プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. SANDRA M.に依頼

Brazil

I'm dedicated to understand the transcriptional and posttranscriptional gene expression regulation cell metabolism.

プロフィール概要

My research is focused on elucidating the signs from parasite, such as L-arginine metabolism, to regulate lncRNAs, microRNAs and mRNAs profile of macrophages to enable the establishment of parasite infection. I'm dedicate ro study the immunometabolism during interaction of pathogen and host

専門分野

• ★ Biochemistry
• ★ Molecular Biology
• ☆ RNA Sequencing
• ☆ Immunohistochemistry
• ☆ Allergy & Clinical Immunology
• ☆ Molecular Pathology
• ☆ Inflammation

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing

Research Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Big Data Analytics

職務経験

Lab specialist

Universidade de São Paulo - Instituto de Ciências Biomédicas - SPPU

4月 2021 - 現在

Lab Specialist

Universidade de São Paulo Instituto de Biociências

2月 2010 - 4月 2021

Research

Universidad CEU San Pablo

11月 2017 - 12月 2017

学歴

PhD (Immunology)

Universidade de São Paulo

8月 2005 - 4月 2011

Bch Biomedicine (Centro de Ciências Biológicas)

Universidade Estadual de Londrina

2月 2001 - 12月 2004

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Vinicius Queiroz, Sandra M. Muxel, Luigi Inguglia, Marco Chiaramonte, Márcio R. Custódio(2021). Comparative study of coelomocytes from Arbacia lixula and Lythechinus variegatus: Cell characterization and in vivo evidence of the physiological function of vibratile cells . Fish & Shellfish Immunology. 110. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--9. Elsevier {BV}

G. S. Kinker and L. H. Ostrowski and P. A. C. Ribeiro and R. Chanoch and S. M. Muxel and I. Tirosh and G. Spadoni and S. Rivara and V. R. Martins and T. G. Santos and R. P. Markus and P. A. C. M. Fernandes(2021). MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression . Journal of Molecular Medicine. Springer Science and Business Media {LLC}

Pedro A Fernandes and Gabriela S Kinker and Bruno V Navarro and Vinicius C Jardim and Edson D Ribeiro-Paz and Marlina O C{\'{o}}rdoba-Moreno and D{\'{e}}bora Santos-Silva and Sandra M Muxel and Andr{\'{e}} Fujita and Carolina Borsoi Moraes and Helder I Nakaya and Marcos S Buckeridge and Regina P Markus(2021). Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers . Melatonin Research. 4. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 189--205. {ST} Bio-life

(2020). Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis . Scientific Reports.

Marlina O. Córdoba-Moreno, Ewerton da Silva de Souza, Caroline L. Quiles, Débora dos Santos-Silva, Gabriela S. Kinker, Sandra M. Muxel, Regina P. Markus, Pedro A. Fernandes(2020). Rhythmic expression of the melatonergic biosynthetic pathway and its differential modulation in vitro by LPS and IL10 in bone marrow and spleen . Scientific Reports. 10. (1). Springer Science and Business Media {LLC}

Juliana Ide Aoki, Sandra Marcia Muxel, Maria Fernanda Laranjeira-Silva, Ricardo Andrade Zampieri, Karl Erik Müller, Audun Helge Nerland, Lucile Maria Floeter-Winter (2020). Dual transcriptome analysis reveals differential gene expression modulation influenced by Leishmania arginase and host genetic background . Microbial Genomics.

Juliana Ide Aoki, Sandra Marcia Muxel, Maria Fernanda Laranjeira-Silva, Ricardo Andrade Zampieri, Karl Erik Müller, Audun Helge Nerland, Lucile Maria Floeter-Winter(2020). Dual transcriptome analysis reveals differential gene expression modulation influenced by Leishmania arginase and host genetic background . Microbial Genomics. Microbiology Society

(2020). Dual transcriptome analysis reveals differential gene expression modulation influenced by Leishmania arginase and host genetic background . Microbial Genomics.

Stephanie Maia Acuña, Lucile Maria Floeter-Winter, Sandra Marcia Muxel(2020). MicroRNAs: Biological Regulators in Pathogen–Host Interactions . Cells. 9. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 113. {MDPI} {AG}

Malta-Santos, H., França-Costa, J., Macedo, A., Queiroz, A.T.L., Fukutani, K.F., Muxel, S.M., Khouri, R., Van Weyenbergh, J., Boaventura, V., Barral, A., et al.(2020). Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis . Scientific Reports. 10. (1).

Aoki, J.I., Muxel, S.M., Zampieri, R.A., Müller, K.E., Nerland, A.H., Floeter-Winter, L.M.(2020). Author Correction: Differential immune response modulation in early Leishmania amazonensis infection of BALB/c and C57BL/6 macrophages based on transcriptome profiles (Scientific Reports, (2019), 9, 1, (19841), 10.1038/s41598-019-56305-1) . Scientific Reports. 10. (1).

Córdoba-Moreno, M.O., de Souza, E.S., Quiles, C.L., dos Santos-Silva, D., Kinker, G.S., Muxel, S.M., Markus, R.P., Fernandes, P.A.(2020). Rhythmic expression of the melatonergic biosynthetic pathway and its differential modulation in vitro by LPS and IL10 in bone marrow and spleen . Scientific Reports. 10. (1).

Sandra Marcia Muxel, Maricruz Mamani-Huanca, Juliana Ide Aoki, Ricardo Andrade Zampieri, Lucile Maria Floeter-Winter, Ángeles López-Gonzálvez, Coral Barbas(2019). Metabolomic Profile of BALB/c Macrophages Infected with Leishmania amazonensis: Deciphering L-Arginine Metabolism . International Journal of Molecular Sciences. 20. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6248. {MDPI} {AG}

Sandra Marcia Muxel, Maricruz Mamani-Huanca, Juliana Ide Aoki, Ricardo Andrade Zampieri, Lucile Maria Floeter-Winter, &#193;ngeles L&#243;pez-Gonz&#225;lvez, Coral Barbas (2019). Metabolomic Profile of BALB/c Macrophages Infected with <i>Leishmania amazonensis</i>: Deciphering <span style="font-variant: small-caps">L</span>-Arginine Metabolism . International Journal of Molecular Sciences.

Juliane Fernandes, Stephanie M. Acu&#241;a, Juliana I. Aoki, Lucile M. Floeter-Winter, Sandra Marcia Muxel (2019). Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease . Non-Coding RNA.

Muxel, S.M., Mamani-Huanca, M., Aoki, J.I., Zampieri, R.A., Floeter-Winter, L.M., L&#243;pez-Gonz&#225;lvez, &#193;., Barbas, C.(2019). Metabolomic profile of BALB/c macrophages infected with Leishmania amazonensis: Deciphering L-arginine metabolism . International Journal of Molecular Sciences. 20. (24).

Fernandes, J.C.R., Acu&#241;a, S.M., Aoki, J.I., Floeter-Winter, L.M., Muxel, S.M.(2019). Long non-coding RNAs in the regulation of gene expression: Physiology and disease . Non-coding RNA. 5. (1).

Aoki, J.I., Muxel, S.M., Zampieri, R.A., M&#252;ller, K.E., Nerland, A.H., Floeter-Winter, L.M.(2019). Differential immune response modulation in early Leishmania amazonensis infection of BALB/c and C57BL/6 macrophages based on transcriptome profiles . Scientific Reports. 9. (1).

Barbosa Lima, L.E., Muxel, S.M., Kinker, G.S., Carvalho-Sousa, C.E., da Silveira Cruz-Machado, S., Markus, R.P., Fernandes, P.A.C.M.(2019). STAT1-NFκB crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production . Journal of Pineal Research. 67. (3).

Fernandes, J.C.R., Aoki, J.I., Acuna, S.M., Zampieri, R.A., Markus, R.P., Floeter-Winter, L.M., Muxel, S.M.(2019). Melatonin and infection altered mir- 294, mir-30e, and mir-302d impacting on , , and 2 expression . Frontiers in Cellular and Infection Microbiology. 9. (MAR).

Aoki, J.I., Laranjeira-Silva, M.F., Muxel, S.M., Floeter-Winter, L.M.(2019). The impact of arginase activity on virulence factors of Leishmania amazonensis . Current Opinion in Microbiology. 52. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 110-115.

M&#252;ller, K.E., Zampieri, R.A., Aoki, J.I., Muxel, S.M., Nerland, A.H., Floeter-Winter, L.M.(2018). Amino acid permease 3 (aap3) coding sequence as a target for Leishmania identification and diagnosis of leishmaniases using high resolution melting analysis . Parasites and Vectors. 11. (1).

Muxel, S.M., Aoki, J.I., Fernandes, J.C.R., Laranjeira-Silva, M.F., Zampieri, R.A., Acu&#241;a, S.M., M&#252;ller, K.E., Vanderlinde, R.H., Floeter-Winter, L.M.(2018). Arginine and polyamines fate in leishmania infection . Frontiers in Microbiology. 8. (JAN).

Muxel, S. M., Acu&#241;a, S. M., Aoki, J. I., Zampieri, R. A., Floeter-Winter, L. M.(2018). Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in . Front Immunol. 9. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2792.

Muxel, S.M., Acu&#241;a, S.M., Aoki, J.I., Zampieri, R.A., Floeter-Winter, L.M.(2018). Toll-like receptor and miRNA-let-7e expression alter the inflammatory response in leishmania amazonensis-infected macrophages . Frontiers in Immunology. 9. (NOV).

M&#252;ller, K. E., Zampieri, R. A., Aoki, J. I., Muxel, S. M., Nerland, A. H., Floeter-Winter, L. M.(2018). Amino acid permease 3 (aap3) coding sequence as a target for Leishmania identification and diagnosis of leishmaniases using high resolution melting analysis . Parasit Vectors. 11. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 421.

Aoki, J.I., Muxel, S.M., Zampieri, R.A., Acu&#241;a, S.M., Fernandes, J.C.R., Vanderlinde, R.H., Sales, M.C.O.D.P., Floeter-Winter, L.M.(2017). L-arginine availability and arginase activity: Characterization of amino acid permease 3 in Leishmania amazonensis . PLoS Neglected Tropical Diseases. 11. (10).

Muxel, S.M., Laranjeira-Silva, M.F., Zampieri, R.A., Floeter-Winter, L.M.(2017). Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism . Scientific Reports. 7.

Aoki, J.I., Muxel, S.M., Zampieri, R.A., Laranjeira-Silva, M.F., M&#252;ller, K.E., Nerland, A.H., Floeter-Winter, L.M.(2017). RNA-seq transcriptional profiling of Leishmania amazonensis reveals an arginase-dependent gene expression regulation . PLoS Neglected Tropical Diseases. 11. (10).

Acu&#241;a, S.M., Aoki, J.I., Laranjeira-Silva, M.F., Zampieri, R.A., Fernandes, J.C.R., Muxel, S.M., Floeter-Winter, L.M.(2017). Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis . PLoS ONE. 12. (11).

Zampieri, R.A., Laranjeira-Silva, M.F., Muxel, S.M., Stocco de Lima, A.C., Shaw, J.J., Floeter-Winter, L.M.(2016). High Resolution Melting Analysis Targeting hsp70 as a Fast and Efficient Method for the Discrimination of Leishmania Species . PLoS Neglected Tropical Diseases. 10. (2).

Aoki, J.I., Coelho, A.C., Muxel, S.M., Zampieri, R.A., Sanchez, E.M.R., Nerland, A.H., Floeter-Winter, L.M., Cotrim, P.C.(2016). Characterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in Leishmania major . PLoS Neglected Tropical Diseases. 10. (9).

Fernandes, P.A., Tamura, E.K., D&#39;Argenio-Garcia, L., Muxel, S.M., Da Silveira Cruz-Machado, S., Mar&#231;ola, M., Carvalho-Sousa, C.E., Cecon, E., Ferreira, Z.S., Markus, R.P.(2016). Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis . Neuroendocrinology. 104. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 126-134.

Kinker, G.S., Oba-Shinjo, S.M., Carvalho-Sousa, C.E., Muxel, S.M., Marie, S.K.N., Markus, R.P., Fernandes, P.A.(2016). Melatonergic system-based two-gene index is prognostic in human gliomas . Journal of Pineal Research. 60. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 84-94.

Muxel, S.M., Laranjeira-Silva, M.F., Carvalho-Sousa, C.E., Floeter-Winter, L.M., Markus, R.P.(2016). The RelA/cRel nuclear factor-κB (NF-κB) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages . Journal of Pineal Research. 60. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 394-404.

Castilho-Martins, E.A., Canuto, G.A.B., Muxel, S.M., daSilva, M.F.L., Floeter-Winter, L.M., del Aguila, C., L&#243;pez-Gonz&#225;lvez, &#193;., Barbas, C.(2015). Capillary electrophoresis reveals polyamine metabolism modulation in Leishmania (Leishmania) amazonensis wild-type and arginase-knockout mutants under arginine starvation . Electrophoresis. 36. (18). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2314-2323.

Laranjeira-Silva, M.F., Zampieri, R.A., Muxel, S.M., Floeter-Winter, L.M., Markus, R.P.(2015). Melatonin attenuates Leishmania (L.) amazonensis infection by modulating arginine metabolism . Journal of Pineal Research. 59. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 478-487.

dos Santos, M.G., Muxel, S.M., Zampieri, R.A., Pomorski, T.G., Floeter-Winter, L.M.(2013). Transbilayer Dynamics of Phospholipids in the Plasma Membrane of the Leishmania Genus . PLoS ONE. 8. (1).

ZagoCl&#225;, C.A., Bortoluci, K.R., Sardinha, L.R., Pretel, F.D., Castillo-M&#233;ndez, S.I., do Ros&#225;rio, A.P., Hiyane, M.I., Muxel, S.M., Rodriguez-M&#225;lagaS&#233;, S.M., Abrahamsohn, I.A., et al.(2012). Anti-IL-2 treatment impairs the expansion of t<inf>reg</inf> cell population during acute malaria and enhances the Th1 cell response at the chronic disease . PLoS ONE. 7. (1).

da Silva, M.F.L., Zampieri, R.A., Muxel, S.M., Beverley, S.M., Floeter-Winter, L.M.(2012). Leishmania amazonensis arginase compartmentalization in the glycosome is important for parasite infectivity . PLoS ONE. 7. (3).

Muxel, S.M., Pires-Lapa, M.A., Monteiro, A.W.A., Cecon, E., Tamura, E.K., Floeter-Winter, L.M., Markus, R.P.(2012). NF-κB Drives the Synthesis of Melatonin in RAW 264.7 Macrophages by Inducing the Transcription of the Arylalkylamine-N-Acetyltransferase (AA-NAT) Gene . PLoS ONE. 7. (12).

Castilho-Martins, E.A., da Silva, M.F.L., dos Santos, M.G., Muxel, S.M., Floeter-Winter, L.M.(2011). Axenic leishmania amazonensis promastigotes sense both the external and internal arginine pool distinctly regulating the two transporter-coding genes . PLoS ONE. 6. (11).

Muxel, S.M., do Ros&#225;rio, A.P., Zago, C.A., Castillo-M&#233;ndez, S.I., Sardinha, L.R., Rodriguez-M&#225;laga, S.M., C&#226;mara, N.O.S., &#193;lvarez, J.M., Lima, M.R.(2011). The spleen CD4 ⁺ T cell response to Blood-Stage Plasmodium chabaudi malaria develops in two phases characterized by different properties . PLoS ONE. 6. (7).

Carvalho-Sousa, C.E., da Silveira Cruz-Machado, S., Tamura, K.E., Fernandes, P.A.C.M., Pinato, L., Muxel, S.M., Cecon, E., Markus, R.P.(2010). Molecular basis for defining the pineal gland and pinealocytes as targets for tumor necrosis factor . Frontiers in Endocrinology. 2. (MAY).

Muxel, S.M., Freitas Do Ros&#225;rio, A.P., Sardinha, L.R., Castillo-M&#233;ndez, S.I., Zago, C.A., Rodriguez-M&#225;laga, S.M., &#193;lvarez Mosig, J.M., D&#39;Imp&#233;rio Lima, M.R.(2010). Comparative analysis of activation phenotype, proliferation, and IFN-γ production by spleen NK1.1⁺ and NK1.1^- T cells during plasmodium chabaudi as malaria . Journal of Interferon and Cytokine Research. 30. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 417-426.

Freitas Do Ros&#225;rio, A.P., Muxel, S.M., Rodr&#237;guez-M&#225;laga, S.M., Sardinha, L.R., Zago, C.A., Castillo-M&#233;ndez, S.I., &#193;lvarez, J.M., D&#39;Imp&#233;rio Lima, M.R.(2008). Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody . Journal of Immunology. 181. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 8344-8355.

Muxel, S.M., Borelli, S.D., Amarante, M.K., Voltarelli, J.C., Aoki, M.N., De Oliveira, C.E.C., Watanabe, M.A.E.(2008). Association study of CCR5 delta 32 polymorphism among the HLA-DRB1 Caucasian population in northern Paraná, Brazil . Journal of Clinical Laboratory Analysis. 22. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 229-233.

Amarante, M.K., De Lucca, F.L., Coral De Oliveira, C.E., Pelegrinelli Fungaro, M.H., Vissoci Reiche, E.M., Muxel, S.M., Ehara Watanabe, M.A.(2005). Expression of noncoding mRNA in human blood cells activated with synthetic peptide of HIV . Blood Cells, Molecules, and Diseases. 35. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 286-290.

OTHER

Sandra Marcia Muxel ,, Maria Fernanda Laranjeira-Silva ,, Ricardo Andrade Zampieri ,, Juliana Ide Aoki ,, Stephanie Maia Acu&#241;a, &amp;amp, Lucile Maria Floeter-Winter(2017). Functional validation of miRNA-mRNA interactions in macrophages by inhibition/competition assays based in transient transfection .