プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

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Dr. Sharadkumar K.に依頼

United Kingdom

Biomedical scientist/medical writer: expert in extracellular vesicles, oncology, biomarkers & regenerative medicine

プロフィール概要

Biomedical Scientist | Medical Writer | Expert in Extracellular Vesicles, Oncology & Regenerative Medicine I am an experienced biomedical scientist, medical writer, and researcher with a strong background in oncology, immunology, cardiovascular biology, and regenerative medicine. With two PhDs and over a decade of research experience, I specialize in biomarker discovery, extracellular vesicles, and personalized medicine. Currently, I serve as a Post-Doctoral Senior Researcher at the University of Turin and an Honorary Research Associate at Imperial College London, where I lead and contribute to high-impact research projects. My work focuses on: ✔ Biomarker Discovery: Developing novel miRNA-based methods for predicting acute kidney injury (AKI) in cardiovascular patients. ✔ Extracellular Vesicles & Regenerative Medicine: Investigating stem cell-derived extracellular vesicles for therapeutic applications in kidney fibrosis and cancer. ✔ Oncology Research: Exploring the role of Interleukin-3 in driving the aggressiveness of triple-negative breast cancer. ✔ Medical & Scientific Writing: Authoring high-impact peer-reviewed publications, medical content, and congress materials. I have authored multiple first-author publications in leading journals (Int. J. Mol. Sci, Front. Immunol, J. Extracell. Vesicles), served as a peer reviewer for high-impact journals, and presented my research at international conferences (ISEV, Gordon Research Conference, EVITA Symposium). Additionally, I have successfully secured research grants, including the Rosetree Seedcorn 2022 grant for bioprinting-based wound healing therapies. With expertise in scientific consulting, manuscript development, and medical communications, I am available for collaborations in medical writing, grant writing, literature reviews, and research consulting. Let’s work together to advance impactful scientific solutions. 📩 Let's connect!

専門分野

• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Structural Biology
• ☆ Apoptosis
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Antioxidants
• ☆ Enzyme Activity Assays
• ☆ Binding Assays
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Microarrays
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Gene Expression Analysis
• ☆ Recombinant DNA
• ☆ RNA Synthesis
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cytochemistry
• ☆ Cytogenetics
• ☆ Cell Signaling Pathways
• ☆ Membrane Biology
• ☆ Gene Regulation
• ☆ Stem Cell Research
• ☆ Neuroscience
• ☆ Neurophysiology
• ☆ Neuroanatomy
• ☆ Basic Immunology
• ☆ Adjuvant & Antigen Research
• ☆ Histology
• ☆ Microscopy
• ☆ Cryosectioning
• ☆ Light Microscopy
• ☆ Fluorescence Microscopy
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Banking
• ☆ Cell Line Engineering
• ☆ Large Scale Cell Culture
• ☆ Cell Surface Receptors
• ☆ Biomolecular Engineering
• ☆ Genetic Engineering
• ☆ Immunohistochemistry
• ☆ Cell Aging
• ☆ Human Biology
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Feasibility Studies
• ☆ Fact Checking
• ☆ Literature Search
• ☆ Medical Writing
• ☆ Medical Content Writing
• ☆ Research Summaries & Abstracts
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing
• ☆ Instructional Materials
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Textbook Content Writing
• ☆ Science Communication
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Systematic Literature Review

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing, Technical Writing, Creative Writing, Newswriting, General Proofreading & Editing

Research Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Image Analysis

職務経験

Post doctoral researcher

Imperial College London

2021 - 現在

Senior Researcher

University of Turin

2月 2024 - 1月 2025

Scientific Consultant

Unicyte srl

1月 2021 - 12月 2021

Postdoctoral Researcher

University of Turin

10月 2017 - 1月 2021

Marie Curie Fellow

Bioindustry park

8月 2016 - 9月 2017

Marie Curie Fellow

Fresenius Medical Care Italia SpA

4月 2015 - 3月 2016

Part time Lecturer

London Metropolitan University

9月 2010 - 2016

学歴

PhD - Medical Physiopathology

University of Turin

9月 2017 - 3月 2021

PhD Cancer Immunology

London Metropolitan University

9月 2010 - 1月 2014

Biomedical Sciences (MSc)

London Metropolitan University

9月 2007 - 6月 2009

Biomedical Sciences BSC(Hons)

King's College London

9月 2003 - 6月 2006

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Monica Maccagno, Marta Tapparo, Gabriele Saccu, Letizia Rumiano, Sharad Kholia, Lorenzo Silengo, Maria Beatriz Herrera Sanchez (2024). Emerging Cancer Immunotherapies: Cutting-Edge Advances and Innovations in Development . Medical Sciences.

Spokeviciute B, Kholia S, Brizzi MF (2024). Chimeric antigen receptor (CAR) T-cell therapy: Harnessing extracellular vesicles for enhanced efficacy . Pharmacological research.

Monica Maccagno, Marta Tapparo, Gabriele Saccu, Letizia Rumiano, sharad kholia, Lorenzo Silengo, Maria Beatriz Herrera Sanchez (2024). Emerging Cancer Immunotherapies: Cutting-Edge Advances and Innovations in Development . Medical Sciences.

Kholia, S., Sanchez, M.B.H., Deregibus, M.C., Sassoè‐pognetto, M., Camussi, G., Brizzi, M.F.(2021). Human liver stem cell derived extracellular vesicles alleviate kidney fibrosis by interfering with the β‐catenin pathway through mir29b . International Journal of Molecular Sciences. 22. (19).

Kholia, S., Herrera Sanchez, M.B., Cedrino, M., Papadimitriou, E., Tapparo, M., Deregibus, M.C., Bruno, S., Antico, F., Brizzi, M.F., Quesenberry, P.J., et al.(2020). Mesenchymal Stem Cell Derived Extracellular Vesicles Ameliorate Kidney Injury in Aristolochic Acid Nephropathy . Frontiers in Cell and Developmental Biology. 8.

Lopatina, T., Grange, C., Fonsato, V., Tapparo, M., Brossa, A., Fallo, S., Pitino, A., Herrera-Sanchez, M.B., Kholia, S., Camussi, G., et al.(2019). Extracellular vesicles from human liver stem cells inhibit tumor angiogenesis . International Journal of Cancer. 144. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 322-333.

Sisa, C., Kholia, S., Naylor, J., Sanchez, M.B.H., Bruno, S., Deregibus, M.C., Camussi, G., Inal, J.M., Lange, S., Hristova, M.(2019). Mesenchymal stromal cell derived extracellular vesicles reduce hypoxia-ischaemia induced perinatal injury . Frontiers in Physiology. 10. (MAR).

Kholia, S., Herrera Sanchez, M.B., Cedrino, M., Papadimitriou, E., Tapparo, M., Deregibus, M.C., Brizzi, M.F., Tetta, C., Camussi, G.(2018). Human liver stem cell-derived extracellular vesicles prevent aristolochic acid-induced kidney fibrosis . Frontiers in Immunology. 9. (JUL).

et al., Bruno S, Tapparo M, Collino F, Chiabotto G, Deregibus MC, Soares Lindoso R, Neri F, Kholia S, Giunti S, Wen S(2017). Renal Regenerative Potential of Different Extracellular Vesicle Populations Derived from Bone Marrow Mesenchymal Stromal Cells . Tissue engineering. Part A.

Herrera Sanchez MB, Previdi S, Bruno S, Fonsato V, Deregibus MC, Kholia S, Petrillo S, Tolosano E, Critelli R, Spada M, et al.(2017). Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency . Stem cell research & therapy.

Lange S, Gallagher M, Kholia S, Kosgodage US, Hristova M, Hardy J, Inal JM(2017). Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release? . International journal of molecular sciences.

Bruno, S., Tapparo, M., Collino, F., Chiabotto, G., Deregibus, M.C., Soares Lindoso, R., Neri, F., Kholia, S., Giunti, S., Wen, S., et al.(2017). Renal Regenerative Potential of Different Extracellular Vesicle Populations Derived from Bone Marrow Mesenchymal Stromal Cells . Tissue Engineering - Part A. 23. (21-22). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1262-1273.

Herrera Sanchez, M.B., Previdi, S., Bruno, S., Fonsato, V., Deregibus, M.C., Kholia, S., Petrillo, S., Tolosano, E., Critelli, R., Spada, M., et al.(2017). Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency . Stem Cell Research and Therapy. 8. (1).

Lange, S., Gallagher, M., Kholia, S., Kosgodage, U.S., Hristova, M., Hardy, J., Inal, J.M.(2017). Peptidylarginine deiminases—roles in cancer and neurodegeneration and possible avenues for therapeutic intervention via modulation of exosome and microvesicle (EMV) release? . International Journal of Molecular Sciences. 18. (6).

Grange, C., Tapparo, M., Kholia, S., Bussolati, B., Camussi, G.(2017). The Distinct Role of Extracellular Vesicles Derived from Normal and Cancer Stem Cells . Current Stem Cell Reports. 3. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 218-224.

Kholia S, Ranghino A, Garnieri P, Lopatina T, Deregibus MC, Rispoli P, Brizzi MF, Camussi G(2016). Extracellular vesicles as new players in angiogenesis . Vascular pharmacology.

Lopatina, T., Gai, C., Deregibus, M.C., Kholia, S., Camussi, G.(2016). Cross talk between cancer and mesenchymal stem cells through extracellular vesicles carrying nucleic acids . Frontiers in Oncology. 6. (MAY).

Burrello J, Monticone S, Gai C, Gomez Y, Kholia S, Camussi G(2016). Stem Cell-Derived Extracellular Vesicles and Immune-Modulation . Frontiers in cell and developmental biology.

Burrello, J., Monticone, S., Gai, C., Gomez, Y., Kholia, S., Camussi, G.(2016). Stem cell-derived extracellular vesicles and immune-modulation . Frontiers in Cell and Developmental Biology. 4. (AUG).

Lopatina T, Gai C, Deregibus MC, Kholia S, Camussi G(2016). Cross Talk between Cancer and Mesenchymal Stem Cells through Extracellular Vesicles Carrying Nucleic Acids . Frontiers in oncology.

Kholia, S., Ranghino, A., Garnieri, P., Lopatina, T., Deregibus, M.C., Rispoli, P., Brizzi, M.F., Camussi, G.(2016). Extracellular vesicles as new players in angiogenesis . Vascular Pharmacology. 86. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 64-70.

Nawaz, M., Fatima, F., Vallabhaneni, K.C., Penfornis, P., Valadi, H., Ekström, K., Kholia, S., Whitt, J.D., Fernandes, J.D., Pochampally, R., et al.(2016). Extracellular Vesicles: Evolving Factors in Stem Cell Biology . Stem Cells International. 2016.

Nawaz M, Fatima F, Vallabhaneni KC, Penfornis P, Valadi H, Ekström K, Kholia S, Whitt JD, Fernandes JD, Pochampally R, et al.(2016). Extracellular Vesicles: Evolving Factors in Stem Cell Biology . Stem cells international.

Jorfi S, Ansa-Addo EA, Kholia S, Stratton D, Valley S, Lange S, Inal J(2015). Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo . Scientific reports.

Jorfi, S., Ansa-Addo, E.A., Kholia, S., Stratton, D., Valley, S., Lange, S., Inal, J.(2015). Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo . Scientific Reports. 5.

Kholia S, Jorfi S, Thompson PR, Causey CP, Nicholas AP, Inal JM, Lange S(2015). A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy . Journal of extracellular vesicles.

Kholia, S., Jorfi, S., Thompson, P.R., Causey, C.P., Nicholas, A.P., Inal, J.M., Lange, S.(2015). A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy . Journal of Extracellular Vesicles. 4. (1).

Stratton D, Lange S, Kholia S, Jorfi S, Antwi-Baffour S, Inal J(2014). Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance . Biochemical and biophysical research communications.

Stratton, D., Lange, S., Kholia, S., Jorfi, S., Antwi-Baffour, S., Inal, J.(2014). Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance . Biochemical and Biophysical Research Communications. 453. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 619-624.

Inal JM, Ansa-Addo EA, Stratton D, Kholia S, Antwi-Baffour SS, Jorfi S, Lange S(2012). Microvesicles in health and disease . Archivum immunologiae et therapiae experimentalis.

Inal, J.M., Ansa-Addo, E.A., Stratton, D., Kholia, S., Antwi-Baffour, S.S., Jorfi, S., Lange, S.(2012). Microvesicles in health and disease . Archivum Immunologiae et Therapiae Experimentalis. 60. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 107-121.

Grant R, Ansa-Addo E, Stratton D, Antwi-Baffour S, Jorfi S, Kholia S, Krige L, Lange S, Inal J(2011). A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma . Journal of immunological methods.

Grant, R., Ansa-Addo, E., Stratton, D., Antwi-Baffour, S., Jorfi, S., Kholia, S., Krige, L., Lange, S., Inal, J.(2011). A filtration-based protocol to isolate human Plasma Membrane-derived Vesicles and exosomes from blood plasma . Journal of Immunological Methods. 371. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 143-151.

Antwi-Baffour S, Kholia S, Aryee YK, Ansa-Addo EA, Stratton D, Lange S, Inal JM(2010). Human plasma membrane-derived vesicles inhibit the phagocytosis of apoptotic cells--possible role in SLE . Biochemical and biophysical research communications.

Antwi-Baffour, S., Kholia, S., Aryee, Y.K.-D., Ansa-Addo, E.A., Stratton, D., Lange, S., Inal, J.M.(2010). Human plasma membrane-derived vesicles inhibit the phagocytosis of apoptotic cells - Possible role in SLE . Biochemical and Biophysical Research Communications. 398. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 278-283.

BOOK CHAPTER

Bruno, S., Kholia, S., Deregibus, M.C., Camussi, G.(2019). The role of extracellular vesicles as paracrine effectors in stem cell-based therapies . Advances in Experimental Medicine and Biology. 1201. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 175-193.

Lange, S., Kholia, S., Kosgodage, U.S., Inal, J.M.(2017). Treatment of prostate cancer using deimination antagonists and microvesicle technology . Protein Deimination in Human Health and Disease: Second Edition. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 413-425.