プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Selene D.に依頼

France

Senior Scientist | Expert in Tumor Microenvironment & Fibrosis | Driving Innovation in Translational & Applied Research

プロフィール概要

Senior Scientist with 15+ years of experience in cancer microenvironment and fibrotic diseases, with a strong background in translational research and academic–industry collaborations. Currently leading research projects at the Institut Pasteur in Paris, I specialize in stromal–immune cell interactions, co-target therapies (including ADCC and CAR-T combinations), and single-cell analysis of fibrotic and tumor tissues. I have developed patented strategies for targeting the tumor stroma in melanoma and breast cancer and collaborated with pharmaceutical companies on antibody development for kidney fibrosis. My expertise spans oncology, immunology, fibrosis, and tissue repair in skin, heart, kidney, and muscle models. I bring a creative yet pragmatic approach, with a solid track record in generating high-impact data and innovative therapeutic strategies.

専門分野

• ☆ Molecular Biology
• ☆ Genetics
• ☆ Omics
• ☆ Genomics
• ☆ PCR
• ☆ Gene Expression Analysis
• ☆ RNA Sequencing
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Stem Cell Research
• ☆ Basic Immunology
• ☆ Adjuvant & Antigen Research
• ☆ Histology
• ☆ Recombinant Protein Expression
• ☆ Microscopy
• ☆ Cryosectioning
• ☆ Light Microscopy
• ☆ Fluorescence Microscopy
• ☆ Scanning Probe Microscopy
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cytometry
• ☆ Cell Aging

サービス

• Consulting

Consulting Scientific and Technical Consulting

職務経験

Permanent researcher

Institut Pasteur

- 現在

Postdoc fellow

Institut Pasteur

3月 2011 - 8月 2017

PhD Fellow

Regina Elena Cancer Institute

9月 2007 - 1月 2011

学歴

PhD

University of Roma "La Sapienza" - Italy

1月 2007 - 1月 2011

認定資格

• Certified in Experimental Rodent Surgery for Biomedical Research | In Vivo Project Designer

  Institut Pastur

  1月 2015 - 現在

出版物

JOURNAL ARTICLE

Selene E. Di Carlo, Jerome Raffenne, Hugo Varet, Anais Ode, David Cabrerizo Granados, Merle Stein, Rachel LEGENDRE, Jan Tuckermann, Corinne Bousquet, Lucie Peduto (2023). Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis . Nature Immunology.

Jean-Marie Jacob, Selene E. Di Carlo, Igor Stzepourginski, Anthony Lepelletier, Papa Diogop Ndiaye, Hugo Varet, Rachel Legendre, Etienne Kornobis, Adam Benabid, Giulia Nigro, et al.(2022). PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms . Cell Stem Cell. 29. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 856--868.e5. Elsevier {BV}

Naciri I, Laisné M, Ferry L, Bourmaud M, Gupta N, Di Carlo S, Huna A, Martin N, Peduto L, Bernard D, et al.(2019). Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors . Nucleic acids research.

Selene E. Di Carlo, Lucie Peduto(2018). The perivascular origin of pathological fibroblasts . Journal of Clinical Investigation. 128. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 54--63. American Society for Clinical Investigation

Di Carlo SE, Peduto L(2018). The perivascular origin of pathological fibroblasts . The Journal of clinical investigation.

Tang A, Dadaglio G, Oberkampf M, Di Carlo S, Peduto L, Laubreton D, Desrues B, Sun CM, Montagutelli X, Leclerc C(2016). B cells promote tumor progression in a mouse model of HPV-mediated cervical cancer . International journal of cancer.

Stagni V, Manni I, Oropallo V, Mottolese M, Di Benedetto A, Piaggio G, Falcioni R, Giaccari D, Di Carlo S, Sperati F, et al.(2015). ATM kinase sustains HER2 tumorigenicity in breast cancer . Nature communications.

Loria R, Bon G, Perotti V, Gallo E, Bersani I, Baldassari P, Porru M, Leonetti C, Di Carlo S, Visca P, et al.(2015). Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells . Oncotarget.

Folgiero V, Di Carlo SE, Bon G, Spugnini EP, Di Benedetto A, Germoni S, Pia Gentileschi M, Accardo A, Milella M, Morelli G, et al.(2012). Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells . Cell death & disease.

Dulauroy S, Di Carlo SE, Langa F, Eberl G, Peduto L(2012). Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury . Nature medicine.

Bon G, Di Carlo SE, Folgiero V, Avetrani P, Lazzari C, D'Orazi G, Brizzi MF, Sacchi A, Soddu S, Blandino G, et al.(2009). Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression . Cancer research.

Folgiero V, Avetrani P, Bon G, Di Carlo SE, Fabi A, Nisticò C, Vici P, Melucci E, Buglioni S, Perracchio L, et al.(2008). Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas . PloS one.