プロフィール詳細

プロジェクトを作成

★★★★★

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★★★★★

☆☆☆☆☆

Dr. Robin C.に依頼

Singapore

Biomedical Data Analytics & Research Consultant | AI, Multiomics, Study Design & Scientific Writing

プロフィール概要

Biochemist and data scientist with 15+ years of experience in biomedical research and AI-driven data analysis. I help researchers extract insights from omics, clinical, and public datasets using machine learning, survival models, and statistical pipelines.

専門分野

• ☆ Computational Biology
• ☆ Biostatistics
• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Omics
• ☆ Transcriptomics
• ☆ Lipidomics
• ☆ Proteomics
• ☆ Metabolomics
• ☆ Neuroscience
• ☆ Molecular Neuroscience
• ☆ Data Analysis
• ☆ Data Processing
• ☆ Data Exploration
• ☆ Big Data Analytics
• ☆ Machine Learning
• ☆ Data Mining
• ☆ Artificial Intelligence
• ☆ Biomarker Discovery

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing, Technical Writing, Copywriting, General Proofreading & Editing

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling, Big Data Analytics, Text Mining & Analytics, Data Mining, Data Insights

職務経験

Chief Scientist

AliveX Biotech

10月 2021 - 3月 2025

Director Of Business Development

My-Biomed Biotechnology Co

4月 2020 - 9月 2021

Assistant Professor

Columbia University Medical Center

9月 2009 - 6月 2016

Assistant Professor/Director of Lipidomics Lab

Columbia University Medical Center

8月 2009 - 6月 2016

学歴

PhD, Biochemistry

National University of Singapore

8月 2004 - 12月 2008

BSc (Hons)

National University of Singapore

8月 2000 - 5月 2004

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

An F, Ge Y, Ye W, Ji L, Chen K, Wang Y, Zhang X, Dong S, Shen Y, Zhao J, et al. (2024). Machine learning identifies a 5-serum cytokine panel for the early detection of chronic atrophy gastritis patients . Cancer biomarkers : section A of Disease markers.

Yu Z, Yang Y, Chan RB, Shi M, Stewart T, Huang Y, Liu Z, Lan G, Sheng L, Tian C, et al. (2023). GV-971 attenuates α-Synuclein aggregation and related pathology . CNS neuroscience & therapeutics.

Chen J, Amaury Cazenave-Gassiot, Xu Y, Piroli P, Hwang R Jr, DeFreitas L, Chan RB, Gilbert Di Paolo, Nandakumar R, Wenk MR, et al. (2023). Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate . Communications biology.

Ikjae Lee, Stingone JA, Chan RB, Mitsumoto H (2023). Utilizing machine learning and lipidomics to distinguish primary lateral sclerosis from amyotrophic lateral sclerosis . Muscle & nerve.

André Miranda, Ashok A, Chan RB, Zhou B, Xu Y, McIntire LB, Estela Area Gomez, Di Paolo G, Karen E Duff, Tiago Gil Oliveira, et al. (2022). Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice . Translational psychiatry.

Liu Z, Chan RB, Cai Z, Liu X, Wu Y, Yu Z, Feng T, Ying Yang, Jing Zhang (2022). α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson's disease . Journal of neuroinflammation.

Lan G, Wang P, Chan RB, Liu Z, Yu Z, Liu X, Ying Yang, Zhang J (2021). Astrocytic VEGFA: An essential mediator in blood-brain-barrier disruption in Parkinson's disease . Glia.

Estela Area Gomez, Larrea D, Yun T, Xu Y, Hupf J, Zandkarimi F, Chan RB, Mitsumoto H (2021). Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders . Scientific reports.

Santa-Marinha L, Castanho I, Silva RR, Bravo FV, Miranda AM, Torcato Meira, Morais-Ribeiro R, Marques F, Xu Y, Point du Jour K, et al. (2020). Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning . Cell reports.

Iaea DB, Zachary Spahr, Singh RK, Chan RB, Bowen Zhou, Bareja R, Elemento O, Di Paolo G, Zhang X, Maxfield FR (2020). Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis . Biochimica et biophysica acta. Molecular and cell biology of lipids.

André Miranda, Bravo FV, Chan RB, Sousa N, Di Paolo G, Tiago Gil Oliveira (2019). Differential lipid composition and regulation along the hippocampal longitudinal axis . Translational psychiatry.

Evan Quon, Sere YY, Neha Chauhan, Johansen J, David P Sullivan, Dittman JS, William Rice, Chan RB, Di Paolo G, Christopher Beh, et al. (2018). Endoplasmic reticulum-plasma membrane contact sites integrate sterol and phospholipid regulation . PLoS biology.

Bravo FV, Jorge Diogo Da Silva, Chan RB, Di Paolo G, Andreia Teixeira-Castro, Tiago Gil Oliveira (2018). Phospholipase D functional ablation has a protective effect in an Alzheimer's disease Caenorhabditis elegans model . Scientific reports.

André Miranda, Lasiecka ZM, Xu Y, Neufeld J, Sanjid Shahriar, Simoes S, Chan RB, Tiago Gil Oliveira, Small SA, Di Paolo G (2018). Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures . Nature communications.

Shen Y, Zhilun Zhao, Zhang L, Lingyan Shi or L. Shi, Sanjid Shahriar, Chan RB, Di Paolo G, Min W (2017). Metabolic activity induces membrane phase separation in endoplasmic reticulum . Proceedings of the National Academy of Sciences of the United States of America.

Marta Pera, Larrea D, Cristina Guardia-Laguarta, Jorge Montesinos, Velasco KR, Rishi R Agrawal, Xu Y, Chan RB, Di Paolo G, Mehler MF, et al. (2017). Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease . The EMBO journal.

Guedes LC, Chan RB, Marcos Gomes, Conceição VA, Machado RB, Soares T, Xu Y, Gaspar P, Joao Andre Carrico, Alcalay RN, et al. (2017). Serum lipid alterations in GBA-associated Parkinson's disease . Parkinsonism & related disorders.

Bertaggia E, Jensen KK, Castro-Perez J, Xu Y, Di Paolo G, Chan RB, Wang L, Rebecca Haeusler (2017). <i>Cyp8b1</i> ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption . American journal of physiology. Endocrinology and metabolism.

Chan RB, Perotte AJ, Bowen Zhou, Liong C, Shorr EJ, Marder KS, Un Jung Kang, Waters CH, Levy OA, Xu Y, et al. (2017). Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis . PloS one.

Petter Holland, Kn&#230;velsrud H, S&#248;reng K, Mathai BJ, Lystad AH, Serhiy Pankiv, Bj&#248;rndal GT, Schultz SW, Viola Lobert, Chan RB, et al. (2016). HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels . Nature communications.

Donna Conlon, Thomas T, Fedotova T, Antonio Hernandez-Ono, Di Paolo G, Chan RB, Kelly V. Ruggles, Gibeley S, Liu J, Ginsberg HN (2016). Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis . The Journal of clinical investigation.

Tulodziecka K, Barbara Diaz-Rohrer, Farley MM, Chan RB, Di Paolo G, Levental KR, M. Neal Waxham, Levental I (2016). Remodeling of the postsynaptic plasma membrane during neural development . Molecular biology of the cell.

Hsieh J, Koseki M, Matthew M Molusky, Yakushiji E, Ichi I, Marit Westerterp, Jahangir Iqbal, Chan RB, Abramowicz S, Tascau L, et al. (2016). TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis . Nature.

Marquer C, Tian H, Yi J, Bastien J, Dall&#39;Armi C, Yang-Klingler Y, Bowen Zhou, Chan RB, Di Paolo G (2016). Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism . Nature communications.

Mitchell E, Klein SL, Argyropoulos KV, Ali Sharma, Chan RB, Toth JG, Barboza L, Charlotte Bavley, Analia Bortolozzi Biassoni, Chen Q, et al. (2016). Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms . Nature communications.

Jason D Vevea, Enrique J Garcia, Chan RB, Bowen Zhou, Schultz M, Di Paolo G, McCaffery JM, Pon LA (2015). Role for Lipid Droplet Biogenesis and Microlipophagy in Adaptation to Lipid Imbalance in Yeast . Developmental cell.

Agarwal S, Kim H, Chan RB, Williamson R, Cho W, Paolo GD, Satchell KJ (2015). Autophagy and endosomal trafficking inhibition by Vibrio cholerae MARTX toxin phosphatidylinositol-3-phosphate-specific phospholipase A1 activity . Nature communications.

Gulati S, Ekland EH, Kelly V. Ruggles, Chan RB, Jayabalasingham B, Bowen Zhou, Pierre-Yves Mantel, Marcus Lee, Spottiswoode N, Coburn-Flynn O, et al. (2015). Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum . Cell host & microbe.

Sarvenaz Sarabipour, Chan RB, Bowen Zhou, Di Paolo G, Hristova K (2015). Analytical characterization of plasma membrane-derived vesicles produced via osmotic and chemical vesiculation . Biochimica et biophysica acta.

Kett LR, Barbara Stiller, Bernath MM, Tasset I, Blesa J, Jackson-Lewis V, Chan RB, Bowen Zhou, Di Paolo G, Przedborski S, et al. (2015). α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2 . The Journal of neuroscience : the official journal of the Society for Neuroscience.

Tiago Gil Oliveira, Chan RB, Bravo FV, Andr&#233; Miranda, Silva RR, Bowen Zhou, Fernanda Marques, V&#237;tor Pinto, Joao Cerqueira, Di Paolo G, et al. (2015). The impact of chronic stress on the rat brain lipidome . Molecular psychiatry.

Etienne MOREL, Chamoun Z, Lasiecka ZM, Chan RB, Williamson RL, Vetanovetz C, Dall&#39;Armi C, Simoes S, Point Du Jour KS, Brian D. McCabe, et al. (2013). Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system . Nature communications.

Chan RB, Di Paolo G (2012). Knockout punch: cardiolipin oxidation in trauma . Nature neuroscience.

Roach AN, Wang Z, Wu P, Zhang F, Chan RB, Yonekubo Y, Di Paolo G, Gorfe AA, Guangwei Du (2012). Phosphatidic acid regulation of PIPKI is critical for actin cytoskeletal reorganization . Journal of lipid research.

MAGALI DUMONT, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, Calingasan NY, Yang L, Davide Tampellini, Anatoly A Starkov, et al. (2012). Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice . Human molecular genetics.

Chan RB, Tiago Gil Oliveira, Cortes EP, Honig LS, Karen E Duff, Small SA, Wenk MR, Guanghou Shui, Di Paolo G (2011). Comparative lipidomic analysis of mouse and human brain with Alzheimer disease . The Journal of biological chemistry.

Chang-Ileto B, Frere SG, Chan RB, Voronov SV, Aurelien Roux, Di Paolo G (2011). Synaptojanin 1-mediated PI(4,5)P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission . Developmental cell.

Tiago Gil Oliveira, Chan RB, Tian H, Mikael Laredo, Guanghou Shui, Staniszewski A, Zhang H, Wang L, Kim TW, Karen E Duff, et al. (2010). Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits . The Journal of neuroscience : the official journal of the Society for Neuroscience.

Chan RB, Tanner L, Wenk MR (2010). Implications for lipids during replication of enveloped viruses . Chemistry and physics of lipids.

Dall&#39;Armi C, Andres Hurtado-Lorenzo, Tian H, Etienne MOREL, Nezu A, Chan RB, Wai Haung Yu, Robinson KS, Yeku O, Small SA, et al. (2010). The phospholipase D1 pathway modulates macroautophagy . Nature communications.

Yeo DS, Chan R, Brown G, Ying L, Richard Sutejo, Aitken J, Boon Huan Tan, Wenk MR, Sugrue RJ (2009). Evidence that selective changes in the lipid composition of raft-membranes occur during respiratory syncytial virus infection . Virology.

Chan R, Pradeep Uchil, Jing Jin, Guanghou Shui, Ott DE, Mothes W, Wenk MR (2008). Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides . Journal of virology.