プロフィール詳細

プロジェクトを作成

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Dr. Santiago L.に依頼

Luxembourg

Neuroscientist & Data Analysis Specialist | Expert in Omics, Data Interpretation, Electrophysiology & Machine Learning

プロフィール概要

I am a highly skilled scientist with over 15 years of experience in neurodegeneration research, specializing in electrophysiology and omics data analysis. My background includes extensive work on understanding the molecular and cellular mechanisms underlying neurodegenerative diseases, as well as the development and application of cutting-edge methodologies to dissect these processes at multiple levels. Areas of Expertise: - Neurodegeneration Research: Deep knowledge in disease mechanisms and pathophysiology, with experience in preclinical and translational models. - Electrophysiology: Proficient in recording and analyzing electrophysiological data, with a strong focus on synaptic and neural network dynamics. - Omics Data Analysis: Expertise in processing and interpreting large-scale omics datasets (genomics, transcriptomics, proteomics) to uncover novel biomarkers and therapeutic targets. - Machine Learning & Artificial Intelligence: Skilled in programming and deploying machine learning models for biological data analysis and predictive modeling, integrating bioinformatics tools to accelerate discovery. Collaborative Interests: In addition to my core scientific expertise, I have a growing interest in collaborative projects related to Arduino and open-hardware, specifically in the design of hardware platforms for experimental research. This includes working on custom Arduino-based solutions for neuroscience and other scientific disciplines, contributing to the growing field of open-hardware for research applications. Consulting & Collaborations: I am actively exploring opportunities in scientific consulting, where I can leverage my diverse skill set to assist in experimental design, data analysis, and scientific communication. Whether you're looking to optimize research workflows, interpret complex datasets, or develop innovative solutions to biological problems, I offer tailored services to meet your project needs. Let’s collaborate to advance scientific understanding and drive impactful outcomes in your research.

専門分野

• ☆ Molecular Biology
• ☆ Genetics
• ☆ Omics
• ☆ Transcriptomics
• ☆ Proteomics
• ☆ Metabolomics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Neuroscience
• ☆ Electrophysiology
• ☆ Patch-Clamp Electrophysiology
• ☆ Immunohistochemistry
• ☆ R

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Medical Writing, Translation

Research Scientific and Technical Research, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Image Processing, Image Analysis, Algorithm Design-Non ML, Algorithm Design-ML, Data Visualization, Big Data Analytics, Text Mining & Analytics, Data Mining, Data Cleaning, Data Processing, Data Insights

Product Development Prototyping, Device Fabrication

職務経験

PostdoctoralResearcher

Luxembourg Centre for System Biomedicine

10月 2023 - 現在

PostDoc

University of Luxembourg

10月 2023 - 現在

Postdoc

Instituto de Biomedicina de Sevilla

6月 2017 - 10月 2023

PostDoc

University of Barcelona

11月 2016 - 6月 2017

学歴

Big data and data science applied to economy and business administration and management

Universidad Nacional de Educación a Distancia

1月 2023 - 現在

PhD in Neurosciences (Department of Physiology)

Universitat de Barcelona

9月 2012 - 11月 2016

Master's Degree in Neurosciences (Department of Physiology)

Universitat de Barcelona

9月 2010 - 9月 2011

Bachelor's Degree in Biochemistry

Universidad de Sevilla Facultad de Biología

9月 2003 - 9月 2009

認定資格

• Specialization diploma in Big Data and Data Science applied to economics and business management and administration

  Universidad Nacional de Educación a Distancia (UNED)

  9月 2023 - 現在

出版物

JOURNAL ARTICLE

Santiago López-Begines, Rafael Fernández-Chacón (2024). Handshaking for ultrafast endocytosis: Dynamin1xA and Endophilin A1 sealed the deal . The EMBO Journal.

Anna Plana-Bonamaisó, Santiago López-Begines, David Fernández-Justel, Alexandra Junza, Ariadna Soler-Tapia, Jordi Andilla, Pablo Loza-Alvarez, Jose Luis Rosa, Esther Miralles, Isidre Casals, et al.(2020). Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions . eLife. 9. {eLife} Sciences Publications, Ltd

GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Cell Death & Disease.

Santiago L&#243;pez-Begines, Anna Plana-Bonamais&#243;, Ana M&#233;ndez (2018). Molecular determinants of Guanylate Cyclase Activating Protein subcellular distribution in photoreceptor cells of the retina . Scientific Reports.

Hoyo NL, López-Begines S, Rosa JL, Chen J, Méndez A, PLoS genetics, 2014, vol. 10, no. 7, pp. e1004480, 2014 .

López-del Hoyo N, Fazioli L, López-Begines S, Fernández-Sánchez L, Cuenca N, Llorens J, de la Villa P, Méndez A, PloS one, 2012, vol. 7, no. 8, pp. e42994, 2012 .

PREPRINT

Santiago L&#243;pez-Begines, &#193;ngela Lavado-Rold&#225;n, Cristina Mesa-Cruz, Fabiola Mavillard, Nozha Borjini, Vera I. Wiersma, Carolina Aguado, Rafael Luj&#225;n, Wiep Scheper, Jos&#233; L. Nieto-Gonz&#225;lez, et al. (2023). Neuronal lipofuscinosis caused by Kufs disease/CLN4DNAJC5mutations but not by a CSPα/DNAJC5 deficiency .