プロフィール詳細

プロジェクトを作成

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Dr. Sharif A.に依頼

United States

Highly accomplished Medicinal/Organic chemist with 8 years of industrial small molecule drug discovery experience

プロフィール概要

Accomplished synthetic organic and medicinal chemist — 8 years of biopharmaceutical industry experience with proven track records in small molecule drug discovery. Skilled in hit screening, hit to lead, lead op, and preclinical development. Experience in leading projects from several disease areas, e.g., oncology and autoimmune diseases. Key inventor of various kinase, protease, and other physiological pathway inhibitors. Gained practical know-how of evaluating candidates for IND enabling studies. Successfully completed process development and impurity ID profiling of IND candidates and approved drugs. Inventor of novel methodologies to enantioselectively synthesize all-carbon quaternary building blocks and natural products. − Highly skilled in organic & medicinal chemistry bench activities — organic method development, total synthesis, multistep/parallel synthesis, asymmetric synthesis, heterocyclic chemistry, metal catalysis, air/moisture sensitive reactions, optimization & scale-up, and purification & characterization of compounds with a wide range of modern chromatographic and spectroscopic techniques. − Adept in conceiving and investigating new synthetic routes, troubleshooting existing routes, and well-versed in practical know-how of process development and impurity ID profiling. − Skilled in structure-based drug design (SBDD) utilizing CADD tools such as Schrodinger Maestro/Glide, MOE and seeSAR (BiosolveIT) as well as traditional SAR based drug design. − Adept in summarizing chemical, physicochemical, biochemical, biophysical, & ADME/PK data, extracting clues, and implementing these clues in rational drug design in all stages of drug discovery processes. − Highly competent in conceiving new scientific ideas as well as skilled in designing and executing experiments to obtain sound POC data. Expertise in IP space and patentability. − Skilled in chemical and biological databases, softwares, and ELNs such as Scifinder, Reaxys, Dotmatics, Scilligence, RegMol, BIOVIA, CDD Vault, Chemdraw, ACD, Mnova, PDB, Schrodinger, MOE, seeSAR, Vortex data analysis & visualization, BOX, etc. − Experience in managing FTEs in CROs and in-house research associates, mentoring undergraduate and fellow graduate student researchers, mentoring newly appointed TAs and skilled in conducting large group of students in a class setting. − Gained exposure to multiple therapeutics areas and earned capability to promptly acquire advanced know-how associated with the newly exposed therapeutic areas. − Effective writer, communicator, and reviewer of complex scientific concepts and findings with experience in delivering high quality data packages, written reports, and slide decks. − A regular reader of scientific literatures — most up to date with news, literatures, and emerging trends in small molecule drug discovery R&D.

専門分野

• ☆ Chemoinformatics
• ☆ Separation & Purification
• ☆ Spectroscopy
• ☆ NMR Spectroscopy
• ☆ Mass Spectrometry
• ☆ Liquid Chromatography/HPLC
• ☆ Retrosynthesis
• ☆ Computational Chemistry
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Small Molecule Drug Development
• ☆ Preclinical ADME/PK/PD

サービス

• Research
• Consulting

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

職務経験

Associate director, medicinal chemistry

Athos Therapeutics

8月 2022 - 現在

Contract Consultant, Medicinal Chemistry

Alexion-Astrazeneca Rare Disease

2月 2021 - 12月 2021

Senior Scientist, Medicinal Chemistry

Turning Point Therapeutics

11月 2019 - 9月 2020

Scientist, Medicinal Chemistry

Samumed, LLC

8月 2018 - 11月 2019

Research Scientist, Medicinal Chemistry

NantBioscience, Inc.

8月 2015 - 4月 2018

学歴

PhD (Chemistry)

University of Wisconsin System - United States

9月 2009 - 7月 2015

認定資格

• Pharmacokinetics for Chemists: Essential Concepts for Drug Development

  AMERICAN CHEMICAL SOCIETY

  1月 2023 - 現在

出版物

JOURNAL ARTICLE

M. Shahnawaz Ali, Mizzanoor Rahaman, Jawad Bin Belayet, Sharif A. Asad, M. Mahmun Hossain(2022). An approach for preparing 3,3-disubstituted oxindole from acyclic tetrasubstituted aldehyde: Total synthesis of (-)-coerulescine & (-)-coixspirolactam A . Results in Chemistry. 4. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 100389. Elsevier {BV}

Sharif Asad, Matthew Huisman, Mizzanoor Rahaman, Sarah Oehm, Sherwin Novin, Arnold L. Rheingold, M Mahmun Hossain(2019). Total Synthesis of Tryprostatin B: Synthesis and Asymmetric Phase-Transfer-Catalyzed Reaction of Prenylated Gramine Salt . Organic Letters. 21. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 134--137. American Chemical Society ({ACS})

Nazim Uddin, Mizzanoor Rahaman, Eduardo Alberch, Sharif A. Asad, M. Mahmun Hossain(2018). Palladium(0)-catalyzed rearrangement of allyl enol ethers to form chiral quaternary carbon centers via asymmetric allylic alkylation . Tetrahedron Letters. 59. (37). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3401--3404. Elsevier {BV}

Sharif Asad, M. Hossain, Eduardo Alberch, Colin Brook, Maria Shevyrev, Joseph Ulicki(2015). Stereoselective Allyl Enol Carbonates for the Synthesis of Chiral Aldehydes Bearing All Carbon Quaternary Stereocenters via the Decarboxylative Asymmetric Allylic Alkylation (DAAA) . Synlett. 26. (03). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 388--392. Georg Thieme Verlag {KG}

Sharif A. Asad, Joseph Ulicki, Maria Shevyrev, Nazim Uddin, Eduardo Alberch, M. Mahmun Hossain(2014). First Example of the Intermolecular Palladium-Catalyzed Asymmetric Allylic Alkylation of Hydroxyacrylates: Synthesis of All-Carbon α-Aryl Quaternary Aldehydes . European Journal of Organic Chemistry. 2014. (26). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5695--5699. Wiley

PATENT

Sharif (2020). Trk inhibition . USPTO.

Sharif (2020). Trk inhibition . USPTO.

DISSERTATION THESIS

Sharif (2015). Asymmetric synthesis of all-carbon α-aryl quaternary carbonyl compounds by palladium-catalyzed asymmetric allylic alkylation (Pd-AAA) and their application to the synthesis of biologically important 3,3 ′-disubstituted oxindole and α-disubstituted quaternary β-lactone frameworks .

BOOK CHAPTER

Eduardo Alberch, Joseph S. Ulicki, MD. Sharif Asad, M. Mahmun Hossain(2013). The Chemistry of Iron-Alkyl Complexes . PATAI'S Chemistry of Functional Groups. John Wiley {\&} Sons, Ltd