プロフィール詳細

プロジェクトを作成

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Sergii P.に依頼

Czech Republic

Digital Pathology, Computational Oncology, Whole Slide Image AI Analysis, Spatial Biology

プロフィール概要

I am a researcher working in digital pathology, computational oncology, and AI based analysis of whole slide histological images. Together with a multidisciplinary team of pathologists, machine learning specialists, and biostatisticians, I support the full practical workflow of computational pathology projects. This includes dataset organization, annotation strategy, QuPath project setup, export of regions of interest and detected objects, machine learning dataset preparation, deep learning model development, whole slide inference, quantitative analysis, statistical evaluation, and preparation of publication ready outputs. A key part of our work is the development of workflows for serial section registration, cross slide alignment, and integration of multiple histological or immunohistochemical markers. We can align serial sections, transfer regions of interest or cell level data between slides, create spatial maps, and support multi marker tumor microenvironment analysis. We also develop custom computational pathology pipelines and software tools for image registration, automated quantification, spatial analysis, model inference, and integration of QuPath, Python, and PyTorch based workflows. This allows us to support both standard image analysis tasks and more complex projects that require custom solutions. Typical projects include tissue compartment segmentation, tumor and stromal region analysis, immune cell quantification, biomarker analysis, whole slide image processing, AI model training, spatial biology analysis, serial section alignment, and statistical reporting. My goal is to provide clear, practical, reproducible, and scientifically reliable results that can be used for research projects, thesis work, grant applications, reports, and peer reviewed publications. Key publications include: Pavlov S, Ali E, Ye W, Červenková L, Ambrozkiewicz F, Vyčítal O, Daum O, Liška V, Hemminki K, Trailin A. Spatial patterns and prognostic relevance of CD1a+ immature and CD208+ mature dendritic cells in colorectal cancer from non tumor adjacent mucosa to liver metastases. Cancer Immunology, Immunotherapy. 2025. doi: 10.1007/s00262-xxxxxxxxxxx. Pavlov S, Ali E, Ambrozkiewicz F, Ye W, Rajtmajerová M, Liška V, Hemminki K, Trailin A. Macrophages in Colorectal Cancer: from Normal Mucosa to Distant Metastasis: Beyond the M1/M2 Paradigm. Journal of Cancer. 2026. doi: 10.7150/jca.126772. Ye WJ, Ali E, Pavlov S, Červenková L, Ambrozkiewicz F, Vyčítal O, Hošek P, Zitrický F, Daum O, Liška V, Hemminki K, Trailin A. Distribution and prognostic value of macrophages in colorectal cancer and adjacent mucosa in patient stages I III vs IV. World Journal of Gastroenterology. 2026. doi: 10.3748/wjg.v32.i10.115130. Trailin A, Ali E, Ye W, Pavlov S, Červenková L, Vyčítal O, Ambrozkiewicz F, Hošek P, Daum O, Liška V, Hemminki K. Prognostic assessment of T cells in primary colorectal cancer and paired synchronous or metachronous liver metastasis. International Journal of Cancer. 2025. doi: 10.1002/ijc.35252. Ali E, Červenková L, Pálek R, Ambrozkiewicz F, Pavlov S, Ye W, Hošek P, Daum O, Liška V, Hemminki K, Trailin A. Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software. Journal of Visualized Experiments. 2024. doi: 10.3791/66743.

専門分野

• ☆ Biostatistics
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Data Analysis
• ☆ Image Processing
• ☆ Machine Learning
• ☆ Artificial Intelligence
• ☆ Deep Learning
• ☆ Computer Vision
• ☆ Immunohistochemistry
• ☆ Python
• ☆ Tensorflow
• ☆ Scikit-learn
• ☆ In vitro Diagnostics
• ☆ Clinical Laboratory Science
• ☆ Anatomic Pathology
• ☆ Molecular Pathology
• ☆ Cytopathology & Histopathology
• ☆ Histopathology
• ☆ Tissue Microarray

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Medical Writing, Technical Writing

Research Meta-Research, Feasibility Study, Gap Analysis, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Digital Strategy Consulting, Healthcare Consulting, Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Image Processing, Image Analysis, Algorithm Design-ML, Data Visualization, Data Cleaning, Data Processing

Product Development Product Validation, Concept Development, Prototyping

職務経験

Resarch Scientist

Charles University, Faculty of Medicine in Pilsen

5月 2023 - 現在

Professor

Zaporizhzhia State Medical University

1月 2003 - 現在

学歴

PhD (2008), Doctor of science (2015)

State Institution "Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine", Kyiv

1月 2003 - 1月 2008

認定資格

• 認定資格の詳細は未入力です。