プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Said A.に依頼

United States

Translating Vascular Biology into Therapeutics | mRNA, ASO and peptide R&D | Ocular & Neurodegenerative Disease | S

プロフィール概要

I am a biomedical scientist and drug development specialist with over a decade of experience spanning biomaterials engineering, vascular biology, ocular disease, and neurodegeneration. My work bridges molecular discovery and translational application — from identifying disease targets using single-cell transcriptomics and proteomics, to designing and validating mRNA, antisense oligonucleotide (ASO), Antibody and peptide based therapeutics, and nanoemulsion-based drug delivery systems in pre-clinical models. At Harvard Medical School and Mass Eye and Ear, I have contributed to landmark discoveries in Alzheimer's disease resilience (published in Nature Medicine) and developed the first mRNA-encoded dominant-negative therapeutic for vitreoretinal disease (published in Science Translational Medicine). I consult on drug discovery strategy, pre-clinical study design, therapeutic modality selection, and drug delivery system development for ocular and neurodegenerative disease programs.

専門分野

• ☆ Molecular Biology
• ☆ Monoclonal Antibody Production
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Drug Design
• ☆ Drug Development
• ☆ Drug Formulation
• ☆ Small Molecule Drug Development
• ☆ Biosafety Testing
• ☆ Bioanalytical Testing
• ☆ Preclinical ADME/PK/PD
• ☆ Preclinical Pharmacology
• ☆ In vitro Preclinical Toxciology
• ☆ Drug Efficacy Testing
• ☆ Neurology
• ☆ Alzheimer's Disease
• ☆ Blindness & Visual Impairment

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing

Research Feasibility Study, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting, Manufacturing Consulting

Data & AI Predictive Modeling, Statistical Analysis, Data Visualization

Product Development Formulation, Product Evaluation, Product Validation, Manufacturing, Concept Development, Prototyping

職務経験

Research Fellow

Mass. Eye and Ear

9月 2021 - 現在

Postdoctoral Research Fellow

Harvard University

9月 2021 - 現在

lecturer

Universidad de La Sabana

1月 2018 - 12月 2021

学歴

Doctor in Biosciences

Universidad de La Sabana - Colombia

7月 2016 - 3月 2021

BS in Chemical Engineering

Universidad de La Sabana - Colombia

1月 2011 - 11月 2015

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

ApoE3 Christchurch and tau interaction as a protective mechanism against Alzheimer's disease @article{Perez_Corredor_2025, title={ApoE3 Christchurch and tau interaction as a protective mechanism against Alzheimer’s disease}, volume={21}, ISSN={1552-5279}, url={http://dx.doi.org/10.1002/alz.70396}, DOI={10.1002/alz.70396}, number={7}, journal={Alzheimer’s & Dementia}, publisher={Wiley}, author={Perez‐Corredor, Paula and Arevalo‐Alquichire, Said and Mazzarino, Randall C. and O’Hare, Michael and Muriel‐Torres, Andres F. and Vacano, Guido N. and Vanderleest, Timothy E. and Miller, William P. and Pineda‐Lopez, Lina and Patel, Shivani and Obar, Robert A. and Polat, Nihat and Kim, Leo A. and Arboleda‐Velasquez, Joseph F. and Marino, Claudia}, year={2025}, month=jul } . Alzheimer's & Dementia.

Michael O’Hare, William P. Miller, Said Arevalo-Alquichire, Dhanesh Amarnani, Evhy Apryani, Paula Perez-Corredor, Claudia Marino, Daisy Y. Shu, Timothy E. Vanderleest, Andres Muriel-Torres, et al. (2024). An mRNA-encoded dominant-negative inhibitor of transcription factor RUNX1 suppresses vitreoretinal disease in experimental models . Science Translational Medicine.

Development of a Resveratrol Nanoformulation for the Treatment of Diabetic Retinopathy @article{Gonzalez_Perez_2024, title={Development of a Resveratrol Nanoformulation for the Treatment of Diabetic Retinopathy}, volume={17}, ISSN={1996-1944}, url={http://dx.doi.org/10.3390/ma17061420}, DOI={10.3390/ma17061420}, number={6}, journal={Materials}, publisher={MDPI AG}, author={Gonzalez-Perez, Juliana and Lopera-Echavarría, A. M. and Arevalo-Alquichire, Said and Araque-Marín, Pedronel and Londoño, Martha E.}, year={2024}, month=mar, pages={1420} } . Materials.

APOE Christchurch‐mimetic therapeutic antibody reduces APOE‐mediated toxicity and tau phosphorylation @article{Marino_2023, title={APOE Christchurch‐mimetic therapeutic antibody reduces APOE‐mediated toxicity and tau phosphorylation}, volume={20}, ISSN={1552-5279}, url={http://dx.doi.org/10.1002/alz.13436}, DOI={10.1002/alz.13436}, number={2}, journal={Alzheimer’s & Dementia}, publisher={Wiley}, author={Marino, Claudia and Perez‐Corredor, Paula and O’Hare, Michael and Heuer, Annie and Chmielewska, Natalia and Gordon, Harper and Chandrahas, Anita S. and Gonzalez‐Buendia, Lucia and Delgado‐Tirado, Santiago and Doan, Tri H. and Vanderleest, Timothy E. and Arevalo‐Alquichire, Said and Obar, Robert A. and Ortiz‐Cordero, Carolina and Villegas, Andres and Sepulveda‐Falla, Diego and Kim, Leo A. and Lopera, Francisco and Mahley, Robert and Huang, Yadong and Quiroz, Yakeel T. and Arboleda‐Velasquez, Joseph F.}, year={2023}, month=oct, pages={819–836} } . Alzheimer's & Dementia.

Jhoan F. Cespedes, Said Arévalo-Alquichire, Luis E. Diaz, Manuel F. Valero(2022). Assessment of the Anti-Thrombogenic Activity of Polyurethane Starch Composites . Journal of Functional Biomaterials. 13. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 184. {MDPI} {AG}

Said Arévalo-Alquichire(2022). Topical Nanoemulsion of an Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis . Ophthalmology Science. 2. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 100163. Elsevier {BV}

Said Arévalo-Alquichire(2022). Influence of Starch on the Structure–Properties Relationship in Polyethylene Glycol/Polycaprolactone Diol Polyurethanes . Polymers. 14. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3184. {MDPI} {AG}

Said Arévalo-Alquichire(2020). Hydrolytic stability and biocompatibility on smooth muscle cells of polyethylene glycol–polycaprolactone-based polyurethanes . Journal of Materials Research. 35. (23-24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3276--3285. Springer Science and Business Media {LLC}

Said Arévalo-Alquichire(2020). Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy . Scientific Reports. 10. (1). Springer Science and Business Media {LLC}

Arévalo-Alquichire Said, Dominguez-paz Carlos, Valero Manuel F. (2020). Mechanical Assessment and Hyperelastic Modeling of Polyurethanes for the Early Stages of Vascular Graft Design . Materials.

Arévalo-Alquichire Said, Dominguez-paz Carlos, Valero Manuel F. (2020). Mechanical Assessment and Hyperelastic Modeling of Polyurethanes for the Early Stages of Vascular Graft Design . Materials.

Said Arévalo-Alquichire, Maria Morales-Gonzalez, Kelly Navas-Gómez, Luis E. Diaz, José A. Gómez-Tejedor, María-Antonia Serrano, Manuel F. Valero (2020). Influence of Polyol/Crosslinker Blend Composition on Phase Separation and Thermo-Mechanical Properties of Polyurethane Thin Films . Polymers.

Said Arévalo-Alquichire, Maria Morales-Gonzalez, Kelly Navas-Gómez, Luis E. Diaz, José A. Gómez-Tejedor, María-Antonia Serrano, Manuel F. Valero (2020). Influence of Polyol/Crosslinker Blend Composition on Phase Separation and Thermo-Mechanical Properties of Polyurethane Thin Films . Polymers.

Surface Response Methodology-Based Mixture Design to Study the Influence of Polyol Blend Composition on Polyurethanes’ Properties @article{Ar_valo_Alquichire_2018, title={Surface Response Methodology-Based Mixture Design to Study the Influence of Polyol Blend Composition on Polyurethanes’ Properties}, volume={23}, ISSN={1420-3049}, url={http://dx.doi.org/10.3390/molecules23081942}, DOI={10.3390/molecules23081942}, number={8}, journal={Molecules}, publisher={MDPI AG}, author={Arévalo-Alquichire, Said and Morales-Gonzalez, Maria and Diaz, Luis E. and Valero, Manuel F.}, year={2018}, month=aug, pages={1942} } . Molecules.

Said Arévalo-Alquichire(2018). Polyurethanes from modified castor oil and chitosan . Journal of Elastomers & Plastics. 50. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 419--434. {SAGE} Publications

Said Arévalo-Alquichire(2017). Polyurethane-based bioadhesive synthesized from polyols derived from castor oil (Ricinus communis) and low concentration of chitosan . Journal of Materials Research. 32. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3699--3711. Springer Science and Business Media {LLC}

OTHER

Said Arévalo-Alquichire, María Morales-González, Luis E. Barrera, Manuel F. Valero(2018). Surface Response Methodology-Based Mixture Design to Study the Influence of Polyol Blend Composition on Polyurethanes Properties . {MDPI} {AG}

BOOK CHAPTER

Said Arévalo-Alquichire(2017). Castor Oil Polyurethanes as Biomaterials . Elastomers. {InTech}