プロフィール詳細

プロジェクトを作成

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Dr. Roland J.W. M.に依頼

Netherlands

(Bio)analytical scientist BMV & Development | Expert in Bioanalysis with 10+ years of experience. Editor-in-Chief.

プロフィール概要

Passionate bioanalytical scientist and academic scholar with many years of hands-on experience in translational clinical research. Academic background as an analytical/bioanalytical chemist with a strong interest in applied clinical pharmacological translational research. Specific interest in metabolomics, proteomics, pharmacology, clinical chemistry and toxicology, and bioanalytical chemistry. Highly experienced with sophisticated techniques like LC-ESI-MS/(MS), GC-MS/(MS), MALDI-MS and LC-HR-MS systems.

専門分野

• ★ Chemistry
• ★ Analytical Chemistry
• ★ Applied Statistics
• ☆ Mass Spectrometry
• ☆ Liquid Chromatography/HPLC
• ☆ Gas Chromatography
• ☆ Molecular Biology
• ☆ Omics
• ☆ Metabolomics
• ☆ Statistics
• ☆ Regression Analysis
• ☆ Environmental Chemistry
• ☆ Stable Isotope Analysis
• ☆ Educational Statistics

サービス

• Writing
• Research
• Data & AI

Writing Technical Writing

Research Gray Literature Search, Systematic Literature Review

職務経験

Scientist II / Senior Scientist

Lonza Netherlands BV

12月 2020 - 現在

Sr. Scientist & Team Lead Bioanalytical Method Development and Validation

MLM Medical Labs GmbH

1月 2018 - 現在

学歴

Ph.D

Bioanalytical Chemistry/Clinical chemistry

2月 2008 - 11月 2011

M.Sc

Natural and Environmental Sciences

8月 2004 - 7月 2006

B.Sc.

Natural and Environmental Sciences

8月 2001 - 7月 2004

B.Sc

Analytical Chemistry

8月 1990 - 7月 1994

認定資格

• 20.373x: Making a Cell Therapy: Principles and Practice of Manufacturing

  MITx

  https://courses.edx.org/certificates/b03273283b044b2ead669a235ed577f9

  4月 2022 - 現在

出版物

JOURNAL ARTICLE

Roland JW Meesters (2019). Welcome to the fifth Volume of Journal of Applied Bioanalysis . Journal of Applied Bioanalysis.

(2018). Urinary metabolite and lipid alterations in Colombian Hispanic women with breast cancer: A pilot study . Journal of Pharmaceutical and Biomedical Analysis.

Mónica P. Cala, Tone Frost Bathen, Julian Aldana, Jessica Medina, Julián Sánchez, José Guio, Julien Wist, Roland J. W. Meesters (2018). Multiplatform plasma metabolic and lipid fingerprinting of breast cancer: A pilot control-case study in Colombian Hispanic women . PLOS ONE.

Roland JW Meesters (2018). Welcome to the fourth volume of the Journal of Applied Bioanalysis . Journal of Applied Bioanalysis.

Roland JW Meesters(2017). Welcome to the third volume of Journal of Applied Bioanalysis . Journal of Applied Bioanalysis. 3. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--4. Betasciencepress Publishing

(2016). First anniversary of the Journal of Applied Bioanalysis . Journal of Applied Bioanalysis.

(2016). Bioanalytical evaluation of dried plasma spot microsampling methodologies in pharmacokinetic studies applying Acetaminophen as model drug . Journal of Applied Bioanalysis.

(2016). Bioanalytical evaluation of dried plasma spot microsampling methodologies in pharmacokinetic studies applying Acetaminophen as model drug . Journal of Applied Bioanalysis.

(2015). Welcome from the Journal of Applied Bioanalysis . Journal of Applied Bioanalysis.

(2015). Ghent Symposium on Alternative Sampling Strategies in Toxicology and Therapeutic Drug Monitoring . Journal of Applied Bioanalysis.

van der Vries, E., Stittelaar, K.J., van Amerongen, G., Veldhuis Kroeze, E.J.B., de Waal, L., Fraaij, P.L.A., Meesters, R.J., Luider, T.M., van der Nagel, B., Koch, B., et al.(2013). Prolonged Influenza Virus Shedding and Emergence of Antiviral Resistance in Immunocompromised Patients and Ferrets . PLoS Pathogens. 9. (5).

van Velzen, M., Missotten, T., van Loenen, F.B., Meesters, R.J.W., Luider, T.M., Baarsma, G.S., Osterhaus, A.D.M.E., Verjans, G.M.G.M.(2013). Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients . Journal of Clinical Virology. 57. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 215-221.

Meesters, R.J.(2013). Bioanalytical LC separation techniques for quantitative analysis of free amino acids in human plasma . Bioanalysis. 5. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 495-512.

Baarsma, G. S., Luider, T. M., Meesters, R. J., Missotten, T., Osterhaus, A. D., Verjans, G. M., van Loenen, F. B., van Velzen, M.(2013). Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients . J Clin Virol. 57. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 215-21.

Meesters, R.J.W., Hooff, G.P.(2013). State-of-the-art dried blood spot analysis: An overview of recent advances and future trends . Bioanalysis. 5. (17). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2187-2208.

Den Boer, E., Meesters, R.J.W., Van Zelst, B.D., Luider, T.M., Hazes, J.M.W., Heil, S.G., De Jonge, R.(2013). Measuring methotrexate polyglutamates in red blood cells: A new LC-MS/MS-based method . Analytical and Bioanalytical Chemistry. 405. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1673-1681.

Meesters, R. J., Hooff, G. P.(2013). State-of-the-art dried blood spot analysis: an overview of recent advances and future trends . Bioanalysis. 5. (17). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2187-208.

Hazes, J. M. W., Heil, S. G., Luider, T. M., Meesters, R. J. W., de Jonge, R., den Boer, E., van Zelst, B. D.(2013). Measuring methotrexate polyglutamates in red blood cells: a new LC-MS/MS-based method . Analytical and Bioanalytical Chemistry. 405. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1673-1681.

Rincón, J. P., Meesters, R. J.(2013). Evaluation of peripheral blood microsampling techniques in combination with liquid chromatography-high resolution mass spectrometry for the determination of drug pharmacokinetics in clinical studies . Drug Test Anal.

Hooff, G.P., Van Kampen, J.J.A., Meesters, R.J.W., Van Belkum, A., Goessens, W.H.F., Luider, T.M.(2012). Characterization of β-lactamase enzyme activity in bacterial lysates using MALDI-mass spectrometry . Journal of Proteome Research. 11. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 79-84.

Goessens, Wil H. F., Hooff, Gero P., Luider, Theo M., Meesters, Roland J. W., van Belkum, Alex, van Kampen, Jeroen J. A.(2012). Characterization of beta-Lactamase Enzyme Activity in Bacterial Lysates using MALDI-Mass Spectrometry . Journal of Proteome Research. 11. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 79-84.

Van Velzen, M., Van Loenen, F.B., Meesters, R.J.W., De Graaf, M., Remeijer, L., Luider, T.M., Osterhaus, A.D.M.E., Verjans, G.M.G.M.(2012). Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals . Journal of Infectious Diseases. 205. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1539-1543.

Den Boer, E., Heil, S.G., Van Zelst, B.D., Meesters, R.J.W., Koch, B.C.P., Te Winkel, M.L., Van Den Heuvel-Eibrink, M.M., Luider, T.M., De Jonge, R.(2012). A U-HPLC-ESI-MS/MS-based stable isotope dilution method for the detection and quantitation of methotrexate in plasma . Therapeutic Drug Monitoring. 34. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 432-439.

Meesters, R.J., Zhang, J., Van Huizen, N.A., Hooff, G.P., Gruters, R.A., Luider, T.M.(2012). Dried matrix on paper disks: The next generation DBS microsampling technique for managing the hematocrit effect in DBS analysis . Bioanalysis. 4. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2027-2035.

Heil, S. G., Koch, B. C. P., Luider, T. M., Meesters, R. J. W., de Jonge, R., den Boer, E., te Winkel, M. L., van Zelst, B. D., van den Heuvel-Eibrink, M. M., Heil, S. G., et al.(2012). A U-HPLC-ESI-MS/MS-Based Stable Isotope Dilution Method for the Detection and Quantitation of Methotrexate in Plasma . Therapeutic Drug Monitoring. 34. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 432-439.

Stoop, M.P., Rosenling, T., Attali, A., Meesters, R.J.W., Stingl, C., Dekker, L.J., Van Aken, H., Suidgeest, E., Hintzen, R.Q., Tuinstra, T., et al.(2012). Minocycline effects on the cerebrospinal fluid proteome of experimental autoimmune encephalomyelitis rats . Journal of Proteome Research. 11. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4315-4325.

Meesters, R.J.W., Hooff, G.P., Gruters, R., Van Kampen, J.J.A., Luider, T.M., Meesters, R.J.W., Hooff, G.P., Gruters, R., Van Kampen, J.J.A., Luider, T.M.(2012). Incurred sample reanalysis comparison of dried blood spots and plasma samples on the measurement of lopinavir in clinical samples . Bioanalysis. 4. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 237-240.

Lindemans, Jan, Luider, Theo M., Meesters, Roland J. W., de Jonge, Robert, den Boer, Ethan, Lindemans, Jan, Luider, Theo M., Meesters, Roland J. W., de Jonge, Robert, den Boer, Ethan(2011). Assessment of intracellular methotrexate and methotrexate-polyglutamate metabolite concentrations in erythrocytes by ultrafast matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry . Rapid Communications in Mass Spectrometry. 25. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3063-3070.

Lindemans, Jan, Luider, Theo M., Mathot, Ron A. A., Meestersy, Roland J. W., de Jonge, Robert, den Boer, Ethan, van Klaveren, Rob J., Lindemans, Jan, Luider, Theo M., Mathot, Ron A. A., et al.(2011). Ultrafast selective quantification of methotrexate in human plasma by high-throughput MALDI-isotope dilution mass spectrometry . Bioanalysis. 3. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1369-1378.

Meesters, R.J.W., Van Kampen, J.J.A., Scheuer, R.D., Van Der Ende, M.E., Gruters, R.A., Luider, T.M.(2011). Determination of the antiretroviral drug tenofovir in plasma from HIV-infected adults by ultrafast isotope dilution MALDI-triple quadrupole tandem mass spectrometry . Journal of Mass Spectrometry. 46. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 282-289.

Gruters, Rob, Hooff, Gero, Luider, Theo, Meesters, Roland, van Huizen, Nick(2011). Impact of internal standard addition on dried blood spot analysis in bioanalytical method development . Bioanalysis. 3. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2357-2364.

Meesters, R., Hooff, G., Van Huizen, N., Gruters, R., Luider, T.(2011). Impact of internal standard addition on dried blood spot analysis in bioanalytical method development . Bioanalysis. 3. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2357-2364.

Hooff, G.P., Meesters, R.J.W., Van Kampen, J.J.A., Van Huizen, N.A., Koch, B., Al Hadithy, A.F.Y., Van Gelder, T., Osterhaus, A.D.M.E., Gruters, R.A., Luider, T.M.(2011). Dried blood spot UHPLC-MS/MS analysis of oseltamivir and oseltamivircarboxylate-a validated assay for the clinic . Analytical and Bioanalytical Chemistry. 400. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3473-3479.

Meesters, R.J.W., Den Boer, E., Mathot, R.A.A., De Jonge, R., Van Klaveren, R.J., Lindemans, J., Luider, T.M.(2011). Ultrafast selective quantification of methotrexate in human plasma by high-throughput MALDI-isotope dilution mass spectrometry . Bioanalysis. 3. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1369-1378.

Meesters, R.J.W., Den Boer, E., De Jonge, R., Lindemans, J., Luider, T.M.(2011). Assessment of intracellular methotrexate and methotrexate-polyglutamate metabolite concentrations in erythrocytes by ultrafast matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry . Rapid Communications in Mass Spectrometry. 25. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3063-3070.

Hooff, G.P., van Huizen, N.A., Meesters, R.J.W., Zijlstra, E.E., Abdelraheem, M., Abdelraheem, W., Hamdouk, M., Lindemans, J., Luider, T.M.(2011). Analytical investigations of toxic p-phenylenediamine (PPD) levels in clinical urine samples with special focus on MALDI-MS/MS . PLoS ONE. 6. (8).

Meesters, R.J.W., Van Kampen, J.J.A., Reedijk, M.L., Scheuer, R.D., Dekker, L.J.M., Burger, D.M., Hartwig, N.G., Osterhaus, A.D.M.E., Luider, T.M., Gruters, R.A., et al.(2010). Ultrafast and high-throughput mass spectrometric assay for therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots . Analytical and Bioanalytical Chemistry. 398. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 319-328.

Meesters, R.J.W., Cornelissen, R., Van Klaveren, R.J., De Jonge, R., Den Boer, E., Lindemans, J., Luider, T.M.(2010). A new ultrafast and high-throughput mass spectrometric approach for the therapeutic drug monitoring of the multi-targeted anti-folate pemetrexed in plasma from lung cancer patients . Analytical and Bioanalytical Chemistry. 398. (7-8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2943-2948.

Meesters, R.J.W., Wolfe, R.R., Deutz, N.E.P.(2009). Application of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the analysis of stable isotope enrichments of phenylalanine and tyrosine . Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 877. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 43-49.

Meesters, R.J.W., Duisken, M., Hollender, J.(2009). Cytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: Indication for the formation of a reactive allergenic intermediate? . Xenobiotica. 39. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 663-671.

Meesters, R.J.W., Duisken, M., Jähnigen, H., Hollender, J., Meesters, R.J.W., Duisken, M., Jähnigen, H., Hollender, J.(2008). Sensitive determination of monoterpene alcohols in urine by HPLC-FLD combined with ESI-MS detection after online-solid phase extraction of the monoterpene-coumarincarbamate derivates . Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 875. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 444-450.

Corvini, P.F.X., Meesters, R., Mundt, M., Schäffer, A., Schmidt, B., Schröder, H.-Fr., Verstraete, W., Vinken, R., Hollender, J.(2007). Contribution to the detection and identification of oxidation metabolites of nonylphenol in Sphingomonas sp. strain TTNP3 . Biodegradation. 18. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 233-245.

Meesters, R.J.W., Duisken, M., Hollender, J.(2007). Study on the cytochrome P450-mediated oxidative metabolism of the terpene alcohol linalool: Indication of biological epoxidation . Xenobiotica. 37. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 604-617.

Meesters, R.J.W., van Eijk, H.M.H., ten Have, G.A.M., de Graaf, A.A., Venema, K., van Rossum, B.E.J., Deutz, N.E.P.(2007). Application of liquid chromatography-mass spectrometry to measure the concentrations and study the synthesis of short chain fatty acids following stable isotope infusions . Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 854. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 57-62.

Schröder, H.Fr., Meesters, R.J.W.(2005). Stability of fluorinated surfactants in advanced oxidation processes - A follow up of degradation products using flow injection-mass spectrometry, liquid chromatography-mass spectrometry and liquid chromatography-multiple stage mass spectrometry . Journal of Chromatography A. 1082. (1 SPEC. ISS.). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 110-119.

Corvini, P.F.X., Meesters, R.J.W., Schäffer, A., Schröder, H.F., Vinken, R., Hollender, J.(2004). Degradation of a nonylphenol single isomer by Sphingomonas sp. strain TTNP3 leads to a hydroxylation-induced migration product . Applied and Environmental Microbiology. 70. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6897-6900.

Meesters, R.J.W., Schröder, H.F., Meesters, R.J.W., Schröder, H.F.(2002). Simultaneous determination of 4-nonylphenol and bisphenol A in sewage sludge . Analytical Chemistry. 74. (14). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3566-3574.

(1995). Das Verhalten von Atrazin und Simazin im Trinkwasseraufbereitungsprozess mittels Ozon und Ozon/UV. Vom Wasser.

BOOK

Meesters, R.J.W.(2015). Capillary blood collection by the finger prick practice: An alternative blood collection procedure to venipuncture . New Sampling Strategies in Toxicology and Therapeutic Drug Monitoring. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 23-34.

Meesters, R.J.W., Schröder, H.Fr.(2004). Perfluorooctane sulfonate - A quite mobile anionic anthropogenic surfactant, ubiquitously found in the environment . Water Science and Technology. 50. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 235-242.

Stehmann, A., Meesters, R.J.W., Schröder, H.F.(2004). Mass spectrometric analytical methods for the determination of endocrine disrupting chemicals (EDCs) . Water Science and Technology. 50. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 165-171.