). Data from Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colón, Zoe Fleishmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2023). Supplementary Tables S1-S24 from Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colón, Zoe Fleishmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2023). Supplementary Figures S1-S22 from Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colón, Zoe Fleishmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2023). Supplementary Tables S1-S24 from Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colón, Zoe Fleishmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2023). Supplementary Figures S1-S22 from Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colón, Zoe Fleishmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2023). Supplementary Tables S1-S24 from Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colón, Zoe Fleishmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2023). Supplementary Tables S1-S24 from Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colón, Zoe Fleishmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2023). Data from Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colón, Zoe Fleishmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2023). Supplementary Figures S1-S22 from Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation .

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colón, Zoe Fleishmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2023). Supplementary Figures S1-S22 from Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation .

Radwa Sharaf, Meagan Montesion, Karthikeyan Murugesan, Dexter X. Jin, Nora Sanchez, Ameet Guria, Max Minker, Gerald Li, Virginia Fisher, Ethan S. Sokol, et al. (2023). Data from Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response .

Radwa Sharaf, Meagan Montesion, Karthikeyan Murugesan, Dexter X. Jin, Nora Sanchez, Ameet Guria, Max Minker, Gerald Li, Virginia Fisher, Ethan S. Sokol, et al. (2023). Data from Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response .

JOURNAL ARTICLE

Radwa Sharaf, James F Haberberger, Worthy Pegram, Nicholas Britt, Kelsie Schiavone, Eric Severson, Lee A Albacker, Erik Williams, Mirna Lechpammer, Amanda Hemmerich, et al. (2024). A Retrospective Genomic Landscape of 661 Young Adult Glioblastomas Diagnosed Using 2016 WHO Guidelines for Central Nervous System Tumors . The Oncologist.

Radwa Sharaf, Dexter X. Jin, John Grady, Christine Napier, Ericka Ebot, Garrett M. Frampton, Lee A. Albacker, David M. Thomas, Meagan Montesion (2023). A pan-sarcoma landscape of telomeric content shows that alterations in RAD51B and GID4 are associated with higher telomeric content . npj Genomic Medicine.

Radwa Sharaf, Jay A. Moore, Kuei-Ting Chen, Russell Madison, Justin Y. Newberg, Zoe Fleischmann, Shuoguo Wang, Karthikeyan Murugesan, Bernard J. Fendler, Jason Hughes, et al. (2023). Pan-Cancer Analysis of Copy-Number Features Identifies Recurrent Signatures and a Homologous Recombination Deficiency Biomarker to Predict Poly (ADP-Ribose) Polymerase Inhibitor Response . JCO Precision Oncology.

Radwa Sharaf, Smruthy Sivakumar, Jay A. Moore, Meagan Montesion, Douglas I. Lin, Caterina I. Colón, Zoe Fleishmann, Ericka M. Ebot, Justin Y. Newberg, Jennifer M. Mills, et al. (2023). Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation . Cancer Discovery.

Radwa Sharaf, Elmira Esmaeilzadeh, Behzad Etemad, Christy L. Lavine, Lauren Garneau, Yijia Li, James Regan, Colline Wong, Elizabeth Connick, Paul Volberding, et al. (2023). Autologous neutralizing antibodies increase with early antiretroviral therapy and shape HIV rebound after treatment interruption . Science Translational Medicine.

Radwa Sharaf, Michel M. Ouellette, Garrett M. Frampton, Lee A. Albacker (2022). Mutations in the TERC template sequence can be incorporated into the telomeres of human tumors . PLOS ONE.

Radwa Sharaf, Karthikeyan Murugesan, Meagan Montesion, Jay A. Moore, James Pao, Dean C. Pavlick, Garrett M. Frampton, Vivek A. Upadhyay, Brian M. Alexander, Vincent A. Miller, et al.(2021). Genomic Profiling of Combined Hepatocellular Cholangiocarcinoma Reveals Genomics Similar to Either Hepatocellular Carcinoma or Cholangiocarcinoma . JCO Precision Oncology. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1285--1296. American Society of Clinical Oncology ({ASCO})

Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Nature Communications.

Radwa Sharaf, Meagan Montesion, Karthikeyan Murugesan, Dexter X. Jin, Nora Sanchez, Ameet Guria, Max Minker, Gerald Li, Virginia Fisher, Ethan S. Sokol, et al.(2021). Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response . Cancer Discovery. 11. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 282--292. American Association for Cancer Research ({AACR})

Radwa Sharaf, Dean C Pavlick, Garrett M Frampton, Maureen Cooper, Jacqueline Jenkins, Natalie Danziger, James Haberberger, Brian M Alexander, Timothy Cloughesy, William H Yong, et al.(2021). FoundationOne CDx testing accurately determines whole arm 1p19q codeletion status in gliomas . Neuro-Oncology Advances. 3. (1). Oxford University Press ({OUP})

(2020). Mechanisms and therapeutic implications of hypermutation in gliomas . Nature.

Radwa Sharaf, Kevin B. Einkauf, Guinevere Q. Lee, Ce Gao, Xiaoming Sun, Stephane Hua, Samantha M.Y. Chen, Chenyang Jiang, Xiaodong Lian, Fatema Z. Chowdhury, et al.(2019). Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy . Journal of Clinical Investigation. American Society for Clinical Investigation

(2019). HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission . Cell host & microbe.

(2018). The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies . The Journal of infectious diseases.

Sharaf R, Lee GQ, Sun X, Etemad B, Aboukhater LM, Hu Z, Brumme ZL, Aga E, Bosch RJ, Wen Y, et al.(2018). HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers . The Journal of clinical investigation.

Strongin Z, Sharaf R, VanBelzen DJ, Jacobson JM, Connick E, Volberding P, Skiest DJ, Gandhi RT, Kuritzkes DR, O&#39;Doherty U, et al.(2018). Effect of Short-Term Antiretroviral Therapy Interruption on Levels of Integrated HIV DNA . Journal of virology.

Sharaf RR, Li JZ(2017). The Alphabet Soup of HIV Reservoir Markers . Current HIV/AIDS reports.

Sharaf R, Mempel TR, Murooka TT(2016). Visualizing the Behavior of HIV-Infected T Cells In Vivo Using Multiphoton Intravital Microscopy . Methods in molecular biology (Clifton, N.J.).

Murooka TT, Sharaf RR, Mempel TR(2015). Large Syncytia in Lymph Nodes Induced by CCR5-Tropic HIV-1 . AIDS research and human retroviruses.

Schmueck-Henneresse M, Sharaf R, Vogt K, Weist BJ, Landwehr-Kenzel S, Fuehrer H, Jurisch A, Babel N, Rooney CM, Reinke P, et al.(2015). Peripheral blood-derived virus-specific memory stem T cells mature to functional effector memory subsets with self-renewal potency . Journal of immunology (Baltimore, Md. : 1950).

Aziz RK, Khalifa MM, Sharaf RR(2013). Contaminated water as a source of Helicobacter pylori infection: A review . Journal of advanced research.

Khalifa MM, Sharaf RR, Aziz RK(2010). Helicobacter pylori: a poor man's gut pathogen? . Gut pathogens.