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プロフィール詳細

プロジェクトを作成

★★★★★

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Sara A.に依頼

United States

Freelance consultant and Writer, A Pharmacist with Expertise in Drug development and Cancer research

プロフィール概要

•	Highly qualified and experienced molecular biologist with a proven track record of success in research and development, regulatory affairs, and teaching.
•	PhD in Molecular Biology from Johannes Gutenberg University, Mainz, Germany 
•	Master of Science in Regulatory Affairs from Northeastern University, Boston, USA
•	Extensive experience in leading and managing research projects, developing and implementing new drug discovery methods, and conducting regulatory compliance assessments.
•	Led projects on targeted anticancer therapies and cancer multidrug resistance, resulting in the identification of candidate compounds acting selectively on potential cancer targets.
•	Managed project and team on lead discovery for treatment of SARS-CoV-2 virus, developing high throughput in-silico and in-vitro screening assays to identify Pan-coronaviral inhibitors.
•	Established an HPC-compatible snakemake workflow for structure-based ligand screening, which has been used to perform virtual screening of huge chemical libraries and identify hit candidates for selected targets.
•	Published 30 research articles in internationally well-reputed journals.
•	Strong communication and interpersonal skills, with the ability to work independently and as part of a team.

専門分野

サービス

Writing
Research
Consulting

Writing Clinical Trial Documentation

Research Meta-Research, Systematic Literature Review

Consulting Regulatory Consulting

職務経験

Postdoctoral researcher

Johannes Gutenberg Universität Mainz

7月 2019 - 現在

学歴

Masters (Science)

Northeastern University

7月 2022 - 現在

PhD (Department of pharmaceutical biology)

Johannes Gutenberg Universität Mainz

10月 2015 - 5月 2019

Master

Institute of Endemic Diseases

2012 - 2014

Bachelor (Faculty of Pharmacy)

University of Khartoum

2004 - 2009

認定資格

認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Sara Abdelfatah, Ejlal A. Omer, Max Riedl, Christian Meesters, Andreas Hildebrandt, Thomas Efferth (2023). Coronavirus Inhibitors Targeting nsp16 . Molecules.

Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Pharmaceuticals.

Sara Abdelfatah, Alexander Panossian, Thomas Efferth (2022). Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics . Pharmaceuticals.

Sara Abdelfatah, Alexandra Pohler, Max Riedl, Christian Meesters, Andreas Hildebrandt, Thomas Efferth (2022). Potential Coronaviral Inhibitors of the Nucleocapsid Protein Identified In Silico and In Vitro from a Large Natural Product Library . Pharmaceuticals.

Correction to: Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma @article{_zenver_2021, doi = {10.1007/s10637-021-01193-4}, url = {https://doi.org/10.1007%2Fs10637-021-01193-4}, year = 2021, month = {oct}, publisher = {Springer Science and Business Media {LLC}}, volume = {40}, number = {2}, pages = {462--462}, author = {Nadire Ãzenver and Sara Abdelfatah and Anette Klinger and Edmond Fleischer and Thomas Efferth}, title = {Correction to: Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma}, journal = {Investigational New Drugs} } . Investigational New Drugs.

Sara Abdelfatah, Nasim Shahhamzehei, Thomas Efferth(2022). In Silico and In Vitro Identification of Pan-Coronaviral Main Protease Inhibitors from a Large Natural Product Library . Pharmaceuticals. 15. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 308. {MDPI} {AG}

Sara Abdelfatah, Nasim Shahhamzehei, Thomas Efferth (2022). In Silico and In Vitro Identification of Pan-Coronaviral Main Protease Inhibitors from a Large Natural Product Library . Pharmaceuticals.

Sara Abdelfatah, Alexander Panossian, Thomas Efferth(2021). Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics . Pharmaceuticals. 14. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1010. {MDPI} {AG}

Sara Abdelfatah, Alexander Panossian, Thomas Efferth (2021). Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations . Pharmaceuticals.

Sara Abdelfatah, Alexander Panossian, Thomas Efferth (2021). Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics . Pharmaceuticals.

Sara Abdelfatah, Madeleine Böckers, Maitane Asensio, Onat Kadioglu, Anette Klinger, Edmond Fleischer, Thomas Efferth(2021). Isopetasin and S-isopetasin as novel P-glycoprotein inhibitors against multidrug-resistant cancer cells . Phytomedicine. 86. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 153196. Elsevier {BV}

Sara Abdelfatah, Nadire Özenver, Anette Klinger, Edmond Fleischer, Thomas Efferth (2021). Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma . Investigational New Drugs.

Sara Abdelfatah, Aveen N. Adham, Alaadin M. Naqishbandi, Nuha Mahmoud, Thomas Efferth(2021). Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells . Phytomedicine. 80. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 153371. Elsevier {BV}

Sara Abdelfatah, Armelle T. Mbaveng, Godloves F. Chi, Idrios N. Bonsou, Alfred N. Tamfu, Elisabeth M.O. Yeboah, Victor Kuete, Thomas Efferth(2020). N-acetylglycoside of oleanolic acid (aridanin) displays promising cytotoxicity towards human and animal cancer cells, inducing apoptotic, ferroptotic and necroptotic cell death . Phytomedicine. 76. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 153261. Elsevier {BV}

Sara Abdelfatah, Armelle T. Mbaveng, Francois Damen, Michel-Gael F. Guefack, Simplice Beaudelaire Tankeo, Gabin T.M. Bitchagno, İlhami Çelik, Victor Kuete, Thomas Efferth(2020). 8,8-bis-(Dihydroconiferyl)-diferulate displayed impressive cytotoxicity towards a panel of human and animal cancer cells . Phytomedicine. 70. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 153215. Elsevier {BV}

(2019). The antioxidant 2,3-dichloro,5,8-dihydroxy,1,4-naphthoquinone inhibits acetyl-cholinesterase activity and amyloid β42 aggregation: A dual target therapeutic candidate compound for the treatment of Alzheimer's disease . Biotechnology and applied biochemistry.

(2019). Cytotoxicity and antimitotic activity of Rhinella schneideri and Rhinella marina venoms . Journal of ethnopharmacology.

Sara Abdelfatah, Mohamed-Elamir F. Hegazy, Ahmed R. Hamed, Tarik A. Mohamed, Abdelsamed A. Elshamy, Ibrahim A. Saleh, Eman H. Reda, Nahla S. Abdel-Azim, Khaled A. Shams, Mahmoud Sakr, et al.(2019). Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells . Phytomedicine. 59. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 152771. Elsevier {BV}

(2019). Identification of inhibitors of the polo-box domain of polo-like kinase 1 from natural and semisynthetic compounds . Investigational new drugs.

Sara Abdelfatah, Angela Berg, Madeleine Böckers, Thomas Efferth(2019). A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening . Journal of Advanced Research. 16. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 145--156. Elsevier {BV}

(2019). MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate . Acta pharmaceutica Sinica. B.

(2018). Treatment of Multidrug-Resistant Leukemia Cells by Novel Artemisinin-, Egonol-, and Thymoquinone-Derived Hybrid Compounds . Molecules.

(2016). Identification of Phlogacantholide C as a Novel ADAM10 Enhancer from Traditional Chinese Medicinal Plants . Medicines (Basel, Switzerland).

Efferth, T., Banerjee, M., Paul, N.W., Abdelfatah, S., Arend, J., Elhassan, G., Hamdoun, S., Hamm, R., Hong, C., Kadioglu, O., et al.(2016). Biopiracy of natural products and good bioprospecting practice . Phytomedicine. 23. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 166-173.

Abdelfatah, S.A.A., Efferth, T.(2015). Cytotoxicity of the indole alkaloid reserpine from Rauwolfia serpentina against drug-resistant tumor cells . Phytomedicine. 22. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 308-318.

OTHER

Sara Abdelfatah, Alexander Panossian, Thomas Efferth(2021). Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations . {MDPI} {AG}

WORKING PAPER

Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations .

Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics .

level-one heading

Freelance consultant and Writer, A Pharmacist with Expertise in Drug development and Cancer research

Postdoctoral researcher

Johannes Gutenberg Universität Mainz

Masters (Science)

Northeastern University

PhD (Department of pharmaceutical biology)

Johannes Gutenberg Universität Mainz

Master

Institute of Endemic Diseases

Bachelor (Faculty of Pharmacy)

University of Khartoum