プロフィール詳細

プロジェクトを作成

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Ramya Y.に依頼

United States

In-silico protein design, Strcutural bioinformatics, Ab, sc-Fv. sc-Fab optimize, Immuno & gene therapy, viral protein

プロフィール概要

Accomplished protein engineer and bioinformatician with 13+ years of industrial R&D experience in immuno- oncology, monoclonal antibodies, CAR-T engineering, viral envelope engineering, and vaccine design. Proven track record of innovation with multiple granted patents and contributions to therapeutic discovery platforms. Expertise in rational protein design, structural analysis, and computational biology to drive high-impact research in gene therapy and cancer immunotherapies. • Therapeutic Modalities: Engineered CAR-T constructs, viral vectors (lentiviral/paramyxovirus), antibody humanization, and novel biologics (IL-12, Bispecific, kill switches). • Protein & Antibody Engineering: Designed and optimized antigen-binding domains, CAR-T signaling components, and epitope-grafted scaffolds for enhanced efficacy. • Computational & Structural Biology: Applied AI/ML (Rosetta, R-studio), homology modeling (AlphaFold, PyMOL), and docking studies for protein design and stability prediction. • Vaccine & Gene Therapy: Co-invented HPV/HBV vaccines and improved viral vector tropism for in vivo CAR-T delivery. • Cross-Functional Leadership: Collaborated with software teams to develop bioinformatics tools and mentored junior scientists. Bridged computational/experimental teams to iteratively refine protein designs.

専門分野

• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Biologic & Biosimilar Development
• ☆ Drug-Drug Interactions
• ☆ Investigational New Drug (IND) Application Consulting
• ☆ Vaccine Development
• ☆ Immunotherapy
• ☆ Gene Therapy
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Fact Checking
• ☆ Literature Search
• ☆ Gap Analysis
• ☆ Gray Literature Search

サービス

• Research
• Consulting
• Data & AI

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling

職務経験

Protein design consultant

VyteK

1月 2024 - 現在

Senior Scientist

Exuma Bio

6月 2020 - 4月 2024

Research Scientist and Scientist

Precigen

5月 2010 - 5月 2020

学歴

Master of Science in Bioinformatics

Saint Joseph's University - United States

1月 2008 - 5月 2010

認定資格

• 認定資格の詳細は未入力です。

出版物

OTHER

Yarlagadda, Ramya, Brough, Douglas E, BOLINGER, Cheryl G, KURELLA, Vinodhbabu, Ponraj, Prabakaran, METENOU, Simon, Ding, Kuan-Fu(2025). Hepatitis b vaccines and uses of the same.

Yarlagadda, Ramya, Brough, Douglas E, BOLINGER, Cheryl G, KURELLA, Vinodhbabu, Ponraj, Prabakaran, METENOU, Simon, Ding, Kuan-Fu(2025). Hepatitis B vaccines and uses of the same.

Yarlagadda, Ramya, Shah, Rutul, Emtage, Peter(2024). Expression of novel cell tags. Google Patents

Yarlagadda, Ramya, Brough, Douglas E, BOLINGER, Cheryl, KURELLA, Vinodhbabu, Ponraj, Prabakaran, METENOU, Simon, Ding, Kuan-Fu(2024). Human papillomavirus vaccines and uses of the same.

Yarlagadda, Ramya, Shah, Rutul, Chan, Tim, Emtage, Peter(2024). Cd33 specific chimeric antigen receptors. Google Patents

Yarlagadda, Ramya, Shah, Rutul, Emtage, Peter(2024). Expression of novel cell tags. Google Patents

Yarlagadda, Ramya, Shah, Rutul, Chan, Tim, Emtage, Peter(2023). CD33 specific chimeric antigen receptors. Google Patents

Yarlagadda, Ramya, Brough, Douglas E, BOLINGER, Cheryl G, KURELLA, Vinodhbabu, Ponraj, Prabakaran, METENOU, Simon, Ding, Kuan-Fu(2023). Hepatitis B vaccines and uses of the same.

Yarlagadda, Ramya, Shah, Rutul, Emtage, Peter(2021). Expression of novel cell tags. Google Patents

Yarlagadda, Ramya, Brough, Douglas E, BOLINGER, Cheryl G, KURELLA, Vinodhbabu, PRABAKARAN, Ponraj, METENOU, Simon, Ding, Kuan-Fu(2021). Human papillomavirus vaccines and uses of the same.

YARLAGADDA, Ramya, Chan, Tim, Emtage, Peter, others(2017). Cd33 specific chimeric antigen receptors. Google Patents

Yarlagadda, Ramya, Reed, Charles, STEWART, Charles Andrew, Emtage, Peter, Shah, Rutul, Chan, Timothy(2017). Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12. Google Patents

JOURNAL ARTICLE

Gattinger, Pia, Kozlovskaya, Luibov I, Lunin, Alexander S, Gancharova, Olga S, Sirazova, Dina I, Apolokhov, Vasiliy D, Chekina, Egor S, Gordeychuk, Ilya V, Karaulov, Alexander V, Valenta, Rudolf, et al.(2025). Fusion protein-based COVID-19 vaccines exemplified by a chimeric vaccine based on a single fusion protein (W-PreS-O). Frontiers in Immunology. 16. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1452814. Frontiers Media SA

Oliveira, Jamille Ramos, Ruiz, Cesar Manuel Remuzgo, Machado, Rafael Rahal Guaragna, Magawa, Jhosiene Yukari, Daher, Isabela Pazotti, Urbanski, Alysson Henrique, Schmitz, Gabriela Justamante Händel, Arcuri, Helen Andrade, Ferreira, Marcelo Alves, Sasahara, Greyce Luri, et al.(2023). Immunodominant antibody responses directed to SARS-CoV-2 hotspot mutation sites and risk of immune escape. Frontiers in Immunology. 13. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1010105. Frontiers Media SA

Vigant, Frederic, Kundu, Anirban, Zhang, Dongming, Zhang, Wei, Jaruga-Killeen, Ewa, Andraza, Michelle, Schreiber, Gregory, Kerner, Alissa, Zhang, Junyi, Henkelman, John, et al.(2022). In vivo delivery of a novel CD3-targeted lentiviral vector generates CD19 CAR-T cells in two different humanized mouse models and results in complete B cell depletion. Cancer Research. 82. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3294. The American Association for Cancer Research

Zhong, Xiaotian, D’Antona, Aaron M(2022). A potential antibody repertoire diversification mechanism through tyrosine sulfation for biotherapeutics engineering and production. Frontiers in Immunology. 13. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1072702. Frontiers Media SA

D’Angelo, Sara, Ferrara, Fortunato, Naranjo, Leslie, Erasmus, M Frank, Hraber, Peter, Bradbury, Andrew RM(2018). Many routes to an antibody heavy-chain CDR3: necessary, yet insufficient, for specific binding. Frontiers in immunology. 9. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 395. Frontiers Media SA

Yarlagadda, Ramya, Jia, Lei, Reed, Charles C(2015). Structure based thermostability prediction models for protein single point mutations with machine learning tools. PloS one. 10. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e0138022. Public Library of Science San Francisco, CA USA

CONFERENCE PAPER

Yarlagadda, Ramya, Vigant, Frederic, Kundu, Ani, Gowan, Cody, Betts, Michael, Kato, Jonathan, Soares, Renata, Ponce, Alan, Liu, Lintao, Zhang, Junyi, et al.(2023). In vivo delivery of CD3-directed CD19-CAR lentivectors leads to the generation of CAR T and NK-like (CAR-TaNK) cells capable of complete ablation of B cells in the blood, bone marrow, and tissue of NSG-SGM3 CD34+ humanized mice. Cancer Research. 83. (7).