プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Sakshi M.に依頼

India

PhD Environmental Science/Toxicologist | Scientific & Medical Writer | Food Toxicology Expert | Research Consultant

プロフィール概要

I am a PhD toxicologist with more than 15 years of research experience in molecular toxicology, food toxicology, and environmental health. I have authored 22 peer-reviewed research publications with more than 1000 citations. My research focuses on toxicological mechanisms of food contaminants, oxidative stress, and carcinogenesis. I have also served as Principal Investigator on DST-funded projects investigating mycotoxin-induced neurotoxicity. I help researchers, universities, and companies with scientific writing, literature reviews, toxicology risk assessment, manuscript editing, and research proposal development.

専門分野

• ☆ Biochemistry
• ☆ Apoptosis
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Environmental Science
• ☆ Environmental Health
• ☆ Food Additives
• ☆ Food Safety
• ☆ Drug Development
• ☆ In vivo Preclinical Toxicology
• ☆ Medical Toxicology
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Systematic Literature Review

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing

Research Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Analysis

職務経験

DST Women Scientist-A

Central Drug Research Institute

4月 2022 - 4月 2025

ICMR-Reeasrch Associate

Central Drug Research Institute

2月 2021 - 4月 2022

DST- Women Scientist

CSIR-Central Drug Research Institute

7月 2016 - 6月 2019

学歴

Ph.D (Food, Drug & Chemical Toxicology)

Indian Institute of Toxicology Research CSIR

8月 2008 - 2月 2013

認定資格

• NET-JRF

  Univeristy Grants Comission, India

  1月 2026 - 現在

• Medical writing for non Medical Writers

  Indain Society for Clinical Research

  1月 2026 - 現在

出版物

JOURNAL ARTICLE

Sakshi Mishra, Gaurav Jha, Divyansh Sharma, Bhawna Tomar, Sonam Kanchan, Sushma, Srikanta Kumar Rath (2025). Comprehensive Survey of Mycotoxin Occurrence in Indian Food Commodities . Chemical Research in Toxicology.

Gaurav Jha, Bhawna Tomar, Sakshi Mishra, Divyansh Sharma, Radhika Kapoor, Sonam Kanchan, Sushma, Srikanta Kumar Rath (2025). Gilteritinib suppresses prostate cancer cell proliferation and migration and induces ER stress-mediated non-autophagic cytoplasmic vacuolization cell death . Medical Oncology.

Sakshi Mishra, Radhika Kapoor, Sushma, Sonam Kanchan, Gaurav Jha, Divyansh Sharma, Bhawna Tomar, Srikanta Kumar Rath (2024). Deoxynivalenol Induces Drp-1-Mediated Mitochondrial Dysfunction via Elevating Oxidative Stress . Chemical Research in Toxicology.

Kanchan S, Marwaha D, Tomar B, Agrawal S, Mishra S, Kapoor R, Sushma, Jha G, Sharma D, Bhatta RS, et al. (2024). Nanocarrier - Mediated Salinomycin Delivery Induces Apoptosis and Alters EMT Phenomenon in Prostate Adenocarcinoma . AAPS PharmSciTech.

Sushma, Sakshi Mishra, Sonam Kanchan, Aman Divakar, Gaurav Jha, Divyansh Sharma, Radhika Kapoor, Srikanta Kumar Rath (2023). Alcohol induces ER stress and apoptosis by inducing oxidative stress and disruption of calcium homeostasis in glial cells . Food and Chemical Toxicology.

Sushma, Mishra S, Kanchan S, Divakar A, Jha G, Sharma D, Kapoor R, Kumar Rath S (2023). Alcohol induces ER stress and apoptosis by inducing oxidative stress and disruption of calcium homeostasis in glial cells . Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Sushma, Aman Divakar, Sonam Kanchan, Gaurav Jha, Sakshi Mishra, Divyansh Sharma, Srikanta Kumar Rath(2021). Alcohol induced impairment/abnormalities in brain: Role of MicroRNAs . NeuroToxicology. 87. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 11--23. Elsevier {BV}

Srivastava S, Dewangan J, Mishra S, Divakar A, Chaturvedi S, Wahajuddin M, Kumar S, Rath SK (2021). Piperine and Celecoxib synergistically inhibit colon cancer cell proliferation via modulating Wnt/β-catenin signaling pathway . Phytomedicine : international journal of phytotherapy and phytopharmacology.

Sakshi Mishra, Aman Divakar, Sonal Srivastava, Jayant Dewangan, Divyansh Sharma, Somya Asthana, Swati Chaturvedi, Muhammad Wahajuddin, Sadan Kumar, Srikanta Kumar Rath(2020). N-acetyl-cysteine in combination with celecoxib inhibits Deoxynivalenol induced skin tumor initiation via induction of autophagic pathways in swiss mice . Free Radical Biology and Medicine. 156. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 70--82. Elsevier {BV}

(2020). Celecoxib reduces Deoxynivalenol induced proliferation, inflammation and protein kinase C translocation via modulating downstream targets in mouse skin . Chemico-Biological Interactions.

Sakshi Mishra and Sonal Srivastava and Jayant Dewangan and Aman Divakar and Srikanta Kumar Rath(2019). Global occurrence of deoxynivalenol in food commodities and exposure risk assessment in humans in the last decade: a survey . Critical Reviews in Food Science and Nutrition. 0. (0). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-29. Taylor & Francis

Jayant Dewangan and Sonal Srivastava and Sakshi Mishra and Prabhash Kumar Pandey and Aman Divakar and Srikanta Kumar Rath(2018). Chetomin induces apoptosis in human triple-negative breast cancer cells by promoting calcium overload and mitochondrial dysfunction . Biochemical and Biophysical Research Communications. 495. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1915 - 1921.

Prachi Tewari and Ruchi Roy and Sakshi Mishra and Payal Mandal and Ashish Yadav and Bhushan P. Chaudhari and Rajnish K. Chaturvedi and Premendra D. Dwivedi and Anurag Tripathi and Mukul Das(2015). Benzanthrone induced immunotoxicity via oxidative stress and inflammatory mediators in Balb/c mice . Immunobiology. 220. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 369 - 381.

Sakshi Mishra and Anurag Tripathi and Bhushan P. Chaudhari and Premendra D. Dwivedi and Haushila P. Pandey and Mukul Das(2014). Deoxynivalenol induced mouse skin cell proliferation and inflammation via MAPK pathway . Toxicology and Applied Pharmacology. 279. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 186 - 197.

Sakshi Mishra and Sumita Dixit and Premendra D. Dwivedi and Haushila P. Pandey and Mukul Das(2014). Influence of temperature and pH on the degradation of deoxynivalenol (DON) in aqueous medium: comparative cytotoxicity of DON and degraded product . Food Additives & Contaminants: Part A. 31. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 121-131. Taylor & Francis

Sakshi Mishra and Premendra D. Dwivedi and Haushila P. Pandey and Mukul Das(2014). Role of oxidative stress in Deoxynivalenol induced toxicity . Food and Chemical Toxicology. 72. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 20 - 29.

Sakshi Mishra and Kausar M. Ansari and Premendra D. Dwivedi and Haushila P. Pandey and Mukul Das(2013). Occurrence of deoxynivalenol in cereals and exposure risk assessment in Indian population . Food Control. 30. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 549 - 555.

Deoxynivalenol induced mouse skin tumor initiation: Elucidation of molecular mechanisms in human HaCaT keratinocytes @article{doi:10.1002/ijc.30260, author= {Mishra, Sakshi and Tewari, Prachi and Chaudhari, Bhushan P. and Dwivedi, Premendra D. and Pandey, Haushila P. and Das, Mukul}, title= {Deoxynivalenol induced mouse skin tumor initiation: Elucidation of molecular mechanisms in human HaCaT keratinocytes}, journal= {International Journal of Cancer}, volume= {139}, number= {9}, pages= {2033-2046}, keywords= {mycotoxins, deoxynivalenol, tumor initiation, DNA damage, oxidative stress, HaCaT cells}, doi= {10.1002/ijc.30260}, url= {https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.30260}, eprint= {https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.30260}, abstract= {Among food contaminants, mycotoxins are toxic to both human and animal health. Our prior studies suggest that Deoxynivalenol (DON), a mycotoxin, behaves as a tumor promoter by inducing edema, hyperplasia, ODC activity and activation of MAPK's in mouse skin. In this study, topical application of DON, 336 and 672 nmol significantly enhanced ROS levels, DNA damage and apoptosis with concomitant downregulation of Ki-67, cyclin D, cyclin E, cyclin A and cyclin-dependent kinases (CDK4 and CDK2) thereby resulting in tumor initiation in mouse skin. Further, the elucidation of molecular mechanisms of tumor initiation by DON (0.42–3.37 nmol/ml) in HaCaT keratinocytes, revealed (i) enhanced ROS generation with cell cycle phase arrest in G0/G1 phase, (ii) increase in levels of 8-OxoG (6–24 hr) and γH2AX protein, (iii) significant enhancement in oxidative stress marker enzymes LPO, GSH, GR with concomitant decrease in antioxidant enzymes catalase, GPx, GST, SOD and mitochondrial membrane potential after DON (1.68 nmol) treatment, (iv) suppression of Nrf2 translocation to nucleus, enhanced phosphorylation with subsequent activation ERK1/2, p38 and JNK MAPK's following DON (1.68 nmol) treatment, (v) overexpression of c-jun, c-fos proteins, upregulation of Bax along with downregulation of Bcl-2 proteins, (vi) increase in cytochrome-c, caspase-9, caspase-3 and poly ADP ribose polymerase levels leads to apoptosis. Pretreatment of superoxide dismutase, mannitol and ethanol to HaCaT cells resulted in significant reduction in ROS levels and apoptosis indicating the role of superoxide and hydroxyl radicals in DON induced apoptosis as an early event and skin tumor initiation as a late event.}} . International Journal of Cancer.

BOOK CHAPTER

Sonal Srivastava and Sakshi Mishra and Jayant Dewangan and Aman Divakar and Prabhash K. Pandey and Srikanta K. Rath(2018). Chapter 2 - Principles for In Vitro Toxicology . In Vitro Toxicology. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 21 - 43. Academic Press

Payal Mandal and Ankita Rai and Sakshi Mishra and Anurag Tripathi and Mukul Das(2018). Chapter Seven - Mutagens in Food . Mutagenicity: Assays and Applications. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 133 - 160. Academic Press

Jayant Dewangan and Prabhash Kumar Pandey and Aman Divakar and Sakshi Mishra and Sonal Srivastava and Srikanta Kumar Rath(2018). Chapter Three - Detection of Gene Mutation in Cultured Mammalian Cells . Mutagenicity: Assays and Applications. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 49 - 67. Academic Press