プロフィール詳細

プロジェクトを作成

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Dr. Ryan R.に依頼

United States

Biostatistician & Associate Professor | Statistical review, survival analysis, clinical trials, R & Python

プロフィール概要

I am an Associate Professor of Bioinformatics at the Karolinska Institute with twenty years in clinical biostatistics and computational oncology. PhD in Medical Science, MBA. What I do most often: Statistical review and reviewer response. When reviewers raise methodological objections, I reanalyze the data, redo the figures, and draft the point-by-point response. Typical turnaround five days. Analysis for manuscripts and grants. Survival and time-to-event analysis, Cox regression, Kaplan-Meier, power and sample size calculations, biomarker-stratified and subgroup analyses, GWAS, multi-omic integration, machine learning applied to clinical outcomes. Study and trial design. Endpoint selection, powering, subgroup pre-specification, multiplicity handling. I have designed a Phase III protocol and served as site lead for a Phase IV trial. I have 37 peer-reviewed publications including in JAMA Neurology, Brain and Foundations of Computational Mathematics, and I taught biostatistics at Masters and PhD level. I work in R and Python. Most experienced in oncology, neurology, and autoimmune/inflammatory disorders, though the methods apply across clinical and biological research.

専門分野

• ★ Biostatistics
• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Data Analysis
• ☆ Statistics
• ☆ Applied Statistics
• ☆ Medical Statistics
• ☆ Health Data Analysis
• ☆ Bioinformatics
• ☆ Pure Mathematics
• ☆ Topology
• ☆ Biomarker Discovery
• ☆ Python
• ☆ R
• ☆ Biomarker Analysis
• ☆ Clinical Trials
• ☆ Clinical Trial Design
• ☆ Clinical Data Management
• ☆ Clinical Trials Data Analysis
• ☆ Neurology
• ☆ Precision Medicine
• ☆ Public Health
• ☆ Epidemiology
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing

サービス

• Writing

Writing Clinical Trial Documentation, Medical Writing

職務経験

Karolinska Institutet

- 現在

Karolinska University Hospital

- 現在

CEO, Founder

The Responder Lab

8月 2022 - 現在

Senior Statistical Analyst

American Heart Association

5月 2021 - 12月 2021

Co-Founder and Managing Partner

DataVerge

1月 2017 - 4月 2021

Researcher, Department of Mathematics

KTH Royal Institute of Technology

8月 2012 - 4月 2021

学歴

PhD in Medical Science (Laboratory Medicine)

Karolinska Institutet

6月 2006 - 1月 2011

International MBA

IE Business School

8月 2002 - 12月 2003

Master of Science (Material Science and Engineering)

Kungliga Tekniska Hogskolan

1月 1999 - 6月 2000

Bachelor of Science with Honors (Engineering Science and Mechanics)

Pennsylvania State University

9月 1992 - 5月 1996

認定資格

• 認定資格の詳細は未入力です。

出版物

PREPRINT

Ryan Ramanujam, Wojciech Chachólski (2024). Geometry based gene expression signatures detect cancer treatment responders in clinical trials .

JOURNAL ARTICLE

Ryan Ramanujam, Graysen Steele Boles, Jan Hillert, Helga Westerlind, Tomas Olsson, Ingrid Kockum, Ali Manouchehrinia (2023). The familial risk and heritability of multiple sclerosis and its onset phenotypes: A case–control study . Multiple Sclerosis Journal.

Ryan Ramanujam, Lars Forsberg, Tim Spelman, Pernilla Klyve, Ali Manouchehrinia, Elena Mouresan, Jiri Drahota, Dana Horakova, Hanna Joensen, Luigi Pontieri, et al. (2023). Proportion and characteristics of secondary progressive multiple sclerosis in five European registries using objective classifiers . Multiple Sclerosis Journal - Experimental, Translational and Clinical.

Ryan Ramanujam, Ali Manouchehrinia, Elaine Kingwell, Feng Zhu, Helen Tremlett, Jan Hillert (2021). A multiple sclerosis disease progression measure based on cumulative disability . Multiple Sclerosis Journal.

Ryan Ramanujam, Henri Riihimäki, Wojciech Chachólski, Jakob Theorell, Jan Hillert(2020). A topological data analysis based classification method for multiple measurements . BMC Bioinformatics. 21. (1). Springer Science and Business Media {LLC}

Ryan Ramanujam, Loes Crielaard, Andrius Kavaliunas, Tomas Olsson, Jan Hillert, Pernilla Stridh, Ingrid Kockum, Ali Manouchehrinia(2019). Factors associated with and long-term outcome of benign multiple sclerosis: a nationwide cohort study . Journal of Neurology, Neurosurgery & Psychiatry. 90. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 761--767. {BMJ}

Manouchehrinia, A, Westerlind, H, Kingwell, E, Zhu, F, Carruthers, R, Ramanujam, R, Ban, M, Glaser, A, Sawcer, S, Tremlett, H, et al. (2017). Age Related Multiple Sclerosis Severity Score: Disability ranked by age . Mult. Scler.

Link, J, Ramanujam, R, Auer, M, Ryner, M, Hässler, S, Bachelet, D, Mbogning, C, Warnke, C, Buck, D, Hyldgaard Jensen, PE, et al. (2017). Clinical practice of analysis of anti-drug antibodies against interferon beta and natalizumab in multiple sclerosis patients in Europe: A descriptive study of test results . PLoS ONE.

Kavaliunas, A, Manouchehrinia, A, Stawiarz, L, Ramanujam, R, Agholme, J, Hedström, AK, Beiki, O, Glaser, A, Hillert, J (2016). Importance of early treatment initiation in the clinical course of multiple sclerosis . Mult. Scler.

Bachelet, D, Hässler, S, Mbogning, C, Link, J, Ryner, M, Ramanujam, R, Auer, M, Hyldgaard Jensen, PE, Koch-Henriksen, N, Warnke, C, et al. (2016). Occurrence of Anti-Drug Antibodies against Interferon-Beta and Natalizumab in Multiple Sclerosis: A Collaborative Cohort Analysis . PLoS ONE.

Ramanujam, R, Hedström, AK, Manouchehrinia, A, Alfredsson, L, Olsson, T, Bottai, M, Hillert, J (2015). Effect of Smoking Cessation on Multiple Sclerosis Prognosis . JAMA Neurol.

Westerlind, H, Imrell, K, Ramanujam, R, Myhr, KM, Celius, EG, Harbo, HF, Oturai, AB, Hamsten, A, Alfredsson, L, Olsson, T, et al. (2015). Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort . Eur. J. Hum. Genet.

Warnke C, Dehmel T, Ramanujam R, Holmen C, Nordin N, Wolfram K, Leussink VI, Hartung HP, Olsson T, Kieseier BC, Neurology, 2014, vol. 83, no. 23, pp. 2153-2157 .

Westerlind H, Imrell K, Ramanujam R, Myhr KM, Celius EG, Harbo HF, Oturai AB, Hamsten A, Alfredsson L, Olsson T, Kockum I, Koski T, Hillert J, European journal of human genetics : EJHG, 2014 .

Westerlind H, Kuja-Halkola R, Ramanujam R, Hillert J, Brain : a journal of neurology, 2014, vol. 137, no. Pt 7, pp. e288 .

Engdahl E, Gustafsson R, Ramanujam R, Sundqvist E, Olsson T, Hillert J, Alfredsson L, Kockum I, Fogdell-Hahn A, Human immunology, 2014, vol. 75, no. 6, pp. 524-530 .

Westerlind H, Ramanujam R, Uvehag D, Kuja-Halkola R, Boman M, Bottai M, Lichtenstein P, Hillert J, Brain : a journal of neurology, 2014, vol. 137, no. Pt 3, pp. 770-778 .

Westerlind, H., Ramanujam, R., Uvehag, D., Kuja-Halkola, R., Boman, M., Bottai, M., Lichtenstein, P., Hillert, J.(2014). Modest familial risks for multiple sclerosis: A registry-based study of the population of Sweden . Brain. 137. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 770-778.

Westerlind, H, Ramanujam, R, Uvehag, D, Kuja-Halkola, R, Boman, M, Bottai, M, Lichtenstein, P, Hillert, J (2014). Modest familial risks for multiple sclerosis: a registry-based study of the population of Sweden . Brain.

Engdahl, E., Gustafsson, R., Ramanujam, R., Sundqvist, E., Olsson, T., Hillert, J., Alfredsson, L., Kockum, I., Fogdell-Hahn, A.(2014). HLA-A*02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 . Human Immunology. 75. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 524-530.

Engdahl, E, Gustafsson, R, Ramanujam, R, Sundqvist, E, Olsson, T, Hillert, J, Alfredsson, L, Kockum, I, Fogdell-Hahn, A (2014). HLA-A(∗)02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 . Hum. Immunol.

Westerlind, H., Imrell, K., Ramanujam, R., Myhr, K.-M., Celius, E.G., Harbo, H.F., Oturai, A.B., Hamsten, A., Alfredsson, L., Olsson, T., et al.(2014). Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort . European Journal of Human Genetics.

Westerlind, H., Kuja-Halkola, R., Ramanujam, R., Hillert, J.(2014). Reply: Shared environmental effects on multiple sclerosis susceptibility: Conflicting evidence from twin studies . Brain. 137. (7).

Westerlind, H, Kuja-Halkola, R, Ramanujam, R, Hillert, J (2014). Reply: Shared environmental effects on multiple sclerosis susceptibility: conflicting evidence from twin studies . Brain.

Warnke, C, Dehmel, T, Ramanujam, R, Holmen, C, Nordin, N, Wolfram, K, Leussink, VI, Hartung, HP, Olsson, T, Kieseier, BC (2014). Initial lymphocyte count and low BMI may affect fingolimod-induced lymphopenia . Neurology.

Warnke C, Ramanujam R, Plavina T, Bergström T, Goelz S, Subramanyam M, Kockum I, Rahbar A, Kieseier BC, Holmén C, Olsson T, Hillert J, Fogdell-Hahn A, Journal of neurology, neurosurgery, and psychiatry, 2013, vol. 84, no. 11, pp. 1199-1205 .

Warnke, C., Ramanujam, R., Plavina, T., Bergström, T., Goelz, S., Subramanyam, M., Kockum, I., Rahbar, A., Kieseier, B.C., Holmén, C., et al.(2013). Changes to anti-JCV antibody levels in a Swedish national MS cohort . Journal of Neurology, Neurosurgery and Psychiatry. 84. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1199-1205.

Warnke, C, Ramanujam, R, Plavina, T, Bergström, T, Goelz, S, Subramanyam, M, Kockum, I, Rahbar, A, Kieseier, BC, Holmén, C, et al. (2013). Changes to anti-JCV antibody levels in a Swedish national MS cohort . J. Neurol. Neurosurg. Psychiatr.

Ramanujam R, Ramanujam S, Hillert J, PloS one, 2013, vol. 8, no. 8, pp. e71614 .

Ramanujam, R., Ramanujam, S., Hillert, J.(2013). Considerations for Subgroups and Phenocopies in Complex Disease Genetics . PLoS ONE. 8. (8).

Ramanujam, R, Ramanujam, S, Hillert, J (2013). Considerations for subgroups and phenocopies in complex disease genetics . PLoS ONE.

Jungedal R, Lundkvist M, Engdahl E, Ramanujam R, Westerlind H, Sominanda A, Hillert J, Fogdell-Hahn A, Multiple sclerosis (Houndmills, Basingstoke, England), 2012, vol. 18, no. 12, pp. 1775-1781 .

Jungedal, R., Lundkvist, M., Engdahl, E., Ramanujam, R., Westerlind, H., Sominanda, A., Hillert, J., Fogdell-Hahn, A.(2012). Prevalence of anti-drug antibodies against interferon beta has decreased since routine analysis of neutralizing antibodies became clinical practice . Multiple Sclerosis. 18. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1775-1781.

Jungedal, R, Lundkvist, M, Engdahl, E, Ramanujam, R, Westerlind, H, Sominanda, A, Hillert, J, Fogdell-Hahn, A (2012). Prevalence of anti-drug antibodies against interferon beta has decreased since routine analysis of neutralizing antibodies became clinical practice . Mult. Scler.

Ramanujam R, Piehl F, Pirskanen R, Gregersen PK, Hammarström L, Journal of neuroimmunology, 2011, vol. 236, no. 1-2, pp. 118-122 .

Ramanujam R, Pirskanen R, Ramanujam S, Hammarström L, Twin research and human genetics : the official journal of the International Society for Twin Studies, 2011, vol. 14, no. 2, pp. 129-136 .

Ramanujam, R., Pirskanen, R., Ramanujam, S., Hammarström, L.(2011). Utilizing twins concordance rates to infer the predisposition to myasthenia gravis . Twin Research and Human Genetics. 14. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 129-136.

Ramanujam, R, Pirskanen, R, Ramanujam, S, Hammarstrom, L (2011). Utilizing Twins Concordance Rates to Infer the Predisposition to Myasthenia Gravis . Twin Res. Hum. Genet.

Ramanujam, R., Piehl, F., Pirskanen, R., Gregersen, P.K., Hammarström, L.(2011). Concomitant autoimmunity in myasthenia gravis - Lack of association with IgA deficiency . Journal of Neuroimmunology. 236. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 118-122.

Ramanujam, R, Piehl, F, Pirskanen, R, Gregersen, PK, Hammarstrom, L (2011). Concomitant autoimmunity in myasthenia gravis - Lack of association with IgA deficiency . J. Neuroimmunol.

Mohammadi J, Ramanujam R, Jarefors S, Rezaei N, Aghamohammadi A, Gregersen PK, Hammarström L, Journal of clinical immunology, 2010, vol. 30, no. 1, pp. 138-143 .

Mohammadi, J., Ramanujam, R., Jarefors, S., Rezaei, N., Aghamohammadi, A., Gregersen, P.K., Hammarström, L.(2010). IgA deficiency and the MHC: Assessment of relative risk and microheterogeneity within the HLA A1 B8, DR3 (8.1) Haplotype . Journal of Clinical Immunology. 30. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 138-143.

Mohammadi, J, Ramanujam, R, Jarefors, S, Rezaei, N, Aghamohammadi, A, Gregersen, PK, Hammarstrom, L (2010). IgA Deficiency and the MHC: Assessment of Relative Risk and Microheterogeneity Within the HLA A1 B8, DR3 (8.1) Haplotype . J. Clin. Immunol.

Ramanujam R, Zhao Y, Pirskanen R, Hammarström L, BMC medical genetics, 2010, vol. 11, pp. 147 .

Ramanujam, R, Zhao, YF, Pirskanen, R, Hammarstrom, L (2010). Lack of association of the CIITA-168A -> G promoter SNP with myasthenia gravis and its role in autoimmunity . BMC Med. Genet.

Ramanujam, R., Zhao, Y., Pirskanen, R., Hammarström, L.(2010). Lack of association of the CIITA -168A→G promoter SNP with myasthenia gravis and its role in autoimmunity . BMC Medical Genetics. 11. (1).

Ramanujam R, Pirskanen R, Hammarström L, BMC research notes, 2010, vol. 3, pp. 292 .

Ramanujam, R., Pirskanen, R., Hammarström, L.(2010). The CD45 77C/G allele is not associated with myasthenia gravis - A reassessment of the potential role of CD45 in autoimmunity . BMC Research Notes. 3.

Ramanujam, R, Pirskanen, R, Hammarström, L (2010). The CD45 77C/G allele is not associated with myasthenia gravis - a reassessment of the potential role of CD45 in autoimmunity . BMC Res Notes.

Sakthivel P, Giscombe R, Ramanujam R, Lefvert AK, Rheumatology international, 2009, vol. 29, no. 10, pp. 1247-1250 .

Sakthivel, P., Giscombe, R., Ramanujam, R., Lefvert, A.K.(2009). Polymorphisms in PDCD1 gene are not associated with Wegener's granulomatosis . Rheumatology International. 29. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1247-1250.

Sakthivel, P, Giscombe, R, Ramanujam, R, Lefvert, AK (2009). Polymorphisms in PDCD1 gene are not associated with Wegener's granulomatosis . Rheumatol. Int.

Lefvert AK, Zhao Y, Ramanujam R, Yu S, Pirskanen R, Hammarström L, Journal of neuroimmunology, 2008, vol. 197, no. 2, pp. 110-113 .

Sakthivel P, Ramanujam R, Wang XB, Pirskanen R, Lefvert AK, Journal of neuroimmunology, 2008, vol. 193, no. 1-2, pp. 149-155 .

Sakthivel, P., Ramanujam, R., Wang, X.B., Pirskanen, R., Lefvert, A.K.(2008). Programmed Death-1: From gene to protein in autoimmune human myasthenia gravis . Journal of Neuroimmunology. 193. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 149-155.

Sakthivel, P, RamanujaM, R, Wang, XB, Pirskanen, R, Lefvert, AK (2008). Programmed Death-1: From gene to protein in autoimmune human myasthenia gravis . J. Neuroimmunol.

Lefvert, A.K., Zhao, Y., Ramanujam, R., Yu, S., Pirskanen, R., Hammarström, L.(2008). PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis . Journal of Neuroimmunology. 197. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 110-113.

Lefvert, AK, Zhao, YF, Ramanujam, R, Yu, SY, Pirskanen, R, Hammarstrom, L (2008). PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis . J. Neuroimmunol.

Brungart, T.A., Lauchle, G.C., Ramanujam, R.K.(1999). Installation effects on fan acoustic and aerodynamic performance . Noise Control Engineering Journal. 47. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3-7.

Brungart, TA, Lauchle, GC, Ramanujam, RK (1999). Installation effects on fan acoustic and aerodynamic performance. Noise Control Eng. J.